• Title/Summary/Keyword: WHO 분류

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Analysis of Prognostic Factors according to WHO Classification for Thymic Epithelial Tumor (흉선종의 WHO 분류에 따른 예후인자의 임상적 고찰)

  • 서영준;금동윤;권건영;박창권
    • Journal of Chest Surgery
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    • v.37 no.8
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    • pp.684-690
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    • 2004
  • Background: Primary thymic epithelial neoplasm is a type of mediastinal tumors that have various biologic and morphologic features. In this study, we reclassified 59 cases of thymic epithelial tumors by the new WHO classification. We inquired whether the new WHO classification has independent prognostic relevance by analyzing clinical characteristics of thymic epithelial tumors including Masaoka's clinical stage. Material and Method: From December 1986 to August 2003, 59. patients who underwent surgery in the Keimyung University Dongsan Medical Center with definite diagnosis of thymic epithelial tumor were studied. We analyzed the histologic subtype (WHO classification). clinical stage (Masaoka's clinical stage) and patient's characteristics (sex, age, myasthenia gravis, tumor size, invasion. recurrence, metastasis) as prognostic factors. We analyzed the relationship between histologic subtype and clinical stage. Result: 32 patients were male and 27 were female. Mean age was 50.1$\pm$14.2. From WHO A to C, all thymic epithelial tumors were reclassified by the new WHO classification. Six patients (10.2%) had Type A, 7 (11.9%) had Type AB, 7 (11.9%) had Type B$_1$, 10 (16.9%) had Type B$_2$ and 7 (11.9%) had Type B$_3$, 22 (37.3%) had Type C. Two factors were shown by multivariate analysis to be associated with a favorable prognosis: completeness of resection (p=0.003) and non-invasiveness (p=0.001). The overall 5-year survival of the 59 patients was 53%, subtype A and AB were 92.3%, B$_1$ and B$_2$ were 70.2%, and B$_3$ and C were 26.1%. The association between histologic subtype and invasive behavior (stage) was statistically significant (p<0.001). Conclusion: The WHO classfication is not only a histologic classfication of the thymic epithelial tumors but also a significant prognostic factor that influence the survival of thymic epithelial tumors.

Vascular Tumors, Chondroid-osseous Tumors, Tumors of Uncertain Differentiation: An Update Based on the New WHO Soft Tissue Classification (연조직종양의 새로운 WHO 분류를 중심으로: 혈관종, 연골-골종과 불확실한분화종에 대하여)

  • Suh, Kyung-Jin
    • The Journal of the Korean bone and joint tumor society
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    • v.14 no.2
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    • pp.79-85
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    • 2008
  • Soft tissue tumor classifications should be an important part of radiology, oncology and, for orthopedic clinicians and pathologists, they provide diagnostic instruction and prognostic guidelines. In soft tissue tumor classification systems, the World Health Organization (WHO) classifications have become dominant, enabled by the timely publication of new blue books which included detailed text and numerous good illustrations. The new WHO classification of soft tissue tumors was introduced in 2002. Because the classification represents a broad consensus concept, it has gained widespread acceptance around the globe. This article reviews the changes which were introduced the vascular tumors, chondroid-osseous tumors and tumors of uncertain differentiation which have been first recognized or properly classified during the past decade.

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Prognostic Relevance of WHO Classification and Masaoka Stage in Thymoma (흉선종양에서의 WHO 분류와 Masaoka 병기, 임상양상간의 상관관계연구)

  • Kang Seong Sik;Chun Mi Sun;Kim Yong Hee;Park Seung Il;Eeom Dae W.;Ro Jaee Y.;Kim Dong Kwan
    • Journal of Chest Surgery
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    • v.38 no.1 s.246
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    • pp.44-49
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    • 2005
  • Although thymomas are relatively common mediastinal tumors, to date not only has a universal system of pathologic classification not been established but neither has a clearly defined predictable relationship between treatment and prognosis been made. Recently, a new guideline for classification was reported by WHO, and efforts, based on this work, have been made to better define the relationship between treatment and pro­gnostic outcome. In the present study a comparative analysis between the WHO classification and Masaoka stage system with the clinical disease pattern was conducted. Material and Method: A total of 98 patients undergoing complete resection for mediastinal thymoma between Juanuary 1993 and June 2003 were included in the present study. The male female ratio was 48 : 50 and the mean age at operation was $49.6{\pm}13.9\;years.$ A retrospective analytic comparison studying the relationship between the WHO classification and the Masaoka stage system with the clinical disease pattern of thymoma was conducted. Pathologic slide specimens were carefully examined, details of postoperative treatment were documented, and a relationship with the prognostic outcome and recurrence was studied. Result: There were 7 patients in type A according to the WHO system of classification, 14 in AB, 28 in B 1, 23 in B2, 18 in B3, and 9 in type C. The study of the relationship between the Masaoka stage and WHO classification system showed 4 patients to be in WHO system type A, 7 in type AB, 22 in B 1, 17 in B2, and 3 in type B3 among 53 $(54{\%})$ patients shown to be in Masaoka stage I. Among 28 $(28.5{\%})$ patients in Masaoka stage II system, there were 2 patients in type A, 7 in AB, 4 in B 1, 2 in B2, 8 in B3, and 5 in type C. Among 15 $(15.3{\%})$ in Masaoka stage III, there were 1 patient in type B1, 3 in B2, 7 in B3, and 4 in type C. Finally, among 2 $(2{\%})$ patients found to be in Masaoka stage IV there was 1 patient in type B1, and 1 in type B2. The mean follow up duration was $28{\pm}6.8$ months. There were 3 deaths in the entire series of which 2 were in type B2 (Masaoka stages III and IV), and 1 was in type C (Masaoka stage II). Of the patients that experienced relapse, 6 patients remain alive of which 2 were in type B2 (Masaoka III), 2 in type B3 (Masaoka I and III) and 2 in type C (Masaoka stage II). The 5 year survival rate by the Kaplan-Meier method was $90{\%}$ for those in type B2 WHO classification system, $87.5{\%}$ for type C. The 5 year freedom from recurrence rate was $80.7{\%}$ for those in WHO type B2, $81.6{\%}$ for those in type B3, and $50{\%}$ for those in type C. By the Log-Rank method, a statistically significant correlation between survival and recurrence was found with the WHO system of classification (p<0.05). An analysis of the relationship between the WHO classification and Masaoka stage system using the Spearman correction method, showed a slope=0.401 (p=0.023), showing a close correlation. Conclusion: As type C of the WHO classification system is associated with a high postoperative mortality and recurrence rate, aggressive treatment postoperatively and meticulous follow up are warranted. The WHO classification and Masaoka stage system were found to have a close relationship with each other and either the WHO classification method or the Masaoka stage system may be used as a predict prognostic outcome of Thymoma.

Adipose Tumor, Fibroblastic/Myofibroblastic Tumors, So-called Fibrohistiocytic Tumors, Smooth Muscle Tumors, Pericytic Tumors and Skeletal Muscle Tumors: An Update Based on the New WHO Soft Tissue Classification (연조직종양의 새로운 WHO 분류를 중심으로: 지방세포종, 섬유모세포성/근육섬유모세포성종, 소위섬유조직구종, 평활근종, 혈관주위종과 근골격종에 대하여)

  • Suh, Kyung-Jin
    • The Journal of the Korean bone and joint tumor society
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    • v.14 no.1
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    • pp.1-9
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    • 2008
  • Soft tissue tumor classifications should be an important part of radiology, oncology and, for clinicians and pathologists, they provide diagnostic instruction and prognostic guidelines. In soft tissue tumor classification systems, the World Health Organization (WHO) classifications have become dominant, enabled by the timely publication of new 'blue books' which included detailed text and numerous good illustrations. The new WHO classification of soft tissue tumors was introduced in 2002. Because the classification represents a broad consensus concept, it has gained widespread acceptance around the globe. This article reviews the changes which were introduced the adipose tumors, fibroblastic/myofibroblastic tumors, so-called fibrohistiocytic tumors, smooth muscle tumors, pericytic tumors and skeletal muscle tumors which have been first recognized or properly classified during the past decade.

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A study on Survive and Acquisition for YouTube Partnership of Entry YouTubers using Machine Learning Classification Technique (머신러닝 분류기법을 활용한 신생 유튜버의 생존 및 수익창출에 관한 연구)

  • Hoik Kim;Han-Min Kim
    • Information Systems Review
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    • v.25 no.2
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    • pp.57-76
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    • 2023
  • This study classifies the success of creators and YouTubers who have created channels on YouTube recently, which is the most influential digital platform. Based on the actual information disclosure of YouTubers who are in the field of science and technology category, video upload cycle, video length, number of selectable multilingual subtitles, and information from other social network channels that are being operated, the success of YouTubers using machine learning was classified and analyzed, which is the closest to the YouTube revenue structure. Our findings showed that neural network algorithm provided the best performance to predict the success or failure of YouTubers. In addition, our five factors contributed to improve the performance of the classification. This study has implications in suggesting various approaches to new individual entrepreneurs who want to start YouTube, influencers who are currently operating YouTube, and companies who want to utilize these digital platforms. We discuss the future direction of utilizing digital platforms.

선천성.감음성 최중도 난청아를 위한 음성언어지도

  • 한옥희
    • Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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    • v.7 no.1
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    • pp.113-122
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    • 1996
  • 장애복지 선진국의 통계에 의하면 감음성 난청아의 약 80%가 중도(severe, 71-90dB, WHO 분류)와 최중도(profound, 91dB이상, WHO 분류) 난청이라고 한다. 출생 이전 및 출생시(선천성)에, 또는 2세 이전의 전언어기부터 청력을 않은 감음성 난청아 중에서, 청력 손상 정도가 심한 중도 이상인 경우에는 음성언어능력의 발달을 기대할 수 없는 것으로 간주되어, 즘은 의미에서의 구화에 의한 의사소통 내지 일반교육장에서의 교육도 불가능한 것으로 여겨져 왔다. (중략)

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Harmful Document Classification Using the Harmful Word Filtering and SVM (유해어 필터링과 SVM을 이용한 유해 문서 분류 시스템)

  • Lee, Won-Hee;Chung, Sung-Jong;An, Dong-Un
    • The KIPS Transactions:PartB
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    • v.16B no.1
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    • pp.85-92
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    • 2009
  • As World Wide Web is more popularized nowadays, the environment is flooded with the information through the web pages. However, despite such convenience of web, it is also creating many problems due to uncontrolled flood of information. The pornographic, violent and other harmful information freely available to the youth, who must be protected by the society, or other users who lack the power of judgment or self-control is creating serious social problems. To resolve those harmful words, various methods proposed and studied. This paper proposes and implements the protecting system that it protects internet youth user from harmful contents. To classify effective harmful/harmless contents, this system uses two step classification systems that is harmful word filtering and SVM learning based filtering. We achieved result that the average precision of 92.1%.

Survival Rates after Operation for Gastric Cancer: Fifteen-year Experience at a Korea Cancer Center Hospital (위암 수술 후 생존율 분석: 원자력병원의 15년간 경험)

  • Park, Jong-Ik;Jin, Sung-Ho;Bang, Ho-Yoon;Paik, Nam-Sun;Moon, Nan-Mo;Lee, Jong-Inn
    • Journal of Gastric Cancer
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    • v.8 no.1
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    • pp.9-19
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    • 2008
  • Purpose: Gastric cancer is the most common malignant tumor in Korea. We reviewed the cases at our institution to identify the survival rates and clarify the prognostic factors of patients with gastric cancer. Materials and Methods: We conducted a retrospective study of 6,918 patients who had received a diagnosis of gastric cancer, and they underwent surgery at Korea Cancer Center Hospital during a 15-year period from 1991 to 2005. Results: The overall 5-year survival rate was 66.8%. The univariate analysis revealed that age, location of tumor, gross type of tumor, the histology according to the WHO classification, the Lauren classification, depth of invasion (T stage), lymph node metastasis (N stage), distant metastasis (M stage), the type of surgery, the UICC TNM stage, postoperative complications, adjuvant chemotherapy, lymphatic invasion, venous invasion and perineural invasion were the significantly different factors of the survival rates. The multivariate analysis revealed that age, Borrmann type 4, the histology according to the WHO classification, depth of invasion (T stage), lymph node metastasis (N stage), distant metastasis (M stage), the type of surgery, UICC TNM stage, postoperative complications, adjuvant chemotherapy and lymphatic invasion were the independent prognostic factors. Conclusion: We have shown a statistically significant association between the survival rates after operation for gastric cancer and the clinicopathologic factors. Early diagnosis of gastric cancer, appropriate surgeryand adjuvant therapy might improve the quality of life and the survival rates of gastric cancer patients.

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