• Steel and Composite Structures
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• v.28 no.5
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• pp.573-588
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• 2018

The objective of this paper is to investigate the mechanical performances of polygonal concrete-filled circular steel tubular (CFT) stub columns under axial loading through combined experimental and numerical study. A total of 32 specimens were designed to investigate the effect of the concrete strength and steel ratio on the compressive behavior of polygonal CFT stub columns. The ultimate bearing capacity, ductility and confinement effect were analyzed based on the experimental results and the failure modes were discussed in detail. Besides, ABAQUS was adopted to establish the three dimensional FE model. The composite action between the core concrete and steel tube was further discussed and clarified. It was found that the behavior of CFT stub column changes with the change of the cross-section, and the change is continuous. Finally, based on both experimental and numerical results, a unified formula was developed to estimate the ultimate bearing capacity of polygonal CFT stub columns according to the superposition principle with rational simplification. The predicted results showed satisfactory agreement with both experimental and FE results.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2003.10b
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• pp.47-50
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• 2003

Grain size of the $\alpha$ phase is computed during isothermal forging of the TC6 aerofoil blade, by combining FE with the Yada's model of grain size. The present results illustrate the grain size and distribution of the $\alpha$ phase during isothermal forging of the TC6 aerofoil blade' in detail. The computed results show that height reduction, deformation temperature, hammer velocity and friction have significant effect on distribution of the equivalent strain, and that height reduction, deformation temperature and hammer velocity have more significant effect on grain size of the $\alpha$ phase than friction between billet and die.

• Structural Engineering and Mechanics
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• v.60 no.5
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• pp.903-921
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• 2016

To study the effect of looseness on mechanical behavior of dovetail mortise-tenon joints, five dovetail mortise-tenon joints, including one intact joint and four loose joints, were fabricated and tested under cycle lateral loadings, and non-linear finite element models using the software ABAQUS were also developed. The effects of looseness on stress distribution, rotational stiffness and bearing capacity of joints were studied based on the analysis of test and simulation results. The results indicate that the hysteretic loops are anti-Z-shaped and present typical characteristics of pinching and slippage, the envelop curves of joints are classified as following two stages: elastic and strengthening stage. The peak stress, rotational stiffness and bearing capacity of joints were reduced due to looseness. The moment-rotation theoretical model of intact joint was simplified in terms of the relation of construction dimensions for buildings, and the moment-rotation theoretical model considering the effect of looseness was proposed and validated.

• International Journal of Industrial Entomology and Biomaterials
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• v.12 no.1
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• pp.1-5
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• 2006

Cordyceps, one of the well-known traditional Chinese medicines, consists of the dried fungus C. sinensis growing on the larva of caterpillar. It is commonly used as a tonic of restoring vital body functions. In order to evaluate the pharmacological effects of C. militaris, the anti-oxidation and antiaging effect of cultured C. militaris growing on pupa of silkworm Bombyx mori, were investigated. The results showed! that the contents of lipofusin in myocardium were reduced and the SOD activity in the liver were elevated in a dose-dependent manner while no effect was observed for blood GSH-Px activity and liver MDA content in mice perfused with the cultured C. militaris compared to those untreated mice. Furthermore, the average life span, maximum life span and 50% death time of the fruit flies treated with cultured C. militaris were markedly prolonged. The results suggest that the cultured C. militaris growing on pupa of silkworm possesses anti-oxidation and delay senescence activity.

• Nuclear Engineering and Technology
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• v.53 no.8
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• pp.2591-2599
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• 2021

The effect of thermal aging at 475 ℃ and 750 ℃ of Z3CN20.09M cast duplex stainless steel (CDSS) on microstructure, mechanical and intergranular corrosion properties were investigated by transmission electron microscope (TEM), nano indenter, scanning electron microscope (SEM) and corrosion fatigue test system. The result indicated that the spinodal decomposition and G precipitated were occurred after aged at 475 ℃, as well as sigma precipitated at 750 ℃. The microstructure degeneration of ferrite was saturated after aged for 2000h and 200 h at 475 ℃ and 750 ℃ respectively. The mechanical properties, intergranular corrosion resistance and corrosion fatigue lives were continuing deteriorated with increasing the aging time at both temperatures. The difference of the degeneration mechanisms of Z3CN20.09M CDSS aged at 475 ℃ and 750 ℃ was analyzed.

• Geomechanics and Engineering
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• v.18 no.6
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• pp.567-574
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• 2019

In order to study the effect of stress and water pressure on the permeability of fractured rock mass under three-dimensional stress conditions, a single fracture triaxial stress-seepage coupling model was established; By using the stress-seepage coupling true triaxial test system, large-scale rock specimens were taken as the research object to carry out the coupling test of stress and seepage, the fitting formula of permeability coefficient was obtained. The influence of three-dimensional stress and water pressure on the permeability coefficient of fractured rock mass was discussed. The results show that the three-dimensional stress and water pressure have a significant effect on the fracture permeability coefficient, showing a negative exponential relationship. Under certain water pressure conditions, the permeability coefficient decreases with the increase of the three-dimensional stress, and the normal principal stress plays a dominant role in the permeability. Under certain stress conditions, the permeability coefficient increases when the water pressure increases. Further analysis shows that when the gob floor rock mass is changed from high stress to unloading state, the seepage characteristics of the cracked channels will be evidently strengthened.

• The Korean Journal of Pain
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• v.35 no.1
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• pp.59-65
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• 2022

Background: There is still unmet need in treating neuropathic pain and increasing awareness regarding the use of drug combinations to increase the effectiveness of treatment and reduce adverse effects in patients with neuropathic pain. Methods: This study was performed to determine the individual and combined effects of pregabalin, tianeptine, and clopidogrel in a rat model of neuropathic pain. The model was created by ligation of the L5-L6 spinal nerve in male Sprague-Dawley rats; mechanical allodynia was confirmed using von Frey filaments. Drugs were administered to the intrathecal space and mechanical allodynia was assessed; drug interactions were estimated by isobolographic or fixed-dose analyses. Results: Intrathecal pregabalin and tianeptine increased the mechanical withdrawal threshold in a dose-dependent manner, but intrathecal clopidogrel had little effect on the mechanical withdrawal threshold. An additive effect was noted between pregabalin and tianeptine, but not between pregabalin and clopidogrel. Conclusions: These findings suggest that intrathecal coadministration of pregabalin and tianeptine effectively attenuated mechanical allodynia in the rat model of neuropathic pain. Thus, pregabalin plus tianeptine may be a valid option to enhance the efficacy of neuropathic pain treatment.

• Nuclear Engineering and Technology
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• v.56 no.6
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• pp.2367-2374
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• 2024

In this paper, based on the need for high-strength connections between all-tungsten-oriented plasma materials and thermal sinking materials of copper and its alloys in nuclear fusion devices, a study on the effect of tungsten surface laser micro structuring on the interfacial bonding properties of W/Cu joints was carried out. In the experiment, the connectors were prepared by vacuum fusion infiltration technology, and the effects of microgroove structure on the mechanical and thermal conductivity of W/Cu connectors were investigated under different parameters (including microgroove pitch, microgroove depth, and microgroove taper). The maximum shear strength is 126.0 MPa when the pitch is 0.15 mm and the depth is 34 ㎛. In addition, the negative taper structure, i.e., the width of the entrance of the microstructure is smaller than the width of the interior of the microstructure, is also investigated. The shear tests show that there is an approximately linear relationship between the shear strength of W/Cu and taper. Compared with the positive taper, the shear strength of the samples with the same morphological density and depth of the tungsten surface is significantly higher.

• Biomolecules & Therapeutics
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• v.25 no.2
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• pp.186-193
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• 2017

Tetrandrine (Tet), a bisbenzylisoquinoline alkaloid, has been reported to have a radiosensitization effect on tumors. However, its effects on human glioma and the specific molecular mechanisms of these effects remain unknown. In this study, we demonstrated that Tet has a radiosensitization effect on human glioma cells. It has been hypothesized that Tet has a radiosensitization effect on glioma cells by affecting the glioma cell cycle and DNA repair mechanism and that ERK mediates these activities. Therefore, we conducted detailed analyses of the effects of Tet on the cell cycle by performing flow cytometric analysis and on DNA repair by detecting the expression of phosphorylated H2AX by immunofluorescence. We used western blot analysis to investigate the role of ERK in the effect of Tet on the cell cycle and DNA repair. The results revealed that Tet exerts its radiosensitization effect on glioma cells by inhibiting proliferation and decreasing the expression of phosphorylated ERK and its downstream proteins. In summary, our data indicate that ERK is involved in Tet-induced radiosensitization of glioma cells via inhibition of glioma cell proliferation or of the cell cycle at G0/G1 phase.

• Journal of Korea Society of Digital Industry and Information Management
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• v.15 no.1
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• pp.157-172
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• 2019

The purpose of this study was to explore the moderating effect of food safety scandals on the relationship between food company's Corporate Social Responsibility(CSR) engagement at different levels and brand image in the Chinese dairy company context. In addition, this study also examined the mediating effect of brand image on CSR engagement and consumer loyalty. The study adopted a $2{\times}2$ between-subjects experimental design using scenarios. Four scenarios provided a mixed combination of yes or no cases for food safety scandal, and high or low cases for a dairy company's CSR engagement. In this study, survey was used to collect data from Chinese consumers. Of these, 377 valid data were collected from a sample of average Chinese consumers over the age of 20, collected through the internet. The results show that CSR engagement at different levels has a significant effect on brand image and food safety scandal has a significant moderating effect on the relationship between the two. This study expanded the previous study on the sensitivity of consumers to CSR activities in eastern China. At the same time, according to the results of the study, different CSR engagement of food enterprises does have a significant impact on brand image and consumer loyalty. In particular, high CSR engagement reduces negative impact on brand image through the moderating effect of food safety scandals. Therefore, for food business managers, actively participate in CSR activities, and actively enhance the engagement has a significant influence on the management of brand image.