Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics (대한후두음성언어의학회지)

The Korean Society of Laryngology, Phoniatrics and Logopedics. (대한후두음성언어의학회)
권호 표지

The Effect of Nasal Steroid Spray on Contact Granuloma of Larynx

접촉성 육아종 치료에 비강 스테로이드 분무가 미치는 영향

  • Lee, GilJoon (Department of Otorhinolaryngology-Head and Neck Surgery, Kyungpook National University School of Medicine) ;
  • Ahn, Dongbin (Department of Otorhinolaryngology-Head and Neck Surgery, Kyungpook National University School of Medicine) ;
  • Sohn, Jin Ho (Department of Otorhinolaryngology-Head and Neck Surgery, Kyungpook National University School of Medicine)
  • 이길준 (경북대학교 의과대학 이비인후-두경부외과학교실) ;
  • 안동빈 (경북대학교 의과대학 이비인후-두경부외과학교실) ;
  • 손진호 (경북대학교 의과대학 이비인후-두경부외과학교실)
  • Received : 2018.01.09
  • Accepted : 2018.10.30
  • Published : 2018.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

Background and Objectives : Laryngeal contact granuloma is benign inflammatory disease induced by excessive mechanical contact of larynx such as endotracheal intubation, voice abuse, laryngeal microsurgery as well as laryngopharygeal reflux. Because it is caused by various risk factors, multiple treatment modalities are required. The purpose of study is to evaluate treatment effect of topical steroid through nasal cavity in contact granuloma. Materials and Method : Fifty-two patients were enrolled in this study with exception of intubation granuloma. Patients were classified with four groups (Proton pump inhibitor (PPI), Nasal steroid spray (SPR), PPI+SPR, Observation) according to treatment modality. Results : Patients who treated with PPI (Odds ratio 2.45, p=0.03) and combination of PPI and SPR (Odds ratio 2.88, p<0.01) had significantly better response than patients who not treated with medical therapy. Conclusion : Combination therapy of nasal steroid spray and PPI is effective for contact granuloma of larynx and considered as a treatment of choice rather than PPI only treatment.

Keywords

References

  1. Carroll TL, Gartner-Schmidt J, Statham MM, Rosen CA. Vocal process granuloma and glottal insufficiency: an overlooked etiology? Laryngoscope 2010;120:114-20. https://doi.org/10.1002/lary.21321
  2. Ylitalo R, Linestad PA. Laryngeal findings in patients with contact granuloma: A Long-Term Follow-Up study. Acta Otolaryngol 2000;120:655-9. https://doi.org/10.1080/000164800750000504
  3. Lee JC, Wang SG. Management of vocal process granuloma. Korean J Otolaryngol 2005;48:70-3.
  4. Ylitalo R, Ramel S. Gastroesophagopharyngeal reflux in patients with contact granuloma: A prospective controlled study. Ann Otol Rhinol Laryngol 2002;111:178-83. https://doi.org/10.1177/000348940211100213
  5. Roh HJ, Goh EK, Chon KM, Wang SG. Topical inhalant steroid (budesonide, Pulmicort nasal) therapy in intubation granuloma. J Laryngol Otol 1999;113:427-32. https://doi.org/10.1017/S0022215100144147
  6. Lee JC, Wang SG. Management of vocal process granuloma. Korean J Otolaryngol 2005;48:70-3.
  7. Blafsky PC, Postma GN, Koufman JA. The validity and reliability of the reflux finding score (RFS). Laryngoscope 2001;111:1313-7. https://doi.org/10.1097/00005537-200108000-00001
  8. Cherry J, Margulies SI. Contact ulcer of the larynx. Laryngoscope 1968;78:1937-40. https://doi.org/10.1288/00005537-196811000-00007
  9. Wani MK, Woodson GE. Laryngeal contact granuloma. Laryngoscope 1999;109:1589-93. https://doi.org/10.1097/00005537-199910000-00008
  10. HM Park, NR Oh, MK Baek, DY Kim, JH Woo. Treatment Result of Proton Pump Inhibitor, Steroid Inhaler and Botulinum Tonxin Injection for Contact Granuloma. J Korean Soc Laryngol Phoniatr Logop 2017;28(1):32-37. https://doi.org/10.22469/jkslp.2017.28.1.32
  11. Nasri S, Sercarz JA, McAlpin T, Berke GS. Treatment of vocal fold granuloma using botulinum toxin type A. Laryngoscope 1995;105(6):585-8. https://doi.org/10.1288/00005537-199506000-00005
  12. Havas TE, Priestley J, Lowinger DS. A management strategy for vocal process granulomas. Laryngoscope 1999;109:301-6. https://doi.org/10.1097/00005537-199902000-00023
  13. Damrose EJ, Damrose JF. Botulinum toxin as adjunctive therapy in refractory laryngeal granuloma. J Laryngol Otol 2008;122(8):824-8. https://doi.org/10.1017/S0022215107000710
  14. Lee SW, Hong HJ, Choi SH, Sun DI, Park YH, Lee BJ, et al. Comparison of treatment modalities for contact granuloma: a nationwide multicenter study. Laryngoscope 2014;124:1187-91. https://doi.org/10.1002/lary.24470
  15. Hillel AT, Lin LM, Samlan R, Starmer H, Leahy K, Flint PW. Inhaled triamcinolone with proton pump inhibitor for treatment of vocal process granulomas: a series of 67 granulomas. Ann Otol Rhinol Laryngol 2010;119(5):325-30. https://doi.org/10.1177/000348941011900509