• Korean Journal of Pharmacognosy
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• v.42 no.2
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• pp.201-208
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• 2011

Obesity occur from the imbalance between energy intake and energy expenditure. Obesity is a complex chronic disease that is suggested to cause other metabolic disorders such as type 2 diabetes, hyperlipidemia, hypertension, and arteriosclerosis. In this study, our purpose is to investigate the anti-hyperglycemic and anti-obesitic effects of Maydis stigma water extract in 3T3-L1 adipocytes and db/db mice. Maydis stigma water extract at dose of 100 and 500 ${\mu}g/ml$ slowly inhibited cell viability as compared to that of control in mature adipocytes. Also, the additions of 50 and 250 ${\mu}g/ml$ of Maydis stigma water extract significantly inhibited the lipid accumulations and CCAAT/enhancer-binding protein(C/EBP) ${\alpha}$ and peroxisome proliferator-activated receptor(PPAR) ${\gamma}$ expressions with dose-dependent manner in 3T3-L1 adipocytes. Maydis stigma water extract at 250, 500, and 1000 ${\mu}g/ml$ only showed the increasing pattern on lipolysis activity. The oral treatment of Maydis stigma water extract (100 or 400 mg/kg body weight) in db/db mice only showed tendency to decrease body weight, food efficiency ratio (FER), HbA1c, blood glucose, total cholesterol, triglyceride, and the adipocyte size of in db/db mice. However, Maydis stigma water extract increased the insulin level in a dose dependent manner. Thus these results indicate that Maydis stigma water extracxt inhibits adipogenesis through regulation of C/EBP${\alpha}$ and PPAR${\gamma}$ expressions in 3T3-L1 adipocytes and shows anti-hyperglycemic effect through increase of insulin secretion in db/db mice.

• Journal of the Korean Society for Marine Environment & Energy
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• v.17 no.3
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• pp.189-197
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• 2014

Collection and management of various information related to the ballast water are the essential components for the efficient implementation of the IMO Ballast Water Management Convention. Based upon the ballast water risk assessment and information system developed by other states, regions or even at global level, an integrated information system has been established to be applied to our domestic ports. The integrated information system is composed of four DataBases (DB) which are the Shipping DB, Ballast water DB, Port Environment DB and Species DB. The Shipping DB has been established based on the data collected from the Port Management Information System (Port-MIS). For the Ballast water DB, Ballast water has only been estimated by the loading/unloading of the cargoes as the convention has not come into effect yet. The Port Environment DB and Species DB are being established based on the reference documents and existing and newly collected monitoring data. From these DB, the integrated information system will be able to provide a base for the information search, statistic analysis and risk assessment of ballast water. Once the convention comes into effect, this integrated information system will be applied to manage the domestic ballast water discharge and also the port management.

• The Korea Journal of Herbology
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• v.37 no.4
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• pp.1-8
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• 2022

Objectives : Dioscorea batas Decaisne (DB) has been known to be good for the digestive system on Eastern Asia. However, the protective effect of DB on acute pancreatitis (AP) has not been studied. In this study, we tried to investigate the protective effect of DB water extract on caerulein-induced AP. Methods : To measure the protective effect of DB on AP, Mice were injected with cholecystokinin analogue caerulein (50 ㎍/kg) hourly for 6 times. DB water extract (200 or 400 mg/kg) or saline (control group) was administered orally 1 h before the first injection of caerulein. The mice were sacrificed at 6 h after the last injection of caerulein. The pancreas tissues and serum samples were immediately taken for further analysis. Results : Administration of DB water extract showed the inhibitory effect on the increase of pancreas weight/body weight ratio, pancreatic histological damage. And the rise of serum lipase level was significantly reduced in DB water extract treatment group during AP in mice. However administration of DB water extract did not show significant reduction in serum amylase level. Also, mRNA levels of pro-inflammatory cytokines Interleukin (IL)-6 and Tumor necrosis factor (TNF)-𝛼 but not IL-1𝛽 were inhibited by administration of DB water extract. Conclusions : Taken together, we found that administration of DB water extract ameliorates the severity of caerulein-induced AP, which suggests the potential to be an effective treatment on AP.

• Proceedings of the Korea Water Resources Association Conference
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• 2004.05b
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• pp.1219-1222
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• 2004

임의의 유역에서 유역을 관리할 목적으로 GIS DB를 구축할 경우 DEM을 이용하여 유역의 Framework 공간 DB를 구축하는 절차에 대해 고찰해 보고자 한다. 유역의 Framework 공간 DB를 DEM을 이용하여 구축할 경우는 DEM을 이용하여 유역의 수문지형학적 특성인자를 손쉽게 추출할 수 있으며 이들이 자동으로 공간 DB의 속성으로 입력되어 관리될 수 있다. 본 연구에서는 유역정보를 관리하기 위한 기반정보인 Framework 공간 DB의 형성 과정에 대해 정의하고 HyGIS를 개발하여 Network 기반의 수자원 통합 유역관리시스템의 개발 방향을 제시하고자 한다.

• Proceedings of the Korea Water Resources Association Conference
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• 2011.05a
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• pp.232-236
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• 2011

우리나라의 물관련 정보는 국토해양부 및 관련 기관에서 구축 및 운영, 개발 중에 있다. 이러한 시스템들은 치수, 이수, 환경 및 생태분야에 다양한 정보를 제공하고 있으나 제방에 관련된 다양하고 구체적인 정보를 획득하지 못하며, 시스템 DB간의 상호 연계가 어려운 실정이다. 따라서 제방에 대한 DB관리 및 향후 제방의 안전모니터링을 위해 정확하고 다양한 제방관련 DB구축이 요구된다. 이러한 제방관련 DB구축을 위한 과정은 다음과 같다. 제방제원 및 관리정보의 DB구축을 위하여 국내에서 수행하고 있는 사업인 하천일람의 "하천이력관리체계", 유역조사사업의 "WAMIS", 하천정보를 제공하고 있는 "RIMGIS"의 관련 자료를 분석한다. 기구축된 시스템과의 연계를 고려하여 물관리정보 표준과 RIMGIS 관련코드를 적용한 도형 및 속성 정보의 테이블 설계를 수행하며, 기구축된 시스템의 제방관련 수집자료 DB 및 관련 항목을 추가함으로써 제방제원 및 관리정보의 DB를 구축하도록 한다. 또한 향후 제방의 안전모니터링을 위한 관련항목을 포함하여 제방 유지 및 보수에 활용될 수 있도록 한다. 제방관련 DB구축은 치수시설물 안전모니터링의 기초를 마련하여 홍수방어 및 관리시스템 구축에 활용되어 인명 및 재산피해를 절감하고 기술수준을 향상시킴으로서 홍수 재해로부터 안전한 국토 건설 및 국민의 삶의 질을 향상시킬 것이다. 이러한 제방관련 DB구축은 기구축된 시스템과 연계하여 국가 홍수관리 시스템 구축, 치수능력증대, 장래유역단위 통합홍수방어 및 관리기술 개발에 기여할 것으로 판단된다.

• Journal of the Korean Association of Geographic Information Studies
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• v.7 no.2
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• pp.87-96
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• 2004

When watershed spatial database is constructed from DEM, hydrological geographic characteristics of watershed can be easily extracted. And the characteristics can be assigned and managed as the attribute of spatial database. In this study the scheme of constructing framework spatial database which is basic information for managing watershed information is examined. We established framework spatial data and defined the relationship of the data. And framework spatial database of test site was constructed. In this study, HyGIS(Hydrological Geographic Information System) which is developed by domestic technology for making hydrological spatial data and developing water resources system is used. Hydrological geographic characteristics and spatial data is extracted by HyGIS. And the data from HyGIS is used for constructing framework spatial database of test site. Finally, this study suggests the strategy of constructing framework spatial database for developing watershed management system based on river network.

• Journal of the Korean Society of Food Science and Nutrition
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• v.36 no.3
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• pp.291-297
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• 2007

This study was conducted to investigate the hepatic detoxification effect of microcluster-water (McW). Animal experiments were divided into 4 groups: distilled water intake group (DC), distilled water intake-bromobenzene treated group (DB), McW intake group (MC), and McW intake-bromobenzene treated group (MB). There were no significant differences in alanine aminotransferase and aspartate aminotransferase activities between DC and MC groups, but the activities in MB group were significantly (p<0.05) lower than those in DB group. No apparent changes of aniline hydrolase activity were shown in all experimental groups, while glutathione S-transferase activity in MC and MB groups was higher than that in DC and DB, respectively. The content of hepatic lipid peroxide in DC group was similar to that of MC group. In addition, the contents in DB and MB groups were significantly (p<0.05) increased than that of DC group. The increasing rate in MB group was lower than that of DB group. Also, the electron donating activity of McW was significantly (p<0.05) higher than that of distilled water. From these results, it could be suggested that McW has the possibility of having detoxification effect of bromobenzene induced hepatic injury by increasing glutathione S-transferase, which is known as a kind of hepatiic detoxification enzyme.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2017.10a
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• pp.501-503
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• 2017

In the water sector, various data such as flow rate, pressure, water quality and water level are collected during the whole process of water purification plant and piping system. The collected data is stored in each water treatment plant's DB, and the collected data are combined in the regional DB and finally stored in the database server of the head office of the Korea Water Resources Corporation. Various abnormal data can be generated when a measuring instrument measures data or data is communicated over various processes, and it can be classified into missing data and wrong data. The cause of each abnormal data is different. Therefore, there is a difference in the method of detecting the wrong side and the missing side data, but the method of cleansing the data is the same. In this study, a program that can automatically refine missing or wrong data by applying deep learning LSTM (Long Short Term Memory) algorithm will be studied.

• Journal of Soil and Groundwater Environment
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• v.19 no.4
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• pp.12-22
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• 2014

This study evaluated the pattern of groundwater fluctuation in cyrstalline rock using time series and factor analyses. From the results, groundwater level for the 18 wells was classified into 4 types reflecting the hydrogeological properties and rainfall event. Type 1 (DB1-5, DB1-6, DB2-2, KB-10, KB-13) was significantly influenced by groundwater flow through water-conducting features, whereas type 2 (DB1-3, DB1-7, KB-1~KB-3, KB-7, KB-11, KB-14, KB-15) was affected by minor fracture network as well as rainfall event. Type 3 (DB1-1, DB1-2) was mainly influenced by surface infiltration of rainfall event. Type 4 (DB1-8, KB-9) was reflected by the irregular variation of groundwater level caused by anisotropy and heterogeneity of crystalline rock.

• Korean Journal of Pharmacognosy
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• v.41 no.4
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• pp.282-288
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• 2010

We evaluated the anti-diabetic effects of Triticum aestivum sprout water extract (TA) in diabetes mellitus type 2. For the experiments, the diabetic animal model db/db mice were divided to 3 groups: diabetic control (db/db) and two experimental groups orally treated with 25 and 100 mg/kg single dose of TA (TA-25 and TA-100, respectively). The lean mice were used as the non-diabetic normal control. All mice have free access to water and AIN-93 diet. TA was administrated to diabetic mice for 5 weeks and the diabetic clinical markers, including blood glucose level, body weight, food intake and insulin level, were measured at a time. After administration for 5 weeks, the blood glucose level was decreased 1.10 and 1.98 folds in TA-25 and TA-100 groups, respectively, compared with db/db group. The body weight and diet consumption were significantly reduced by TA treatment in dose-dependent manner. The treatments of TA-100 also significantly decreased remarkedly liver weight and slightly serum insulin levels when compared with them of the diabetic control group. However the immunohistochemical staining for insulin clearly showed high expression of insulin in the pancreatic islet cells derived from all db/db mice, even if TA was administrated. Moreover, TA-100 treatment significantly improved impaired glucose tolerance in diabetic db/db mice. The results suggest that TA has anti-hyperglycemic effect attenuating blood glucose in the animal model of type 2 diabetes and might be useful as a functional diet for human diabetic diseases.