• Journal of Astronomy and Space Sciences
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• v.30 no.2
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• pp.83-85
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• 2013

Anomalous X-ray pulsars (AXPs) are thought to be magnetars which are young isolated neutron stars with extremely strong magnetic fields of > $10^{14}$ Gauss. Their tremendous magnetic fields inferred from the spin parameters provide a huge energy reservoir to power the observed X-ray emission. High-energy emission above 0.3 MeV has never been detected despite intensive search. Here, we present the possible Fermi Large Area Telescope (LAT) detection of ${\gamma}$-ray pulsations above 200 MeV from the AXP, 1E 2259+586, which puts the current theoretical models of ${\gamma}$-ray emission mechanisms of magnetars into challenge. We speculate that the high-energy ${\gamma}$-rays originate from the outer magnetosphere of the magnetar.

• Korean Journal of Ichthyology
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• v.21 no.sup1
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• pp.63-72
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• 2009

The taxonomic research based on extensive investigations and specimen collections throughout all varieties of freshwater and marine habitats of Chinese waters, including mainland China, Hong Kong and Taiwan, which involved accounting the vast number of collected specimens, data and literature (both within and outside China) were carried out over the last 40 years. There are totally 361 recorded species of gobioid fishes belonging to 113 genera, 5 subfamilies, and 9 families. This gobioid fauna of China comprises 16.2% of 2211 known living gobioid species of the world. This report represents a summary of previous researches on the suborder Gobioidei. A recently diagnosed subfamily, Polyspondylogobiinae, were assigned from the type genus and type species: Polyspondylogobius sinensis Kimura & Wu, 1994 which collected around the Pearl River Delta with high extremity of vertebral count up to 52-54. The undated comprehensive checklist of gobioid fishes in China will be provided in this paper.

• Proceedings of the Korean Magnestics Society Conference
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• 2008.12a
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• pp.157.2-157.2
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• 2008

• Proceedings of the Korean Magnestics Society Conference
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• 2008.12a
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• pp.158.1-158.1
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• 2008

• Proceedings of the Korean Magnestics Society Conference
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• 2008.12a
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• pp.111.1-111.1
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• 2008

• Journal of Ginseng Research
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• v.46 no.3
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• pp.418-425
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• 2022

Background: Sorafenib is effective in treating hepatoma, but most patients develop resistance to it. STAT3 signaling has been implicated in sorafenib resistance. Artesunate (ART) and 20(R)-ginsenoside Rg3 (Rg3) have anti-hepatoma effects and can inhibit STAT3 signaling in cancer cells. This study aimed to evaluate the effects of Rg3 in combination with ART (Rg3-plus-ART) in overcoming sorafenib resistance, and to examine the involvement of STAT3 signaling in these effects. Methods: Sorafenib-resistant HepG2 cells (HepG2-SR) were used to evaluate the in vitro anti-hepatoma effects of Rg3-plus-ART. A HepG2-SR hepatoma-bearing BALB/c-nu/nu mouse model was used to assess the in vivo anti-hepatoma effects of Rg3-plus-ART. CCK-8 assays and Annexin V-FITC/PI double staining were used to examine cell proliferation and apoptosis, respectively. Immunoblotting was employed to examine protein levels. ROS generation was examined by measuring DCF-DA fluorescence. Results: Rg3-plus-ART synergistically reduced viability of, and evoked apoptosis in HepG2-SR cells, and suppressed HepG2-SR tumor growth in mice. Mechanistic studies revealed that Rg3-plus-ART inhibited activation/phosphorylation of Src and STAT3 in HepG2-SR cultures and tumors. The combination also decreased the STAT3 nuclear level and induced ROS production in HepG2-SR cultures. Furthermore, overactivation of STAT3 or removal of ROS diminished the anti-proliferative effects of Rg3-plus-ART, and removal of ROS diminished Rg3-plus-ART's inhibitory effects on STAT3 activation in HepG2-SR cells. Conclusions: Rg3-plus-ART overcomes sorafenib resistance in experimental models, and inhibition of Src/STAT3 signaling and modulation of ROS/STAT3 signaling contribute to the underlying mechanisms. This study provides a pharmacological basis for developing Rg3-plus-ART into a novel modality for treating sorafenib-resistant hepatoma.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• v.1
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• pp.247-250
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• 2006

Integrating a GPS based vehicle navigation system and the latest optimal algorithms, this research aims to develop a real-time decision support platform for concrete plant to provide the optimal solutions for ready mixed concrete delivery. The platform includes fleet tracking system, simulation and optimization tools, and visual interface which is useful to monitor delivery progress, to obtain crucial historical and real-time data for simulation, and to improve the efficiency of the plant operation. This paper presents configuration of the system and performance evaluation based on operational data.

• Proceedings of the Korea Water Resources Association Conference
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• 2005.09a
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• pp.817-817
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• 2005

• 한국전산유체공학회:학술대회논문집
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• 2003.10a
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• pp.29-32
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• 2003

It is shown that using the unified coordiantes of Hui et al.[1 - 4], one can now compute fluid flow without prior grid generation. This represents a great saving of computing time.

• 지역과문화
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• v.7 no.4
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• pp.69-81
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• 2020

As internet companies advance into the film industry, China's IP movies have grown rapidly and brought huge business benefits to the movie market. This paper tried to diagnose the phenomenon of the Chinese IP film craze and derive its meaning and implications. To this end, we selected representative cases to examine the problems and the corresponding improvement measures. Among the three genres of novels, cartoons, and music that are currently drawing the most attention in IP film adaptation, the examples were "Wu Kong", "Take My Brother Away", "My Old Classmate". The research results show that there are problems such as the unification of Chinese IP films, the lack of screenplay ability, and the copyright. Some improvement measures such as establishing IP copyright trading platform, strengthening IP creation, and promoting the value chain of IP industry are put to solve these problems. We hope that China's IP film market create a value chain on the basis of this paper.