• The Journal of Internal Korean Medicine
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• v.27 no.2
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• pp.521-532
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• 2006

Backgrounds and Objectives: A major goat in asthma therapy isto reduce or prevent the inflammatory response associated with bronchial hyperresponsiveness, reversible airway obstruction and airway remodelling. Many studies have shown that eosinophilic infiltration is a prominent feathure in the pathophysiology of asthma. The importance of the Presence of eosinophils in the airways of asthmatics has long been recognized, but the mechanism by which these cells are recruited and retained in the lung are only now being elucidated Production of chemotactic cytokines by bronchial epithelial cells may contribute to the local accumulation of eosinophils in Patients with bronchial asthma. This study was designed to investigate the inhibitory effect of extraction of herbal dicoction, Gamichungsangbohatang(GMCSBHT) on eosinophil chemotactic cytokines. Material and Methods:We used water and 70% ethanol extracts of GMCSBHT and pulmonary epithelial cell lines A549(human type II -like epithelial cells). We estimated cytotoxic effects of GMCSBHT, and estimated the effects of water and 70% ethanol extracts of GMCSBHT on chemokines from prestimulated A549 cells by sandwich ELISA. Results: Chemokines of eotaxin, IL-8 were inhibited by GMCSBHT in dose-dependent manner. And ethanol extract of GMCSBHT has more inhibitory effects on eotaxin, IL-8 than hot water extract. Conculusions: These findings indicate that the supression of the expression of chemokines can be accomplished by GMCSBHT treatment, so GMCSBHT may inhibit the iuflammatory process by eosinophils in asthma.

• Journal of the Korean Geotechnical Society
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• v.28 no.11
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• pp.69-78
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• 2012

Conventional numerical analysis for rainfall-induced slope stability has been estimated by separating seepage and stress-strain behavior, respectively. Many researchers' models from commercial softwares and literatures define that partially saturated permeability is the only function of degree of saturation (or matrix suction) and then they do not consider hydraulic-mechanical characteristics for the analysis. However, in practice, the water flow processes in a deformable soil are influenced by soil skeleton movement and the pore water pressure changed due to seepage will lead to changes in stress and to deformation of a soil. The relationship between seepage and soil behavior causes a change of partially saturated permeability as well as saturated permeability with the lapse of time. Instability of partially saturated soil slopes due to infiltration would be analyzed from reduction of negative pore water pressure calculating the process of water flow based on predicted partially saturated permeability. Therefore, partially saturated permeability should be defined by the function of degree of saturation (or matric suction) and porosity. The paper presents the comparison between staggered and monolithic coupled analysis regarding seepage and stress deformation problems. As a result, the decrease in matric suction on soil slope from monolithic analysis is slower than that from staggered analysis.

• Korean Journal of Agricultural and Forest Meteorology
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• v.9 no.2
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• pp.88-99
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• 2007

Soil moisture is one of the essential components in determining surface hydrological processes such as infiltration, surface runoff as well as meteorological, ecological and water quality responses at watershed scale. This paper discusses soil moisture transfer processes measured at hillslope scale in the Gwangneung forest catchment to understand and provide the basis of stochastic structures of soil moisture variation. Measured soil moisture series were modelled based upon the developed univariate model platform. The modeling consists of a series of procedures: pre-treatment of data, model structure investigation, selection of candidate models, parameter estimation and diagnostic checking. The spatial distribution of model is associated with topographic characteristics of the hillslope. The upslope area computed by the multiple flow direction algorithm and the local slope are found to be effective parameters to explain the distribution of the model structure. This study enables us to identify the key factors affecting the soil moisture distribution and to ultimately construct a realistic soil moisture map in a complex landscape such as the Gwangneung Supersite.

• Journal of Korea Water Resources Association
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• v.38 no.8 s.157
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• pp.605-616
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• 2005

In this paper, runoff curve numbers (CN's) for a small forested mountainous catchment are estimated using rainfall-runoff data measured at Sulma experimental catchment every 10 minutes and a new guideline for applying the antecedent rainfall conditions (ARC's) for small mountainous watersheds in Korea is proposed. Sulma experimental catchment is a typical natural mountainous basin with $97\%$ of forested land cover and CN's are estimated to be in the range between 51 and 89 with median value of 72. The test hypothesis stating as 1-day ARC is better than 5-day ARC in determining CN's for a small mountainous watershed is shown to be acceptable. Also, linear regression equations for the estimation of CN's for small mountainous catchments are proposed. As there is no significant investigations available on CN's for small mountainous catchments, the newly proposed relationships between CN's and ARC may be used as a preliminary guideline to assign CN's for the estimation of floods from rainfall data on mountainous regions.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.4
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• pp.545-553
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• 2021

The frequency by water disaster in urban areas are increasing continuously due to climate change and urbanization. Countermeasures are being conducted to reduce the damage caused by water disasters. An analysis based on permeability, one of the parameters that affect runoff, is needed to predict quantitative runoff in urban watersheds and study runoff reduction. In this study, the SWAT model was simulated for the oncheon stream basin, a representative urban stream in Busan. The permeability map was prepared by calculating the CN values for each hydrologic response unit. Based on the permeability map prepared, EPA SWMM analyzed the effect of LID technology application on the water cycle in the basin for short-term rainfall events. The LID element technology applied to the oncheon stream basin was rooftop greening in the residential complex, and waterproof packaging was installed on the road. The land cover status of the land selected based on the permeability map and the application of LID technology reduced the outflow rate, peak flow rate, and outflow rate and increased the infiltration. Hence, LID technology has a positive effect on the water cycle in an urban basin.

• Journal of the Korean Geotechnical Society
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• v.34 no.11
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• pp.81-92
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• 2018

For a marine bridge foundation construction, a large-circular-steel-pipe has been proposed for supporting vertical load and preventing water infiltration. However, a ship collision can adversely affect the structural stability. This paper presents a fundamental study on dynamic responses of the large-circular-steel-pipe by an impact load. In laboratory experiments, small-scaled steel pipe is installed in a soil tank. The soil height and water level are set to 23 cm and 25~70 cm, respectively. The upper part of the steel pipe is impacted using a hammer to simulate the ship collision. The dynamic responses are measured using accelerometers and strain gauges. Experimental results show that the strain decreases as the measured location is lowered. The higher frequency components appear in the impact load condition compared to the microtremor condition. However, the higher frequency components measured at the strain gauge located below the water level do not appear. For the accelerometer signal, the maximum frequency under the impact load is higher than that of the microtremor. The maximum frequency decreases as water level increases but it is larger than the maximum frequency of the microtremor. This study shows that strain gauge and accelerometer can be useful for evaluating the dynamic responses of large-circular-steel-pipes.

• Journal of Korea Water Resources Association
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• v.55 no.3
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• pp.191-203
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• 2022

This study is a follow-up study of vulnerable areas according to the vulnerability assessment of groundwater resource management in Korea. In this study, an optimal operation plan for groundwater resource management was proposed for areas vulnerable to groundwater resource management in Korea derived from previous studies. Prior to presenting the optimal operation plan for groundwater resource management, this study grasped the current status of changes in groundwater level and seawater penetration area for vulnerable areas using MODFLOW, a groundwater flow analysis program. As a result of the analysis using basic data for 10 years from 2009 to 2018, the groundwater level fell and the sea infiltration area increased. The final purpose of this study, the optimal operation plan for groundwater resource management, was selected as a total of four alternatives that can be expected to have positive effects to increase groundwater level and reduce seawater penetration. As a result of analyzing the amount of change in groundwater level and seawater penetration by applying the selected optimal operation plan, positive effects were found in all methods. It is expected that the optimal operation plan for groundwater resource management proposed in this study will be applied not only to vulnerable areas of groundwater resources in Korea but also to areas requiring development to establish efficient groundwater resource management measures.

• Journal of Veterinary Science
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• v.24 no.3
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• pp.44.1-44.17
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• 2023

Background: Antibiotic resistance is a significant public health concern around the globe. Antimicrobial peptides exhibit broad-spectrum and efficient antibacterial activity with an added advantage of low drug resistance. The higher water content and 3D network structure of the hydrogels are beneficial for maintaining antimicrobial peptide activity and help to prevent degradation. The antimicrobial peptide released from hydrogels also hasten the local wound healing by promoting epithelial tissue regeneration and granulation tissue formation. Objective: This study aimed at developing sodium alginate based hydrogel loaded with a novel antimicrobial peptide Chol-37(F34-R) and to investigate the characteristics in vitro and in vivo as an alternative antibacterial wound dressing to treat infectious wounds. Methods: Hydrogels were developed and optimized by varying the concentrations of crosslinkers and subjected to various characterization tests like cross-sectional morphology, swelling index, percent water contents, water retention ratio, drug release and antibacterial activity in vitro, and Pseudomonas aeruginosa infected wound mice model in vivo. Results: The results indicated that the hydrogel C proved superior in terms of cross-sectional morphology having uniformly sized interconnected pores, a good swelling index, with the capacity to retain a higher quantity of water. Furthermore, the optimized hydrogel has been found to exert a significant antimicrobial activity against bacteria and was also found to prevent bacterial infiltration into the wound site due to forming an impermeable barrier between the wound bed and external environment. The optimized hydrogel was found to significantly hasten skin regeneration in animal models when compared to other treatments in addition to strong inhibitory effect on the release of pro-inflammatory cytokines (interleukin-1β and tumor necrosis factor-α). Conclusions: Our results suggest that sodium alginate -based hydrogels loaded with Chol-37(F34-R) hold the potential to be used as an alternative to conventional antibiotics in treating infectious skin wounds.

• Horticultural Science & Technology
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• v.19 no.4
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• pp.596-601
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• 2001

This study was carried out to determine the effect of base carriers such as zeolite or vermiculite on change of concentration of polyoxyethylene laury ether[$C_{12}H_{25}O(C_{2}H_{4}O)_{3}H$, PLE] and on initial wetting of peat-vermiculite medium in the development of a soil wetting agent using the mixture of PLE and polyoxyethylene+polyppro-pyleneoxide tridecylether (1:1, w/w, CM-1). The concentration of PLE in the treatment of vermiculite was higher than that of zeolite during the period from 2 to 6 weeks. The cumulative concentration of PLE released in the treatment of vermiculite was about $2800mg{\cdot}L^{-1}$ and zeolite was about $2300mg{\cdot}L^{-1}$. The treatments of PLE+CM-1 with zeolite or vermiculite as a carrier were effective in initial water retention of root media having more than 510 mL of water per pot, where as those of $AquaGro^{G}$ and control had 490 mL and 400 mL of water per pot, respectively. In the evaporative water loss, the treatment of zeolite and $AquaGro^{G}$ were faster than that of control and vermiculite. The control treatment had the fastest water movement in and the highest volume of water infiltrating into root medium among all treatments. Increased application rate of PLE+CM-1 did not increase water retention capacity. The treatment of $0.6g{\cdot}L^{-1}$ had the highest evaporative water loss and that of $0.3g{\cdot}L^{-1}$ had the highest amount of water infiltrating into root media among all other treatments.

• The Journal of Engineering Geology
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• v.7 no.3
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• pp.191-205
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• 1997

Measurements on subsurface movement of the Songsanri tomb site including the Muryong royal tomb was conducted using a tiltmeter system for the period of 15 months form July 7, 1996 to September 30, 1997. Two coordinate tilt monitoring data shows the biggest movement rate of 2.3mm/m/yr toward south in the frontal wall(N-S tilt) of the Muryong royal tomb. Southward tilting of bricks above the southern fire place in the western wall of the Muryong royal tomb is a proof of southward tilting of the royal tomb since its excavation in 1971. The eastern wall of the Muryong royal tomb is also tilting toward inside the tomb with the rate of 1.523mm/m/yr. Furthermore, tilting rate of wall increases twice in rainy season. It is interpreted tbat infiltration of water into the tomb and nearby ground in rainy season results in dangerous status for the safety of tomb structure. On the whole, normal component tilting of the walls of the 5th tomb is large than its shear component. It shows a small displacement toward one direction without no abrupt change in its direction and amount of tilting. The tilting rate of walls of the 6th tomb is about 8.8mm/m/yr in the dry season which is much bigger than those of other tombs in rainy season. Deformation events of walls of the tombs are closely related to amount of precipitation and variation of temperature. In comparison with different weather conditions, tilting is much bigger during the period of rainy weather than sunny weather. It is interpreted that rainwater flew into the turm through faults and nearby ground. High water content in nearby ground resulted strength of ground. The tilting event of walls shows a hysterisis phenomenon in analysis of temperature effect on tilting event. The walls tilt rapidly with steep rising of temperature, but the tilted walls do not come back to original position with temperature falling. Therefore, a factor of steep increase of the temperature must be removed. It means the tomb have to be kept with constant temperature. The observation of groundwater level using three boreholes located in construction site and original ground represented that groundwater level in construction site is higher than that of original ground during the rainy season from the end of June to August. It means that the drainage system of the Muryong royal tomb is worse than original ground, and it is interpreted that the poor drainage system is related to safety of tomb structure. As above mentioned, it is interpreted that artificial changes of the tomb environment since the excavation, infiltration of rainwater and groundwater into the tomb site and poor drainage system had resulted in dangerous situation for the tomb structure. According to the result of the long period observation for the tomb site, it is interpreted that protection of the tomb site from high water content should be carried out at first, and the rise of temperature by means of the dehumidifier inside the tomb must be removed.