Background: Differences in clinicopathological characteristics of gastric cancer (GC) between young and older patients are controversial and a matter of debate. Determining the statistical significance of clinicopathological information with respect to age might provide clues for better management and treatment ofGC. Materials and Methods: A total ofl03 Indiao GC patients were enrolled for study and specimens were classified according to the AjCC-TNM system. Patients were grouped into two age-wise categories, young patients (<40 years; n=13) and older patients (${\geq}40$ years, n=90). The clinicopathological features of both groups were retrospectively examined and compared. p53 alterations were analyzed by polymerase chain reaction-single strand conformational polymorphism and immunohistochemistry methods at gene and protein levels respectively. The cases were considered p53 over-expressed if it was present in more than 25% of the tumor cells and p53 alterations was correlated with the clinicopathological characteristics of the patients as well as etiological factors for GC in both groups. Results: We found significant association of young patients with cancer stage (p=0.01), and very strong association with histology grade (p=0.064) and poorly differentiated (p=0.051) state of GC. However, neither young nor elderly patients showed associations with location, gender, etiological factors and p53 expression and alteration. Overall the male-to-female ratio of GC patients was 3.12 and the value was higher in the young (5.5) than in the older group (2.91). Conclusions: Clinicopathological features of GC like caocer stage, cell differentiation and histological grades were significantly different among young and old age cohorts. We observed a male predominance among the young group that decreased significantly with advancing age. More awareness of GC onset is required to detect cancer at an early stage for successful treatment.
The definite objects of this study are as follows ; 1. The study presents concrete objects of the shape of adult women's neck and shoulder after comparing and analyzing the features of five age groups ; the former young age, the latter young age, the former middle age, the latter middle age, the latter middle age and the old age. 2. The study presents concrete objects of adult women's neck and shoulder by the body types ; bend-forward type, straight type and lean-back type in order to be examined the body types. The results of this study are as follows ; 1. The shape of neck and shoulder needs the several concrete objects of each types because of the variable factors in size and body types. But the concrete objects of the types referred in five age groups contain all the important factors and enable to design the body suitable clothes. 2. This study shows that generally bend-forward type contains rising shoulder and lean-back type contains drooping shoulder, and straight type contains average value of neck and shoulder. The results of this study developed the body-suitable clothes of bend-forward type, straight type and lean-back type.
This study investigated the prevalence of unmet needs for health care among Korean adults and related factors. Using data from the 2012 Korea Health Panel, 1,896 adults aged 65 and over and two age groups(Young-Old(66-74) and Old-Old($65{\leq}$)) were analyzed to identify these factors. Logistic regression analysis was used to examine the main factors associated with unmet medical needs. According to the results of this study, the factors influencing unmet medical needs with regard to economic factors were Subjective Health Status(young-old), Disability(young-old), Activity Limitation(young-old), Education Level(old) and Economic Activity(old). The factors influencing unmet medical needs were factors of attitude, information, and disease. factors were Disability(young-old), Activity Limitation(young-old), Education Level(old) and Economic Activity(old). Therefore, further research that investigates unmet needs depending on age group in the elderly would suggest helpful policy implications.
Objective: The purpose of this study was to examine the impact of children's age and their fathers' childrearing involvement on the social morality of young children. Methods: The data were gathered from parents who had 3-5 year old children enrolled in daycare centers and from their daycare teachers. The parents answered questions about their children's socio-demographic background and the father's childrearing involvement. And the teachers rated children's social morality. The data from a total of 245 questionnaires were analyzed by SPSS 25.0. Results: First, there was a statistically significant difference between young children's morality score and convention score. Young children's morality scores were higher than their convention scores. Second, children's age was a significant influential factor on both their moral and conventional social morality. Third, father's care-discipline had the only impact on children's conventional social morality. That is, children's social morality was higher when their fathers gave them more care and guidance. Forth, an interaction effect between children's age and father's development-support on children's conventional social morality was found. Conclusion/Implications: The results from this study suggest that a differentiated approach is needed according to the types of childrearing involvement of fathers in order to improve children's social morality.
Purpose: There have been several comparative studies that have focused on elderly groups of patients with gastric cancer. However, new criteria are needed for this elderly group because of the longer life span of Korean people. The diagnosis of gastric cancer has sometimes been missed in the young age group. The perioperative risk is high in the elderly age group because of their combined diseases. This study was designed to determine the differences of the clinicopathologic features and the prognosis between young and elderly patients with gastric cancer. Materials and Methods: Eighty patients were divided in two groups and these patients were selected for making comparison between young and elderly groups of patients with gastric cancer. The young age group consisted of 31 patients who were aged 35 years old or less. The elderly age group was made up of 49 patients who were aged 75 years old or above. Results: For the clinicopathologic features, the young age group was characterized by a high incidence of the poorly differentiated type of adenocarcinoma and the diffuse type too, according to the Lauren classification. On the other hand, the elderly group was characterized by a high incidence of poorly to moderate differentiated adenocarcinoma and also the intestinal type according to the Lauren classification. The other clinical differences were unremarkable. Additionally, there was no survival advantage in the young age group compared to the elderly group. Conclusion: There were no clinicopathologic and prognostic differences between both extreme age groups. So, active surgical treatment is recommended even for the elderly patients group.
Objective : The incidence of aneurysmal subarachnoid hemorrhage has been increasing. At the same time, surgical results for elderly patients are unsatisfactory and no guidelines of treatment are available. We carried out a study comparing variable factors and surgical results between young and old age groups to find ways to improve prognosis. Methods : A retrospective study was carried out on 754 patients who were operated on between 1990 and 2004 by the same surgeon in our hospital. The patients were divided into seven groups according to age : 93 patients below 40 years of age [Group I], 419 patients aged $40{\sim}59$ [Group II], 115 patients aged $60{\sim}64$ [Group III], 82 patients aged $65{\sim}69$ [Group IV], 28 patients aged $70{\sim}74$ [Group V], 12 patients aged $75{\sim}79$ [Group VI] and 5 patients over the age of 80 [Group VII]. We then checked their medical history, Fisher's grade, Hunt-Hess grade, postoperative complications, and Glasgow Outcome Scale. Results : Age was not a statistically significant factor among patients below 70 years of age [P $value{\ge}0.05$]. But for those aged 70 and older, the age factor had a statistical value [P $value{\le}0.001$]. In addition, there was a close correlation between Hunt-Hess grade IV and V patients, and those with vasospasm, and hydrocephalus after surgery, with poor prognosis in elderly patients as well as young patients [P $value{\le}0.001$]. Conclusion : Advanced age [under the age of 70] dose not precluded adequate surgical treatment in patient with AN SAH, and we should be also alert to preventable causes of delayed neurological deterioration for improving the outcome in all elderly groups.
The purpose of this study is to investigate the user characteristics in different age groups by investigating the level of satisfaction and preference of design and function of mobile phone. 160 subjects participated in the experiment. Subjects with different ages were selected and divided into four groups: young age group (20 to less than 45), $1^{st}$ middle age group (45 to less than 55), $2^{nd}$ middle age group(55 to less than 65), and elderly group(over 65). A questionnaire was developed based on the previous design guideline, and additional questions were made to test newly developed function and design of the mobile phone. In particular, depth interviews were conducted in order to have a proper response from old subjects who have difficulties in completing written questionnaire. In result, it was found that except for price the major criterion to purchase mobile phone was the design, and the function of phone was the next except for elderly group. In the case of elderly group, the screen size is the first. Statistical results indicated that 37.5% of the young age group, 22.5% of $1^{st}$ middle age group, 22.5% of $2^{nd}$ middle age group and 10.0% of the elderly group preferred the design to function when they purchase mobile phones. Most elderly people were not satisfied with the supplementary function of the mobile phone. The $1^{st}$ middle age group did not know exactly how to use the supplementary service although they were willing to use it. Regarding the emotional preference on the type of phone, the sliding type was preferred most. Current results can be used to anticipate the future trend of mobile phone and design a user-friendly product for the aged population.
The study examined the influences of age, empathy and perspective taking ability on altruistic lying in 5 and 6 year old children. Eighty three children answered a question as to whether a protagonist would lie after listening to three vignettes involving altruistic lies. Korean versions of the Affective Situation Test(AST) and cognitive perspective taking task were used to measure children's empathy and perspective taking respectively. The results of the study showed that there were significant differences in altruistic lying by age. Altruistic lie by children was positively related with their age, empathy and perspective taking ability. In particular, age and perspective taking ability are important factors influencing children's altruistic lie in young children in Korea.
This study examined the population movement of the young generation in accordance with the characteristics of housing market focusing on the housing problem of youth issues. Targeting 64 local governments in the seoul metropolitan area, the temporal range was decided as 2015. Setting up the rising population in 19-34 as a dependent variable, supposing that each age group shows different characteristics, it was divided into age groups in 19~34, 19~29, and 25~34. The population movement of the young generation in accordance with the characteristics of housing market was considered through the multiple regression analysis. In the results, the population movement of the young generation was influenced by the change in detached multi-family housing and the rate of housing supply. The increase of detached multi-family housing promoted the population inflow of the young generation while the population movement of the young generation was disturbed by the rising rate of housing supply. Also, when the local characteristics are not controlled, the young generation hesitates to enter the region where relatively high rent should be paid while the new housing supply focusing on apartment is hard to be selected by the young generation for residence because of the size and price. The population movement of the young generation looked quite different in each age group. The population inflow of the young generation in 19~29 was influenced when there were many officetels and non-apartments on top of detached multi-family housing. On the contrary, the population movement of the young generation in 25~34 was significantly influenced by the increase of the whole size of completed apartment area. Even though it was not the research subject of this study, among control variables, the financial independence and daily average number of get-on/off had effects on the movement of the young generation. It means that the housing type preferred by college students and social novices is different from the housing type preferred by the group with experiences in marriage and childbirth within the same young generation. Thus, it would be necessary to divide the purposes of policies for each subject when executing the youth housing policies.
Proceedings of the Korean Society of Applied Pharmacology
/
1995.04a
/
pp.90-90
/
1995
The Influence of age on the endothelial modulation of angiotensin II (AII)-induced contractile response was investigated in isolated aortic rings of rats ranging in age from 0.7 to 20 months. Hemoglobin and L-NAME were used to examine whether age-related changes in the EDRF-releasing system were involved in endothelial modulation of All-induced contraction in rat aorta. In all five age groups (0.7, 1.5, 3, 6, 20 months), hemoglobin (10 ${\mu}$M) significantly enhanced All-induced contractile response only in aorta with endothelium intact. L-NAME (10 ${\mu}$M) Produced a significant enhancement in All responses in endothelium-intact aortas from rats aged 0.7 and 1.5 months, but it had no effect in aortas from older rats aged 6 and 20 months. Indomethacin (10 ${\mu}$M) did not affect All-induced contractile responses in both endothelium intact and removed aortas from rats at the age of 0.7 to 20 months. Hemoglobin (10 ${\mu}$M) abolished acetylcholine-induced relaxation response in aortas from young and old rats. L-NAME completely abolished the relaxation in aortas from young (0.7 and 1.5 months), but incompletely in aortas from older (6 and 20 months) rats. The sensitivity of endothelium-dependent relaxation to A23187 increased with age between ages of 0.7 and 6 months, with no further increase noted up to 20 months of age. These results suggest that endothelial modulation of AII-induced contraction in rat aorta might involve age-related alteration in EDRF-releasing system, probably via post-receptor mechanism.
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