Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
권호 표지
DOI QR코드

DOI QR Code

Current Status of Intervention Studies on Acupuncture for Parkinson's Disease

  • Kim, Deok Hyun (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Gachon University) ;
  • Sin, Dae Chul (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Gachon University) ;
  • Song, Ho Sueb (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Gachon University)
  • Received : 2017.06.26
  • Accepted : 2017.08.01
  • Published : 2017.08.20
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : The purpose of this study was to investigate the effect of acupuncture treatment (AT) in the tendency of increase of the need for AT for the treatment of Parkinson's disease (PD) worldwide and to investigate the advancements in AT research in Korea and the future directions of research on this topic. Methods : Until May 2017, the PubMed, Scopus, Medline, and four Korean databases were searched. The searched keywords were "Parkinson's disease", "Acupuncture", and "Intervention study". The intervention groups from all screened original studies were analyzed and the methods used to determine the effect of AT on PD were examined. Results : A total of 17 studies were grouped by country on the basis of the first author's position, of which 10 studies were conducted in China, four in the United States, two in Korea, and one in Brazil. The most common type of intervention was electroacupuncture (nine studies), followed by AT (six studies), and a combination of AT and bee venom AT (two studies). The most frequently used acupoints in AT were Baihui (GV20), Taichong (LR3), Zusanli (ST36), Sanyinjiao (SP6), and Yanglingquan (GB34). The most commonly used tool for evaluation of PD was the Unified Parkinson's Disease Rating Scale III, which assesses motor functions. Conclusion : The screened studies reported that there were no adverse effects of AT on drug therapy, and AT reduced the dose of drugs used in PD treatment. Future studies on PD treatment with AT should use the acupoints GV20, LR3, ST36, SP6, and GB34, and the meridians Gallbladder meridian and Governor Vessel. Clinical studies on PD should use CONSORT or STRICTA to ensure the quality of national studies and allow the development of new tools for the assessment of the effect of AT on PD using the above criteria.

Keywords

References

  1. Korean neurological association. Neurology. Seoul: Koonja. 2007:466-75.
  2. Verhagen Metman L. Recognition and treatment of response fluctuations in parkinson's disease: review article. Amino Acids. 2002; 23(1-3):141-5. https://doi.org/10.1007/s00726-001-0119-1
  3. NPF. What is Parkinson's? [Internet]. Miami: National Parkinson Foundation [cited 2017 Jun 19]. Available from: http://www.parkinson.org/understandingparkinsons/what-is-parkinsons
  4. Shulman LM, Wen X, Weiner WJ et al. Acupuncture therapy for the symptoms of Parkinson's disease. Mov Disord. 2002;17(4): 799-802. https://doi.org/10.1002/mds.10134
  5. Lokk J, Nilsson M. Frequency, type and factor associated with the use of complementary and alternative medicine in patients with parkinson's disease at a neurological outpatient clinic. Parkinsonism Relat Disord. 2010;16(8):540-4. https://doi.org/10.1016/j.parkreldis.2010.06.007
  6. Adrian C, Meredith K, Eileen C, Ruth H. Walker. Evaluation of acupuncture in the treatmentofparkinson'sdisease: adouble-blind pilot study. Mov Disord. 2005;20(9):1185-8. https://doi.org/10.1002/mds.20503
  7. Lee MS, Shin BC, Kong JC, Ernst E. Effectiveness of acupuncture for parkinson's disease: a wywtematic review. Mov Disord. 2008;23(11): 1505-15. https://doi.org/10.1002/mds.21993
  8. Kang JM, Park HJ, Choi YG et al. Acupuncture inhibits microglial activation and inflammatory events in the MPTP-induced mouse model. Brain Res. 2007;1131(1):211-9. https://doi.org/10.1016/j.brainres.2006.10.089
  9. Liu XY, Zhou HF, Pan YL et al. Electroacupuncture stivulation protects dopaminergic neurons from inflammation-mediated damage in medial forebrain bundle-transected rats. Exp Neurol. 2004;189(1):189-96. https://doi.org/10.1016/j.expneurol.2004.05.028
  10. Wattanathorn J, Sutalangka C. Laser acupuncture at HT7 acupoint improves cognitive deficit, neuronal loss, oxidative stress, and functions of cholinergic and dopaminergic systems in animal model of parkinson's disease. Evid Based Complement Alternat Med. 2014; 2014:937601.
  11. NPF. Clinical Studies and Clinical Trials [Internet]. Miami: National Parkinson Foundation [cited 2017 Jun 19]. Available from: http://www.parkinson.org/understandingparkinsons/treatment/clinical-trials-andclinical-studies
  12. Amorim Aroxa FH, Oliveira Gondim ITG, Santos ELW, Sales MDGW, Asano AGC, Asano NMJ. Acupuncture as Adjuvant Therapy for Sleep Disorders in Parkinson's Disease. J Acupunct Meridian Stud. 2017;10(1):33-8. https://doi.org/10.1016/j.jams.2016.12.007
  13. Liu CH, Wang R, Jin YB, Sun ZL, Zhou X, He JY. Acupoint injection of kakkonein for earlyor mid-stage Parkinson's disease: a multicenter randomized controlled clinical trial. Zhen Ci Yan Jiu. 2015;40(1):56-60.
  14. Toosizadeh N, Lei H, Schwenk M et al. Does integrative medicine enhance balance in aging adults? Proof of concept for the benefit of electroacupuncture therapy in Parkinson's disease. Gerontology. 2015;61(1):3-14. https://doi.org/10.1159/000363442
  15. Xia Y, Wang HD, Ding Y, Kang B, Liu WG. Parkinson's disease combined with depression treated with electroacupuncture and medication and its effect on serum BDNF. Zhongguo Zhen Jiu. 2012;32(12):1071-4.
  16. Cho SY, Shim SR, Rhee HY et al. Effectiveness of acupuncture and bee venom acupuncture in idiopathic Parkinson's disease. Parkinsonism Relat Disord. 2012;18(8):948-52. https://doi.org/10.1016/j.parkreldis.2012.04.030
  17. Chen YL, Feng WJ, Zhang XL. Parkinson's disease combined with overactive bladder syndrome treated with acupuncture andmedication. Zhongguo zhen Jiu. 2012;32(3):215-8.
  18. Huang Y, Jiang X, Zhuo Y, Wik G. Complementary acupuncture in Parkinson's disease: a spect study. Int J Neurosci. 2010;120(2):150-4. https://doi.org/10.3109/00207450903316527
  19. Chae YB, Lee HJ, Kim HJ et al. Parsing brain activity associated with acupuncture treatment inParkinson'sdiseases. MovDisord. 2009;24(12): 1794-802.
  20. REN XM. Fifty cases of Parkinson's disease treatedbyacupuncturecombinedwithmadopar. J Tradit Chin Med. 2008;28(4):255-7. https://doi.org/10.1016/S0254-6272(09)60004-2
  21. Chang XH, Zhang LZ, Li YJ. Observation on therapeutic effect of acupuncture combined with medicine on Parkinson disease. Zhongguo Zhen Jiu. 2008;28(9):645-7.
  22. Chen XH, Li Y, Kui Y. Clinical observation on abdominal acupuncture plus Madopa for treatment of Parkinson's disease. Zhongguo Zhen Jiu. 2007;27(8):562-4.
  23. Huang Y, Jiang XM, Li DJ. Effects on electroscaip acupuncture on cerebral dopamine transporter in patients with Parkinson's disease. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006; 26(4):303-7.
  24. Wang S, Cai YY, Shang YJ, Jin-rong L. Effects of head point-through-point electroacupuncture on SOD and LPO in the patient of Parkinson's disease. Zhongguo Zhen Jiu. 2006;26(4): 240-2.
  25. Jiang XM, Huang Y, Zhuo Y, Gao YP. Therapeutic effect of scalp electroacupuncture on Parkinson disease. Nan Fang Yi Ke Da Xue Xue Bao. 2006;26(1):114-6.
  26. Cristian A, Katz M, Cutrone E, Walker RH. Evaluation of acupuncture in the treatment of Parkinson's disease: A double-blind pilot study. Mov Disord. 2005;20(9):1185-8. https://doi.org/10.1002/mds.20503
  27. Kluger BM, Rakowski D, Christian M et al. Randomized, controlled trial of acupuncture for fatigue in Parkinson's disease. Mov Disord. 2016;31(7):1027-32. https://doi.org/10.1002/mds.26597
  28. Lei H, Toosizadeh N, Schwenk M et al. A Pilot Clinical Trial to Objectively Assess the Efficacy of Electroacupuncture on Gait in Patients with Parkinson's Disease Using Body Worn Sensors. PloS one. 2016;11(5):e0155613. https://doi.org/10.1371/journal.pone.0155613
  29. Joao M, Kailash P. Bhatia. Clinical approach to Parkinson's disease: features, diagnosis, and principles of management. Cold Spring Harb Perspect Med. 2012;2(6):a008870. https://doi.org/10.1101/cshperspect.a008870
  30. Park HJ, Lim S, Hoo WS et al. Acupuncture prevent 6-hydroxydopamine-induced neuronal death in the nigrostriatal dopaminergic system in the rat Parkinson's disease model. Exp Neurol. 2003;180(1):93-8. https://doi.org/10.1016/S0014-4886(02)00031-6
  31. Kang JM, Park HJ, Choi YG et al. Acupuncture inhibits microglial activation and inflammatory events in the MPTP-induced mouse model. Brain Res. 2007;1131:211-9. https://doi.org/10.1016/j.brainres.2006.10.089
  32. Choi YG, Park JH, Lim S. Acupuncture inhibits ferric iron deposition and ferritin-heavy chain reduction in an MPTP-induced parkinsonism model. Neurosci Lett. 2009;450(2):92-6. https://doi.org/10.1016/j.neulet.2008.11.049
  33. Doo AR, Kim ST, Kim SN et al. Neuroprotective effects of bee venom pharmaceutical acupuncture in acute 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced mouse model of Parkinson's disease. Neurol Res. 2010;32(Suppl 1):88-91. https://doi.org/10.1179/016164109X12537002794282
  34. Jia J, Li B, Sun ZL, Yu F, Wang X, Wang XM. Electro-acupuncture stimulation acts on the basal ganglia output pathway to ameliorate motor impairment in Parkinsonian model rats. Behav Neurosci. 2010;124(2):305-10. https://doi.org/10.1037/a0018931
  35. Lee HS, Park HL, Lee SJ, Shin BC, Choi JY, Lee MS. Scalp acupuncture for Parkinson's disease: a systematic review of randomized controlled trials. Chin J Integr Med. 2013;19(4):297-306. https://doi.org/10.1007/s11655-013-1431-9
  36. Ramaker C, Marinus J, Stiggelbout AM, Van Hilten BJ. Systematic evaluation of rating scales for impairment and disability in Parkinson's disease. Mov Disord. 2002;17(5):867-76. https://doi.org/10.1002/mds.10248
  37. Leon S. Comprehensive pharmacy review. 6th ed. New York: Lippincott-Raven Publishers. 2007:998.
  38. Corbin L, Childs R, Dilli C. Acupuncture for Symptomatic Treatment of Fatigue in Parkinson's Disease: Trial Design and Implementation. Med Acupunct. 2016;28(4):194-205. https://doi.org/10.1089/acu.2016.1185
  39. Chen W, Lian X, Systematic evaluation of traditional chinese medicine for treating parkinson's disease. Neural Regen Res. 2010;5(8): 602-10.
  40. Lam YC, Kum WF, Durairajan SS et al. Efficacy and safety of acupuncture for idiopathic Parkinson's disease: a systematic review. J Altern Complement Med. 2008;14(6)663-71. https://doi.org/10.1089/acm.2007.0011
  41. Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMC Med. 2010;8(1):18. https://doi.org/10.1186/1741-7015-8-18
  42. MacPherson H, Altman DG, Hammerschlag R et al. Revised standards for reporting interventions in clinical trials of acupuncture (STRICTA): extending the CONSORT statement. PLoS Med. 2010;7(6):e1000261. https://doi.org/10.1371/journal.pmed.1000261

Cited by

  1. Acupuncture Treatment in Clinical Studies for Parkinson's Disease : A Literature Review vol.35, pp.4, 2017, https://doi.org/10.13045/jar.2018.00157
  2. Drug-Induced Gastrointestinal Dysfunction in Parkinson's Disease: Treatment with Korean Medicine vol.36, pp.2, 2019, https://doi.org/10.13045/jar.2019.00066