• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5973-5981
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• 2013

At present, the most common cause of cancer-related death in women is breast cancer. In a large proportion of breast cancers, there is the overexpression of human epidermal growth factor receptor 2 (HER2). This receptor is a 185 KDa growth factor glycoprotein, also known as the first tumor-associated antigen for different types of breast cancers. Moreover, HER2 is an appropriate cell-surface specific antigen for passive immunotherapy, which relies on the repeated application of monoclonal antibodies that are transferred to the patient. However, vaccination is preferable because it would stimulate a patient's own immune system to actively respond to a disease. In the current study, several bioinformatics tools were used for designing synthetic peptide vaccines. PEPOP was used to predict peptides from HER2 ECD subdomain III in the form of discontinuous-continuous B-cell epitopes. Then, T-cell epitope prediction web servers MHCPred, SYFPEITHI, HLA peptide motif search, Propred, and SVMHC were used to identify class-I and II MHC peptides. In this way, PEPOP selected 12 discontinuous peptides from the 3D structure of the HER2 ECD subdomain III. Furthermore, T-cell epitope prediction analyses identified four peptides containing the segments 77 (384-391) and 99 (495-503) for both B and T-cell epitopes. This work is the only study to our knowledge focusing on design of in silico potential novel cancer peptide vaccines of the HER2 ECD subdomain III that contain epitopes for both B and T-cells. These findings based on bioinformatics analyses may be used in vaccine design and cancer therapy; saving time and minimizing the number of tests needed to select the best possible epitopes.

• Journal of the Korean Association of Geographic Information Studies
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• v.6 no.2
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• pp.46-64
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• 2003

The vector shaped object is generally very long (hundreds or thousands of kilometers) and very narrow (10-100 meters). Image mapping techniques and tools for these objects should be totally different from the traditional area-based targets. Acknowledging these unique characteristics of the vector shaped object, a motion picture mapping system has been developed by combining internet GIS technology with airborne video. In particular, integration between airborne video and digital maps took advantage of each component, and enabled the landscape structure to be visualized, interacted with and deployed all on the Web. The motion picture maps provided a completely new means for disseminating information for area-wide landscape in a visual and interactive manner to the general public while digital map with location information revealed successfully the major parameters that influence an area-wide spatial structure in the study area. The remote video approach breaks down the usual concept of image mapping in a conventional cartography. As a result, the research findings have established the new concept of 'internet airborne video mapping for vector shaped object', proposed as an initial aim of this paper. It would playa crucial role in improving the quality of public information service if the mapping system is operationally introduced into the Government since the highly user-friendly moving picture provides a completely new means for disseminating spatia) information for vector shaped object.

• Archives of design research
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• v.14 no.1
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• pp.35-46
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• 2001

Recently varieties of user groups are formed as the number of people using cyber chatting gets increased and there are many changes in the range and field of its use. But because most of the cyber chatting systems are being operated to enlarge the additional sonics use, the using environments are stereotyped. And as its function is being various as well, it can not provide with a user-centered environment. So this thesis compares and analyzes the problems derived from the usability evaluation for solving the problems in using cyber chatting systems, and presents the guidelines of emotion-intended user interface design for improving the usability as the result of the analysis. First, this study investigates cyber chatting systems as a means of web communication tools through the existing literatures. Secondly, this study finds out the problems in using them through satisfaction evaluation, heuristic evaluation, performance evaluation, and observation evaluation and presents a way of solving the provisional problems in using them as the analysis of the result of usability evaluation. And this was proceeded for the purpose of applying and activating the better usability evaluation of cyber chatting systems later. Through the usability evaluation, it is found out that the structuralization of chatting function, the screen visibility by the size and arrangement of the compositional elements of a screen, and the improvement and development of the proper metaphor use of images and functions by the communication environment are necessary.

• Journal of Animal Science and Technology
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• v.46 no.4
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• pp.525-536
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• 2004

The objective of this study was to identify the quantitative traits loci(QTL) for meat quality traits in pigs. Three-generation resource population was constructed from a cross between Korean native boars and Landrace sows. The resource population including founders, $F_1$ and $F_2$ was genotyped for 23 microsatellite markers on chromosome 7. The sex average total length of linkage map on chromosome 7 was estimated 154.6 cM. Meat quality traits including meat pH, meat color, drip loss, shear force, heating loss, crude fat, crude protein, crude ash and water content in muscle were collected from $F_2$ animals. For the QTL mapping, we used $F_2$ QTL Analysis Servlet of QTL express for web-based QTL mapping tools(http://qtl.cap.ed.ac.uk/). The QTLs for CIE-a and CIE-b on SSC7 were significantly detected at 1% and 5% chromosome-wide level, respectively.

• International Journal of Contents
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• v.11 no.2
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• pp.37-49
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• 2015

Sensors, equipment, ICT facilities and their corresponding software have a relatively short lifetime relative to that of constructional structure, so these devices have to be continuously fixed or exchanged during maintenance and management. Furthermore, software or analysis tools should be periodically upgraded according to advances in ICT and analysis technology. Conventional monitoring systems have serious problems in that it is difficult for site engineers to modify or upgrade hardware and analysis algorithms. Moreover, we depend on the original system developer when we want to modify or upgrade inner program structures. In this paper, we propose a novel design for integrated maintenance and management of a monitoring system by applying the mobile cloud concept. The system is intended for use in disaster prevention of constructional structures, including bridges, tunnels, and in traditional buildings in a local heritage village, we analyze the status of these structures over a long term or a short-term period as well as in disaster situations. Data are collected over a mobile cloud and future expectations are analyzed according to probabilistic and statistical techniques. We implement our integrated monitoring system to solve the existing problems mentioned above. The final goal of this study is to design and implement a monitoring system for more than 10,000 structures spread within Korea. Furthermore, we can specifically apply the monitoring system presented here to a bridge made from timber in Asan Oeam Village and a traditional house in Andong Hahoe Village to monitor for possible disasters. The entire system design and implementation can be developed on the LinkSaaS platform and the monitoring services can also be implemented on the platform. We prove that the proposed system has good performance by performing a TTA authentication test, web accommodation test, and operation test using emulated data.

• Journal of the Korean Institute of Gas
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• v.21 no.2
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• pp.32-40
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• 2017

Safety Instrumented Systems (SIS) have wide application area. They are of vital importance at process plants to detect the onset of hazardous events, for instance, a release of some hazardous material, and for mitigating their consequences to humans, material assets, and the environment. The integrated safety systems, where electrical, electronic, and/or programmable electronic (E/E/PE) devices interact with mechanical, pneumatic, and hydraulic systems are governed by international safety standards like IEC 61508. IEC 61508 organises its requirements according to a Safety Life Cycle (SLC). Fulfilling these requirements following the SLC can be complex without the aid of SIS supporting tools. This paper presents simple SIS support tool which can greatly help the user to implement the design phase of the safety lifecycle. This tool is modelled in the form of Android application which can be integrated with a Web-based data reading and modifying system. This tool can reduce the computation time spent on the design phase of the SLC and reduce the possible errors which can arise in the process. In addition, this paper presents an optimization approach to SISs based on cost measures. The multi-objective genetic algorithm has been used for the optimization to search for the best combinations of solutions without enumeration of all the solution space.

• Journal of Digital Convergence
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• v.16 no.7
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• pp.107-116
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• 2018

One of the key mission is to develop and prompte the use National Competency Standards, which is defined to be the systemization of competencies(knowledge, skills and attitudes) required to perform duties at the workplace by the nation for each industrial sector and level. This provides the basis for the design of training and detailed specifications for workplace assessment. To promote the data-driven service improvement, the commercial product Splunk was introduced, and has grown to become an extremely useful platform because it enables the users to search, collect, and organize data in a far more comprehensive, far less labor-intensive way than traditional databases. Leveraging Splunk's built-in data visualization and analytical features, HRD Korea have built custom tools to gain new insight and operational intelligence that organizations have never had before. This paper analyzes the NCS homepage. Concretely, applying Splunk in creating visualizations, dashboards and performing various functional and statistical analysis and structure without Web development skills. We presented practical use and implications through case studies.

• Journal of the Korean Association of Geographic Information Studies
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• v.10 no.2
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• pp.23-35
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• 2007

With the development of semantic web technologies in information retrieval area, the necessity for thesaurus is recently increasing along with internet lexicons. A thesaurus is the combination of classification and a lexicon, and is the topic map of knowledge structure expressing relations among concepts(terms) subject to human knowledge activities such as learning and research using formally organized and controlled index terms for clarifying the context of superordinate and subordinate concepts. However, although thesaurus are regarded as essential tools for controlling and standardizing terms and searching and processing information efficiently, we do not have a Korean thesaurus for geology. To build a thesaurus, we need standardized and well-defined guidelines. The standardized guidelines enable efficient information management and help information users use correct information easily and conveniently. The present study purposed to build a thesaurus system with terms used in geology. For this, First, we surveyed related works for standardizing geological terms in Korea and other countries. Second, we defined geological topics in 15 areas and prepared a classification system(draft) for each topic. Third, based on the geological thesaurus classification system, we created the specification of geological thesaurus. Lastly, we designed and implemented an internet-based geological thesaurus system using the specification.

• The KIPS Transactions:PartD
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• v.11D no.2
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• pp.443-452
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• 2004

The paper presents an intelligent space management system for ubiquitous computing. The system is basically a home/office automation system that could control light, electronic key, and home appliances such as TV and audio. On top of these basic capabilities, there are four elegant features in the system. First, we can access the system using either a cellular Phone or using a browser on the PC connected to the Internet, so that we control the system at any time and any place. Second, to provide more human-oriented interface, we integrate voice recognition functionalities into the system. Third, the system supports not only reactive services but also proactive services, based on the regularities of user behavior. Finally, by exploiting embedded technologies, the system could be run on the hardware that has less-processing power and storage. We have implemented the system on the embedded board consisting of StrongARM CPU with 205MHz, 32MB SDRAM, 16MB NOR-type flash memory, and Relay box. Under these hardware platforms, software components such as embedded Linux, HTK voice recognition tools, GoAhead Web Server, and GPIO driver are cooperated to support user-friendly intelligent space.

• Journal of the Korea Society of Computer and Information
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• v.15 no.1
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• pp.31-42
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• 2010

GPM(Generic Product Model) developed by Hitachi in Japan is a common data model to integrate and share life cycle data of nuclear power plants. GPM consists of GPM core model, an abstract model, implementation language for the model and reference library written in the language. GPM core model has a feature that it can construct a semantic network model consisting of relationships among objects. Initial GPM developed and provided GPML as an implementation language to support the feature of the core model, but afterwards the GPML was replaced by GPM-XML based on XML to achieve data interoperability with heterogeneous applications accessing a GPM data model. However, data models written in GPM-XML are insufficient to be used as a semantic network model for lack of studies which support GPM-XML and enable the models to be used as a semantic network model. This paper proposes OWL as the implementation language for GPM core model because OWL can describe ontologies similar to semantic network models and has an abundant supply of technical standards and supporting tools. Also, OWL which can be expressed in terms of RDF/XML based on XML guarantees data interoperability. This paper uses OWL DL, one of three sublanguages of OWL, because it can guarantee complete reasoning and the maximum expressiveness at the same time. The contents of this paper introduce the way how to overcome the difference between GPM and OWL DL, and, base on this way, describe how to convert the reference library written in GPML into ontologies based on OWL DL written in RDF/XML.