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Effects of 『Persicae Semen』 on the Hyperlipidemia Rats Induced by Triton WR-1339 (도인약침액(桃仁藥鍼液)의 투여가 흰쥐의 고지혈증 예방에 미치는 영향)

  • Kang, Dae-In;Jeong, Chan-Gil;Kim, Kwang-Ho;Soh, Kyeong-Sun
    • Journal of Pharmacopuncture
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    • v.7 no.3
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    • pp.47-57
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    • 2004
  • Objective : In order to study effects of ${\lceil}Persicae\;Semen{\rfloor}$ on the hyperlipidemia rats induced by Triton WR, we have made hyperlipidemia rats by administering Triton WR-1339 for 3 days, then have administered. The results were summerized as follows : 1. The Total cholesterol, triglyceride, LDL-cholesterol, Free fatty acid, phospholipid and CRF(Cardiak Risk Factor) by hypercholesteremic rats injected by Triton WR-1339 of the herb-Acupuncture group were decreased as compared with those of the control group, especialy hypercholesteremic rats injected by Triton WR- 1339 of the herb-Acupuncture+Acupuncture group were some more decreased as compared with those of the control group. 2. The HDL-cholesterol by hypercholesteremic rats injected by Trion WR -1339 of the herb-Acupuncture group were increased as compeared those of control group, especialy hypercholesteremic rats injected by Triton WR-1339 of the herb-Acupuncture+Acupuncture group were some more increased as compared with those of the control group. According to the above results, Persicae Semen showed inhibition on decrease of serum total cholesterol, triglyceride and phosholipid contents as well as inhibition on increase of HDL-cholesterol contents in hyperlipidemia.

Optimization of TDA Recycling Process for TDI Residue using Near-critical Hydrolysis Process (근임계수 가수분해 공정을 이용한 TDI 공정 폐기물로부터 TDA 회수 공정 최적화)

  • Han, Joo Hee;Han, Kee Do;Jeong, Chang Mo;Do, Seung Hoe;Sin, Yeong Ho
    • Korean Chemical Engineering Research
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    • v.44 no.6
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    • pp.650-658
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    • 2006
  • The recycling of TDA from solid waste of TDI plant(TDI-R) by near-critical hydrolysis reaction had been studied by means of a statistical design of experiment. The main and interaction effects of process variables had been defined from the experiments in a batch reactor and the correlation equation with process variables for TDA yield had been obtained from the experiments in a continuous pilot plant. It was confirmed that the effects of reaction temperature, catalyst type and concentration, and the weight ratio of water to TDI-R(WR) on TDA yield were significant. TDA yield decreased with increases in reaction temperature and catalyst concentration, and increased with an increase in WR. As a catalyst, NaOH was more effective than $Na_2CO_3$ for TDA yield. The interaction effects between catalyst concentration and temperature, WR and temperature, catalyst type and reaction time on TDA yield had been defined as significant. Although the effect of catalyst concentration on TDA yield at $300^{\circ}C$ as subcritical water was insignificant, the TDA yield decreased with increasing catalyst concentration at $400^{\circ}C$ as supercritical water. On the other hand, the yield increased with an increase in WR at $300^{\circ}C$ but showed negligible effect with WR at $400^{\circ}C$. The optimization of process variables for TDA yield has been explored with a pilot plant for scale-up. The catalyst concentration and WR were selected as process variables with respect to economic feasibility and efficiency. The effects of process variables on TDA yield had been explored by means of central composite design. The TDA yield increased with an increase in catalyst concentration. It showed maximum value at below 2.5 of WR and then decreased with an increase in WR. However, the ratio at which the TDA yield showed a maximum value increased with increasing catalyst concentration. The correlation equation of a quadratic model with catalyst concentration and WR had been obtained by the regression analysis of experimental results in a pilot plant.

The Effects of Weekly Reports as a Method for Encouraging Student Questions in Middle School Science Instruction (중학교 과학 수업에서 학생 질문을 촉진하는 방안으로서의 주단위 보고서의 효과)

  • Kang, Hun-Sik;Lee, Sung-Mi;Kwon, Eun-Kyung;Noh, Tae-Hee
    • Journal of The Korean Association For Science Education
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    • v.26 no.3
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    • pp.385-392
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    • 2006
  • This study investigated the effects of weekly reports as a method for encouraging student questions in middle school science instruction by focusing on student conceptual understanding, achievement, concept map, and perceptions of weekly reports. Seventh graders (N=211) from a middle school were assigned to control and weekly reports (WR) groups. All students were taught about the 'three states of matter', the 'motion of molecules', and the 'change of states and thermal energy' for eighteen class hours. Students in the WR group were required to write weekly reports for six of those periods. Results revealed that conception test scores for the WR group were significantly higher than those for the control group. Compared conception test scores by learning strategy, students using a surface learning strategy in the WR group scored significantly higher than those in the control group. While students employing a deep learning strategy in the WR group also performed better than those in the control group, the difference was relatively small. The scores of an achievement test and a concept map test for the WR group were significantly higher than those for the control group. However, there were no significant interactions between instruction and students' learning strategy in the two variables. It was also found that most students in the WR group positively perceived weekly reports.

An Experimental Study on Radioprotective Effect of DDC, MEA, and WR-2721 (DDC, MEA, WR-2721의 방사선(放射線) 방호효과(防護效果)에 관(關)한 연구(硏究))

  • Chung, In-Young;Koh, Joo-Hwan;Chung, Hyun-Woo;Chil, Soo-Yil;Yoo, Seong-Yul;Koh, Kyoung-Hwan
    • Journal of Radiation Protection and Research
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    • v.11 no.2
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    • pp.114-122
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    • 1986
  • At present, the treatments of the radiation-induced diseases are only performing by the palliative treatment technique. Moreover, radiation protective agents are a little toxic for human being and this seriously limits their applicability with various complications in clinical uses. Accordingly, as a part of the aim of gain of the basic data for protective roles of some radioprotectors, the present investigation was carried out to evaluate the comparative radioprotective effects by the administration of DDC, MEA, WR-2721. Results are shown for statistically significant analysis and correlation with each group as follows; 1. The proper doses of the radioprotectors were DDC; 1,550 mg/kg, MEA; 450 mg/kg, WR-2721; 780 mg/kg of the mouse body weight. 2. DMF(Dose modification factor) of LD 50/10 and LD 50/30 for whole body irradiation was DDC; 1.2, MEA; 1.4, WR-2721; 1.9 and DDC; 1.7, MEA; 1.8, WR-2721; 2.5 respectively. 3. DMF for radiation reaction of jejunal crypt was DDC: 1.07, MEA: 1.21 and WR-2721: 1.76 and that of jejunal crypt cell was DDC: 1.04, MEA: 1.08 and WR-2721: 1.38 respectively. 4. Conclusively, WR-2721 was the most effective drung among the three radioprotectors and this result must be a supportive data for further study for clinical application.

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Influence of Painting Materials based on Wasted Oil and Applying Timing on Carbonation and Chloride Resistances of High Volume SCM Concrete (폐유지류를 중심으로 한 도포제 종류 및 도포시기 변화가 혼화재 다량치환 콘크리트의 탄산화 및 염해저항성에 미치는 영향)

  • Han, Cheon-Goo;Choi, Young-Doo
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.3 no.3
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    • pp.228-236
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    • 2015
  • In this research, the influence of painting materials and applying timing on carbonation and chloride resistances of high volume SCMs concrete was evaluated. As a durability improving method, comparative tests were conducted with painting materials of ERCO (emulsified refined cooking oil), RCO (refined cooking oil), WR (water repellent agent), and ERCO + WR and with painting timings of right after demolding, and 28 days after the wet curing. From the experiment results, in the case of carbonation and chloride resistance, the carbonation depth and chloride penetration depth were decreased when the painting materials were applied in 28 days of wet curing. Additionally, for painting materials, with the order of ERCO, RCO, ERCO+WR, and WR, the carbonation and chloride penentration was delayed. Hence it is considered that ERCO shows the most favorable performance of resistance against carbonation and chloride penetration.

Lipid lowering activity of Ponciri Fructus and Aurantii Fructus Immaturus on hyperlipemia rats induced by Triton WR-1339. (국산과 중국산 지실(枳實)의 Triton WR-1339 유발 고지혈증(高脂血症) 흰쥐에 대한 효능 연구)

  • Ham, In-hye;Lee, Ung-Cheol;Lee, Byong-hee;Choi, Ho-young
    • The Korea Journal of Herbology
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    • v.22 no.3
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    • pp.109-116
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    • 2007
  • Objective : In order to elucidate hyperlipidemic effects of the fruits of Poncirus trifoliata and Citrus aurantium, our experimental study was performed on hyperlipidemia rats induced by Triton WR-1339. Method : The hyperlipidemia rats induced by intraperitonial injection of triton WR-1339 were treated with the fruits of P. trifoliata (rare and preparata) and C. aurantium 50 and 200mg/kg. The amount of triglyceride. total cholesterol. HDL-cholesterol, LDL-cholesterol, AST. and ALT levels were measured. Results: The levels of triglyceride. total cholesterol and LDL-cholesterol were significantly reduced in fruits of P. trifoliata (rare and preparata) and C. aurantiu. Simvastatine treated group compared with those of control but the level of HDL-cholesterol was incresed. The level of AST and ALT were not significantly reduced by the treatment to the fruits of P. trifoliata (rare and preparata) and C. aurantium. Conclusion : In the hyperlipidemia rats induced by triton WR-1339. the fruits of P. trifoliata (rare and preparata) and C. aurantium showed a hyperlipidemic effect.

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Vr-Wr Analysis of Yield Characters in Cotton (목화 주요형질의 Vr-Wr그래프 분석)

  • Choi Chu-Ho;Lee Shin-Woo;Lee Cheol-Ho;Chun Hyun-Sik
    • Journal of Life Science
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    • v.15 no.3 s.70
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    • pp.365-373
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    • 2005
  • The quantitative inheritance of some yield characters in Gosyium spp was carried out by means of a $10\times10$ diallel cross. In this study, 45 combinations of $F_1\;and\;F_2$ generations were genetically analyzed through 10 different cultivars diallel cross population of cotton (Gosyium spp) at an experimental field. The results of Vr-Wr graph analysis of six characters such as number of boll, boll weight, lint weight per boll, 100 seeds weight, fiber fineness and fiber length in those combinations by the Hayman's method were as follow: 1. The significant difference was observed from the genetic variance of all the examined characters. 2. On based the Vr-Wr graphical analysis, $F_1$ showed a complete dominance in all the experimental characters except boll weight, lint weight per boll and fiber fineness, but the dominance degree and gene arrangement of $F_2$ were somewhat different from those of $F_1$.

Radioprotective Effects of Cysteamine, Isothiouronium Derivatives and Their Combinations with a Phosphorothioate (Cysteamire, Isothiouronium 유도체(誘導體) 및 이들과 Phosphorothioate와의 혼합물(混合物)들의 방사선(放射線) 방호효과(防護效果))

  • Kim, You-Sun;Kim, Ok-Hee
    • Journal of Radiation Protection and Research
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    • v.7 no.1
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    • pp.11-16
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    • 1982
  • Cysteamine(Mercaptoethyiamine, MEA), S,2-Aminoethylisothiouronium Bromide. HBr (AET), and S-(2-Aminoethyl) Dihydrogen Phosphorothioate (WR-638) were prepared and radioprotective effects of these chemicals and their combinations against $^{60}Co$ ${\gamma}-ray$ radiation were studied ,in irradiated ICR mice. Intraperitonially administered chemicals or their combinations resulted drug deaths in cases of MEA, AET, and their combinations, whereas there were a slight or no drug death in cases of WR-638 and the combination of AET with WR-638. All tested chemicals and their combinations yielded radioprotective effects against $^{60}Co$ $\gamma-ray$ radiation. An additive radioprotection effect was observed in case of the combination of AET with WR-638.

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The effect of water restriction on physiological and blood parameters in lactating dairy cows reared under Mediterranean climate

  • Benatallah, Amel;Ghozlane, Faissal;Marie, Michel
    • Asian-Australasian Journal of Animal Sciences
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    • v.32 no.1
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    • pp.152-158
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    • 2019
  • Objective: This study was conducted to evaluate the effect of water restriction (WR) on physiological and blood parameters in lactating dairy cows reared under Mediterranean climate. Methods: The trial lasted 16 days preceded by two weeks of adaptation to the experimental condition in spring 2014 on 6 dairy cows in mid-lactation. These cows were allowed water ad libitum for 4 days (W100) (hydration period), then split into 2 groups, one group has received 25% and the other 50% of water compared to their mean water consumption during the hydration period; then rehydrated for 4 days. Feed intake and physiological parameters: respiratory rate (RR), heart rate (HR), and rectal temperature (RT) were recorded twice a day. Blood was collected once a day and analyzed for serum concentration of glucose (Glc), triglycerides (TG), cholesterol (Chol), urea (Ur), creatinine (Crea), and total protein (TP) by enzymatic colorimetric method and cortisol (Cort) by radioimmunoassay. Results: Total dry matter intake (TDMI) was affected by WR. A decrease in TDMI was observed in WR groups compared to W100 group (effect, group, period, day, $group{\times}day$, $period{\times}day$: p<0.001). Also, WR resulted in a significant increase in RR, HR, RT in WR groups than in W100 group (effect, group: p<0.001). In addition, an increase in the serum concentration of Glc, TG, Chol, Ur, Crea, TP, and Cort was noted in WR groups (effect, group, period, day: p<0.001). Conclusion: This study has shown the ability of cows raised in a Mediterranean climate to cope with different levels of WR and thus reach a new equilibrium. As result, elucidates the important role of water as a limiting factor for livestock in environments with low water availability.

Experimental Study on the Effects of Carthami Flos on the Hyperlipidemic Rats Induced by Triton WR-1339 (Triton WR-1339로 유발된 흰쥐의 고지혈증에 대한 홍화의 효과에 관한 실험적 연구)

  • Kim Tae-Hyung;Soh Kyung-Sun;Jeong Chan-Gil
    • Journal of Society of Preventive Korean Medicine
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    • v.7 no.2
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    • pp.75-83
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    • 2003
  • In order to study the effects of Carthami Flos on the hyperlipidemia, we made hyperlipidemic model by injection of Triton WR-1339 150mg/kg to rats during 3 days. 1 hour after the final injection of Triton WR-1339, Carthami Flos extracts were administered to rats 2ml/200g(p.o.). And after 24 hours, we measured the levels of serum total cholesterol, triglyceride, phospholipid and HDL-cholesterol. The results are summarized as follows. 1) Serum total cholesterol levlel of Sample group was significantly decreased compared with Control group(p<0.05). 2) Serum triglyceride level of Sample group was significantly decreased compared with Control group(p<0.01) 3) Serum phospholipid levlel of Sample group was significantly decreased compared with Control group(p<0.05). 4) Serum HDL-cholesterol level of Sample group was significantly increased compared with Control group(p<0.05).

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