• Korean Journal of Veterinary Research
• /
• v.45 no.1
• /
• pp.85-91
• /
• 2005

Much of the interest on the chemopreventive properties of herbs and plants has been raised, whereas little is regarding to anti-tumor effect of farming and aquatic products. In the present study, the anti-tumor effect of hot-water extract of a seaweed, BLC (Sargassum fulvellum) and BLC/HEN egg was investigated using MCF-7 cells in vitro and in vivo systems. We found that the BLC extract and BLC/HEN egg inhibited cell proliferation in a dose-dependent manner, which might be mediated through up-regulation of p53. Furthermore, this test compound can directly induce apoptosis in MCF-7 cells, which might be mediated through up-regulation of a pro-apoptotic Bax protein and down-regulation of a anti-apoptotic Bcl-2 protein, not by immune system. Nude mice bearing established breast tumors (with exogenous estradiol) were treated with BLC extract and BLC/HEN egg. Treatment BLC extract and BLC/HEN egg caused a 42% and 71% inhibition of tumor growth, respectively. Both agents caused a significant inhibition of volume and weight growth of estrogen independent human breast tumors established from MCF-7 cells. Our results suggested that BLC extract and BLC/HEN egg have the efficacious effect of human breast cancer not only in vitro but also in vivo.

• KIPS Transactions on Software and Data Engineering
• /
• v.5 no.3
• /
• pp.145-154
• /
• 2016

Because of the recent interest in the u-Health and development of IT technology, a need of utilizing a medical information data has been increased. Among previous studies that utilize various data mining algorithms for processing medical information data, there are studies of association rule analysis. In the studies, an association between the symptoms with specified diseases is the target to discover, however, infrequent terms which can be important information for a disease diagnosis are not considered in most cases. In this paper, we proposed a new association rule mining system considering the importance of each term using TF-IDF weight to consider infrequent but important items. In addition, the proposed system can predict candidate diagnoses from medical text records using term similarity analysis based on medical ontology.

• KSBB Journal
• /
• v.24 no.2
• /
• pp.113-121
• /
• 2009

As one of the new areas of 'omics' technology, there is increasing interest in metabolomics, which involves the analysis of low-molecular-weight compounds in cells, tissues, and biofluids, and considers interactions within various organisms and reactions of external chemicals with those organisms. However, metabolomics research is still at a fundamental stage in Korea. Therefore, the purpose of this study was to establish a strategic long-term plan to revitalize the national metabolomics approach and obtain the elementary data necessary to determine a policy for effectively supporting metabolomics research. These investigations clarified the state of metabolomics study both in Korea and internationally, from which we attempted to find the potentiality and fields where a metabolomics approach would be applicable, such as in medical science. We also discuss strategies for developing metabolomics research. This study revealed that promoting metabolomics in Korea requires cooperation with metabolomics researchers, acquisition of advanced technology, capital investment in metabolomics approach, establishment of metabolome database, and education of metabolome analysis experts. This would reduce the gap between the national and international levels of metabolomics research, with the resulting developments in metabolomics having the potential to greatly contribute to promoting biotechnology in Korea.

• The Journal of Fisheries Business Administration
• /
• v.29 no.1
• /
• pp.121-137
• /
• 1998

This study was conducted to examine the economic evaluation of the newly developed fish meal analog (BAIFA-M) in Korean rockfish feed. A raw fish feed (MP) and two commercially formulated diets (EP) were employed to compare weight gain (WG), feed conversion ratio (FCR) and survival rate (SR) from the sea cage culture system. By using the economic model in the practical sea cage culture system, feed cost, production cost and gross profit per kg production, rate of profit to gross revenue (RPGR), and internal rate of return (IRR) were calculated based upon the results of the experiment and the information of the private aquaculture farm (Young Chang) in Tong young, Korean. IRR criteria is one of the popular economic feasibility analysis methods applicable far aquaculture industry. This is an economic evaluation method to compare the given interest rate or the discount rate with IRR which can be calculated by the difference between the present value of the benefit stream and of the cost stream. The benefits of using EP on WG, FCR, SR, and production cost will be emphasized in this study. Fish averaging 20$\pm$3.6g (Mean$\pm$SD) were randomly distributed in each small cage (6m$\times$6m) as groups of 2,000 fish. By using 3 large size cages (12m$\times$12m), 12 small cages were constructed, and only 9 small cages were employed for three replicates of each diet treatment. To compare with MP diet, two sinking EP diets were designed by our laboratory and produced by the local feed company who wanted to promote these EP diets for the mass cage culture of Korean rockfish in the future. Two EP diets contain white fish meal and/or BAIFA-M as the main animal protein sources : WFM diet, maximum 43% of white fish meal : BAIEA- M diet, 30% of white fish meal nab replaced by BAIFA- M from WFM diet. Results are summarized in Table 1. Fish fed MP diet showed significantly lower SR than does fish fed two EP diets(P<0.05). However, there Were no significant difference on FCR among fish fed three practical diets. Table 1. Average feed conversion ratio (FCR), accumulative average survival rate (SR) and economic evaluation data far three practical diets. As we expected, BAIFA-M diet is more economical than WFM diet as well as MP diet. Feed cost and production cost per kg production from BAIEA - M diet were lower than those from WFM and MP diets. Moreover, gross profit per Kg production, RPGR and IRR from BAIFA- M diet were higher than those from WFM and MP diets. This economic evaluation study clearly indicated that MP diet should be replaced by the commerical formulated EP diets as soon as possible in the near future because MP diet is not economical in the practical sea cage culture system.

• The Korean Journal of Community Living Science
• /
• v.26 no.2
• /
• pp.287-301
• /
• 2015

This study provides basic data for the development of nutrition education programs for high schools by examining adolescents' demand for nutrition education and their dietary and health behaviors. A survey was conducted for 500 students attending two high schools in the Gwangmyeong area. The questionnaire addressed their dietary habits, health behaviors, and nutrition education. In terms of meal conditions, 70.6% of all respondents had meals at least four times a day, 67.2% skipped breakfast frequently, and only 29.9% had breakfast with their family members. In addition, 66.0% reported a slightly unbalanced diet depending on the food (35.1% for vegetables and 28.2% for legumes). Nutrition labeling was checked occasionally (44.4%) by male respondents and surely (39.3%) by female respondents (p<0.01). In terms of health behaviors, 67.4% of male respondents reported a lack of sleep (5-7 hours), 33.3% of male respondents reported exercising three to four times a week, and 42.7% of female respondents reported no exercise. For the level of stress, 58.9% of male respondents reported "sometimes", and 43.0% of female respondents reported "always". For interest in nutrition education, 58.3% of the respondents reported "no". A majority of the respondents learned about nutrition through "the media or the Internet" (89.6%). The health behavior score was significantly carelated with dietary habits (p<0.01) and the stress score (p<0.05) for male students, and it was negatively correlated with checking nutrition labels (p<0.01) and positively correlated with the BMI for female students. These results suggest that appropriate health behaviors can help overcome stress and produce better dietary habits for male students, but for females, the results are ambiguous. A majority of the respondents (57.9%) perceived a need for nutrition education as part of the high school curriculum, and the content of such a curriculum included more meals with family members and the importance of breakfast. Based on the results, nutrition education for male students should focus on nutrition labeling, whereas that for female students, on exercise frequency and proper weight management.

• Spatial Information Research
• /
• v.15 no.3
• /
• pp.267-278
• /
• 2007

Internationally many models are developed and applied to predict the impact of the climate change, as occurring a lot of symptoms by climate change. Also, in Korea, according to increasing the application of the climate effect model in many research fields, it is required to study the method for preparing climate data and the characteristics of the climate. In this study IDSW (Inverse Distance Squared Weighting), one of the spatial statistic methods, is applied to interpolate. This method estimates a point of interest by assigning more weight to closer points, which are limited to be select by 3 in 100 km radius. As a result, annual average temperature and precipitation had increased by $0.4^{\circ}C$ and 412 mm during 1977 to 2006. They are also predicted to increase by $3.96^{\circ}C$, 319 mm in the 2100 compared to 2007. High variability of temperature and precipitation for last 30 years shows in some part of the Gangwon-do and in the southern part of Korea. Besides in the study of the variable trend, the variability of temperature and precipitation is inclined to increase in Gangwon-do and southern east part, respectively. However, during 2071 to 2100 variability of temperature is predicted to be high in midwest of Korea and variability of precipitation in the east. In the trend of variability, variability of temperature is apt to increase into west south, and variability of precipitation increase in midwest and a part of south.

• Journal of Korean Academy of Nursing
• /
• v.13 no.3
• /
• pp.1-33
• /
• 1983

The role and function of nursing care nowadays, tend to acquire sophisicated technology because specialization has expended due to increase of the medical population and the improvement of national health standards. To implement nursing care independently as a professional nurse, the apprehension of specific knowledge and skill should be acquired during basic nursing education. So it is important for nursing education not only to include theory and actual techniques, but also to strengthen the practical training in the actual clinical setting. This study was carried out with the following objectives; 1. To survey the detailed content and frequency of actual nursing students display during their clinical training. 2. To investigate the detailed content and frequency of actual nursing behavior which students display in each clinical a area. 3. To identify the motive for selection of nursing as their major and to determine the degree of self confidence, extent of knowledge and recognition of nursing responsibility. 4. To observe the relationship between actual nursing behavior and each of the following; 1) Motive for selecting nursing as a major 2) Self confidence 3) Knowledge of nursing care 4) Recognition of nursing responsibility The conclusions of this study were as follows; 1. Among the detailed nursing behavior which junior nursing college students carry out in clinical training; taking respiration's showed the highest frequency, and taking body temperatures, blood pressures, and pulses and making beds were next in frequency in this order. 2. In detailed nursing behaviors according to clinical area; taking vital signs showed the highest frequency in the emergency room, pediatric ward, orthopedic ward, general surgical ward and internal medicine ward. However, in the operating room, assisting with endotracheal tube insertion and sterile techniques were showen to have the highest frequencies. In nursery, umbilical cord care and the measurement of body weight were the highest in frequency In neurosurgical ward, the measurement of vital signs, changing position and tracheostomy care were the highest in frequency. In obstetric and gynecological ward and in the delivery room, checking duration, intensity and frequency of contractions was the highest in frequency. 3. In regard to the motive for majoring in nursing, the aptitude and interest of the student had the highest percentage(32.86%), and self-confidence in nursing activities (M=3.36), knowledge in nursing activities.(M=3. 09), and the recognition of the nursing activity (M= 3.76) wire in the middle range. 4. When the detailed nursing behaviors were compared with motive, self confidence, knowledge and recognition, it was found that when the nursing behavior was difficult and regarding much endeavor although the motive was high, the frequency of the nursing behavior was rather low. But in the cases in which there was much self confidence and a high level of skill was required, nursing behavior was carried more frequently. When there was muck self confidence and skill was not required, the frequency of nursing behavior was rather low. In the cases of a high level of knowledge, the frequency of nursing behavior was low and when recognition for nursing behavior was given the frequency of nursing behavior was low.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.39 no.1
• /
• pp.55-63
• /
• 2013

Applications of nano-emulsion for cosmetics as a means of promoting dermal absorption have been the subject of interest. In this study, the stability of nano-emulsions prepared by low-energy emulsification method and varying the composition of raw materials was investigated. By measuring the particle size of the nano-emulsion against time, the stability of nano-emulsions prepared by adding polyol to water phase was increased significantly compared with the nano-emulsions prepared by adding polyol to ethanol phase. The speed of adding ethanol phase to water phase did not have a significant impact on the particle size and stability. Depending on the type of oil, stability was not affected. However, there would be a correlation between the initial size of the nano-emulsion droplets and the molecular weight and polarity of the oil. Stability and the initial particle size according to the type of polyols showed a similar trend except 1,2 hexanediol. The initial droplet size was affected by the concentration of surfactant and oil. However, the initial droplet size did not change against time. Concentration of ethanol was observed to have a significant impact on the initial particle size and stability.

• Journal of the Korean Society for Railway
• /
• v.19 no.2
• /
• pp.262-269
• /
• 2016

Subway station scales are determined by peak predictions. In this study, the purpose behind the installation of a subway is public transportation convenience and public interest, but economic validity is also important. By proving that the scale of the station is excessive with regard to the target station size for Seoul subway Line 5-8, a reasonable plan. can be sought. According to station installation standards, the area of the station under investigation here is out of the service levels by six stages (A~F), and it must be four or more levels (D). The Actual level for the B level is a two-step design. The Actual ratio for over- Peak predictions is only 17.8% on average. The results of measurements of the excess area and determination of the excessive costs were analyzed by subdividing the area and by calculating it based on the B level, finding that it is possible to provide benefits for customers only in the current design, with an area ratio of 16.3%. Given the weight, it was estimated that current conditions can meet the needs of only 18.6% of the current area. Simplifying the scale calculation method of the station, it is convenient, safe, and advantageous to move citizens only if the scale can be streamlined. Then, with a reduced initial investment, maintenance costs during the operation can be reduced.

• Journal of Korean Home Economics Education Association
• /
• v.21 no.4
• /
• pp.145-158
• /
• 2009

The purpose of this study was to find out how much home economics(HE) textbook was focused on what kind of factors in career education, by analyzing the HE textbooks from the 7th grade(1st grade of the middle school) to the 10th grade(1st grade of high school), which were developed by applying the 7th educational process. 12 textbooks which were published by three publishers were randomly selected by grade. This study used the instrument developed by Korea Research Institute for Vacational Education & Training(2001) as an analysis frame, along with a content analysis system. The results of this study were as follows. The publishers of HE textbook stressed similar points in each section of career education, evenly reflecting the objectives and contents of career education. Three kinds of publishers also placed the same weight on the factors of career education in each unit, and suggested the contents related to career education in the whole units. HE textbook was designed to lead learners to understand self and have interest in varied occupations. Additionally, it provided the learners with a chance to consider their career and occupation by means of detailed job information, and its contents including learning of occupational ability for job selection were useful to plan and prepare for career. Accordingly, as HE textbook is most effective to promote connection between work and learning and contains proper factors of career guidance, it is one of the most appropriate textbooks to deal with career education.