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Synthesis and Structural Analysis of 2-Amino-4-(4-hydroxy-3-methoxyphenyl)-7,9-dimethyl-5-oxo-4, 5, 6, 7-tetrahydropyrano [2, 3-d] pyrazolo [3, 4-b] pyridine-3-carbonitrile through X-ray Crystallography

  • Ganapathy, Jagadeesan;Jayarajan, R.;Vasuki, G.;Sanmargam, Aravindhan
    • Journal of Integrative Natural Science
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    • v.8 no.1
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    • pp.30-39
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    • 2015
  • The crystal structure of the potential active 2-amino-4-(4-hydroxy-3-methoxyphenyl)-7, 9-dimethyl-5-oxo-4, 5, 6, 7-tetrahydropyrano [2, 3-d] pyrazolo [3, 4-b] pyridine-3-carbonitrile ($C_{21}H_{22}N_5O_6S$) has been determined from single crystal X-ray diffraction data. In the title compound crystallizes in the monoclinic space group P-1 with unit cell dimension a=8.1201(9)${\AA}$, b=12.2684(4)${\AA}$ and c=12.387(2)${\AA}$ [${\alpha}=69.573^{\circ}$, ${\beta}=12.168^{\circ}$ and ${\gamma}=76.060^{\circ}$]. In the structure the pyrazole, pyridine and pyran are almost coplanar each other. The crystal packing is stabilized by intermolecular C-H...O and N-H... O hydrogen bond interaction.

The Retrospective Study of Essential X-ray in Emergency Multiple Trauma Patients (응급 다발성 외상환자의 기본적 방사선 촬영부위에 관한 조사연구)

  • Yoo, Beong-Gyu
    • Journal of radiological science and technology
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    • v.19 no.2
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    • pp.51-57
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    • 1996
  • Radiography should be used judiciously and should not delay patients resuscitation. In the patient with emergency multiple trauma, three radiography should be obtained-cervical spine, anteroposterior(AP) chest, and AP pelvis. These examinations can be done in the resuscitation area, usually with a portable X-ray unit, but should not interrupt the resuscitation process. A retrospective study was carried on 157 emergency multiple trauma patients who were admitted to Yong Dong Severance Hospital from January, to December in 1995. I analyzed the types of X-ray examinations in emergency multiple trauma patients, and classified the patients by disoriented group of mentality. The results were as follows: 1. The subjects were 7.1%(157patients) of 2,208 trauma patients(7.3%) in total 30,085 emergency patients. 2. Male to female ratio was 2.57 : 1. The age distribution was highest from 31 years to 40 years(28.0% ). 3. The peak time of patient's entrance in emergency center was between 8 : 00 pm and 2 : 00 am(36.9%), and second peak time was between 2 : 00 pm and 8 : 00 pm (29.3%). 4. According to the injury type, traffic accident, motorcycle accident and falling down were 71.3%, 8.3% and 20.4% respectively. 5. According to the exposure rate of Computed Tomography, chest CT, cervical CT pelvis CT and brain CT were 39.5%, 24.2%, 69.4% and 51.6% respectively.

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Numerical Simulation on Self-heating for Interlayer Tunneling Spectroscopy in $Bi_2Sr_2CaCu_2O_{8+x}$

  • Park, Jae-Hyun;Lee, Hu-Jong
    • Progress in Superconductivity
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    • v.9 no.1
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    • pp.18-22
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    • 2007
  • For interlayer tunneling spectroscopy using a small stack of $Bi_2Sr_2CaCu_2O_{8+x}$ (Bi-2212) intrinsic junctions in a high-bias range, large self-heating takes place due to the poor thermal conductivity of Bi-2212. In this study, we numerically estimate the self-heating around a Bi-2212 sample stack for I-V or dI/dV-V measurements. Our results show that the temperature discrepancy between the Bi-2212 sample stack and top Au electrodes due to bias-induced self-heating is small enough along the c-axis direction of Bi-2212. On the other hand, the lateral temperature discrepancy between the sample stack and the Bi-2212 on-chip thermometer stack can be as large as ${\sim}20\;K$ for the highest bias required to observe the pseudogap hump structure. We thus suggest a new in-situ ac thermometry, employing the Au current-bias electrode itself deposited on top of the sample stack as the resistive thermometer layer, which is supposed to allow safe temperature measurements for the interlayer tunneling spectroscopy.

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Study on Cryopreservation of Epididymal and Ejaculated Semen in Korean Native Canine and Subsequent Pregnancy Rate after Artificial Insemination

  • Kim S. K.;Lee B. K.;Kim M. K.
    • Reproductive and Developmental Biology
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    • v.28 no.3
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    • pp.155-159
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    • 2004
  • This study was carried out to investigate the general characteristics and viability of sperm after freezing and thawing and the pregnancy rates after artificial insemination with thawed semen. The rates of viable sperm after slow and rapid freezing were 87.4±3.85% and 70.8±4.45%, respectively which were significantly lower than that of fresh semen control (91.7±3.45%). The mean concentration of epididymal sperm after dilution in 1.0 ml saline and. 3.0 ml extender in a various concentrations of cryoprotectants was 124.5±48.3 x 10/sup 6/ (range of 45 x 10/sup 6/ to 280 X 10/sup 6/ /ml). There was a significant difference not in the percentage of acrosome-reacted sperm, but in the percentage of capacitated sperm, between fresh and frozen-thawed epididymal semen. When frozen-thawed after diluting with tris-buffer extender containing glycerol, DMSO and ethylene glycol with concentration of 2 to 6%, the rates of epididymal sperm exposed to different cryoprotectants ranged from 14.4±4.7% to 20.7±5.8%, 17.8±5.2% to 36.5±4.9%, and 14.4±4.6% to 18.5±5.3%, respectively which were lower compare to fresh semen control. The pregnancy rate after artificial insemination with frozen semen was 70.6%, whereas that with fresh semen was 90.0% in dogs with naturally induced estrus.

A Study of Recycle of Waste Wood after Cultivating Oak Mushroom - On the Crystal Structure of Cellulose - (표고버섯골목의 재활용에 관한 연구(I) - Cellulose의 결정구조(結晶構造)를 중심으로 -)

  • Kim, Nam-Hun;Lee, Won-Yong
    • Journal of the Korean Wood Science and Technology
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    • v.22 no.3
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    • pp.26-31
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    • 1994
  • To provide further information for reutilization of the waste wood obtained after cultivating oak mushroom in Kangwon-do, the crystal structures of the waste wood were investigated and compared to those of normal woods by a series of x-ray diffraction analysis. The results obtained are as follows: 1. An x-ray diffraction diagram of cultivated wood for 5 years was same as that of typical cellulose with some orientation of cellulose crystallites, but that of cultivated wood for 8 years a random. 2. Crystallinity indices in normal and cultivated woods for 5 years ranged from 57% to 60%. In the cultivated wood for 8 years, however, the value showed about 40%. 3. Crystallite widths of cultivated woods for 5 years and for 8 years were 3 nm and 2.5 nm, respectively. 4. Intensity ratios of equatorial and meridional layers did not show any significant differences. From the above results, it is clear that the waste wood obtained after cultivating oak mush room for 5 years showed basically same crystal structures with normal wood. Therefore, we think that the waste wood may be used available for cellulosic material instead of normal wood.

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A Fabrication and Characteristics of 16x8 Reflection Type Symmetric Self Electro-optic Effect Device Array (16x8 반사형 S-SEED 어레이 제작 및 특성)

  • 김택무;이승원;추광욱;김석태;정문식;김성우;권오대;강봉구
    • Journal of the Korean Institute of Telematics and Electronics A
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    • v.30A no.10
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    • pp.33-40
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    • 1993
  • A reflection type 16x8 S-SEED array from LP(Low Pressure)-MODVD-grown GaAs/AlGaAs extremely shallow quantum well(ESQW) structures, with 4% Al fraction, has been fabricated. Its intrinsic region consists of 50 pairs of alternating 100.angs. GaAs and 100.angs. $Al_{0.04}$Ga$_{0.96}$As layers. A multilayer reflector stack of $Al_{0.04}$/Ga$_{0.96}$ As(599$\AA$)/AlAs(723$\AA$) was incorporated for the reflection plane below the p-i-n structures. The device processing after the MOCVD growth includes the mesa etching, isolation etching, insulator deposition, p & n metallization, and AR(Anti-Reflection) coating. For switching characteristics of the S-SEED in the form of p-i-n ESQW diode, the maximum optical negative resistance was observed at 856nm. Reflectance measurements showed a change from 15.6% to 43.3% for +0.9V to -6V bias. The maximum contrast ration of the S-SEED array was 2.0 and all the 128 devices showed optical bistability with contrast ratios over 2.4 at 5V reverse bias.

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Dyeing of Cotton Knitted Fabrics with Volcanic Ash(I) -The Compositions of Volcanic ash Deposited on the Cotton Knitted Fabrics- (화산재를 이용한 면 편성물의 염색(I) - 면 편성물에 부착된 화산재의 성분분석을 중심으로 -)

  • 유복선;신인수
    • Journal of the Korean Home Economics Association
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    • v.41 no.8
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    • pp.55-62
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    • 2003
  • Natural dyes generally fan into two categories; organic dyes coming from animals and plants and inorganic dyes obtained from various minerals such as bengala, loess, ultramarine, prussian blue and etc. The main components of volcanic ash is clay mineral such as kaolinite, illite, quartz. Clay minerals Composing volcanic ash are kaolinite[$Al_4Si_4O_{10}{(OH)_{8}}$], illite[$K_{X}Al_2(Si,\;Al)_4O_{10}{(OH)}_2$], quartz[$SiO_2$], homblende[$Na_{0-1}\;Ca_2{(Mg,\;Fe,\;Al)}_5{(Si,\;Al)}_{8}O_{22}{(OH)}_2$]and etc. And the redish color mainly comes from iron oxide. In this paper, two different classes of dyeing process were tested; dyeing with volcanic ash only and cationic agent pre-treatment followed by dyeing with volcanic ash. The compositions of the volcanic ash powder and the volcanic ash deposited on the cotton knitted fabrics identified by energy dispersive spectrometer and XRD analysis. The major chemical components of volcanic ash deposited on the cotton knitted fabrics were confirmed to be the saicon oxide, iron oxide, and aluminum oxide and etc. According to the analysis by XRD and EDS-SEM, kaolinite, illite and quartz were also identified.

Studies on the Combining Ability and Inheritance of Major Agronomic Characters in Burley Tobacco(N. tabacum L.Cv. Burley) II . Heterosis. Combining Ability and Correlation (버어리종 담배 (N.tabacum L.Cv.Burley)의 주요형질에 대한 조합능력 및 유전에 관한 연구 II. Heterosis, 조합능력 및 상관)

  • 조천준;민경수
    • Journal of the Korean Society of Tobacco Science
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    • v.5 no.2
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    • pp.39-46
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    • 1983
  • In order to obtain the basic information for the most successful breeding of Burley tobacco, these studies were performed on the correlations among agronomic characters and on the heterosis and combining ability in $F_1$ generation. Heterosis ratio was highly variable in different $F_1$ combinations. Positive heterosis was observed in all characters except days to flowering and yield showed the highest heterosis ratio. As the results of analysis of dialled table, the general combining ability (GCA) in all characters was shown to be significant . All characters except the number of leaves in the specific combining ability (SCA) were significant, Variety, L8, contributed negative GCA for all characters. Burley 21, ky 10 and ky 14 contributed negative GCA for leaf width, quality and yield, respectively. Hybrid of ky 10 x ky 14 showed negative SCA and hybrids of ky I0x L8 and ky 14 x L8 showed positive SCA for all characters. There were significant correlations between yield and number of leaves, leaf length, leaf width or leaf area. Correlation between yield and days to flowering was non- significant .

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A Study on Effects of Fuel Injection System on the Performance in a V8-Type Diesel Engine (V8형 디젤엔진의 성능에 미치는 분사계의 영향에 관한 연구)

  • 박병학
    • Journal of Advanced Marine Engineering and Technology
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    • v.22 no.2
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    • pp.248-256
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    • 1998
  • The effects of fuel injection system on the performance in a V8-type diesel engine was stuided in this paper. Fuel injection system is important factor which influence the engine performance and exhaust emission bcasuse the properties in the injected fuel depend on the atomization characteristics. In this study using diesel engine of 17.7:1 compression ration the engine performance and exhaust emission are measured experimentally according to 1000, 1400, 2200rpm in the full-load conditions. The chosen parameters for the major system are such diameter shape of combustion chamber and intake system. The results are as follows: As the nozzle hole diameter and injection angle become smaller and as the injection timing gets advanced the fuel consumption and concentration of smoke are decreasing whereas concentration of $NO_{x}$ is increasing. Andconcentration of $NO_{x}$ is increasing in accordance with the increase of injection pipe diameter and nozzle protrusion. Also it is shown that re-entrant type combustion chamber is more effective than that of toroidal type in the improvement of $NO_{x}$ reduction.

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Geochemistry and Mineralogy of Precipitates from Oseag Hot Spring (오색온천수의 지화학적 및 침전물에 대한 광물학적 특성)

  • 김정진;김수진;김윤영
    • Journal of the Mineralogical Society of Korea
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    • v.17 no.2
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    • pp.169-176
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    • 2004
  • The Osaeg hotspring (long. $128^{\circ}$ 56'E, tat. $37^{\circ}$ 06'N) located in the northester part of Kangwon-do, Korea. The pH value of the hot spring water is 8.31, and the EC, $SO_4$, F and Na are 196 ${\mu}\textrm{s}$/cm, 10.88 mg/L, 8.19 mg/L, and 37.07 mg/L, respectively. The ocherous precipitates are precipitated on the stream bottom of Osaeg hot spring drainage. X-ray diffraction analysis (XRD), scanning electron microscopy (SEM) and stereo-microscope were used to analyze the precipitates. X-ray diffraction analysis shows that the precipitates consist mainly of poorly crystalline materials and messelite. Many spherical and rod-shaped bacteria-like forms were observed in the precipitates.