• Biomolecules & Therapeutics
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• v.25 no.2
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• pp.140-148
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• 2017

Hyperlipidemia, which is closely associated with a fatty diet and aging, is commonly observed in the western and aged society. Therefore, a novel therapeutic approach for this disease is critical, and an immunological view has been suggested as a novel strategy, because hyperlipidemia is closely associated with inflammation and immune dysfunction. In this study, the effects of an aqueous extract of Rubus occidentalis (RO) in obese mice were investigated using immunological indexes. The mice were fed a high-fat diet (HFD) to induce hyperlipidemia, which was confirmed by biochemical analysis and examination of the mouse physiology. Two different doses of RO and rosuvastatin, a cholesterol synthesis inhibitor used as a control, were orally administered. Disturbances in immune cellularity as well as lymphocyte proliferation and cytokine production were significantly normalized by oral administration of RO, which also decreased the elevated serum tumor necrosis factor $(TNF)-{\alpha}$ level and total cholesterol. The specific immune-related actions of RO comprised considerable improvement in cytotoxic T cell killing functions and regulation of antibody production to within the normal range. The immunological evidence confirms the significant cholesterol-lowering effect of RO, suggesting its potential as a novel therapeutic agent for hyperlipidemia and associated immune decline.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2019.05a
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• pp.423-425
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• 2019

Users may experience a sub-type of motion sickness, called cybersickness, when interacting with virtual reality (VR) applications in the state of wearing head mounted display (HMD) devices. Although the root cause of cybersickness is still unclear, it is believed to result from a sensory mismatch between visual and vestibular systems. However, there is a lack of studies developing data collection and analysis systems to measure cybersickness. In this paper, therefore, a system is designed that collects electroencephalography (EEG) and physiological data from a user wearing a VR HMD device through an internet of things (IoT) platform and decides whether a user experiences a symptom of cybersickness, namely dizziness, or not by using a decision threshold. Experimental results showed that the proposed system achieved about 92% accuracy of a dizziness detection when considering 14 participants.

• Journal of Apiculture
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• v.34 no.4
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• pp.315-323
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• 2019

Large amounts of sludge produced by paper mill industries represent one of the most serious environmental problems in the world. Recently, beekeepers living in the neighborhood of the paper mill in Hwasan County, Youngcheon city, GB, Korea, became alarmed that honey bee colonies were dying off suddenly across the neighborhood. A preliminary study was conducted to evaluate the toxicity (oral, fumigation, repellent) of recycled solid paper mill sludge (SPMS) and leachate paper mill sludge (LPMS) to honey bee workers under laboratory conditions, and to analyze the volatile organic compounds(VOC). The SPMS and LPMS were separately subjected to a liquid-liquid extraction (LLE) at three temperatures to extract VOC(highest VOC yields: 1.52% SPMS and 0.34% LPMS). A total of 70 chemicals were detected in the VOC of paper mill sludges, of which 49 and 21 volatile organic compounds from SPMS and LPMS, respectively. The SPMS was dominated by high degree presence of stanols (saturated sterols), such as cholestanol, cholestan-3-ol and also saturated hydrocarbons. However, LPMS was characterized by the absence of sterols. Both SPMS and LPMS showed an influence on the olfactory behavior of honey bee on Y-tube assay, with repulsion rates of 72 and 68%, respectively. Both SPMS and LPMS at concentration of 100mg/mL caused higher honey bee oral mortality than the untreated controls at 48, 72, 96 and 120 hours after treatment(highest oral mortality at 120 hr: 85.74%(SPMS); 93.51 % (LPMS)). A similar pattern was observed when honey bees were tested to fumigant toxicity. Both SPMS and LPMS caused significant higher mortality than the untreated control 24 hour after the exposure (highest fumigation mortality at 120 hr: 69.4% (SPMS); 56.8% (LPMS)). These preliminary results indicated that paper mill sludge could be partly responsible for sudden death and disappearance of honey bees, especially in hot humid summer days. With climate change, the risk of environmental chemical exposure to honey bee would pose greater attention.

• Convergence Security Journal
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• v.22 no.4
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• pp.109-118
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• 2022

Countries around the world have recognized the importance of personal information protection and have discussed protecting the rights of data subjects in various forms such as laws, regulations, and guidelines. PbD (Privacy by Design) is one of the concepts that are commonly emphasized as a precautionary measure for the protection of personal information, and it is starting to attract attention as an essential element for protecting the privacy of information subjects. However, the concept of PbD to prioritize individual privacy in system development or service operation in advance is still only at the declarative level, so there is relatively little discussion on specific methods to implement it. Therefore, this study discusses which principles and rights should be prioritized to implement PbD based on the basic principles of GDPR and the rights of data subjects. This study is meaningful in that it suggests a plan for the practical implementation of PbD by presenting the privacy considerations that should be prioritized when developing systems or services in the domestic environment.

• Korean Journal of Pharmacognosy
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• v.54 no.1
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• pp.27-37
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• 2023

This research was conducted to investigate the comprehensive effects of methanol extract of Coptidis rhizoma (MECR) against oral pathogen. We studied the antibacterial, anti-biofilm, anti-gingipain and anti-inflammatory activity of MECR. The minimum bactericidal concentration (MBC) of MECR was 100 ㎍/mL against several oral pathogens. The formation of biofilm of Streptococcus mutans was reduced to 8.93~24.12% in the presence of 25 ㎍/mL of MECR. The gingipain activity of Porphyromonas gingivalis were reduced to 3.91~6.23% in case of Kgp and 5.73~7.78% in case of Rgp in the presence of 10 mg/mL of MECR. The expression of fadA mRNA, virulence factor of Fusobacterium nucleatum (F. nucleatum) was 3 folds decreased in the presence of 25 ㎍/mL of MECR. In case of YD-38 cells challenged with F. nucleatum, RQ values of IL-8 and IL-6 were reduced about 12 folds and 5.45 folds in the presence of 2 ㎍/mL of MECR. In case of RAW 264.7 murine cell challenged with F. nucleatum, RQ values of IL-1β and IL-6 were 2.52 folds and 2.55 folds reduced in the presences of 2 ㎍/mL of MECR. Conclusively, MECR showed potent antibacterial and anti-inflammatory effects against oral pathogenic bacteria.

• The Journal of the Convergence on Culture Technology
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• v.9 no.6
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• pp.779-787
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• 2023

Previous research regarding budget analysis has been mostly limited to describing annual changes in defense budgets relative to total budgets without a theoretical background. More empirical defense budget research is needed with better data. This study conducts an empirical analysis of national defense expenditures using Punctuated Equilibrium Theory (PET). The purpose of this study is to examine trends in the Republic of Korea's (ROK) functional defense budgets (total defense budget, force operation budget, force improvement budget) and to identify and analyze radical points of change in the defense budget using punctuated equilibrium theory. This study also explores trends and punctuations in the national defense budgets using annual defense budget data from the ROK for every year from 1998 to 2017. This study finds that from 1998 to 2017 the spending pattern of the total defense budget in the ROK was characterized by 19 years of stable growth and a one-time punctuation (5.0%). The force operation budget exhibited stable growth in eighteen years and was punctuated twice (10%). The force improvement budget was punctuated five times.

• The Journal of Engineering Geology
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• v.11 no.1
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• pp.81-99
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• 2001

In order to clarify an effect of the cutoff grouting, a series of field experiments were performed during construction of the waterway tunnel from the River Gilancheon(Andong) to the Youngcheon dam. The experiments were conducted in three different ways based on the grouting time in the construction sequence, i.e., the pre-grouting, after-grouting and consolidation grouting tests. And those were also planned to compare the efficiency of grouting in relation to the material types of grout, base rock types and other geologic factors such as discontinuities, depth and direction of grouting holes, and number of grouting stages. Among the materials of grout employed in the experiments, such as a common Portland cement, a micro-cement, a micro-cement with sodium silicate, and a urethane, the urethane was the most effective as the cutoff grouting. And for the same grout material, the pre-grouting was more effective to cutoff the water inflow comparing to the after-grouting and the consolidation grouting. For the rock types, the grouting efficiency in the sedimentary rocks as a base rock was less than the other rocks such as granite and volcanic rocks, which is believed due to the smaller separation of joints and the abundance of infilling materials in the joints developed in the sedimentary rocks. There was no direct relationship between the total RMR value of the rock mass and the grouting efficiency, however, the joint separation which is one of the RMR criteria is believed to have positive relation to the grouting efficiency. And the direction of the grouting holes might not so much affect on the grouting efficiency while increasing the number of grouting stage showed the better results.

• Journal of Korean Society of Rural Planning
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• v.20 no.3
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• pp.191-199
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• 2014

The current rural conditions are undergoing the change from the past production-intensive structure to an integral and complex one of producing, processing, selling, touring and lodging owing to the changes of life-style, consumption trend and social environments. The rural area is developing into a community of rural tourism villages to grow into one management system along with the assistance of the government's various supporting projects. Through this, the rural designing has got to play a significant role as one of the factors of the enhancement of competitiveness and the increase of income. Therefore, those previous studies on the variety and possibility of rural development are being employed for the researches which are to develop techniques of branding, marketing and packaging. In particular, the researches for VI (Village Identity), BI (Brand Identity) and designs of landscaping, packaging of agricultural specialties and display stores, which definitely shows that the importance of rural designing, is being paid a lot more attention to. Thus, this study has verified the site commercialization and its effect by developing some practical designing with the focus of package design at rural tourism villages. The Okgye Village in Yoncheon was selected for study subject based on the result of status investigation. This study has analyzed such problems as lack of village identity, non-description of items and their indispensible marks which were seen their designs of village and packaging. The colors of major items and the village image being substituted into the image scale of IRI color were estimated so that the appropriate colors might be selected, along with which the shapes of major items were decided to be motif for the village symbol and design to be created. The designs of such major items as grains, greens and sauces were created with the consideration of the easiness of loading, the continuity of using and the aesthetics. For grains, those outer boxes which are possible for set-packaging and small-sized packaging have been developed. For greens were developed the boxes with the structure of the permeability for the persisten't quality as well as the possibility for packaging small amount. In case of sauces, those outer-boxes equipped with fixing tray were made with the transport-convenience taken into consideration. The sticker-label designs for all those three were also developed which stand for the village identity and are conveniently used in each farm family. When this development was applied at the sites, it was found that the satisfaction and reliability of consumers as well as the satisfaction of farmers were raised along with the increase by more than 30% after the improvement.

• Korean Journal of Soil Science and Fertilizer
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• v.42 no.3
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• pp.145-151
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• 2009

This study was conducted to develop rational soil management and enhance the productivity of lands converted from paddy soils. Specifically, the changes in the soil physical properties brought about by the change in land usage from paddy soil were evaluated. This was carried out from 1999 to 2001 at 50 site in large-scale converted paddy fields of Kimcheon, Youngcheon, Gyeongsan and Milyang in the Youngnam region, categorized according to soil texture and drainage class. The ridge height of converted paddy soils was higher in coarse-textured and poorly-drained soils than in fine-textured and well-drained soils. The gray color of the surface soil was of lesser degree in converted soils than paddy soils and more notable in welldrained soils. The porosity ratio and the formation of aggregate structure were higher, and the appearance of soil mottling was deeper in converted paddy fields than in paddy soils. The glaying layer "g" of surface soil degraded with time. The porosity and amount of water stable aggregate was found to increase with time after conversion. The penetration resistance of the converted paddy soil was lower and deeper with time after conversion. The soil aeration of the converted paddy soil was lower in sandy loam than in loamy soil. Furthermore, soil aeration was influenced by ridge height and drainage class in poorly-drained soils.

• Journal of the Korean Society of Tobacco Science
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• v.22 no.2
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• pp.123-132
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• 2000

Evaluation method of soil fertility by combination of soil color characteristics and survey data from soil map as well as chemical properties was investigated on total 35 field and pot experiments. Total 35 tobacco fields including 11 fields located at Cheonweon county in Chungnam Province, 9 fields located at Goesan county in Chungbuk Province, and 15 fields located at Youngcheon county in Kyongbuk Province were selected in 1984 to cover the wide range of distribution in landscape and soil attributes. Yields of tobacco grown on the plots of both the pot and field experiment which were not applied with any fertilizer were considered as basic fertility of the soil (BFS). The BFS was estimated by 32 independent variables including 15 chemical properties, 3 color characteristics, and 14 soil survey data from soil map. Twenty-four independent variables containing 16 quantitative variables selected from 24 quantitative variables by collinearity diagnostics and 8 qualitative variables, were classified and analyzed by multiple linear regression (MLR) of REG and GLM models of SAS. Tobacco yield of field experiment showed high variations by eight times in difference between minimum and maximum yield indicating the diverse soil fertility among the experimental fields. Evaluation for the BFS by the MLR including quantitative variables was still more confidential than that by a single index and that showed more improvement of coefficient of determination ($R^2$) in pot experiment than in field experiment. Evaluation for the BFS by MLR in field experiment was still improved by adding qualitative variables as well as quantitative variables. The variability in the BFS of field experiment was explained 43.2% by quantitative variables and 67.95% by adding both the quantitative and qualitative variables compared with 21.7% by simple regression with NO$_3$-N content in soil. The regression evaluation for the best evaluation of the BFS of field experiment by MLR included NO$_3$-N content, L value, and a value of soil color as quantitative variables and available soil depth and topography as qualitative variables. Consequently, it is assumed that this approach by the MLR including both the quantitative and qualitative variables was available as an evaluation model of soil fertility for tobacco field.