• Journal of Acupuncture Research
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• 제23권4호
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• pp.123-134
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• 2006

Objectives : To research the study related to acnes with acupuncture In literature, and to establish the hereafter direction of treating acnes with acupuncture. Methods : We searched oriental medical literature, PubMed, NDSL and 1055 related to acne and acupuncture. Results : 1 Among the meridians, the Large Intestine Meridian, the Stomach Meridian, the Bladder Meridian and the Spleen Meridian were commonly used. 2. Among acupuncture point, Zusanli(ST36), Quchi(LI11) and Sanyinjiao(SP6) were mostly used. 3. The methods are focused on expelling wind-damp, heat-clearing, blood-harmony, transport function of stomach and spleen. 4. Auricular acupressure were used on Naebunbijeom, Pijihajeom, Pejeom and Shinmun.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 2009년도 춘계학술대회
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• pp.205-206
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• 2009

To clarify the distinction between three difference acupoints, the effects of acupuncture on a behavioral performance were evaluated following formalin test. Male Sprague-Dawley rats were used. Each rat received a manual acupuncture at ST36 (zusanli), SP9 (yinlingquan) or BL60 (kunlun) acupoint before formalin injection. The flinching and licking responses were counted by two blinder investigators. The pretreatment of BL60 acupoint was showed significantly inhibition in flinch behavior as compared with control group. These results suggest that acupuncture at BL60 acupuncture may be effective in relieving inflammatory pain.

• 동의신경정신과학회지
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• 제15권1호
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• pp.197-209
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• 2004

Objectives : The purpose of this case-control research was to investigate the effects of acupuncture stimulation on autonomic nervous system for patients with HRV and to find out relationship with anti-stress effects. Methods : The study group consists of 24 patients with self-recognition of stress as the case group, and 20 normal person as the control group by similar age. We measured HRV of case and control groups before acupuncture stimulation, prick acupuncture in Hegu(LI4), Taichong(Liv3), Shenme(H7), Neiguan(P6), Zusanli(S36). After treating for 20 minutes, measurement values of HRV and PSV were compared for pre-acupuncture and post-acupuncture. Results : 1. LF norm, HF norm, LF/HF between the case and control groups were significant different in HRV before acupuncture stimulation in the 1st experiment. 2. HRT, SDNN, SDSD, LF norm, HF norm, and LF/HF of the case group were significant different in HRV after acupuncture stimulation in the 1st experiment. HRT of the case group was significantly different in HRV after acupuncture stimulation in the 1st experiment. 3. LF norm, HF norm, LF/HF of the case group were significant different between the 1st and 2nd experiment in HRV before acupuncture stimulation. 4. LF norm, HF norm, and LF/HF were significant different between the 1st and 2nd experiment in HRV of patients whose symptoms improved. But HRV of patients whose symptoms unimproved didn't show significant difference. Conclusion : The results suggest that acupuncture stimulation is associated with changed activity in the sympathetic and parasympathetic nervous system. Measurement values of HRV is suitable to estimate the activity of automatic nervous system.

• 한국임상수의학회지
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• 제24권4호
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• pp.499-502
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• 2007

본 연구는 전기충격 요법으로 얻은 한국산 건조봉독을 랫드의 포르말린 시험으로 항통각 효능을 관찰하였다. 실험동물로 수컷 Spraque-Dawley 랫드(평균 체중 265.38g, 6주령) 56마리를 각 군당 8마리씩 4개군으로 분류하였다. 봉독 투여군은 6 mg/kg 투여군과 0.6 mg/kg 투여군, 0.06 mg/kg 투여군으로 분류하였고, 대조군에는 생리식염수를 투여하였다. 건조 봉독은 포르말린을 투여하기 15분 전에 족삼리(ST-36)에 피하로 투여하였다. 통증은 1%포르말린 $50{\mu}l$을 랫드의 우측 뒷발바닥의 피하에 투여하여 유발하였다. 랫드가 포르말린을 투여한 후 우측 후지를 입으로 핥거나 깨무는 등의 행동을 포르말린 유발 통증행동으로 평가하였으며, 포르말린 투여 후 60분간 랫드의 통증 반응을 관찰하였다. 랫드의 통증반응은 첫 10분간은 5분 간격으로 관찰하였고, 10분 후부터 60분까지 10분 간격으로 관찰하였다. 한국산 건조 봉독은 봉독 투여 후 10분 이내에는 통증 억제 반응을 나타내지 않았으나, 봉독 투여 10분 후에 용량 의존적인 통증 억제 반응을 보였다. 이상의 결과에서 랫드의 포르말린 시험에서 한국산 건조봉독의 통증 억제 반응은 봉독량에 의존성을 보였고, 통증치료에 있어 다른 약물을 대체하여 사용될 수 있을 것으로 생각된다.

• 동의생리병리학회지
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• 제20권2호
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• pp.365-371
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• 2006

Bee Venom aqua-acupuncture (BVA) simultaneously exerts pharmacological effects of biologically active compounds, existed in the whole bee venom, and medicinal effect of the stimulation of acupuncture points. BVA has been considered as a promising therapeutic method for treating various chronic diseases, mainly accompanying severe pain and inflammation. As a painless injection device, jet injectors have been commercially marketed for various clinical applications including insulin injection and vaccination. Among them, a pressure-driven jet injector system could be used for intradermal delivery of a variety of drugs. The aim of this study was to investigate the analgesic effects of the BVA using a needle-free injector (Biojector $2000^{\circledR}$, Bioject Inc., OR, USA), compared to the conventional BV aqua-acupuncture using a typical syringe. Adult Sprague-Dawley rats were injected with bee venom $(0.08mg/kg,\;50{\mu}l)$ using Biojector $2000^{\circledR}$ (BVA-B) or a syringe (BVA-5) into the Zusanli (ST36) acupoint, 30 minutes before plantar injection of 2% formalin. It was found that BVA-B-, or BVA-5-treated rats, compared to controls, exhibited significantly less licking behavior during the late phase in the rat formalin test, when compared to controls. During early phase, however, those effects were not significant but substantial. The analgesic effect of BVA-B was also compatible with that of the conventional BVA-5. In the immunohistochemical studies, BVA-B significantly suppressed the expression of formalin-evoked c-fos, a biomarker of neuronal activity, in the lumbar dorsal horn of the spinal cord. These results indicated that BVA-B waseffective in the modulation of pain in the rat formalin test, compared to BVA-5. Taken together, the needle-free jet injector system could be substituted for the conventional aqua- acupuncture with the advantage of little pain.

• 한국전문물리치료학회지
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• 제17권1호
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• pp.69-76
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• 2010

Ischemia that causes stroke induces inflammation of brain cells and apoptosis and as a result, it influences much on the functional part of a man. The needle electrode electrical stimulation (NEES) that combines acupuncture of oriental medicine with electric therapy of western medicine relieves inflammation of cells and has effect on regrowth of nerve tissues. This study was conducted to verify the influence of NEES on the occurrence of c-Fos of cerebrum after applying NEES to the meridian point, Zusanli (ST 36) of a rats with induced ischemia. Global ischemia was induced by using ligation method on common carotid artery of male Sprague Dawley (SD) rats. The ligation was maintained for 5 minutes and then suture was removed for blood reperfusion. After inducing global ischemia, NEES was done to the left and right meridian points of Joksamri of a rat for 30 minutes after 12 hours, 24 hours, and 48 hours. The findings were as follows. 1. In the result of immunohistochemical method, the number of c-Fos immune response cells significantly decreased (P<.05) in NEES group than the control group (GI) that did not get NEES. 2. In the result of western blotting, the occurrence of c-Fos after 24 hours from the inducement of ischemia significantly decreased (P<.05) in NEES group than the control group (GI) that did not get NEES. Therefore, as the effect of NEES was shown highest after 24 hours from the ischemia, it is suspected that NEES would take important role in early treatment after cerebral stroke.

• 국제물리치료학회지
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• 제1권2호
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• pp.107-112
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• 2010

The majority of strokes are caused by ischemia and result in brain tissue damage, leading to problems of the central nervous system including hemiparesis, dysfunction of language and consciousness, and dysfunction of perception. The purpose of this study was to investigate the effects of Poly(ADP-ribose) polymerase(PARP) on necrosis in neuronal cells that have undergone needle electrode electrical stimulation(NEES) prior to induction of ischemia. Ischemia was induced in male SD rats(body weight 300g) by occlusion of the common carotid artery for 5 min, after which the blood was reperfused. After induction of brain ischemia, NEES was applied to Zusanli(ST 36), at 12, 24 and 48 hours. Protein expression was investigated using immuno-reactive cells, which react to PARP antibodies in cerebral nerve cells, and Western blotting. The results were as follows: In the cerebral cortex, the number of PARP reactive cells after 24 hours significantly decreased(p<.05) in the NEES group compared to the GI group. PARP expression after 24 hours significantly decreased(p<.05) in the NEES group compared to the GI group. As a result, NEES showed the greatest effect on necrosis-related PARP immuno-reactive cells 24 hours after ischemia, indicating necrosis inhibition, blocking of neural cell death, and protection of neural cells. Based on the results of this study, NEES can be an effective method of treating dysfunction and improving function of neuronal cells in brain damage caused by ischemia.

• Journal of Acupuncture Research
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• 제21권5호
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• pp.45-58
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• 2004

It is well known that both of acupuncture and moxibustion are effective for treatment of human disease. For years, they have been utilizing a electro-acupuncture (EA) and moxibustion in attempt to manage gastric symptom. However, the data of combined EA and moxibustion on clinical effectiveness is conflicting and the action of combineAd acupoints is not well known. BL21 and ST36 which belong to bladder Meridian and stomach meridian are acupuncture points frequently used for healing gastrointestinal disease in oriental medicine. The present study was conducted to see the effects produced by combined electro-acupuncture(EA) and moxibustion using BL21 and ST36 on serum gastrin level in rats. In experiment, male Spraque-Dawley rats(body wt 140-160g) were selected. EA (2 Hz, intensity ; 10 times muscle twitch threshold) was applied for 30 minutes to ST36 under halothane anesthesia. Moxibustion($1.6{\pm}0.3 mg$, 5 times of a day) was applied during 3 days to BL21 under halothane anesthesia. Synergy effects of combined EA and moxibustion might be in according to stimulated method and used acupoints. The change of serum gastrin levels produced by combined EA and moxibustion is shown after vagotomy. These data suggested that many factors, such as the selection of acupoints, the stimulated EA methods, are capable of affecting combined EA and moxibustion effects and those effects may be not related with nervous system.

• Journal of Acupuncture Research
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• 제26권6호
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• pp.91-100
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• 2009

Objectives : The objective of this study is to investigate Anti-nociceptive and anti-inflammatory effects of Clematidis Radix (CR) herbal-acupuncture on the test rats with induced acute pain. Methods : The effects of Clematidis Radix (CR)-distillates were investigated in three types of models with three different pain. Highly purified distillate of CR called CR herbal-acupuncture was injected to Zusanli ($ST_{36}$) acupoint. In the tail flick test, the CR herbal-acupuncture treatment did not show a significant effect of relieving acute pain. To investigate the anti-inflammatory effect of CR herbal-acupuncture, the second testing model'pain was induced by injecting formalin to its planter. For the last model, carrageenan was injected into tarsal joint. the medicinal effect of CR herbal-acupuncture was evaluated through the behavioral analyses such as licking time, weight distribution ratio and ankle circumference. Results : In the formalin test, the analgesic effect of CR herbal-acupuncture was more pronounced in the late phase (for 20 min after the early phase) than in the early phase (for the first 10 min post formalin injection). It was proven by weight distribution ratio testing and ankle edema testing that herbal-acupuncture of CR inhibited arthritis caused by the carrageenan. Conclusions : These results revealed that CR herbal-acupuncture was effective to alleviate the inflammatory pain and could be used as an analgesic treatment with an anti-inflammatory effect.

• Journal of Acupuncture Research
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• 제34권3호
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• pp.13-21
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• 2017

Objectives : The purpose of this study was to investigate the effect of acupuncture treatment (AT) in the tendency of increase of the need for AT for the treatment of Parkinson's disease (PD) worldwide and to investigate the advancements in AT research in Korea and the future directions of research on this topic. Methods : Until May 2017, the PubMed, Scopus, Medline, and four Korean databases were searched. The searched keywords were "Parkinson's disease", "Acupuncture", and "Intervention study". The intervention groups from all screened original studies were analyzed and the methods used to determine the effect of AT on PD were examined. Results : A total of 17 studies were grouped by country on the basis of the first author's position, of which 10 studies were conducted in China, four in the United States, two in Korea, and one in Brazil. The most common type of intervention was electroacupuncture (nine studies), followed by AT (six studies), and a combination of AT and bee venom AT (two studies). The most frequently used acupoints in AT were Baihui (GV20), Taichong (LR3), Zusanli (ST36), Sanyinjiao (SP6), and Yanglingquan (GB34). The most commonly used tool for evaluation of PD was the Unified Parkinson's Disease Rating Scale III, which assesses motor functions. Conclusion : The screened studies reported that there were no adverse effects of AT on drug therapy, and AT reduced the dose of drugs used in PD treatment. Future studies on PD treatment with AT should use the acupoints GV20, LR3, ST36, SP6, and GB34, and the meridians Gallbladder meridian and Governor Vessel. Clinical studies on PD should use CONSORT or STRICTA to ensure the quality of national studies and allow the development of new tools for the assessment of the effect of AT on PD using the above criteria.