• Journal of Korean Medical classics
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• v.27 no.3
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• pp.123-140
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• 2014

Objectives : As there was no sufficient research done on Sasang (four harms: 氣[qi], 血[blood], 痰[phlegm], and 鬱[congestion]), which serves as a precept in treatment of miscellaneous diseases, in contrast with 'Yang is always teeming whereas Yin is always scarce' and 'Sanghwa-ron', which are Judangye's major theories, I have come to work on it. I expect that with this, we can understand Judangye's medical theory and therapy for a variety of diseases. Methods : To begin with, I take a look at the definition of Sasang. And then, I make selections of theories and therapy related to Sasang from Gyeokchiyeoron(格致餘論) and Geumgweguhyeon(金匱鉤玄), which are Judangye's writings. My study follows the order of energy, blood, phlegm, and congestion. Results : Through Gyeokchiyeoron, I have learned more about Judangye's theory on how energy, blood, phlegm, and congestion cause diseases. And as for therapy, I have tapped into Geumgweguhyeon to use sagunja-tang(四君子湯) for drained energy, samul-tang(四物湯) for drained blood, ijin-tang(二陳湯) for phlegm, and wolguk-hwan(越鞠丸) for congestion, thus verifying the originality of Judangye's theory. Conclusions : "Judangye for miscellaneous diseases" was confirmed through his treatments for energy, blood, phlegm, and congestion. And his idea of Yang-eum(養陰 'nurturing yin') is now reflected in therapy for miscellaneous diseases, now serving as a study that provides a comprehensive understanding of Judangye's medical theories.

• Journal of Korean society of Dental Hygiene
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• v.15 no.1
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• pp.47-54
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• 2015

Objectives: The aim of this study was to investigate the factors related to dental caries and periodontal disease in Korean adults. Methods: The subjects were 5,149 adults over 19 years old who participated in the 5th Korea National Health and Nutrition Examination Survey 2012. Data were analyzed by chi-square test and logistic regression analysis using SPSS 18.0 statistical package program. The questionnaire consisted of 17 questions of independent variables and 2 kinds of dependent variables including dental caries and periodontal diseases by direct interview. The independent variables included 5 questions of general characteristics, 3 questions of health behavior, 5 questions of oral health behavior, and 4 questions of chronic diseases diagnosed by the doctors. Results: The prevalence rate of dental caries was higher in those who did not regularly work out and did not receive regular checkups including dental floss and dental brush use. The prevalence rate of periodontal diseases was higher in male adults, smokers, and those who were obese and had diabetes mellitus, poor oral health care habit without using dental floss and inter-dental brush. Conclusions: In order to prevent the dental caries in the adults, it is very important to do regular exercise and regular dental checkup. The best ways of dental caries prevention include tooth brushing after meal with use of dental floss and inter-dental brush. This study suggests that dental health promotion can be enhanced by smoking cessation, ideal body weight maintenance, timely tooth brushing after meal, and use of dental floss and inter-dental brush.

• Safety and Health at Work
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• v.3 no.4
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• pp.257-267
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• 2012

Occupational neurotoxic diseases have become increasingly common in Taiwan due to industrialization. Over the past 40 years, Taiwan has transformed from an agricultural society to an industrial society. The most common neurotoxic diseases also changed from organophosphate poisoning to heavy metal intoxication, and then to organic solvent and semiconductor agent poisoning. The nervous system is particularly vulnerable to toxic agents because of its high metabolic rate. Neurological manifestations may be transient or permanent, and may range from cognitive dysfunction, cerebellar ataxia, Parkinsonism, sensorimotor neuropathy and autonomic dysfunction to neuromuscular junction disorders. This study attempts to provide a review of the major outbreaks of occupational neurotoxins from 1968 to 2012. A total of 16 occupational neurotoxins, including organophosphates, toxic gases, heavy metals, organic solvents, and other toxic chemicals, were reviewed. Peer-reviewed articles related to the electrophysiology, neuroimaging, treatment and long-term follow up of these neurotoxic diseases were also obtained. The heavy metals involved consisted of lead, manganese, organic tin, mercury, arsenic, and thallium. The organic solvents included n-hexane, toluene, mixed solvents and carbon disulfide. Toxic gases such as carbon monoxide, and hydrogen sulfide were also included, along with toxic chemicals including polychlorinated biphenyls, tetramethylammonium hydroxide, organophosphates, and dimethylamine borane. In addition we attempted to correlate these events to the timeline of industrial development in Taiwan. By researching this topic, the hope is that it may help other developing countries to improve industrial hygiene and promote occupational safety and health care during the process of industrialization.

• Safety and Health at Work
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• v.1 no.1
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• pp.69-79
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• 2010

Objectives: Various cytokines induced by inhalation of coal dust may mediate inflammation and lead to tissue damage or fibrosis, such as coal workers' pneumoconiosis (CWP). Methods: To investigate the relevance of serum cytokines in CWP, the levels of serum interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-${\alpha}$) as CWP biomarkers in 110 retired coal miners (22 controls and 88 CWP subjects) were related to cross sectional findings and 1-year progressive changes of the pneumoconiosis. Progressive changes of CWP were evaluated by paired comparison of chest radiographs. Analysis by a receiver operating characteristic curve assessed the biomarker potential of each cytokine. Results: The mean serum IL-8 level was significantly higher in CWP compared to controls and IL-8 levels correlated with the degree of CWP. The median serum TNF-${\alpha}$ level was significantly higher in subjects with progressive CWP compared to subjects without CWP progression. The area under the ROC curve for IL-8 (0.70) and TNF-${\alpha}$ (0.72) for CWP identification and progression, respectively, indicated the biomarker potential of the two cytokines. Serum cutoff values of IL-8 and TNF-${\alpha}$ were 11.63 pg/mL(sensitivity, 69%; specificity, 64%) and 4.52 pg/mL (sensitivity, 67%; specificity, 79%), respectively. Conclusion: The results suggest that high levels of serum IL-8 are associated with the presence of CWP and those of serum TNF-${\alpha}$ are associated with the progression of CWP.

• Korean Journal of Construction Engineering and Management
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• v.8 no.3
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• pp.134-141
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• 2007

It is crucial that the WRMSD is realized as a critical job-related diseases for the construction workers. It is caused by the characteristics of repetitive work, uncomfortable work methods and continuous unsuitable physical posture. The objective of this research is to evaluate the workload for the carpenters and structural steel workers. Investigation on the posture and behavior for the workers as well as personal sensitivity to the workload is conducted. The laboratory tests with graduate students are conducted to estimate inconvenience in terms of personal sensitivity to the workload. The results of this research will be used to perform the further researches on ergonomic and technological approaches to improvements of the hand-intensive tasks in the construction industry.

• The Korean Journal of Health Service Management
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• v.9 no.1
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• pp.169-178
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• 2015

This study implemented a health support network project to improve the quality of life of women with musculoskeletal disorders. These activities were intended to analyze the effects of the impact on the quality of life of women with musculoskeletal diseases, continuing to base their future needs for materials and practice so as to provide a method for this purpose. On August 19, 2013 through December, a survey of 320 people living in Seoul included 31 women with symptoms of musculoskeletal disorders. Another, 16 weeks led to a total of 127 people with housewives screened as a subjects for social support networks projects. After the research, the health support network project was implemented, and most musculoskeletal pain was reduced, depression levels were reduced, and a quality improvement was noted in health-related life activities. In particular, mental- health-related quality of life was found to increased. As incidental factors that may cause musculoskeletal disorders, marital status, living with family, low income, and a high depression index were related to low health-related quality of life. Future studies can support continued health at the local business community level rather than with smaller samples. This work can also be supported by follow-up studies to evaluate the effectiveness of program.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.5 no.1
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• pp.87-103
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• 1995

Since being granted permission for self-assessment of the work environment by the Department of Labor in 1992, POSCO's Industrial Hygiene Laboratory has participated in domestic and Foreign Quality Control Programs 8 times and has obtained remarkable results. It has made a lot of effort to be a proficient laboratory with the ability to observe and analyse environmental monitoring data. The summary of results is as follows: 1. POSCO's Industrial Hygiene Laboratory has received a "P(Proficient)" grade from the round 115 to round 119 of AIHA/NIOSH PAT Program for analysis of such metals as lead, cadmium, zinc, and chromium, and also has received a "P(Proficient)" grade from its round 119 of for organic solvent analysis, i,e,. Trichloroethylene(TCE), Carbon Tetr-achloride(CTC), 1,2-Dichloroethane(DCE), 1,1,1-Trichloroethane(MCM), Tetrachloroethylene (PCE), Chloroform(CFM), Benzene(BNZ), toluene(TOL), and O-xylene(OXY). 2. In the Quality Control Evaluation Program performed by the Industrial Health Research Institute,Korea Industrial Safety Corporation, POSCO has passed impressively in the3-metal analysis test for lead, cadmium, cupper, and in the 6 organic solvent analysis test for Benzene(BNZ), toluene(TOL), O-xylene(OXY), Trichloroethylene(TCE) and Methyl isobutyl keton(MIBK), n-Hexane with 2 standard deviations. These analytic techniques should be practically applied to various fields, and reliable results of environmental monitoring should be considered to improve the work environment and to keep workers from occupation related diseases.

• Journal of Korean society of Dental Hygiene
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• v.10 no.5
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• pp.841-849
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• 2010

Objectives : This purpose of this study was to examine worker's Dental care utilization patterns and its related factors, to prepare basic data for oral health promotion of workers. Methods : The study subject were 1016 industrial workers from7 working places in Gyung-Sang-Buk Do and Daegu-City. Data for this study was obtained by self-administrated questionnaire. The questionnaire consists of general characteristics, yes or no of dental care utilization before six month, purpose of visit, yes or no of dental disease form the results of dental examination screening before one years, yes or no of and patterns dental care utilization of workers with dental disease, etc. The data was utilized using frequency test and $x^2-test$. Results : Rate of dental care utilization was 40% within six month last, among the general characteristics, it were statistically significant that higher age, married state, bad oral health state, high Work period. Rate of dental disease as a result of their dental examination last was 53.1% among the general characteristics, it were statistically significant that enough economic state, bad oral health state, blue collar work type. Dental care utilization's rate of dental disease as a result of their dental examination last was 48.6% among the general characteristics, it were statistically significant that Enough economic state, higher age, married state, high Work period. Conclusions : In order to promote workers of abnormal opinions to take the medical treatment on their dental diseases later dental examination, it is necessary to educate them consistently for the importance of early medical treatment.

• Safety and Health at Work
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• v.9 no.1
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• pp.1-9
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• 2018

Background: Work-related musculoskeletal disorders are the most important problems among professions particularly, dentists. This study was conducted to determine the prevalence of musculoskeletal disorders in various parts of the body in Iranian dentists by using systematic review and meta-analysis. Methods: This systematic review and meta-analysis was based on preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines and searching in national databases such as SID, Magiran, Irandoc, IranMedex, and Medlib, and international databases such as MedLine, Web of Sciences, Scopus, PubMed, ScienceDirect, Cochrane, Embase, Springer, Wiley Online Library, Ebsco, CEBM, and Google Scholar search engine which were published by January 1, 2017. Researched keywords were in Persian and their standard English equivalents were in accordance with their MeSH. The obtained documents were analyzed using Comprehensive Meta-analysis version 2. Results: According to 23 studies through 2,531 Iranian dentists which took part in this study, prevalence of skeletal disorders in Iranian dentists has been 17.6% [confidence interval (CI) 95%:11.7-25.5] in knees, 33.2% (CI 95%:24.1-43.8) in shoulders, 33.4% (CI 95%: 26.8-40.8) in the thorax, 51.9% (CI 95%:46.7-57.2) in necks, 33.7% (CI 95%:28.2-39.6) in wrists/hands, 12.9% (CI 95%:7.7-20.6) in elbows, 37.3% (CI 95%: 31.5-43.5) in lower back, 11.9% (CI 95%:8.7-16.1) in thighs, 12.9% (CI 95%:3.8-36) in the foot, and 10.5% (CI 95%:7-15.4) in legs. Conclusion: Considering the high prevalence of musculoskeletal disorders in Iranian dentists, ergonomics should be included as a lesson in preclinic and also, reeducation courses for ergonomics basics should be executed for graduate dentists.

• Genomics & Informatics
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• v.12 no.4
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• pp.181-186
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• 2014

Genome-wide association studies have proven the highly polygenic architecture of complex diseases or traits; therefore, single-locus-based methods are usually unable to detect all involved loci, especially when individual loci exert small effects. Moreover, the majority of associated single-nucleotide polymorphisms resides in non-coding regions, making it difficult to understand their phenotypic contribution. In this work, we studied epistatic interactions associated with three common diseases using Korea Association Resource (KARE) data: type 2 diabetes mellitus (DM), hypertension (HT), and coronary artery disease (CAD). We showed that epistatic single-nucleotide polymorphisms (SNPs) were enriched in enhancers, as well as in DNase I footprints (the Encyclopedia of DNA Elements [ENCODE] Project Consortium 2012), which suggested that the disruption of the regulatory regions where transcription factors bind may be involved in the disease mechanism. Accordingly, to identify the genes affected by the SNPs, we employed whole-genome multiple-cell-type enhancer data which discovered using DNase I profiles and Cap Analysis Gene Expression (CAGE). Assigned genes were significantly enriched in known disease associated gene sets, which were explored based on the literature, suggesting that this approach is useful for detecting relevant affected genes. In our knowledge-based epistatic network, the three diseases share many associated genes and are also closely related with each other through many epistatic interactions. These findings elucidate the genetic basis of the close relationship between DM, HT, and CAD.