• Journal of Acupuncture Research
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• v.27 no.2
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• pp.97-104
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• 2010

Objectives : The authors aimed to determine the presence of relationships between cervical pain and cervical curvature, lumbar curvature, sacral slope and sagittal spinal balance. Methods : Medical records of outpatients who made their first visits to the Department of Acupuncture and Moxibustion in the Spine center at Kyung Hee East-West Neo Medical Center between September 1, 2008 and October 31, 2009 were evaluated. A total of 50 patients visiting within the time period had visited with a chief complaint of cervical pain, and had lateral entire spine X-rays taken. After excluding patients with previous spine operations, 46 patients were selected for the final analysis. The cervical lordotic angle(CLA), lumbar lordotic angle(LLA), Ferguson's angle(FA), and sagittal vertical axis(SVA) were measured on the lateral entire spine X-ray cuts, and the relationships between these values and patient gender, age, chief complaint, and duration of symptoms were assessed. Results : No significant difference was found in relationships between gender and measured values. SVA showed statistically significant correlation between age, but CLA, LLA, and FA was not. There was a significant difference in SVA between patients with only cervical pain and those with both cervical pain and low back pain. Patients with a duration of symptoms longer than 6 months showed a statistically significant difference in SVA with those who had shorter symptoms. Correlation analysis between measured values was statistically significant only between LLA and FA. Conclusions : Evaluation and treatment of sagittal imbalance should be considered in patients presenting with cervical pain if symptoms have persisted for over 6 months or have accompanying low back pain.

• Journal of the Korean Society of Food Science and Nutrition
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• v.35 no.2
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• pp.127-131
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• 2006

A study was carried out to produce antimicrobial peptides from zein treated with pretenses of six kinds. Among the pretenses of six kinds, zein hydrolysate treated with pepsin showed the highest antimicrobial activity. The zein hydrolysate with pepsin was fractionated with membrane filter (30,000 10,000 and 3,000 molecular weight cut-off) and antimicrobial activity was measured for each fractions. Antimicrobial activity appeared greatly in the fraction below 3,000 (molecular weight cut-off) . The fraction was re-fractionated by HPLC and substances of two peaks collected as a sample to measure antimicrobial activity. All of both peaks showed the antimicrobial activity but 1st peak exhibited a consistently higher antimicrobial activity than 2nd peak. Minimum inhibitory concentrations (MIC) were between 2.5 and 3.0 mg/mL. The peptide was heat-stable since antimicrobial activity was maintained after treated with heat for 20 min at $121^{\circ}C$. N-terminal amino acid sequence of peptide fractionated by HPLC was leucine, glutamic acid, proline, phenylalanine, aspartic acid and argenine. These results indicated that peptide isolated from zein hydrosate with pepsin can use as a natural preservative ingredient in food industry.

• Journal of Korean Society of Environmental Engineers
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• v.33 no.5
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• pp.378-383
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• 2011

The policy of total maximum daily load (TMDL) was adopted to manage water pollutants so as to keep the total amount of pollutants in the watersheds within established target water quality. While the TMDL was implemented in all four major river basins, various problems occurred. Even though the corrections for problems were conducted, the role between central and local government was not established exactly. This study was presented to suggest a role between central and local governments for effective implementation of TMDL. When the central government establishes the environmental criteria with water quality standards and pollutants in the main rivers, the local government should establish the level of target pollutants in the watershed. Also, the local government should be continuously implementing the water quality and flowrate monitoring of the tributaries to find out the degree of water quality improvement in the tributaries. Especially, the basic plan of TMDL for the whole watershed should be established by the river basin environmental office at the central government. The local government should be established the implementation plan of TMDL for the watershed where exceeds the established target water quality. The performance assessment of TMDL should be implemented every year to the water quality and flowrate monitoring of the tributaries for satisfaction assessment of target water quality in the watershed by the lower-lever government. The performance assessment report of TMDL included with an analysis of causes for the excess water quality in the watershed should be submitted to the river basin environmental office at the end of the TMDL planning period.

• Genomics & Informatics
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• v.16 no.3
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• pp.52-58
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• 2018

In this report, we present a case study of how pharmacogenomics and pharmacometabolomics can be useful to characterize safety and pharmacokinetic profiles in early phase new drug development clinical trials. During conducting a first-in-human trial for a new molecular entity, we were able to determine the mechanism of dichotomized variability in plasma drug concentrations, which appeared closely related to adverse drug reactions (ADRs) through integrated omics analysis. The pharmacogenomics screening was performed from whole blood samples using the Affymetrix DMET (Drug-Metabolizing Enzymes and Transporters) Plus microarray, and confirmation of genetic variants was performed using real-time polymerase chain reaction. Metabolomics profiling was performed from plasma samples using liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. A GSTM1 null polymorphism was identified in pharmacogenomics test and the drug concentrations was higher in GSTM1 null subjects than GSTM1 functional subjects. The apparent drug clearance was 13-fold lower in GSTM1 null subjects than GSTM1 functional subjects (p < 0.001). By metabolomics analysis, we identified that the study drug was metabolized by cysteinylglycine conjugation in GSTM functional subjects but those not in GSTM1 null subjects. The incidence rate and the severity of ADRs were higher in the GSTM1 null subjects than the GSTM1 functional subjects. Through the integrated omics analysis, we could understand the mechanism of inter-individual variability in drug exposure and in adverse response. In conclusion, integrated multi-omics analysis can be useful for elucidating the various characteristics of new drug candidates in early phase clinical trials.

• The Journal of the Petrological Society of Korea
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• v.27 no.1
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• pp.25-36
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• 2018

The volcanic rocks around Mieukdo Island, Tongyeong, are classified as lower andesitic rocks (Jusasan Subgroup) and rhyolitic rocks (Unmunsa Subgroup), and upper andesitic rocks (Yokji Subgroup) and rhyolitic rocks (Saryang Subgroup). We confirmed their eruption timings and stratigraphic relationships, based on SHRIMP U-Pb zircon dating for zircons from major stratigraphic units of the subgroups. By the SHRIMP U-Pb dating, the samples yield the concordia ages of $88.95{\pm}0.44Ma$(n=11) in Punghwari Tuff and $82.56{\pm}0.95Ma$(n=10) in Chudo Tuff of the lower andesitic rocks, and $73.01{\pm}0.75Ma$(n=11) in Dara Andesite of the upper andesitic rocks. And then samples show a concordia age of $71.74{\pm}0.47Ma$(n=14) in Namsan rhyolite dyke of the upper rhyolitic rocks and an apparent age of $70.7{\pm}3.5Ma$ in granodiorite dyke, These data confirm the eruption or injection timings of the units and allow them to distinguish chronostratigraphy of Jusasan, Unmunsa, Yokji and Saryang Subgroups around the Mireukdo Island. In addition, the subgroups give a clue that can make a chronostratigraphical correlation with different volcanic units of the Late Cretaceous Yucheon Group in the Gyeongsang basin.

• Molecules and Cells
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• v.38 no.11
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• pp.982-990
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• 2015

Exposure of the skin to ultraviolet radiation can cause skin damage with various pathological changes including inflammation. In the present study, we identified the skin-protective activity of 1,2,3,4,6-penta-O-galloyl-${\beta}$-D-glucose (pentagalloyl glucose, PGG) in ultraviolet B (UVB) radiation-induced human dermal fibroblasts and mouse skin. PGG exhibited antioxidant activity with regard to intracellular reactive oxygen species (ROS) generation as well as ROS and reactive nitrogen species (RNS) scavenging. Furthermore, PGG exhibited anti-inflammatory activity, inhibiting the activation of nuclear factor-kappaB (NF-${\kappa}B$) and mitogen-activated protein kinase (MAPK) signaling, resulting in inhibition of the expression of pro-inflammatory mediators. Topical application of PGG followed by chronic exposure to UVB radiation in the dorsal skin of hairless mice resulted in a significant decrease in the progression of inflammatory skin damages, leading to inhibited activation of NF-${\kappa}B$ signaling and expression of pro-inflammatory mediators. The present study demonstrated that PGG protected from skin damage induced by UVB radiation, and thus, may be a potential candidate for the prevention of environmental stimuli-induced inflammatory skin damage.

• Journal of the Earthquake Engineering Society of Korea
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• v.8 no.1
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• pp.67-76
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• 2004

This study presents the evaluation of CSM(Capacity Spectrum Method, ATC-40) in developing fragility curves for a sample concrete bridge. The CSM is originally developed as one of the simplified procedures for building structures, while this study adopts the CSM to develop fragility curves of bridge structures. Four(4) different approaches are demonstrated and the fragility curves developed are compared those by the nonlinear time history analysis. Fragility curves in this study are represented by lognormal distribution functions with two parameters and developed as a function of PGA. The sixty(60) ground acceleration time histories for the Los Angeles area developed for the Federal Emergency Management Agency (FEMA) SAC(SEAOC-ATC-CUREe) steel project are used for the bridge analysis. The comparison of fragility curves by the CSM with those by the time history analysis indicates that the agreement is excellent for one of the methods investigated in this study. In this respect. it is recommended that the demand spectrum might be improved according to the guidelines suggested in this study. However, this observation might not always apply, depending on the details of specific bridge characteristic

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.20 no.1
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• pp.1-6
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• 2010

CuInGaSe(CIGS) mixed-source was prepared by hydride vapor phase epitaxy (HVPE). Each metal was mixed in regular ratio and soaked at $1090^{\circ}C$ for 90 minutes in nitrogen atmosphere. After making the mixed-source to powder state, the pellet was made by the powder. The diameter of pellet is 10 mm. The CIGS thin film was deposited on soda lime glass evaporated Mo layer bye-beam evaporator. To confirm the crystallization, we measured X-ray diffraction (XRD). High intensity X-ray peaks diffracted from (112), (204)/(220), (116)/(312) and (400) of CIGS thin film and from (110) of Mo were confirmed by XRD measurement.

• The Journal of Korean society of community based occupational therapy
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• v.5 no.2
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• pp.43-55
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• 2015

Objective : This study was a meta-analysis of previous studies to examine the integration of related factors depression University students of Korea, and to determine the relative importance among the relevant factors based on it. Methods : 2000-2014 papers posted on the National Science and Technology Information Center (NDSL), Nurimedia (DBpia), Academic Research Information Service (RISS), Korea Research Information(KISS), provide the text of the Library of Congress were collected using the service. The Key words a 'University Student', 'Depression', 'Depression Factors' was used. Used the Down & Black level, evidence-based checklist was developed by the research (1998) (checklist) had analyzed the selected document metadata to assess the quality. Results : 47-studies selected research groups are divided into five factors(self-esteem, suicidal ideation, positive thinking, stresses, Internet and smartphone addiction). Using meta-analysis, we analyzed the effect sizes, statistical heterogeneity and publication amenities. As a result, the self-esteem of the five factors were not found heterogeneity. Effect size is a self-esteem and suicidal ideation "large effect size", positive thinking and stress "medium effect size", internet and smart phone addiction"small effect size". Conclusion : Self-esteem and suicidal ideation are among the factors associated with depression in University students of Korea was found that the most relevant. It identified the factors associated with depression in college students, and could utilized as basis for the prevention of depression.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.29 no.6
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• pp.520-526
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• 2007

The accuracy of model surgery is one of important factors which can influence the outcome of orthognathic surgery. To evaluate the accuracy of digitalized model surgery, we tried the model surgery on a software after transferring the mounted model block into a digital model, and compared the results with that of classical manual model surgery. We could get the following results, which can be used as good baseline analysis for the clinical application. 1. We made the 3D scanning of dental model blocks, and mounted on a software. And we performed the model surgery according to the previously arranged surgical plans, and let the rapid prototyping machine produce the surgical wafer. All through these process, we could confirm that the digital model surgery is feasible without difficulties. 2. The digital model surgery group (Group 2) showed a mean error of $0.0{\sim}0.1mm$ for moving the maxillary model block to the target position. And Group 1, which was done by manual model surgery, presented a mean error of $0.1{\sim}1.2mm$, which is definitely greater than those of Group 2. 3. Remounted maxillary model block with the wafers produced by digital model surgery from Group 2 showed the less mean error (0.2 to 0.4 mm) than that produced by manual model surgery in Group 1 (0.3 to 1.4 mm). From these results, we could confirm that the digital model surgery in Group 2 presented less error than manual model surgery of Group 1. And the model surgery by digital manipulation is expected to have less influence from the individual variation or degree of expertness. So the increased accuracy and enhanced manipulability will serve the digital model surgery as the good candidate for the improvement and replacement of the classical model surgery, if careful preparation works for the clinical adjustment is accompanied.