• Journal of Evidence-Based Herbal Medicine
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• v.2 no.1
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• pp.33-42
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• 2009

Sodium arsenate and Yeonlyeonggobon-dan (nianlinggubendan) extract, a herbal restorative were treated p.o. 20mg/kg and 500mg/kg respectively and concurrently to rats, and examined the variation of the body weight and the accumulation of arsenic in organs. Yeonlyeonggobon-dan (nianlinggubendan) extract(YGD) resulted in the increase of body weight, and the increase ratio of body weight in arsenic-treated group was dropped but the group of concurrent administration with YGD showed significant recovery. The ratio of liver weight / body weight of arsenic-treated group increased but the group of concurrent administration with YGD showed significant decrease. The accumulation of arsenic in liver and kidney of arsenic-treated group increased but the group of concurrent administration with YGD showed significant decrease.

• Journal of Evidence-Based Herbal Medicine
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• v.2 no.1
• /
• pp.43-49
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• 2009

Sodium arsenate and Yeonlyeonggobon-dan (nianlinggubendan) extract (YGD), a herbal restorative were treated p.o. 20 mg/kg and 500 mg/kg, respectively, and concurrently to rats, and examined the biochemical parameters in blood. The values of white blood cell (WBC), red blood cell (RBC), hemoglobin (Hgb) and hematocrit (Hct) in each group did not show significant variance. The value of aspartate aminotrasferase (AST) of arsenic-treated group was increased for 2 weeks significantly while that of the group of concurrent administration with YGD became low significantly compared with arsenic-treated group and the value of alkaline phosphatase (ALP) of arsenic-treated group was decreased while that of the group of concurrent administration with YGD was increased significantly compared with arsenic-treated group. In arsenic-treated groups, the value of glucose (Glu), and those of lactic dehydrogenase (LDH), blood urea nitrogen (BUN) and triglyceride (TG) were decreased at first but increased later while the groups of concurrent administration with YGD showed significant recovery from the toxicity of arsenic.