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Adverse Drug Reactions with Oseltamivir Treatment in the South Korea Outbreak of 2009 Pandemic Influenza A(H1N1) (2009년 국내 신종플루 유행시기의 Oseltamivir 부작용 평가)

  • Do, Youn-A;Lee, Suk-Hyang
    • Korean Journal of Clinical Pharmacy
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    • v.21 no.4
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    • pp.353-363
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    • 2011
  • The World Health Organization (WHO) declared the outbreak of H1N1 pandemic in 2009. South Korea also had outbreaks of H1N1 virus and used oseltamivir in large volume with increased reports of adverse drug reaction(ADR). The present study was aimed to investigate the ADR frequency, the factors related to ADR, and characteristics of oseltamivir's ADR. Participants for the study were patients randomly drawn from those who were prescribed oseltamivir for treatment from CHA Bundang Medical Center during October 1 and October 30. The information examined as factors related to ADR were collected by a subsequent cross-sectional telephone survey. The factors are the following; a) age; b) gender; c) patient medical history; d) diagnosis of H1N1 virus; e) adherence; f) whether taking other medication with oseltamivir or not; and g) the number of combined medications. We also asked ADR after taking oseltamivir. Total subjects were 86 patients. The average age is $22.6{\pm}18.48$ years old. The gender was 45.3% women and 54.7% men. Half (50%) of all respondents showed one or more ADR, 67.4% were positively diagnosed for H1N1 virus, and 54.7% were completed the full course of oseltamivir (i.e. twice daily x 5days). The most frequently reported ADR symptoms were: dizziness (15.1%), nausea (11.6%), lethargy (10.4%), diarrhea (10.4%), abdominal pain (8.1%), headache and vomiting (6.9%). ADR classifications by categories are gastro intestinal (44.2%), neuropsychiatric events (22.1%), systemic symptom (20.9%), skin events (5.8%), eye events (4.7%), and other cases (2.3%). The onset of ADR 'after taking 1~3 doses' was 69.7%. No increase in neuropsychiatric events was detected in children and adolescents. No factors examined for the study do have significant influence on the presence of ADR. This study showed that ADR of oseltamivir have occurred in half of the patients. The use of oseltamivir is essential for treatment and prophylaxis of influenza A(H1N1). But mass treatment should be properly monitored for ADR.

A Study on Behavior Patterns Between Smokes and Non-Smokers (흡연자와 비흡연자의 행동양상 연구)

  • 김화신
    • Journal of Korean Academy of Nursing
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    • v.20 no.1
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    • pp.79-87
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    • 1990
  • Clinical and epedemiologic studies of coronary heart disease(CHD)have from time to time over the last three decades found associations between prevalence of CHD and behavioral attributes and cigarette smoking. The main purpose of this study is reduced to major risk factor of coronary heart disease through prohibition of smoking and control of behavior pattern. The subjects consisted of 120 smokers and 90 non-smokers who were married men older than 30 years working in officers. The officers were surveyed by means of questionnaire September 26 through October 6, 1989. The Instruments used for this study was a self-administered measurement tool composed of 59 items was made through modifications of Jenkuns Activity Survery(JAS). The Data were analysed by SAS(Statistical Analsis System) program personal computer. The statistical technique used for this study were Frequency, x$^2$-test, t-test, ANOVA, Pearson Correlation Coefficient. The 15 items were chosen with items above 0.3 of the factor loading in the factor analysis. In the first factor analysis 19 factors were extracted and accounted for 86% of the total variance. However when the number of factors were limited to 3 in order to derive Jenkins classification, three factors were derived. There names are Job-Involvement, Speed & Impatience, Hard-Driving. Each of them includes 21 items, 21 and 9, respectively. The results of this study were as follow : 1. The score of the smoker group and non-smoker group in Job-Involvement(t=5.7147, p<0.0001), Speed & Impatience(t=4.6756, p<.0001), Hard-Driving(t=8.0822, p<.0001) and total type A behavior pattern showed statistically significant differences(t=8.1224, p<.0001). 2. The score of type A behavior pattern by number of cigarettes smoked daily were not statistically significant differences. 3. The score of type A behavior pattern by duration of smoking were not significant differences. It was concluded that the relationship between smokers and non - smokers of type A behavior pattern was statistically significant difference but number of cigarettes smoked daily and duration of smoking were not significant differences. Therefore this study is needed to adequate nursing intervention of type A behavior pattern in order to elevated to educational effect for prohibition of cigarette smoking.

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Regression of Large Lung Bullae after Peribullous Pneumonia or Spontaneously (큰 폐 공기집의 주변 폐 감염 후 혹은 자연적 소실)

  • Choi, Eun-Young;Kim, Woo-Sung
    • Tuberculosis and Respiratory Diseases
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    • v.72 no.1
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    • pp.37-43
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    • 2012
  • Background: A lung bulla may rarely shrink as a result of an inflammation within the bulla or a closing of a bronchus involved in the inflammation process, which is termed 'autobullectomy'. The purpose of this study was to describe clinical features of patients with regressions of bullae during follow-up. Methods: We retrospectively reviewed the cases and individuals who showed unequivocal evidence of interval regressions in a pre-existing bulla. A total of 477 cases with a bulla >5 cm in diameter were screened manually. Thirty cases with bullae that showed regression during follow-up were selected. Results: Regressions of large bullae occurred in 30 of 477 cases (6.3%). The median age of those patients was 61 (range, 53~66) years and 87% of those patients were men. The main cause of a bulla was emphysema (80%). Among 30 cases, 16 cases had pneumonia in the lung parenchyma of the peribullous area. Another 7 cases had a regressed bulla accompanied by an air-fluid level within the bulla. The remaining 7 cases showed a spontaneous regression of the bulla without such events. Complete regression of a bulla occurred in 25 cases. A follow-up chest-X ray showed that in all cases except one, the bulla remained in a collapsed state after 24 months. Forced expiratory volume in one second ($FEV_1$) improved in 3 cases and the other 2 cases had increased forced vital capacity (FVC). In addition, total lung capacity (TLC) and residual volume (RV) decreased in another 2 cases. Conclusion: Regression of a lung bulla occurred not only after pneumonia or the presence of air-fluid level within the bulla, but also without such episodes. The clinical course of regression of a lung bulla varied. After regression of a bulla, lung function could be improved in some cases.

A Study of the Purchasing Traits and the Wearing Satisfaction of Ski Wear (스키웨어의 구매와 착용만족도에 관한 조사연구)

  • Kim, Soon-Boon
    • Fashion & Textile Research Journal
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    • v.8 no.3
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    • pp.295-302
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    • 2006
  • The purpose of this study was to research the purchasing traits and the wearing satisfaction of ski wears to provide the data needed to design ski wears to the related industries. This survey was performed during 2003's and 2004's winter with the 157 questionnaires containing 16 items of purchasing traits, 8 of design satisfaction, 12 of purchasing satisfaction and 13 of satisfaction of using convenience. The data were analysed with the frequency, the percentile, $X^2$-test, the average, the standard deviation and t-test through comparing with the groups of general people and experts, and the groups of male and female. The results were:1.The most preferred style was the two pieces style(88.5%), and then the loose style(61.1%), and the shoulder-wireless style(36.9%). 2.The imported brands were more preferred because of the design(44.1%). 3.The main place of purchasing was the ski wear speciality shop(48.4%), the main source of the merchandise information was the surrounding men(43.3%), the most significant consideration aspect when purchasing was the design(35.7%), and the rate of size perception was 51.6%. 4.The wearing satisfaction score(5) of ski wears were; the satisfaction of design was 3.24, the satisfaction of material 3.00, and the satisfaction of using convenience 3.07. 5.In the rate of design satisfaction, the female(3.10) showed higher than the male(3.35) (p<.05). 6.In the satisfaction of material, 'the discoloration'(2.37), 'the abrasion'(2.75), 'the sense of volume'(2.76) and 'the sense of touch' showed dissatisfaction. 7.In the satisfaction of using convenience, 'the pollution by lifting ticket'(2.36)was showed most dissatisfaction.

Efficacy of Fluoroscopy-Guided Cutting Needle Lung Biopsy in Patients with Diffuse Infiltrative Lung Disease (미만성 침윤성 폐질환을 보이는 환자에서 방사선투시유도 절단침 폐생검의 유효성)

  • Choi, Soo-Jeon;Shin, Eun-Ah;Kim, Joung-Sook
    • Tuberculosis and Respiratory Diseases
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    • v.70 no.1
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    • pp.43-50
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    • 2011
  • Background: Open lung biopsy is used for diagnosis of diffuse infiltrative lung diseases (DILD), but it is invasive and relatively expensive procedure. Fluoroscopy-guided cutting needle lung biopsy (FCNLB) has merits of avoidance of admission and rapid diagnosis. But diagnostic accuracy and safety were not well known in the diagnosis of DILD. Methods: We included 52 patients (37 men, 15 women) having DILD on HRCT with dyspnea, except the patients who could be confidently diagnosed with clinical and HRCT findings. FCNLB was performed using 16G Ace cut needle (length 1.5 cm, diameter 2 mm) at the area of most active lesion on HRCT. Final diagnoses were made by the consensus. Results: The mean interval between the HRCT and FCNLB was 4.5 days. Most cases were performed one biopsy during 5~10 minutes. Specific diagnosis was obtained in 43 of 52 biopsies (83%). The most common diagnosis was nonspecific interstitial pneumonia (11 cases) and followed by cryptogenic organizing pneumonia (7 cases), diffuse alveolar hemorrhage and usual interstitial pneumonia (5 cases in each), hypersensitivity pneumonitis (3 cases), tuberculosis and drug induced interstitial pneumonitis (2 cases in each), the others are in one respectively. Mild complication was developed in 9 patients (8 pneumothorax, 1 hemoptysis). Most of complications were regressed without treatment except one case with chest tube insertion for pneumothorax. Conclusion: Fluoroscopy-guided 16 G cutting needle lung biopsy was an useful method for the diagnosis of DILD.

A Study on Health Promoting Behavior and Disease Preventive Behavior of a Community Residents - Koje area- (일 지역주민의 질병예방 행위 및 건강증진행위에 관한 연구 -거제지역 중심으로-)

  • Kim, Keum-Ee;Im, Mee-Young
    • Research in Community and Public Health Nursing
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    • v.12 no.1
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    • pp.168-174
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    • 2001
  • This study was conducted to investigate the disease preventive behavior and health promoting behavior of a community residents. The subjects were selected by convenient sampling and the total number was 300(Female, 170, Male, 130). The data were collected by face to face interviews during the period of Sep. 15-30, 1999. The measurement tool for this study was the rating score for disease preventive behavior and health promoting behavior. The instrument was developed by the researcher based on the tool of Korea Institute for Health and Social Affairs. The data were analyzed by percentage, mean, t-test, ANOVA. $x^2-test$ by Windows SPSS/PC program(v7.5). The results were as follows: 1. In the comparison of disease preventive behavior rates between male and female, there was a statistically significant difference in physical examination, measuring the blood pressure and vaccination for B type hepatitis. In the comparison of disease preventive behavior rates among the age, there was a statistically significant difference in physical examination, measuring the blood pressure. 2. The rating score for the health promoting behavior of the men subjects was lower than that of the women subjects. In the comparison of health promoting behavior scores between male and female, there was a statistically significant difference in smoking, drinking, regular exercise, breakfast eating, vegetable consumption and teeth brushing. In the comparison of promoting Behavior scores among the age, there were significant difference, there was a statistically significant difference in smoking, sleeping, seat belt use, breakfast eating and salty eating.

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Study on Fashion Sensibility and Emotion through Tattoo Fashion (타투 패션에 따른 패션감성과 감정연구)

  • Kim, Mi-Young;Lee, Kyoung-Hee
    • Journal of the Korean Society of Clothing and Textiles
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    • v.31 no.3 s.162
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    • pp.331-342
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    • 2007
  • The objective of this study is to provide the basis to planning the design of commercial products and effective image coordination for various situation in investigating the existence of Tattoo with an examination of fashion sensibilities and emotions as well as in analyzing Tattoo fashions which have an effect on the unique image coordinations in the fashion collection. Stimulus pictures have collected from fashion photographs appeared Tattoo expression released on the fashion collection and selected 35 pieces of pictures out of total through the analysing process in many times. Valuation tools have used with 19 pairs of adjective as fashion sensibilities valuation tool and 13 questionnaire as emotion valuation tool. Data has been collected from August 30th to September 17th on the subject of 20's men and women who live in Busan city area and those data has been analyzed by using SPSS statistics package program. The summary and conclusion of verified outcomes on this study are as follows: 1. Main factors of fashion sensibilities about Tattoo fashion are composed of three factors, such as Attractiveness, Visibility, Maturity and those factors have explained by 60.9%. On the other han, the fashion emotions are composed of negative emotion and positive emotion and explained by 66.3%. 2. The image of Tattoo fashion has shown four groups; Sexy, Romantic, Grotesque, Natural. 3. The positioning according to the image of Tattoo fashion has interpreted that X-axis as Grotesque-Romantic, Y-axis as Simple-Dazzling according to design features.

Associations Between Classification of the Geriatric Screening for Care-10 and the Morse Fall Scale (노인환자 스크리닝 결과와 낙상위험도 간의 관계)

  • Kim, Yoon-Sook;Lee, Jong-Min;Choi, Jae-Kyung;Shin, Jin-Yeong;Han, Seol-Heui
    • Quality Improvement in Health Care
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    • v.23 no.2
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    • pp.69-78
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    • 2017
  • Background: The purpose of this study was to examine associations between classification of the Geriatric Screening for Care-10 (GSC-10) and the Morse Fall Scale (MFS) among elderly inpatients. Methods: Among elderly inpatients aged over 65 admitted to hospital (from November 1, 2016 to July 31, 2017), the data for 5,780 patients (who were evaluated using the Morse Fall Scale and the Geriatric Screening for Care-10) were analyzed using x2-tests and t-tests to examine differences between the GSC-10 and MFS, according to general characteristics of elderly inpatients (i.e., gender) using IBM SPSS Statistics 24. Results: : Scores for the GSC-10 were significantly higher in women than men for depression (p<.001), delirium (p=.048), functional decline (p<.001), incontinence (p<.001), and pain (p<.001). Statistically significant differences in all domains of the GSC-10 for elderly hospitalized patients were found for the classification of fall risk. Conclusion: The findings of this study, as supported by the GSC-10, indicate that the most common problems experienced by the elderly are related to the risk of falling. In order to reduce the incidence of falls in elderly inpatients, customized fall prevention based on the GSC-10 results is necessary.

Biomechanical Analysis of Muscle Fatigue and Ground Reaction Force for the Development of Outdoor Walking Shoes

  • Jang, Young-Min;Lee, Joong-Sook;Yang, Jeong-Ok;Lee, Bom-Jin
    • Korean Journal of Applied Biomechanics
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    • v.26 no.4
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    • pp.413-420
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    • 2016
  • Objective: The purpose of this study was to analyze and compare different kinds of outdoor walking shoes in terms of muscle fatigue and ground reaction force on walking, and to provide foundational data for developing and choosing outdoor walking shoes that fit the users. Method: The study subjects were 30 healthy men. The experiment was conducted by using outdoor walking shoes with different inner and outer harnesses of the midsole, and shapes of the outsole. For data collection, electromyography was used to measure the muscle fatigue of the anterior tibial muscle and gastrocnemii, which contribute to the dorsiflexion and plantarflexion of the ankle joint, and the biceps muscle of the thigh and lateral great muscles, which contribute to the flexion and extension of the knee joint. A GRF measurement device was used to measure the X, Y, and Z axes. Results: In the type A outdoor walking shoes, regarding the hardness of the midsole, the inner part was soft, while the outer part was hard. The vertical ground reaction force was the lowest, which means least impact while walking and light load to the knees and ankles. The type C outdoor walking shoes were intended to provide a good feel in wearing the shoes. The tibialis anterior, biceps femoris, and gastrocnemii indicate low fatigue, which means that during a long-distance walk, it will minimize the fatigue in the muscles of the lower limbs. Conclusion: To sum up the study results, the different types of outdoor walking shoes indicate their unique characteristics in the biomechanical comparison and analysis. However, the difference was not statistically significant. Thus, a systematic and constant follow-up research should be conducted to cope with expanding market for outdoor walking shoes. Lastly, this study is expected to present foundational data and directions for developing outdoor walking shoes.

Immediate effects of a neurodynamic sciatic nerve sliding technique on hamstring flexibility and postural balance in healthy adults

  • Park, Jaemyoung;Cha, Jaeyun;Kim, Hyunjin;Asakawa, Yasuyoshi
    • Physical Therapy Rehabilitation Science
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    • v.3 no.1
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    • pp.38-42
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    • 2014
  • Objective: In this study, we applied a neurodynamic sciatic nerve sliding technique to healthy adults to elucidate its effects on hamstring flexibility and postural balance. Design: Cross-sectional study. Methods: This study targeted twenty four healthy adults (16 men, 8 women). A neurodynamic sciatic nerve sliding technique was applied 5 times to all subjects' dominant leg. The subjects were asked to sit on the bed while performing cervical and thoracic flexion, as well as knee flexion with ankle plantar flexion. Then, they were asked to perform cervical and thoracic extension and knee extension with their ankle in dorsiflexion and maintain the position for 60 s. For postural balance, we measured postural sway while the subjects maintained a one-legged standing posture using the Good Balance System and measured the hip joint flexion range of motion using a standardized passive straight leg raise (SLR) test. Results: SLR test increased significantly from $79^{\circ}$ before the intervention to $91.67^{\circ}$ after the intervention (p<0.05). Regarding the participants' balance evaluated using the one-legged standing test, the X-speed decreased significantly from 18.61 mm/s to 17.17 mm/s (p<0.05), the Y-speed decreased from 22.28 mm/s to 20.52 mm/s (p<0.05), and the velocity moment was significantly decreased from $89.33mm^2/s$ to $74.99mm^2/s$ after the intervention (p<0.05). Conclusions: Application of the neurodynamic sciatic nerve sliding technique exhibited improved hamstring flexibility and postural balance of healthy adults.