• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2006년도 춘계학술대회
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• pp.136-136
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• 2006

• 한국임상수의학회지
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• 제6권1호
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• pp.199-208
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• 1989

This study was carried out to Investigate the effects of detomidine and xylazine on physical sign, electrocardiogram, blood pressure, acid-base status and the antagonistic effect of yohimbine on detomidine in goats. Yohimbine was administered 10 minutes after detomidine injection. Maintenance time of sedation was remarkably decreased in yohimbine-treated group(59.5${\pm}$3.8min). compared with detomidine-treated group(99.8 ${\pm}$ 14.7min). Body temperature was slightly decreased, heart rate was markedly decreased in all experimental groups and respiratory rate increased in detomidine-treated group and decreased in zylazine-treated group. However they were recovered rapidly after yohimbine administration In electrocardiogram, there were no significant changes except T waves and RR intervals. T waves showed negative form and RR intervals were increased but they were recovered rapidly in yohimbine-treated group compared with detomidine-treated group. Blood pressure was decreased after detomidine administration but recovered faster in yohimbine-treated group than in detomidine alone group. Blood pH was increased in detomidine-treated and yohimbine-treated groups but unchanged in xylazine-treatd group. It is considered that the effects of detomidine are similar to those of xylaxine and yohimbine is effective antagonist to detomidine in goats.

• 농업과학연구
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• 제17권2호
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• pp.142-145
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• 1990

충남대학교 부속동물병원에 내원(來院)한 우측후지(右側後肢)의 부전골에 골절상(骨折傷)을 받은 6개월금(個月今)의 꽃사슴에 대하여 대퇴골절단술(大腿骨切斷術)을 실시한 증례(症例)를 보고한다. 마취는 체중 kg당 1.2mg의 xylazine을 근육주사하여 실시하였으며, 수술방법은 개에서의 대퇴골절단술(大腿骨切斷術)과 같은 방법(方法)을 시도하였다. 수술직후 일어서기, 걷기, 달리기등의 운동에 불편을 보였지만 시간이 경과함에 따라 숙달되는 것을 관찰할 수 있었으며, 절단수술후(切斷手術後) 현재(現在)까지 (약(約) 6개월(個月)) 병적(病的) 미후(微候)는 인정되지 않았다.

• 대한수의학회지
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• 제45권3호
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• pp.423-427
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• 2005

Color Doppler imaging (CDI) was carried out to evaluate the anesthetics effect on ophthalmic circulation using CDI-derived resistive index (RI) values. CDI was preformed on 24 dogs, and RI values were calculated for the medial long posterior ciliary artery (mLPCA) and ophthalmic artery (OA) before and after administration of anesthetics. After administration of benoxinate or acepromazine, a significant change of the mLPCA RI was not found. But, a significant decrease of the RI following ketamine (p < 0.001) or xylazine (p < 0.01) administration could be observed as compared with the self-control. Mean RI value of OA also showed this same trend. Intraocular pressure was significantly decrease following benoxinate (p < 0.01), acepromazine (p < 0.01), and xylazine (p < 0.001) administration within normal range. The results suggest that some anesthetics influence on ophthalmic vascular resistance. Therefore, chemical restraint was carefully used in clinical application of CDI-derived RI measurement. Particularly, benoxinate and acepromazine is useful chemical restraint without a change of the ophthalmic vascular resistance.

• 대한수의학회지
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• 제31권3호
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• pp.343-353
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• 1991

In order to investigate the histopathological, mechanism of Rompun-induced shock, the development of mammary carcinoma, the numerical changes and the morphological findings of the mast cells appeared in the carcinoma were microscopically observed in the rat treated with DMBA and each chemical of compound 48/80 and Rompun. Also mast cell degranulation induced by Rompun was observed with electron microscope. The results observed were summarized as follows: Tumor appeared in 100% of the animals. Tumors grew more rapidly to $10{\times}10mm$ in rats depleted of mast cells ($37.7{\pm}4.2$ days) than was observed in the control group ($42.5{\pm}4.7$ days) (p<0.005). The mean number of tumors per rat was $2.8{\pm}1.3$ in the compound 48/80- treated group in contrast to $3.4{\pm}1.3$ in the control group. No significant difference was apparent in the tumor induction time of Rompun treated group compared with the compound 48/80-treated group, but the tumor measuring at least $10{\times}10mm$ appeared more quickly in the Rompun treated group than in the control group (p<0.005). The numbers of mast cells in the control group were inclined to increase significantly according to the mammary tumor development (p<0.005). In contrast, the mast cells were fewer significantly in the compound 48/80-treated group and Rompun-treated group than in the control group (p<0.005). The numbers of mast cells in the compound 48/80-treated group and Rompun-treated group were inclined to reduce significantly according to the stages of the mammary carcinoma growth in contrast to the control group respectively. The ultrastructural morphologies of mast cells at 30 minutes after Rompun injection were appeared many normal granules in the cytoplasm, but many normal and degranulated granules were scattered along the cell membrane. And at 1 hour after Rompun injection mast cell granules were disappeared nearly or rarely seen. many long cytoplasmic projections were folded back to adhere to their own surface membrane. and mast cells resulted in a reduced size of these cells. Otherwise. compound 48/80 caused extensive degranulation of mast cells by disrupting cell membrane. but mast cell degranulation by Rompun was observed exocytosis of granules through a channel. From the above results. it is concluded that the Rompun may give rise to the dealth of animals as a shock caused by mast cell degranulation.

• 한국임상수의학회지
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• 제36권6호
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• pp.306-313
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• 2019

It is important to identify the most suitable anesthetic agent that has minimal side effects to be able to control and perform surgeries on bears. In this study, we examined and compared the induction and recovery times as well as the physiological changes occurring during anesthesia induced by medetomidine-zolazepam/tiletamine (MZT) and xylazine-zolazepam/tiletamine (XZT) at general anesthesia for laparoscopic salpingectomy in 326 female Asiatic black bears. The body temperature, heart rate, respiratory rate, and levels of PaO₂ and EtCO₂ were the physiological changes measured during surgical procedures in female bears after anesthesia. In addition, the levels of pO₂, pCO₂, and sO₂ were measured using a portable blood gas analyzer. To induce recovery from anesthesia, bears anesthetized with MZT were intravenously administered atipamezole and bears anesthetized with XZT were intravenously administered yohimbine. The combination MZT, at dosages of 0.019 ± 0.001 mg/kg for medetomidine and 1.4 ± 0.1 mg/kg for ZT, or the combination XZT, at dosages of 2.0 ± 0.1 mg/kg for xylazine and 3.0 ± 0.1 mg/kg for ZT, proved to be reliable and effective in anesthetizing Asiatic black bears for a 40-min handling period for routine clinical procedures. The average anesthesia induction times were 16.5 ± 0.95 min for the bears in the MZT group and 12.0 ± 0.44 min for those in the XZT group. A significant difference was noted between the two drugs (P < 0.001) in terms of the average anesthesia induction time. The anesthesia induction time was shorter for bears with lower body weights than those with higher body weights (P < 0.05). The recovery time of MZT was significantly faster than that of XZT (11.3 ± 0.45 min vs. 18.5 ± 0.83 min) (P < .001). The bears anesthetized with MZT exhibited lower cardiopulmonary suppression than those anesthetized with XZT (P < 0.05). The body temperatures and EtCO₂ of bears in the M ZT group were significantly lower than those in the XZT group as time progressed after anesthesia (P < 0.05). The average pO₂ before the bears were supplied with oxygen was 64.8 ± 3.7 mmHg, but it increased to 211.5 ± 42.5 mmHg afterwards (P < 0.001). In conclusion, our results indicate that bears anesthetized with MZT have longer anesthesia induction time, shorter recovery time, slower heart and respiratory rates, and lower body temperatures and EtCO₂ than those anesthetized with XZT. These findings suggest that XZT is preferable to MZT, warranting further research on its uses and clinical responses in bears.

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2007년도 추계국제학술대회 및 컨퍼런스
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• pp.566-566
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• 2007

• 한국임상수의학회지
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• 제31권4호
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• pp.313-315
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• 2014

13개월령의 중성화하지 않은 암컷 미니어처 슈나우저 개가 귓바퀴의 소양감, 통증 및 상처치유의 지연을 주증으로 내원하였다. 환자의 혈청 성장호르몬 농도가 참고범위 이하로 측정되었으며 자일라진 자극검사를 통해 뇌하수체 왜소증으로 진단되었다. 보호자가 원하지 않아 성장호르몬 및 프로게스틴 치료는 진행하지 않았으며, 탈모의 개선을 목적으로 멜라토닌 투여를 시작하였다. 멜라토닌 투여 이후, 귓바퀴의 탈모가 개선되는 것을 확인할 수 있었다.

• 한국임상수의학회지
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• 제29권1호
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• pp.112-117
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• 2012

This report evaluated the convenience and accessibility of a penile translocation surgery in the lateral recumbency of a calf using a tilt-up mobile compared with that of dorsal recumbency on the ground of a barn. One nine-month-old F-1 (Korean native sire x Holstein dam) calf was sedated with xylazine (0.03 mg/kg, IV) and restrained in the right lateral recumbency position on a tilt-up restraint mobile (90 cm high), whereas the other nine-month-old Korean native calf was administered xylazine (0.3 mg/kg, IV) and restrained in dorsal recumbency position on the ground of a barn, with assistance by one person. For the two calves, lidocaine was administered subcutaneously from the preputial orifice to the S-shaped penis. The preputial orifice was incised, and the preputial sheath and penis were separated bluntly, then laterally translocated to the site toward the left flank at a $40^{\circ}$ angle. Anti-inflammatory drug (ketoprofen) and antibiotics (penicillin) were administered following the surgery. The duration of surgery was 30 min shorter in the calf that received the surgery in lateral recumbency using the tilt-up mobile with operator's standing posture (60 min) than the one that underwent surgery in dorsal recumbency on the ground with operator's bending posture (90 min). One week after the surgery, the operation area, including the translocated preputial orifice, was healed without complications in both cases. The results detailed in this report demonstrate that penile translocation surgery in the lateral recumbency position using a tilt-up mobile might be used conveniently in calves due to the convenience of restraint, reduced surgery time, and reduced physical inconvenience for the surgeon.

• 한국임상수의학회지
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• 제16권2호
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• pp.519-522
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• 1999

This study was performed to determine the effects of anastomosis on the internal diameter and wall thickness of jugular vein. Tro shepherd dogs were used for this experiment. In dog 1, xylazine(2 mg/kg) and ketamine(5.5 mg/kg) were injected intramuscularly for induction followed by enflurane(3%) anesthesia. In dog 2, acepromazine(0.03 mg/kg) and ketamine(5 mg/kg) were injected intravenously for induction followed by enflurane(3%) anesthesia. The dogs were heparinized(1 mg/kg) for the prevention of thrombosis. After jugular vein was exposed by incision of left cervical area, two Johns Hopkins bulldog clamps were clamped. Jugular vein was cut between two clamps, and it was reanastomosed using 5-0 silk. Ultrasonography was done along the jugular vein on both sides of each dogs 21 days after anastomosis surgery. The internal diameter and circumference of the vein in the anastomosis area were markedly reduced with thickening of the vein wall, but no thrombi were observed.