• Journal of the Korean Institute of Telematics and Electronics
• /
• v.11 no.6
• /
• pp.1-15
• /
• 1974

In this paper, the SH mode of elastic surface waves which are used for delay lines of elastic surface wave is the cretically analysed. It is shown that the SH mode has very large electromechanical coupling factor and propagates on the surface with very small decaying coefficient into the medium. In the case of P2T-4, the depth cf piezoelectric medium that contains 80% of energy is 190 wavelengths. An elastic surface wave delay line is discussed from the view point of 2-port network. Center frequency is shifted by the ratio of transducer electrode width to gap between transducer ellcerodes when electromechanical coupling factor is large. Tempera _ore coefficients for bulk waves of LiNbO3 and LiTaO3 are also calculated and the minimum temperature coefficient value of delay time is 5.4X 10-6/$^{\circ}C$ ia the case of transverse wave propagating along Z axis on LiTaO3. Experimental data are in good agreement with theoretical values of the temperature coefficients of delay time for elastic surface waves propagating along X axis of 130$^{\circ}$ and 64$^{\circ}$ rotated Y cut planes of the LiNbO3.

• Molecules and Cells
• /
• v.27 no.6
• /
• pp.651-656
• /
• 2009

The formation of ${\beta}$-amyloid peptide ($A{\beta}$) is initiated from cleavage of amyloid precursor protein (APP) by a family of protease, ${\alpha}$-, ${\beta}$-, and ${\gamma}$-secretase. Sub W, a substrate peptide, consists of 10 amino acids, which are adjacent to the ${\beta}$-cleavage site of wild-type APP, and Sub M is Swedish mutant with double mutations on the left side of the ${\beta}$-cleavage site of APP. Sub W is a normal product of the metabolism of APP in the secretary pathway. Sub M is known to increase the efficiency of ${\beta}$-secretase activity, resulting in a more specific binding model compared to Sub W. Three-dimensional structures of Sub W and Sub M were studied by CD and NMR spectroscopy in water solution. On the basis of these structures, interaction models of ${\beta}$-secretase and substrate peptides were determined by molecular dynamics simulation. Four hydrogen bonds and one water-mediated interaction were formed in the docking models. In particular, the hydrogen bonding network of Sub M-BACE formed spread over the broad region of the active site of ${\beta}$-secretase (P5-P3'), and the side chain of P2- Asn formed a hydrogen bond specifically with the side chain of Arg235. These are more favorable to the cleavage of Sub M by ${\beta}$-secretase than Sub W. The two substrate peptides showed different tendency to bind to ${\beta}$-secretase and this information may useful for drug development to treat and prevent Alzheimer's disease.

• Korean Journal of Crystallography
• /
• v.11 no.1
• /
• pp.22-27
• /
• 2000

The structure of cis-(malonato)[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane]platinum(II) with a potent anticancer activity has been determined by the X-ray crystallographic method. Crystal data are as follows: Pt(C/sub 11/H/sub 20/N₂O/sub 6/), M/sub 4/=471.38, monoclinic, P2₁, a=7.112(1), b=33.615(3), c=7.135(1)Å, β=116.80(1)°, V=1522.6(3)Å, and Z=4. The two independent molecules with very similar structures are approximately related by pseudo two-fold screw axis symmetry, which makes the monolinic cell look like the orthorhombic cell with one molecule in the asymmetric unit and space group C222₁. The crystal packing mode is similar to that of the analogue with the dimethyl substituents instead of the isopropyl group. The Pt atom is coordinate to two O and two N atoms in a square planar structure. The six-membered chelate ring in the leaving ligand assumes a conformation intermediate between the half chair and the boat forms. The seven-membered ring in the carrier ligand assumes a twist-chair conformation and the oxolane ring assumes an envelope conformation. Crystal packing consists of the extensive hydrogen-bonding network in the two-dimensional molecular layers and weak van der Waals interactions between these layers.

• Journal of the Ergonomics Society of Korea
• /
• v.33 no.5
• /
• pp.377-386
• /
• 2014

Objective: In this study, we used resting-state fMRI data to map differences in functional connectivity between a comprehensive set of 8 distinct cortical and subcortical brain regions in healthy controls and Internet addicts. We also investigated the relationship between resting state connectivity strength and the level of psychopathology (ex. score of internet addiction scale and score of Barratt impulsiveness scale). Background: There is a lot of evidence of relationship between Internet addiction and impaired inhibitory control. Clinical evidence suggests that Internet addicts have a high level of impulsivity as measured by behavioral task of response inhibition and a self report questionnaire. Method: 15 Internet addicts and 15 demographically similar non-addicts participated in the current resting-state fMRI experiment. For the connectivity analysis, regions of interests (ROIs) were defined based on the previous studies of addictions. Functional connectivity assessment for each subject was obtained by correlating time-series across the ROIs, resulting in $8{\times}8$ matrixs for each subject. Within-group, functional connectivity patterns were observed by entering the z maps of the ROIs of each subject into second-level one sample t test. Two sample t test was also performed to examine between group differences. Results: Between group, the analysis revealed that the connectivity in between the orbito frontal cortex and inferior parietal cortex, between orbito frontal cortex and putamen, between the orbito frontal cortex and anterior cingulate cortex, between the insula and anterior cingulate cortex, and between amydgala and insula was significantly stronger in control group than in the Internet addicts, while the connectivity in between the orbito frontal cortex and insula showed stronger negative correlation in the Internet addicts relative to control group (p < 0.001, uncorrected). No significant relationship between functional connectivity strength and current degree of Internet addiction and degree of impulsitivy was seen. Conclusion: This study found that Internet addicts had declined connectivity strength in the orbitofrontal cortex (OFC) and other regions (e.g., ACC, IPC, and insula) during resting-state. It may reflect deficits in the OFC function to process information from different area in the corticostriatal reward network. Application: The results might help to develop theoretical modeling of Internet addiction for Internet addiction discrimination.

• The Bulletin of The Korean Astronomical Society
• /
• v.42 no.1
• /
• pp.45.2-46
• /
• 2017

3C 84 (NGC 1275) is one of the most famous radio galaxies and a lot of VLBI observations have been conducted to date because of its brightness and proximity (z = 0.0176; 1 mas = 0.36 pc). The source is entering a significantly active phase with long-term increase in radio flux at cm wavelengths since 2005, and the increased activity at very-high-energy (VHE) gamma rays. In order to study properties of sub-pc-scale structure and the circumnuclear environment in 3C 84, we have conducted multi-epoch VLBI observations with the Korean VLBI Network (KVN) at 86 and 129 GHz, and monthly monitoring by the KVN and VERA Array (KaVA) at 43 GHz from 2015 August. Following the report in the previous KAS meeting (cf. 2016 KAS Autumn Annual Meeting, [구 GC-10]), we present further results mainly on the basis of twelve-epoch observations with KaVA at 43 GHz. Through the monthly monitoring with KaVA, we found that peak intensity of the pc-scale southern lobe (C3) was increased from $2.60\;Jy\;beam^{-1}$ in 2015 October to $9.80\;Jy\;beam^{-1}$ in 2016 June, corresponding to a flux increase of 3.7 times in eight months. We also detected change in direction of motion of C3 from transversal to outward with respect to C1, concurrently with the beginning of its flux increase in 2015 October. We consider that these phenomena are due to interaction of C3 with the ambient medium, and are related to the gamma-ray flare which has been detected with VHE gamma-ray telescopes such as MAGIC and VERITAS.

• Anxiety and mood
• /
• v.10 no.2
• /
• pp.143-150
• /
• 2014

Objective : The subgenual cingulate cortex, a part of default-mode network, has been known to playa key role in the pathophysiology of depression. The previous studies have reported abnormal functional connectivity between the subgenual cingulate cortex and other brain regions in the patients with depression. The goal of this shldy was to explore the resting-state functional connectivity of the subgenual cingulate cortex between the patients with depression and healthy subjects. Methods : Twenty patients with major depression and age- and sex-matched 20 healthy subjects underwent 5-minute resting state fMRI scans. The functional connectivity map in each subject was acquired using seed-based correlation analysis with the seed located in the subgenual cingulate cortex (Talairach coordinates; x=-10, y=5, z=-10). The functional connectivity maps were calculated using AFNI and compared between the patient and healthy subject group via two-sample T-test using 3dttest++ in AFNI package. Results : Functional connectivity was decreased between the subgenual cingulate cortex and both sides of fusiform gyrus in depressed subjects. Connectivity was also decreased between the subgenual cingulate cortex and the left cerebellum in the patient group. There was no correlation between the severity of depression and the degree of functional connectivity between the subgenual cingulate cortex and the regions showing decreased functional connectivity. Conclusion : Decreased resting-state functional connectivity between the subgenual cingulate cortex and both sides of fusiform gyrus, and decreased connectivity between the subgenual cingulate cortex and the left cerebellum found in the patients with major depression in comparison to the healthy subjects might be related to abnormal emotional and cognitive processing of depressed patients.

• The Bulletin of The Korean Astronomical Society
• /
• v.36 no.2
• /
• pp.122.2-122.2
• /
• 2011

For more than a decade, NEA (Near-Earth Asteroid) survey teams equipped with 1 meter-class telescopes discovered thousands of NEAs in the northern sky. As of August 2011, some 8,200 NEAs have been cataloged, yet only five percent of them has been investigated for their physical and chemical properties. In order to improve current situation, we propose a deep ecliptic survey utilizing KMTNet, for detection and characterization of NEAs in the southern sky. Thanks to the wide-field capability (four square degrees) of the telescopes, we will be able to considerably expand the search volume carrying out precision photometry down to 21.5th magnitude. We plan to focus our survey on opposition and two "sweet spots" in the ecliptic belt. Since SDSS colors characterize mineralogical properties of NEAs, g', r', i', z' filters will be employed. Based on the round-the-clock observation, we will study their rotational properties; for multiple systems, mass, density and other physical parameters can be obtained. We plan to maintain a dedicated database of the physical and mineralogical properties of NEAs. With this archive, it is expected that our understanding on the population will see a drastic change. We also plan to participate in the GAIA Follow-Up Network for ground based observation of the Solar System Objects (GAIA-FUN-SSO). The follow- up astrometry will be performed upon alerts issued by the GAIA-FUN-SSO Central Node in France.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.31 no.11A
• /
• pp.1053-1058
• /
• 2006

In this paper, We proposed a efficient OSA(Optical Sub-Assembly) packaging method in use 1.31/1.49um bi-directional hybrid-integrated PLC chip for low-cost OSA in optical access network system applications as GE-PON in FTTH. Fabricated OSA with passive optical fiber alignment and nonhermetic plastic package method and measured optical coupling efficiency and electric-optical characteristics. Its performance is feasible to satisfy the GE-PON ONU specifications with the results as less than 0.5dB coupling losses within 40um alignment of z-axis and less than -24dBm sensitivity. It also has good temperature characteristics to sustain optical output power more than 1.5mW and 10dB extinction ratio, less than 0.3dB tracking error.

• The Korean Journal of Physiology and Pharmacology
• /
• v.24 no.6
• /
• pp.529-543
• /
• 2020

In contrast to ventricular myocytes, the structural and functional importance of atrial transverse tubules (T-tubules) is not fully understood. Therefore, we investigated the ultrastructure of T-tubules of living rat atrial myocytes in comparison with ventricular myocytes. Nanoscale cell surface imaging by scanning ion conductance microscopy (SICM) was accompanied by confocal imaging of intracellular T-tubule network, and the effect of removal of T-tubules on atrial excitation-contraction coupling (EC-coupling) was observed. By SICM imaging, we classified atrial cell surface into 4 subtypes. About 38% of atrial myocytes had smooth cell surface with no clear T-tubule openings and intracellular T-tubules (smooth-type). In 33% of cells, we found a novel membrane nanostructure running in the direction of cell length and named it 'longitudinal fissures' (LFs-type). Interestingly, T-tubule openings were often found inside the LFs. About 17% of atrial cells resembled ventricular myocytes, but they had smaller T-tubule openings and a lower Z-groove ratio than the ventricle (ventricular-type). The remaining 12% of cells showed a mixed structure of each subtype (mixed-type). The LFs-, ventricular-, and mixed-type had an appreciable amount of reticular form of intracellular T-tubules. Formamide-induced detubulation effectively removed atrial T-tubules, which was confirmed by both confocal images and decreased cell capacitance. However, the LFs remained intact after detubulation. Detubulation reduced action potential duration and L-type Ca²⁺ channel (LTCC) density, and prolonged relaxation time of the myocytes. Taken together, we observed heterogeneity of rat atrial T-tubules and membranous ultrastructure, and the alteration of atrial EC-coupling by disruption of T-tubules.

• Experimental and Molecular Medicine
• /
• v.50 no.12
• /
• pp.11.1-11.9
• /
• 2018

Estrogen has diverse effects on cardiovascular function, including regulation of the contractile response to vasoactive substances such as serotonin. The serotonin system recently emerged as an important player in the regulation of vascular tone in humans. However, hyperreactivity to serotonin appears to be a critical factor for the pathophysiology of hypertension. In this study, we examined the modulatory mechanisms of estrogen in serotonin-induced vasoconstriction by using a combinatory approach of isometric tension measurements, molecular biology, and patch-clamp techniques. $17{\beta}$-Estradiol (E2) elicited a significant and concentration-dependent relaxation of serotonin-induced contraction in deendothelialized aortic strips isolated from male rats. E2 triggered a relaxation of serotonin-induced contraction even in the presence of tamoxifen, an estrogen receptor antagonist, suggesting that E2-induced changes are not mediated by estrogen receptor. Patch-clamp studies in rat arterial myocytes showed that E2 prevented Kv channel inhibition induced by serotonin. Serotonin increased Src activation in arterial smooth muscle required for contraction, which was significantly inhibited by E2. The estrogen receptor-independent inhibition of Src by E2 was confirmed in HEK293T cells that do not express estrogen receptor. Taken together, these results suggest that estrogen exerts vasodilatory effects on serotonin-precontracted arteries via Src, implying a critical role for estrogen in the prevention of vascular hyperreactivity to serotonin.