• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2005년도 학술발표회 논문집
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• pp.986-990
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• 2005

본 연구는 입자영상유속계(PIV)와 일차원 프로펠러 유속계를 이용하여 개수로 흐름 외부영역의 연직 유속분포를 측정하고 분석하였다. 수리실험은 크게 두 가지 조건에 대해 수행하였다. 첫 번째는 하상조건에 따른 유속분포의 변화를 파악하였고 두 번째는 흐름특성, 특히 Froude 수의 변화에 따른 유속분포를 파악하였다. 측정 결과 바닥에서부터 최대유속 발생지점까지는 후류법칙과 잘 맞는 경향을 보였으나, 최대 유속발생지점으로부터 수표면까지는 유속이 감소하는 현상이 나타났다. 또한 외부영역의 유속분포는 조도보다 Froude 수의 영향을 많이 받는 것으로 나타났으며 Froude 수가 증가함에 따라 유속감소 현상도 커지는 것을 알 수 있었다. 이에 따라 최대유속과 표면유속의 차와 평균유속과 표면유속의 비가 Froude 수가 증가함에 따라 각각 증가하는 것으로 나타났다.

• Archives of Pharmacal Research
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• 제22권1호
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• pp.48-54
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• 1999

These studies were designed to examine the differential effect of nitric oxide (NO) and cGMP on glutamate neurotransmission. In primary cultures of rat cerebellar granule cells, the glutamate receptor agonist N-methyl-D-aspartate (NMDA) stimulates the elevation of intracellular calcium concentration ($[Ca^{2+}]_i$), the release of glutamate, the synthesis of NO and an increase of cGMP. Although NO has been shown to stimulate guanylyl cyclase, it is unclear yet whether NO alters the NMDA-induced glutamate release and ${[Ca^{2+}]}_i$ elevation. We showed that the NO synthase inhibitor, NG-monomethyl-L-arginine (NMMA), partially prevented the NMDA-induced release of glutamate and elevation of ${[Ca^{2+}]}_i$ and completely blocked the elevation of cGMP. These effects of NO on glutamate release and [Ca2+]i elevation were unlikely to be secondary to cGMP as the cGMP analogue, dibutyryl cGMP (dBcGMP), did not suppress the effects of NMDA. Rather, dBcGMP slightly augmented the NMDA-induced elevation of ${[Ca^{2+}]}_i$ with no change in the basal level of glutamate or ${[Ca^{2+}]}_i$. The extracellular NO scavenger hydroxocobalamine prevented the NMDA-induced release of glutamate providing indirect evidence that the effect of NO may act on the NMDA receptor. These results suggest that low concentration of NO has a role in maintaining the NMDA receptor activation in a cGMP-independent manner.

• Journal of Ginseng Research
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• 제36권2호
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• pp.190-197
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• 2012

Ginseng has a long history of use for health enhancement, and there is some evidence from animal studies that it has a beneficial effect on cognitive performance. The purpose of this study was to investigate the effect of Korean red ginseng on cognitive performance in humans. A total of 15 healthy young males with no psychiatric or cognitive problems were selected based on an interview with a board-certified psychiatrist. The subjects were randomly assigned to receive a daily dose of 4,500 mg red ginseng or placebo for a 2-week trial. There were 8 subjects in the red ginseng group and 7 subjects in the placebo group. All of the subjects were analyzed with the Vienna test system and a P300 event-related potential (ERP) test. There were no significant differences in the Vienna test system scores between the red ginseng group and the placebo group. In the event-related potential test, the C3 latency of the red ginseng group tended to decrease during the study period (p=0.005). After 2 wk, significant decreases were observed in the P300 latencies at Cz (p=0.008), C3 (p=0.005), C4 (p=0.002), and C mean (p=0.003) in the red ginseng group. Our results suggest that the decreased latency in ERP is associated with improved cognitive function. Further studies with a higher dosage of ginseng, a larger sample size, and a longer follow-up period are necessary to confirm the clinical efficacy of Korean red ginseng.

• 대한간호학회지
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• 제50권4호
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• pp.533-540
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• 2020

Purpose: This study aimed to evaluate nursing students' understanding of the prevention of COVID-19, as well as their anxiety towards the disease and their perception of their professional identity in the wake of the pandemic, in Zhengzhou, China. Methods: A cross-sectional study was designed to investigate 474 nursing students by cluster sampling using a stratified questionnaire from February 15 to March 31, 2020. Multiple linear regression was used to identify the factors affecting professional identity. Binary and multiple logistic regression were used to identify the factors affecting anxiety. Results: Responders with a high level of understanding of COVID-19 and frequent use of behavioral strategies for its prevention comprised 93.2% and 30.0% of the cohort, respectively. Professional identity was significantly associated with gender and anxiety (p < .050). The prevalence of anxiety among nursing students was 12.4%. Male (odds ratio [OR] = 2.39; 95% confidence interval [CI] = 1.26~4.52), sophomores (OR = 5.30; 95% CI = 1.61~7.45), and infrequent use of prevention measures (OR = 3.49; 95% CI = 1.16~5.19) had a significant effect on anxiety. Conclusion: Anxiety during the COVID-19 epidemic gives an adverse effect on the professional identity of nursing in students. Nursing education institutions need to provide psychological counseling services for nursing students, in addition to improving their teaching of COVID-19 prevention strategies.

• 대한조선학회논문집
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• 제50권1호
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• pp.1-7
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• 2013

The high-skewed and/or composite propellers of current interests to reduce the ship vibration and to increase the acoustic performance are likely to be exposed to the unexpected structural problems. One typical example is that the added mass effect on the propellers working in the non-uniform wake field reduces the natural frequency of the propeller leading to the resonance with the low-frequency excitation of the external forces. To avoid this resonance problem during the design stage, the technique of fluid-structure interaction has been developed, but the higher-order effect of the blade geometry deformation is not yet considered in evaluating the added mass effects. In this paper the fluid boundary-value problem is formulated by the potential-based panel method in the inviscid fluid region with the velocity inflow due to the body deformation, and the structural response of the solid body under the hydrodynamic loading is solved by applying the finite element method which implements the 20-node iso-parametric element model. The fluid-structure problem is solved iteratively. A basic fluid-sturcture interaction study is performed with the simple rectangular plates of thin thickness with various planform submerged in the water of infinite extent. The computations show good correlation with the experimental results of Linholm, et al. (1965).

• 한국방재학회 논문집
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• 제8권1호
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• pp.89-96
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• 2008

본 연구는 되 메움 된 굴착 양측 벽이 비대칭으로 경사진 경우에 대하여 벽체간의 폭, 벽면경사각, 상대밀도, 벽면마찰각의 크기를 변화시켜 Kellogg의 이론과 이를 보완한 수정식으로 토압을 산정하고 또한, 벽면마찰반력을 고려한 토압 식을 제안하여 상호간 거동을 구명하였다. 이들 결과로부터 구한 지중 토압을 검증하기 위하여 총 62종류의 모형실험을 수행한 결과를 이론식에 의한 거동과 비교, 검토하였다. 본 연구결과 양측 벽이 비대칭으로 경사진 경우, 되 메움 토압에 가장 큰 영향을 미치는 요소는 벽체경사각의 크기였으며, 또한 되 메움 공간이 협소할수록 그리고 수평면과 이루는 벽체의 경사각이 클수록 벽 마찰의 영향이 크게 나타났다. 한편, 실측토압과 가장 근소한 차이를 나타낸 것은 벽면마찰반력을 고려한 제안 식으로 구한 경우였으며 또한, 벽면사이의 폭이 좁은 경우 아칭효과가 크게 나타나 실측토압 및 제안된 이론토압모두 지중 토압과 가장 근소한 차이를 나타내었다.

• 한국항공우주학회지
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• 제33권3호
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• pp.1-9
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• 2005

본 논문에서는 직접모사법을 이용하여 고 고도 희박 영역에서 로켓의 자세 제어에 필수적인 측면 제트 분사와 그에 따른 자유 흐름 유동과 측면 제트의 상호 작용에 대한 연구를 수행하였다. 밀도 차가 큰 자유 흐름 유동과 제트 유동을 동시에 모사하기 위해 입자 가중치 기법을 사용하였다. 두 수직한 평판 사이의 유동 및 측면 제트 분사에 의한 상호 작용 해석을 수행하였고 그 결과를 실험치와 비교하여 프로그램을 검증하였다. 좀 더 실제적인 로켓 모델로 blunted cone cylinder 형상에 대하여 받음각을 변화시켜가며 자유 흐름 유동과 측면 제트의 상호 작용에 대한 연구를 수행하였다. 표면 압력 차이의 분포를 기준으로 람다(lambda) 충격파와 후류의 영향을 토의하였다. 받음각이 있는 유동의 경우 leeward 방향으로는 제트와 자유 흐름 유동의 상호 작용이 약해지며, windward 방향으로는 상호 작용이 매우 강해지는 것을 확인할 수 있었다.

• 스마트미디어저널
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• 제8권4호
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• pp.38-45
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• 2019

회전익 드론의 후류에서 발생하는 강한 유동과 살포되는 농약 노즐에서의 스프레이 유동이 동반될 경우, 극심한 기체의 요동과 함께 액적 유동은 바람의 영향을 크게 받게 된다. 특히 액적은 공기역학적인 항력의 영향을 받기 때문에 단순한 제자리 비행과는 달리 전진 비행을 할 경우 또는 측풍을 받고 있을 경우, 살포 영역에 큰 변화가 발생한다. 이로 인하여 드론을 활용한 농약살포에는 보다 큰 비산의 위험성이나 위치간의 낙하분산에 차이가 커져 효율성이 떨어질 수 있는 문제가 생긴다. 따라서 적절한 수치 모델링과 이를 적용한 전산 시뮬레이션을 통하여 다양한 비행 및 대기 조건을 적용할 수 있는 예측 도구가 필요하다. 본 연구에서는 로터에서 나오는 강한 하풍과 드론의 비행속도에 따른 액적 유동 특성에 대해 실험 및 수치해석을 진행하였으며, 액적이 분포하는 확률밀도함수를 구하여 서로 비교함으로써 농약살포용 드론에서 액적을 살포할 시 효율성을 증진시킬 수 있는 분사 시스템을 구축하고자 한다.

• Journal of Menopausal Medicine
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• 제24권3호
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• pp.183-187
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• 2018

Objectives: The present mini review aimed to summarize the existing knowledge regarding the beneficial and adverse effects of raloxifene in menopausal women. Methods: This study is a review of relevant publications about the effects of raloxifene on sleep disorder, depression, venous thromboembolism, the plasma concentration of lipoprotein, breast cancer, and cognitive function among menopausal women. Results: Raloxifene showed no significant effect on depression and sleep disorder. Verbal memory improved with administration of 60 mg/day of raloxifene while a mild cognitive impairment risk reduction by 33% was observed with administration of 120 mg/day of raloxifene. Raloxifene was associated with a 50% decrease in the need for prolapse surgery. The result of a meta-analysis showed a significant decline in the plasma concentration of lipoprotein in the raloxifene group compared to placebo (standardized mean difference, -0.43; 10 trials). A network meta-analysis showed that raloxifene significantly decreased the risk of breast cancer (relative risk, 0.572; 95% confidence interval, 0.327-0.881; P = 0.01). In terms of adverse effects of raloxifene, the odds ratio (OR) was observed to be 1.54 (P = 0.006), indicating 54% increase in the risk of deep vein thrombosis (DVT) while the OR for pulmonary embolism (PE) was 1.05, suggesting a 91% increase in the risk of PE alone (P = 0.03). Conclusions: Raloxifene had no significant effect on depression and sleep disorder but decreased the concentration of lipoprotein. Raloxifene administration was associated with an increased risk of DVT and PE and a decreased risk of breast cancer and pelvic organ prolapse in postmenopausal women.

• Journal of Ship and Ocean Technology
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• 제10권4호
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• pp.12-23
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• 2006

In this paper, a numerical study is carried out to investigate the turbulent flow around a twin-skeg container ship model with rudders including propeller effects. A commercial CFD code, FLUENT is used with body forces distributed on the propeller disk to simulate the ship stem and wake flows with the propeller in operation. A multi-block, matching, structured grid system has been generated for the container ship hull with twin-skegs in consideration of rudders and body-force propeller disks. The RANS equations for incompressible fluid flows are solved numerically by using a finite volume method. For the turbulence closure, a Reynolds stress model is used in conjunction with a wall function. Computations are carried out for the bare hull as well as the hull with appendages of a twin-skeg container ship model. For the bare hull, the computational results are compared with experimental data and show generally a good agreement. For the hull with appendages, the changes of the stem flow by the rudders and the propellers have been analyzed based on the computed result since there is no experimental data available for comparison. It is found the flow incoming to the rudders has an angle of attack due to the influence of the skegs and thereby the hull surface pressure and the limiting streamlines are changed slightly by the rudders. The axial velocity of the propeller disk is found to be accelerated overall by about 35% due to the propeller operation with the rudders. The area and the magnitude of low pressure on the hull surface enlarge with the flow acceleration caused by the propeller. The propellers are found to have an effect on up to the position where the skeg begins. The propeller slipstream is disturbed strongly by the rudders and the flow is accelerated further and the transverse velocity vectors are weakened due to the flow rectifying effect of the rudder.