• Pediatric Infection and Vaccine
• /
• 제28권2호
• /
• pp.110-117
• /
• 2021

독성거대결장은 염증성 장질환, 감염성 대장염 등에 의해 발생하는 치명적인 합병증이다. 중증도에 따라 장절제부터 사망까지 예후가 나빠 조기 진단과 적절한 치료가 매우 중요한 질환이다. 하지만, 소아에서 그 유병률은 매우 낮으며 염증성 장질환과 같은 기저질환이 없이 발생할 경우 조기진단이 늦어질 수 있다. 기저질환이 없는 12세 남자가 하복부 통증과 발열, 그리고 혈변을 주소로 병원을 방문했다. 항생제 치료에도 불구하고 환자의 증상은 악화되었다. 3병일째 복부 컴퓨터단층촬영에서 횡행결장의 심각한 팽창이 관찰되었고 이를 통해 독성거대결장으로 진단할 수 있었다. 광범위항생제와 함께 정맥 스테로이드 치료를 시행하였으며, 환자의 증상은 호전되었다. 이후 대변 배양 검사에서 Salmonella enteritidis group D가 배양되었으며, 직장 내시경 검사를 통해 염증성 장질환을 배제할 수 있었다. 저자는 독성거대결장을 적절한 영상 검사를 통해 조기 진단하였고, 내과적으로 성공적인 치료를 하여 이에 대한 경험을 공유하고자 한다.

• 한국대기환경학회지
• /
• 제28권5호
• /
• pp.571-580
• /
• 2012

Epidemiologic studies of air pollution need accurate exposure assessments at unmonitored locations. A land use regression (LUR) model has been used successfully for predicting traffic-related pollutants, although its application has been limited to Europe, North America, and a few Asian region. Therefore, we modeled traffic-related pollutants by LUR then examined whether LUR models could be constructed using a regulatory monitoring network in Metropolitan area in Korea. We used the annual-mean nitrogen dioxide ($NO_2$) in 2010 in the study area. Geographic variables that are considered to predict traffic-related pollutants were classified into four groups: road type, traffic intensity, land use, and elevation. Using geographical variables, we then constructed a model to predict the monitored levels of $NO_2$. The mean concentration of $NO_2$ was 30.71 ppb (standard deviation of 5.95) respectively. The final regression model for the $NO_2$ concentration included five independent variables. The LUR models resulted in $R^2$ of 0.59. The mean concentration of $NO_2$ of elementary schools was 34.04 ppb (standard deviation of 5.22) respectively. The present study showed that even if we used regulatory monitoring air quality data, we could estimate $NO_2$ moderately well. These analyses confirm the validity of land use regression modeling to assign exposures in epidemiological studies, and these models may be useful tools for assessing health effects of long-term exposure to traffic related pollution.

• 한국산학기술학회논문지
• /
• 제19권4호
• /
• pp.301-310
• /
• 2018

본 연구는 요양시설 노인의 신체적 기능(ADL, IADL) 및 정신적 기능(우울, 인지기능장애) 수준과 삶의 질과의 관련성을 규명하고자 시도하였다. 조사대상은 D광역시에 소재하고 있는 15개 요양시설에 입소하고 있는 65세 이상 노인 524명으로 하였으며, 자료 수집은 2015년 11월부터 2016년 1월까지의 기간 동안에 조사원이 조사대상 요양시설을 직접 방문하여 면접 조사하였다. 자료의 분석은 각 독립변수에 대한 삶의 질을 종속변수로 하여 평균점수를 비교하기 위해 t-test 및 ANOVA로 검정하였다. 또한, 삶의 질에 영향을 미치는 관련 독립변수들의 설명력을 파악하기 위하여 다중회귀분석을 실시하였다. 연구결과, 조사대상자의 삶의 질은 연령이 높을수록, 학력이 낮을수록, 가족과 함께 산다는 군보다 혼자 산다는 군, 자녀와의 관계가 좋다는 군보다 좋지 않다는 군, 주관적인 건강상태가 건강하다는 군보다 건강하지 않다는 군, 신체의 부자유가 없다는 군보다 있다는 군, 치아상태가 좋다는 군보다 좋지 않다는 군, 아침식사를 한다는 군보다 하지 않는다는 군, 규칙적인 운동을 한다는 군보다 하지 않는다는 군, 정기적인 건강검진을 한다는 군보다 하지 않는다는 군에서 유의하게 낮았다. 또한, 일상생활수행능력(ADL)과 도구적 일상생활수행능력(IADL)이 낮을수록, 우울수준이 높을수록, 인지기능장애점수가 낮을수록 삶의 질 수준이 유의하게 낮은 것으로 나타났다. 이 같은 연구결과는 요양시설 노인의 삶의 질은 인구사회학적특성, 건강상태 및 건강관련행위특성뿐만 아니라 신체적 기능 및 정신적 기능과도 유의한 관련성이 있음을 시사하고 있다.

• Journal of Korean Neurosurgical Society
• /
• 제49권3호
• /
• pp.147-152
• /
• 2011

Objective : The aim of this study was to evaluate the reliability and validity of the Pediatric Functional Assessment of Cancer Therapy Questionnaire Brain Tumor Survivor (version 2.0) Aged 13 years and older (Parent Form) (pedsFACT-BrS parent of adolescent). Methods : The pedsFACT-BrS parent of adolescent was translated and cross-culturally adapted into Korean, following standard Functional Assessment of Chronic Illness Therapy (FACIT) methodology. The psychometric properties of the pedsFACT-BrS parent of adolescent were evaluated in 170 brain tumor patient's mothers (mean age=43.38 years). Pretesting was performed in 30 mothers, and the results indicated good symptom coverage and overall comprehensibility. The participants also completed the Child Health Questionnaire Parent Form 50 (CHQ-PF-50), Neuroticism in Eysenck Personality Questionnaire, and Karnofsky score. Results : In validating the pedsFACT-BrS parent of adolescent, we found high internal consistency, with Cronbach's ${\alpha}$ coefficients ranging from 0.76 to 0.94. The assessment of test-retest reliability using intraclass correlation coefficient revealed satisfactory values with ICCs ranging from 0.84 to 0.93. The pedsFACT-BrS for parent of adolescent also demonstrated good convergent and divergent validities when correlated with the Child Health Questionnaire Parent Form 50 (CHQ-PF-50) and the Neuroticism in Eysenck Personality Questionnaire. The pedsFACT-BrS parent of adolescent showed good clinical validity, and effectively differentiated between clinically distinct patient groups according to the type of treatment, tumor location, shunt, and Karnofsky score of parent proxy report. Conclusion : We confirmed that this reliable and valid instrument can be used to properly evaluate the quality of life of Korean adolescent brain tumor patients by their parents' proxy report.

• 치위생과학회지
• /
• 제6권2호
• /
• pp.79-84
• /
• 2006

본 연구는 초등학생을 위한 학교구강보건 사업에 대한 유용하고 실용적인 도구로서의 구강건강관련 삶의 질 지표의 활용 가능성을 제시하고 학교구강보건사업의 평가에 대한 기초자료를 수집할 목적으로 광주시에 소재한 초등학교 5, 6학년을 대상으로 구강관련일상수행지표(OIDP)와 건강관련 주관인식 및 구강건강상태 등의 연관성을 조사 분석한바 다음과 같은 결과를 얻었다. 1. OIDP 점수 보유자는 전체의 45.5%였으며, 6학년이 5학년보다 그리고 여자가 남자보다 평균 점수가 높았다. 2. OIDP에 유무에 따른 지식, 태도, 행동 수준의 경우 OIDP 점수를 가진 집단보다 갖지 않은 집단에서 구강보건에 대한 지식, 태도, 행동수준이 더 높았고, 지식, 행동의 경우 유의한 차이가 있었다(p < 0.05). 3. OIDP 점수 유무에 따른 구강건강인지, 상태 만족, 치과불필요도는 OIDP 점수를 가진 집단 보다 OIDP 점수를 갖지 않는 집단에서 바람직하였고, 모두 유의한 차이가 있었다(p < 0.05). 4. OIDP 점수 유무에 따른 우식경험영구치아수는 OIDP 점수를 가진 집단보다 갖지 않은 집단에서 적게 나타났고, 유의한 차이가 있었다(p < 0.05). 5. OIDP 점수를 보유한 아동은 잇솔질(49.5%), 식사(47.1%), 감정유지(22%), 발음(19.7%) 등의 순으로 어려움을 경험한 것으로 나타났다. 6. OIDP 항목별 유발 원인에 있어서는 흔들린 치아 및 빠진 치아가 잇솔질에 대한 어려움의 원인으로 나타났고, 치아통증이 식사, 감정유지, 공부에 대한 어려움의 원인이었으며, 부정교합이 발음과 미소 짓기에 대한 어려움으로, 충치가 대인관계와 수면에 대한 어려움의 원인이었다.

• 대한골대사학회지
• /
• 제25권4호
• /
• pp.195-211
• /
• 2018

Background: To develop guidelines and recommendations to prevent and treat glucocorticoid (GC)-induced osteoporosis (GIOP) in Korea. Methods: The Korean Society for Bone and Mineral Research and the Korean College of Rheumatology have developed this guideline based on Guidance for the Development of Clinical Practice Guidelines ver. 1.0 established by the National Evidence-Based Healthcare Collaborating Agency. This guideline was developed by adapting previously published guidelines, and a systematic review and quality assessment were performed. Results: This guideline applies to adults aged ${\geq}19years$ who are using or plan to use GCs. It does not include children and adolescents. An initial assessment of fracture risk should be performed within 6 months of initial GC use. Fracture risk should be estimated using the fracture-risk assessment tool (FRAX) after adjustments for GC dose, history of osteoporotic fractures, and bone mineral density (BMD) results. All patients administered with prednisolone or an equivalent medication at a dose ${\geq}2.5mg/day$ for ${\geq}3months$ are recommended to use adequate calcium and vitamin D during treatment. Patients showing a moderate-to-high fracture risk should be treated with additional medication for osteoporosis. All patients continuing GC therapy should undergo annual BMD testing, vertebral X-ray, and fracture risk assessment using FRAX. When treatment failure is suspected, switching to another drug should be considered. Conclusions: This guideline is intended to guide clinicians in the prevention and treatment of GIOP.

• Korean Journal of Radiology
• /
• 제22권7호
• /
• pp.1172-1184
• /
• 2021

Objective: The purposes of this study were to analyze the radiation doses for pediatric abdominopelvic and chest CT examinations from university hospitals in Korea and to establish the local diagnostic reference levels (DRLs) based on the body weight and size. Materials and Methods: At seven university hospitals in Korea, 2494 CT examinations of patients aged 15 years or younger (1625 abdominopelvic and 869 chest CT examinations) between January and December 2017 were analyzed in this study. CT scans were transferred to commercial automated dose management software for the analysis after being de-identified. DRLs were calculated after grouping the patients according to the body weight and effective diameter. DRLs were set at the 75th percentile of the distribution of each institution's typical values. Results: For body weights of 5, 15, 30, 50, and 80 kg, DRLs (volume CT dose index [CTDI_vol]) were 1.4, 2.2, 2.7, 4.0, and 4.7 mGy, respectively, for abdominopelvic CT and 1.2, 1.5, 2.3, 3.7, and 5.8 mGy, respectively, for chest CT. For effective diameters of < 13 cm, 14-16 cm, 17-20 cm, 21-24 cm, and > 24 cm, DRLs (size-specific dose estimates [SSDE]) were 4.1, 5.0, 5.7, 7.1, and 7.2 mGy, respectively, for abdominopelvic CT and 2.8, 4.6, 4.3, 5.3, and 7.5 mGy, respectively, for chest CT. SSDE was greater than CTDI_vol in all age groups. Overall, the local DRL was lower than DRLs in previously conducted dose surveys and other countries. Conclusion: Our study set local DRLs in pediatric abdominopelvic and chest CT examinations for the body weight and size. Further research involving more facilities and CT examinations is required to develop national DRLs and update the current DRLs.

• Clinical Endoscopy
• /
• 제55권2호
• /
• pp.167-182
• /
• 2022

Sedation can resolve anxiety and fear in patients undergoing endoscopy. The use of sedatives has increased in Korea. Appropriate sedation is a state in which the patient feels subjectively comfortable while maintaining the airway reflex for stable spontaneous breathing. The patient should maintain a state of consciousness to the extent that he or she can cooperate with the needs of the medical staff. Despite its benefits, endoscopic sedation has been associated with cardiopulmonary complications. Cardiopulmonary complications are usually temporary. Most patients recover without sequelae. However, they may progress to serious complications, such as cardiovascular collapse. Therefore, it is essential to screen high-risk patients before sedation and reduce complications by meticulous monitoring. Additionally, physicians should be familiar with the management of emergencies. The first Korean clinical practice guideline for endoscopic sedation was developed based on previous worldwide guidelines for endoscopic sedation using an adaptation process. The guideline consists of nine recommendations based on a critical review of currently available data and expert consensus when the guideline was drafted. These guidelines should provide clinicians, nurses, medical school students, and policy makers with information on how to perform endoscopic sedation with minimal risk.

• Pediatric Infection and Vaccine
• /
• 제18권1호
• /
• pp.40-47
• /
• 2011

목 적 : 노로바이러스는 바이러스성 설사의 흔한 원인이며, 면역 저하 환자에서도 심각한 감염증을 유발하는 것으로 알려져 있어, 소아 암환자에서 노로바이러스 감염의 임상 양상을 알아보고자 하였다. 방 법: 2008년 11월부터 2009년 9월까지 삼성 서울병원에 입원한 환아 중 대변에서 노로바이러스 PCR 양성을 보였던 소아 암환자를 대상으로 하였고, 이들의 의무기록을 후향적으로 분석하였다. 결 과:연구에 포함된 환자는 총 10명이었으며, 이들 연령의 중앙값은 0.83세, 남녀의 비율은 1.5대 1이었다. 기저질환은 혈액암 4명, 신경모세포종 4명, 뇌종양 2명이었고, 감염 진단 당시 조혈모세포이식 수여자는 4명이었다. 모든 환자에서 설사 증상을 보였으며, 설사 횟수의 중앙값은 8.5회/일, 바이러스 배출 기간의 중앙값은 72.5일이었다. 장기종 소견을 보인 4명의 환자는 금식 및 총정맥 영양을 투여 받았으며, 노로바이러스 관련 사망은 관찰되지 않았다. 결 론 : 노로바이러스 감염은 소아 암환자에서 다양한 임상 증상을 유발 할 수 있으며, 이들 면역저하 환자에서 바이러스 배출 기간이 매우 길어, 설사가 있는 암환자에서 고려해야 할 바이러스 감염이다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제23권1호
• /
• pp.23-30
• /
• 2012

Objectives : This study was conducted to investigate the prevalence of victims of bullying and the demographic characteristics of victims, and their related psychopathology, in a Korean nationwide sample of youths in middle and high school over a one month period. Methods : During the autumn of 2009, students in the 7th to 12th grades at 23 secondary schools participated in a nationwide, cross-sectional study. The study subjects completed the Adolescent Mental Health and Problem Behavior Screening Questionnaire-II (AMPQ-II) and Symptom Checklist-90-Revision (SCL-90-R). Based on the data acquired, descriptive statistics, correlation coefficients and multiple logistic regression analysis were performed. Results : Among the 3364 participants, 2272 (67.54%) completed the questionnaire. The prevalence of victimization was 28.9%. Male gender was positively associated with victimization, and grade level was negatively related to victimization. The AMPQ-II bullying score (Factor 4) was significantly (p<.001) and positively correlated to the AMPQ-II student total score (r= 0.50), Worry and thought (Factor 1 ; r=0.38), Mood and suicide (Factor 2 ; r=0.31), Academic and Internet-related problems (Factor 3 ; r=0.24), Rule violations (Factor 5 ; r=0.23), and AMPQ-II teacher total score (r=0.11). Somatization (r=0.23), Obsessive-compulsive behavior (r=0.24), Interpersonal sensitivity (r=0.30), Depression (r=0.33), Anxiety (r=0.26), Hostility (r=0.30), Phobic anxiety (r=0.22), Paranoid ideation (r=0.36), and Psychoticism (r=0.31) results from the SCL-90-R were also found to be positively related to the AMPQ-II bullying score, and remained significant after adjusting for age and gender. A total of 26% of the victims reported suicidal ideations as compared to 9% of non-victims over the month prior to the evaluation ($x^2$=119.595, df=1, p<.001). The multiple logistic regression analysis indicated that the AMPQ-II bullying score significantly increased the risk of suicidal ideation [Exp(b)=1.55, df=1, p<.001] after adjusting for age and gender. Conclusion : School bullying was highly prevalent among Korean middle and high school students. This study provided strong evidence that suicidal ideation and psychopathology were serious problems among the victims of bullying.