• Journal of Korean Neurosurgical Society
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• 제51권1호
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• pp.54-58
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• 2012

We present the rare case of solitary xanthogranuloma in the upper cervical column mimicking a Brown-Sequard syndrome. A 29-year-old man complained with right hemiparesis and left hypoesthesia after a car accident. Computed tomography and magnetic resonance images revealed a lobulated homogenously well-enhancing mass in between posterior arch of the atlas (C1) and spinous process of the axis (C2) resulting in a marked spinal canal narrowing with cortical erosions. The patient was managed by complete resection of the tumor with partial laminectomy with lower half of C1 posterior arch and upper half of C2 spinous process. The authors advise complete removal of the xanthogranuloma and consideration as a differential diagnosis of lesions among upper cervical lesions.

• Journal of Korean Neurosurgical Society
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• 제50권3호
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• pp.271-273
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• 2011

Juvenile xanthogranuloma (JXG) is an uncommon histiocytic cutaneous lesion. An 18-month-old girl visited our clinic due to rapid growing orange-yellowish lesion on scalp. Enlarging time from 1 mm to 12 mm was just 8 weeks. We excised the tumor and adjacent normal tissue. Histopathological study showed numerous eosinophils and Touton giant cells within the lesion. Immunohistochemical study revealed positive immunoreactivity for CD68 in most areas. No recurrence was seen during 12 months after resection. We report a case with rapidly growing JXG on scalp with peculiar histopathologic findings.

• Brain Tumor Research and Treatment
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• 제6권2호
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• pp.82-85
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• 2018

Extremely massive sellar xanthogranuloma (XG) are rare, and the surgical outcome and prognosis are not well known. XG remain unknown whether they are derived from Rathke's cleft cysts (RCCs) or craniopharyngiomas (CPs) following extensive inflammation and metaplasia, to the point that no epithelium is readily identifiable. These lesions usually tend to occur in younger patients (mean 28.3 years), have a smaller diameter, and remain primarily intrasellar region with infrequent calcification. This 36-year-old man presented our hospital with visual deterioration. At the time of visit, there were no neurological problems other than visual field defect and hormonal disorder. He visited our hospital in 2007 due to headache and decreased vision, and underwent transphenoid surgery for pituitary RCC. Since then, he has received treatment at our hospital for postoperative hormonal disorders. Through preoperative imaging study, the author suspected CP and underwent surgery. During the operation, the adhesion of the tumor to the surrounding major neurovascular structures was severe in the naked eyes, but the tumor could be removed more easily than expected. The postoperative histological findings were confirmed as XG. The postoperative course was uneventful. Compared to the previous literature, this case is a case where the size of XG is very large in a sellar region and it can be proved that it originated from the RCC. And regular follow-up is necessary to confirm the prognosis after surgery.

• 대한안과학회지
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• 제59권11호
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• pp.1071-1076
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• 2018

목적: 기존 안와 황색육아종이 진단되었던 환자에서 재발된 피부 황색육아종을 통하여 면역글로불린G4관련안질환이 동반 진단된 증례를 보고하고자 한다. 증례요약: 양안의 눈꺼풀 부종을 주소로 38세 남성이 내원하였다. 전안부 및 후극부에서 특이 소견이 관찰되지 않았다. 조직검사상 포말조직구 및 토우튼 거대세포가 관찰되며 S100 및 CD1 염색에 음성 소견을 보여 성인황색육아종 진단하 경구 아자씨오프린과 프레드리솔론 치료를 받았다. 4년 뒤 양안의 노란색 눈꺼풀 종괴를 주소로 재내원하였다. 자기공명영상에서 양안 안와 상외측의 대칭적인 연부조직 부종이 관찰되었고, 혈액검사상 immunoglobulin G (IgG) 및 IgG4 수치가 상승되었다. 조직검사 후 면역화학염색에서 IgG4+/IgG+ 10-20%, IgG4+ 22/고배율시야가 확인되었으며 과거 조직을 재염색하여 IgG4+/IgG+ 40-50%, IgG4+ 59/고배율시야를 확인하여 전형적인 면역글로불린G4관련안질환으로 새롭게 진단하였다. 결론: 비특이적인 눈꺼풀 부종환자에서 면역글로불린G4관련안질환을 고려해야 하며, 기존 황색육아종 환자에서도 면역글로불린G4관련안질환이 동반될 수 있다.