• International Journal of Computer Science & Network Security
• /
• 제24권5호
• /
• pp.53-63
• /
• 2024

Alzheimer's disease is a brain disorder that worsens over time and affects millions of people around the world. It leads to a gradual deterioration in memory, thinking ability, and behavioral and social skills until the person loses his ability to adapt to society. Technological progress in medical imaging and the use of artificial intelligence, has provided the possibility of detecting Alzheimer's disease through medical images such as magnetic resonance imaging (MRI). However, Deep learning algorithms, especially convolutional neural networks (CNNs), have shown great success in analyzing medical images for disease diagnosis and classification. Where CNNs can recognize patterns and objects from images, which makes them ideally suited for this study. In this paper, we proposed to compare the performances of Alzheimer's disease detection by using two deep learning methods: You Only Look Once (YOLO), a CNN-enabled object recognition algorithm, and Visual Geometry Group (VGG16) which is a type of deep convolutional neural network primarily used for image classification. We will compare our results using these modern models Instead of using CNN only like the previous research. In addition, the results showed different levels of accuracy for the various versions of YOLO and the VGG16 model. YOLO v5 reached 56.4% accuracy at 50 epochs and 61.5% accuracy at 100 epochs. YOLO v8, which is for classification, reached 84% accuracy overall at 100 epochs. YOLO v9, which is for object detection overall accuracy of 84.6%. The VGG16 model reached 99% accuracy for training after 25 epochs but only 78% accuracy for testing. Hence, the best model overall is YOLO v9, with the highest overall accuracy of 86.1%.

• Proceedings of the KIEE Conference
• /
• 대한전기학회 1994년도 하계학술대회 논문집 C
• /
• pp.1603-1605
• /
• 1994

Recently, Gas Circuit Breakers are rapidly replacing Vacuum Circuit Breakers in the medium voltage switchgear. This is due to the improved performance of - GCB in interrupting capability, price, weight, size etc., while the countermeasure to suppress the switching surges of VCB has not been satisfactory. Intensive research works on the GCB have been conducted in the world widely since 1980. Nowadays it is well known that the thermal expansion type GCB can provide- better performance than puffer type in the distribution power system. KERI has conducted researches in the GCB rated at 25.8kV 25kA with Jinkwang Co. using the thermal expantion principle since 1993. In this paper, the calculated results of electric and magnetic fields for the model GCB are presented and analyzed. The effect of permanent magnet used to improve the interruption capabilty at the low current level is also investigated. The design parameters for the interrupter inspected through the short-circuit tests conducted at high power laboratory of KERI.

• Proceedings of the KIEE Conference
• /
• 대한전기학회 1995년도 하계학술대회 논문집 A
• /
• pp.144-146
• /
• 1995

A superconducting 2 tesla MRI magnet for the animal magnetic resonance imaging has been developed as a basic model for the application of the precise supercoducting magnet technology. MRI cryostat with 210mm room temperature bore was designed and manufactured for this magnet. The cryostat was designed basically not only to extract the principal design parameters at the performance test but also for the convenience of the manufacturing. The most extinct feacture of the cryostat is that it does not have $LN_{2}$ tank and the 77K thermal shield is cooled by circuling $LN_{2}$ through copper pipe which is welded around the shield plate. It results in reduction of the total cryostat size(about 30%).

• Progress in Superconductivity and Cryogenics
• /
• 제10권1호
• /
• pp.52-56
• /
• 2008

According to the improvement of HTS conductor, HTS tapes which have the high current capacity have been recently researched in several nations. For large power application, AC loss is the most important issue in the development of AC superconducting power devices because it is closely related to the system operation efficiency. In 1st generation wire of HTS conductor, BSCCO, AC loss is too large to use for power application. Also, It is well known in recently years that YBCO CC, the 2nd generation wire, has also too much AC loss to apply to AC power devices. There are many trials to develop the new HTS wire having the low AC loss around the world. In this research, we present the measurment result of magnetization losses in SmBCO coated conductors. We measured the magnetization loss generated by perpendicularly exposed external magnetic field and compared with the analytic value of the strip model. Also, we presented the results compared with measured magnetization loss of an YBCO coated conductor.

• Korean Journal of Radiology
• /
• 제24권2호
• /
• pp.133-144
• /
• 2023

Objective: Cyclin-dependent kinase inhibitor (CDKN)2A/B homozygous deletion is a key molecular marker of isocitrate dehydrogenase (IDH)-mutant astrocytomas in the 2021 World Health Organization. We aimed to investigate whether qualitative and quantitative MRI parameters can predict CDKN2A/B homozygous deletion status in IDH-mutant astrocytomas. Materials and Methods: Preoperative MRI data of 88 patients (mean age ± standard deviation, 42.0 ± 11.9 years; 40 females and 48 males) with IDH-mutant astrocytomas (76 without and 12 with CDKN2A/B homozygous deletion) from two institutions were included. A qualitative imaging assessment was performed. Mean apparent diffusion coefficient (ADC), 5th percentile of ADC, mean normalized cerebral blood volume (nCBV), and 95th percentile of nCBV were assessed via automatic tumor segmentation. Logistic regression was performed to determine the factors associated with CDKN2A/B homozygous deletion in all 88 patients and a subgroup of 47 patients with histological grades 3 and 4. The discrimination performance of the logistic regression models was evaluated using the area under the receiver operating characteristic curve (AUC). Results: In multivariable analysis of all patients, infiltrative pattern (odds ratio [OR] = 4.25, p = 0.034), maximal diameter (OR = 1.07, p = 0.013), and 95th percentile of nCBV (OR = 1.34, p = 0.049) were independent predictors of CDKN2A/B homozygous deletion. The AUC, accuracy, sensitivity, and specificity of the corresponding model were 0.83 (95% confidence interval [CI], 0.72-0.91), 90.4%, 83.3%, and 75.0%, respectively. On multivariable analysis of the subgroup with histological grades 3 and 4, infiltrative pattern (OR = 10.39, p = 0.012) and 95th percentile of nCBV (OR = 1.24, p = 0.047) were independent predictors of CDKN2A/B homozygous deletion, with an AUC accuracy, sensitivity, and specificity of the corresponding model of 0.76 (95% CI, 0.60-0.88), 87.8%, 80.0%, and 58.1%, respectively. Conclusion: The presence of an infiltrative pattern, larger maximal diameter, and higher 95th percentile of the nCBV may be useful MRI biomarkers for CDKN2A/B homozygous deletion in IDH-mutant astrocytomas.

• Journal of Korean Neurosurgical Society
• /
• 제67권1호
• /
• pp.94-102
• /
• 2024

Objective : The spontaneous intracerebral hemorrhage (ICH) remains a significant cause of mortality and morbidity throughout the world. The purpose of this retrospective study is to develop multiple models for predicting ICH outcomes using machine learning (ML). Methods : Between January 2014 and October 2021, we included ICH patients identified by computed tomography or magnetic resonance imaging and treated with surgery. At the 6-month check-up, outcomes were assessed using the modified Rankin Scale. In this study, four ML models, including Support Vector Machine (SVM), Decision Tree C5.0, Artificial Neural Network, Logistic Regression were used to build ICH prediction models. In order to evaluate the reliability and the ML models, we calculated the area under the receiver operating characteristic curve (AUC), specificity, sensitivity, accuracy, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR). Results : We identified 71 patients who had favorable outcomes and 156 who had unfavorable outcomes. The results showed that the SVM model achieved the best comprehensive prediction efficiency. For the SVM model, the AUC, accuracy, specificity, sensitivity, PLR, NLR, and DOR were 0.91, 0.92, 0.92, 0.93, 11.63, 0.076, and 153.03, respectively. For the SVM model, we found the importance value of time to operating room (TOR) was higher significantly than other variables. Conclusion : The analysis of clinical reliability showed that the SVM model achieved the best comprehensive prediction efficiency and the importance value of TOR was higher significantly than other variables.

• Korean Journal of Radiology
• /
• 제22권2호
• /
• pp.233-242
• /
• 2021

Objective: To evaluate the association of MRI features with the major genomic profiles and prognosis of World Health Organization grade III (G3) gliomas compared with those of glioblastomas (GBMs). Materials and Methods: We enrolled 76 G3 glioma and 155 GBM patients with pathologically confirmed disease who had pretreatment brain MRI and major genetic information of tumors. Qualitative and quantitative imaging features, including volumetrics and histogram parameters, such as normalized cerebral blood volume (nCBV), cerebral blood flow (nCBF), and apparent diffusion coefficient (nADC) were evaluated. The G3 gliomas were divided into three groups for the analysis: with this isocitrate dehydrogenase (IDH)-mutation, IDH mutation and a chromosome arm 1p/19q-codeleted (IDHmut1p/19qdel), IDH mutation, 1p/19q-nondeleted (IDHmut1p/19qnondel), and IDH wildtype (IDHwt). A prediction model for the genetic profiles of G3 gliomas was developed and validated on a separate cohort. Both the quantitative and qualitative imaging parameters and progression-free survival (PFS) of G3 gliomas were compared and survival analysis was performed. Moreover, the imaging parameters and PFS between IDHwt G3 gliomas and GBMs were compared. Results: IDHmut G3 gliomas showed a larger volume (p = 0.017), lower nCBF (p = 0.048), and higher nADC (p = 0.007) than IDHwt. Between the IDHmut tumors, IDHmut1p/19qdel G3 gliomas had higher nCBV (p = 0.024) and lower nADC (p = 0.002) than IDHmut1p/19qnondel G3 gliomas. Moreover, IDHmut1p/19qdel tumors had the best prognosis and IDHwt tumors had the worst prognosis among G3 gliomas (p < 0.001). PFS was significantly associated with the 95th percentile values of nCBV and nCBF in G3 gliomas. There was no significant difference in neither PFS nor imaging features between IDHwt G3 gliomas and IDHwt GBMs. Conclusion: We found significant differences in MRI features, including volumetrics, CBV, and ADC, in G3 gliomas, according to IDH mutation and 1p/19q codeletion status, which can be utilized for the prediction of genomic profiles and the prognosis of G3 glioma patients. The MRI signatures and prognosis of IDHwt G3 gliomas tend to follow those of IDHwt GBMs.

• Progress in Medical Physics
• /
• 제14권1호
• /
• pp.34-42
• /
• 2003

In medical imaging, three-dimensional (3D) display using Virtual Reality Modeling Language (VRML) as a portable file format can give intuitive information more efficiently on the World Wide Web (WWW). The web-based 3D visualization of functional images combined with anatomical images has not studied much in systematic ways. The goal of this study was to achieve a simultaneous observation of 3D anatomic and functional models with planar images on the WWW, providing their locational information in 3D space with a measuring implement using VRML. MRI and ictal-interictal SPECT images were obtained from one epileptic patient. Subtraction ictal SPECT co-registered to MRI (SISCOM) was performed to improve identification of a seizure focus. SISCOM image volumes were held by thresholds above one standard deviation (1-SD) and two standard deviations (2-SD). SISCOM foci and boundaries of gray matter, white matter, and cerebrospinal fluid (CSF) in the MRI volume were segmented and rendered to VRML polygonal surfaces by marching cube algorithm. Line profiles of x and y-axis that represent real lengths on an image were acquired and their maximum lengths were the same as 211.67 mm. The real size vs. the rendered VRML surface size was approximately the ratio of 1 to 605.9. A VRML measuring tool was made and merged with previous VRML surfaces. User interface tools were embedded with Java Script routines to display MRI planar images as cross sections of 3D surface models and to set transparencies of 3D surface models. When transparencies of 3D surface models were properly controlled, a fused display of the brain geometry with 3D distributions of focal activated regions provided intuitively spatial correlations among three 3D surface models. The epileptic seizure focus was in the right temporal lobe of the brain. The real position of the seizure focus could be verified by the VRML measuring tool and the anatomy corresponding to the seizure focus could be confirmed by MRI planar images crossing 3D surface models. The VRML application developed in this study may have several advantages. Firstly, 3D fused display and control of anatomic and functional image were achieved on the m. Secondly, the vector analysis of a 3D surface model was defined by the VRML measuring tool based on the real size. Finally, the anatomy corresponding to the seizure focus was intuitively detected by correlations with MRI images. Our web based visualization of 3-D fusion image and its localization will be a help to online research and education in diagnostic radiology, therapeutic radiology, and surgery applications.