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The Effect of Herbal Formula KH-204 on Erectile Dysfunction in Hyperlipidemic Rat (고지혈증 흰쥐에서 생약제제 KH-204의 발기부전 치료연구)

  • Lee, Eun-Jeong;Kim, Hee-Seok;Sohn, Dong-Wan;Kim, Sae-Woong;Cho, Yong-Hyun;Hwang, Sung-Wan;Hwang, Sung-Yeoun
    • Korean Journal of Pharmacognosy
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    • v.38 no.1
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    • pp.50-55
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    • 2007
  • This study was designed to investigate the effects KH-204 on erectile dysfunction in hyperlipidemic rat. KH-204 has been evaluated antihyperlipidemic and antierectile dysfunction effects on experimental hyperlipidemic rats induced by high fat diet. After oral administration of the water extract KH-204 (50, 100, 200, 300 mg/kg) to hyperlipidemic rats for 8 weeks, the variables including body weight, total cholesterol, HDL and LDL levels in serum, the expression of eNOS and nNOS in penis were measured. And erectile function was determined by measurement of intracavernosal pressure (ICP) and maximal arterial pressure (MAP) after electrical stimulation of the cavernosal nerve. Oral administration of KH-204 significantly inhibited the increases of serum total cholesterol and LDL-cholesterol levels and the decreased of serum HDL-cholesterol levels in hyperlipidemic rats induced by high fat diet. The penile expression level of the two enzyme (eNOS, nNOS) were increased significantly after oral administration of the KH-204 50 mg/kg. Erectile function after 10 volts stimulation was significantly decreased in the hyperlipidemic rat compared with the normal rat, but increased in KH-204 group compared with hyperlipidemic group. These results suggest that KH-204 is effective for erectile dysfunction in hyperlipidemia.

PC controlled Autonomous Navigation System for GPS Guided Field Robot (GPS를 이용한 필드로봇의 PC기반 자율항법 제어 시스템)

  • Han, Jae-Won;Park, Jae-Ho;Hong, Sung-Kyung;Ryuh, Young-Sun
    • Journal of Biosystems Engineering
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    • v.34 no.4
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    • pp.278-285
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    • 2009
  • Navigation system is applied in variety of fields including the simple location positioning, autopilot navigation of unmanned robot tractor, autonomous guidance systems for agricultural vehicles, construction of large field works that require high precision and map making process. Particularly utilization of GPS (Global Positioning System) is very common in the present navigation system. This study introduces a navigation system for autonomous field robot that travels to the pre-input path using GPS information. Performance of the GPS- based navigation is highly depended on its receiving rate because GPS receivers do not acquire any navigation information in the period between the refresh intervals. So this study presents an algorithm that improves an accuracy of the navigation by estimation the positional information during the blind period of a low rate GPS receiver. In fact the algorithm calculated the robot's heading in a 50 Hz rate, so the blind period of an 1 Hz GPS receiver is extensively covered. Consequently implementation of the algorithm to the GPS based navigation showed an improvement in guidance accuracy. The conventional field robot directly carried an expensive control computer and sensors onboard, therefore the miniaturization and weight reduction of the robot was limited. In this paper, the field robot carried only communication equipments such as GPS module, normal RC receiver, and bluetooth modem. This enabled the field robot to be built in an economic cost and miniature size.

A Study on the Analysis of Freezing Soil by Frost Groups and Frost Depth in Korea (우리나라 동결토의 토군별 분석과 동결심도에 관한 연구)

  • 정철호
    • Geotechnical Engineering
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    • v.5 no.4
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    • pp.5-16
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    • 1989
  • This paper statistically analyses the freezing soil by frost group and frost depth in Korea with data from soil testing in the Korea National Housing Corporation, the climate data provided by the Central Weather Office and the data on the frost depth from the National Construction Laboratory Institute. In this paper, freezing variable are analysed such as percentage finer than 0.02 m by weight, plasticity index, freezing index, water contents of soil and frost depth etc‥‥ The result of the analysis is as follows. 1) The frost depth of Korea depends on the properties of soil rather thank the characte fistic of area. 2) The distribution map of design freezing index in 57 cities is drawn up with the maxi- mum freezing index, during past 14 years, calculated by the average of the air temperature observed four times(03 : 00.09 00, 15 : 00, 21 : 00) a day. 3) By correcting the OLS line estimated from the relationship between freezing index and frost depth, a method of utlizing the line with the upper confidence limit of 99.9% int-distribution as predicted maximum frost depth is newly introduced.

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Buckling analysis and optimal structural design of supercavitating vehicles using finite element technology

  • Byun, Wan-Il;Kim, Min-Ki;Park, Kook-Jin;Kim, Seung-Jo;Chung, Min-Ho;Cho, Jin-Yeon;Park, Sung-Han
    • International Journal of Naval Architecture and Ocean Engineering
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    • v.3 no.4
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    • pp.274-285
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    • 2011
  • The supercavitating vehicle is an underwater vehicle that is surrounded almost completely by a supercavity to reduce hydrodynamic drag substantially. Since the cruise speed of the vehicle is much higher than that of conventional submarines, the drag force is huge and a buckling may occur. The buckling phenomenon is analyzed in this study through static and dynamic approaches. Critical buckling load and pressure as well as buckling mode shapes are calculated using static buckling analysis and a stability map is obtained from dynamic buckling analysis. When the finite element method (FEM) is used for the buckling analysis, the solver requires a linear static solver and an eigenvalue solver. In this study, these two solvers are integrated and a consolidated buckling analysis module is constructed. Furthermore, Particle Swarm Optimization (PSO) algorithm is combined in the buckling analysis module to perform a design optimization computation of a simplified supercavitating vehicle. The simplified configuration includes cylindrical shell structure with three stiffeners. The target for the design optimization process is to minimize total weight while maintaining the given structure buckling-free.

Modified Atmosphere Packaging of Leaf Lettuce (잎상치의 MA 포장)

  • Hong, Seok-In;Kim, Yun-Ji;Park, Noh-Hyun
    • Korean Journal of Food Science and Technology
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    • v.25 no.3
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    • pp.270-276
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    • 1993
  • Leaf lettuce (Lactuca sativa L., var. crispa) packed in $20{\mu}m$ LDPE (perforated), $20{\mu}m$ LDPE, $30{\mu}m$ HDPE, and $40{\mu}m$ LDPE pouches was stored at $4^{\circ}C,\;10^{\circ}C\;and\;20^{\circ}C$. The quality of leaf lettuce during the storage was investigated in terms of weight loss, color, soluble solids content, texture and sensory properties. Leaf lettuce exhibited the highest storage stability at $4^{\circ}C$. Shelf-life of the packed leaf lettuce was prolonged approximately $10{\sim}15$ times in comparision with that of the unpacked under all temperature conditions. Among the packed leaf lettuce, self-life in $20{\mu}m$ LDPE (perforated) and $20{\mu}m$ LDPE pouches was relatively short mainly due to discoloration and deterioration. On the other hand, the quality of the leaf lettuce packed in $30{\mu}m$ HDPE and $40{\mu}m$ LDPE pouches was kept well during the storage. Particularly, $40{\mu}m$ LDPE pouches conferred the shelf-life superior to other film pouches.

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Runtime Prediction Based on Workload-Aware Clustering (병렬 프로그램 로그 군집화 기반 작업 실행 시간 예측모형 연구)

  • Kim, Eunhye;Park, Ju-Won
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.38 no.3
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    • pp.56-63
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    • 2015
  • Several fields of science have demanded large-scale workflow support, which requires thousands of CPU cores or more. In order to support such large-scale scientific workflows, high capacity parallel systems such as supercomputers are widely used. In order to increase the utilization of these systems, most schedulers use backfilling policy: Small jobs are moved ahead to fill in holes in the schedule when large jobs do not delay. Since an estimate of the runtime is necessary for backfilling, most parallel systems use user's estimated runtime. However, it is found to be extremely inaccurate because users overestimate their jobs. Therefore, in this paper, we propose a novel system for the runtime prediction based on workload-aware clustering with the goal of improving prediction performance. The proposed method for runtime prediction of parallel applications consists of three main phases. First, a feature selection based on factor analysis is performed to identify important input features. Then, it performs a clustering analysis of history data based on self-organizing map which is followed by hierarchical clustering for finding the clustering boundaries from the weight vectors. Finally, prediction models are constructed using support vector regression with the clustered workload data. Multiple prediction models for each clustered data pattern can reduce the error rate compared with a single model for the whole data pattern. In the experiments, we use workload logs on parallel systems (i.e., iPSC, LANL-CM5, SDSC-Par95, SDSC-Par96, and CTC-SP2) to evaluate the effectiveness of our approach. Comparing with other techniques, experimental results show that the proposed method improves the accuracy up to 69.08%.

Purification and Characterization of Authentic Human Growth Hormone Converted from Methionyl Human Growth Hormone by Immobilized Aminopeptidase M (고정화 Aminopeptidase M에 의해 메치오닐 인간성장호르몬으로부터 전환된 천연형 인간성장호르몬의 정제 및 특성 확인)

  • 이성희;조영우
    • KSBB Journal
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    • v.10 no.3
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    • pp.271-282
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    • 1995
  • The authentic hGH converted from met-hGH by immobilized ApM was purified by successive chromatographic processes based on the differences in isoelectric points, hydrophobicities and charges. The final recovery yield was about 14.1% and the specific activity of the purified hGH was 2.75IU per mg when assayed by enzyme immunoassay. The purified hGH was verified to be authentic hGH through the analysis of amino acid composition, amino-terminal amino acid sequence, carboxy-terminal amino acid and tryptic peptide map. The purity of purified hGH was higher than that of commercial hGH when assessed by SDS-PAGE, PAGE, IEF and HSGF. In weight-gain assay and tibia test with hypophysectomized rats, the hGH produced in this study showed the same growth effect as the commercial hGH.

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Analysis of Relationship between Resistance of Brown Planthopper and Traits Related to the Lodging in Rice (벼멸구 저항성과 도복관련 형질과의 관계분석)

  • Kim, Suk-Man;Qin, Yang;Sohn, Jae-Keun
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.55 no.2
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    • pp.105-110
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    • 2010
  • This study was conducted to analyze the relationships between resistance of brown planthopper and traits related to the lodging in rice. For the linkage analysis of traits tested in this study, a genetic linkage map was created with 162 DNA markers spanning 12 rice chromosomes based on 120 doubled haploid (DH) lines, which were derived from a cross between Samgang', a Tongil type cultivar with BPH resistance, and ‘Nagdong’, a japonica cultivar. QTLs were identified to analyze the agronomic traits including lodging by composite interval mapping. Thirteen QTLs were detected for five traits comprised of plant length (PL), 3rd internode length (3rdIL), moments (Mo), lodging index (LI), and breaking weight (BW). The relationships between the BPH resistance and agronomic traits including lodging revealed that two QTLs (qBPR7, qBPR8) were linked to traits related to lodging. Two QTLs, qBPR7 and qBPR8 on chromosome 7 (RM531-7042) and 8 (RM1148- RM544) showed associations with moments and 3rd internode length, respectively.

Artificial Neural Network Method Based on Convolution to Efficiently Extract the DoF Embodied in Images

  • Kim, Jong-Hyun
    • Journal of the Korea Society of Computer and Information
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    • v.26 no.3
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    • pp.51-57
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    • 2021
  • In this paper, we propose a method to find the DoF(Depth of field) that is blurred in an image by focusing and out-focusing the camera through a efficient convolutional neural network. Our approach uses the RGB channel-based cross-correlation filter to efficiently classify the DoF region from the image and build data for learning in the convolutional neural network. A data pair of the training data is established between the image and the DoF weighted map. Data used for learning uses DoF weight maps extracted by cross-correlation filters, and uses the result of applying the smoothing process to increase the convergence rate in the network learning stage. The DoF weighted image obtained as the test result stably finds the DoF region in the input image. As a result, the proposed method can be used in various places such as NPR(Non-photorealistic rendering) rendering and object detection by using the DoF area as the user's ROI(Region of interest).

Analysis of Human Casualties on the Ground in Urban Area due to UAM Crash (UAM 추락 시 인구 밀접 지역 지상 인명피해 분석)

  • Kim, Youn-sil;Choi, In-ho
    • Journal of Advanced Navigation Technology
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    • v.26 no.5
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    • pp.281-288
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    • 2022
  • This study quantitatively analyzed the human casualties that can occur when a multicopter-type Urban Air Mobility (UAM) with a weight of about 1 ton and a speed of about 100 km/h falls in an urban area. Based on the population density and building database in Seoul, the population exposed to collisions in the event of a UAM crash was derived. Through the ballistic descent model, the accident impact radius of the UAM fall was calculated. In addition, the change in human casualties on the ground was analyzed when the accident impact radius increased. Finally, the ground risk map was created for Seoul, and it was confirmed that about 1 to 10 people could be injured when a UAM crash.