• 한국지역사회생활과학회지
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• 제17권4호
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• pp.49-56
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• 2006

The purpose of this study was to evaluate the thermal and subjective comfort of various pesticide-proof clothes made from different material. Seven male adults took part in the study, conducted in a climate-chamber controlled with an ambient temperature of $30^{\circ}C$ and a relative humidity of 60%RH. The thermal and subjective responses of subjects wearing pesticide-proof clothing made of Goretex(coating treatment), polyester (water-repellent treatment), non-woven(coating) and nylon(coating) were measured. The main results were summarized as follows: (1) Change of rectal temperature and clothing microclimate were inhibited more effectively in pesticide-proof clothing made of Goretex, polyester and non-woven than nylon materials. (2) Mean skin temperature at the end of the experiment was significantly higher in subjects who wore nylon than non-woven and Goretex, and was lowest in those with pesticide-proof clothing made of polyester. (3) Change of heart rate was significantly lower in subjects with Goretex and polyester clothiing than those with non-woven, and in those with nylon, it was highest. (4) Subjective comfort was greater in subjects with Goretex, polyester and nonwoven clothing than nylon, except for thermal sensation. Thermal sensation was greater in order of polyester, Goretex, non-woven and nylon. Thus, it was concluded that pesticide-proof clothing made of Goretex, polyester and non-woven material could reduce thermal stress during the spraying of pesticides in summer.

• 동의생리병리학회지
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• 제34권2호
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• pp.81-87
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• 2020

Cognitive impairment is symptoms of dementia, a degenerative brain disease that is drawing attention in a rapidly aging society. This study was conducted to investigate the improvement of cognitive function of Leonurus japonicus on scopolamine-induced memory impairment in mice and the effect and mechanism of memory recovery. In vivo studies were conducted on mice orally pretreated with L. japonicus in doses of 50, 100 and 200 mg/kg (p.o.) and scopolamine (1 mg/kg, i.p.) were injected 30 min before the behavioral task. Antioxidant activity was assessed by 2,2-diphenyl-1-picryl hydrazyl (DPPH) assay and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay, and acetylcholinesterase (AChE) inhibition activity evaluated by Ellman's method. In behavior studies showed that L. japonicus has an improved the memory of scopolamine-treated mice in Y-maze, passive avoidance and Morris water maze test. In addition, L. japonicus was also exerted free radical scavenging activity and inhibited acetyl cholinesterase activity. These results suggest that L. japonicus improves short-term and long-term memory in scopolamine-induced memory decline model and prevents scopolamine-induced memory impairments through in reduced oxidative stress and acetyl cholinesterase inhibition effect. Thus, L. japonicus is related to functional medicinal materials for prevention and treatment of human dementia patients.

• 해양환경안전학회:학술대회논문집
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• 해양환경안전학회 2004년도 추계학술발표회
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• pp.57-62
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• 2004

선박 조종자는 방파제를 통항할 경우 조선 부담감을 느낀다. 아직까지 선박 운항자의 조선 부담감을 고려한 방파제 배치에 관한 기준은 없다. 이 연구는 해상교통류 시뮬레이션을 이용하여 조선 부담감이 발생하는 상황을 재현하여 선박 운항자의 조선 부담감을 정량적으로 표현한 모델인 환경스트레스모델을 재현된 상황에 적용, 평가하였다. 주요한 결과는 다음과 같다. (1) 방파제 배치 변화에 의한 조선 부담감의 차이는 그다지 크지 않다. (2) 동일한 방파제 폭일 경우에는 선박의 항행속력의 차이로 인하여 선박 운항자의 조선 부담감은 상이하다. (3) 방파제폭의 확장함으로써 선박 운항자의 조선 부담감이 평균적으로 감소한다.

• 한국자원식물학회지
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• 제10권2호
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• pp.135-139
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• 1997

식방풍 1호는 1990년에서 1995년까지 6개년간 전국에서 수집한 11개 식방풍재래종 중 영덕종 등 4계통을 순계분리한 후 생산력 검정시험에 공시한 다음 그 중 생육특성이 우수한 영덕종과 봉화종에 대해 지역적응시험 및 농가실증시험을 실시한 결과 영덕종이 다수성 순계임이 확인되어 1995년도에 농촌진흥청 우량종자선정 심의회에서 우량품종으로 결정되어 식방풍 1호로 명명되었기에 육성 과정에서 나타난 주유특성과 수량성을 요약하면 다음과 같다. 1. 식방풍 1호는 봉화식방풍과 초장은 비슷하고 주근장은 짧았으나 엽수가 많고 경자과 근두직경은 굵었고 종실량도 증수되었다. 2. 식방풍 1호는 근피색이 황갈색이고 근 형태는 식립원추형으로서 양질의 생약 재 생산에 유리한 품종이었다. 3. 식방풍 1호는 근중 엑스함량과 회분 및 산불용성 회분 함량으로 보아 대한 약전 규격집에 규정된 함량치에 적합하여 생약으로 이용시 유효성을 갖추었다. 4. 식방풍 1호는 토양선층에 비교적 강한 편이었고 내병성, 내습성, 내서성 및 내도복성도 강한 특성을 나타내었다. 5. 식방풍 1호의 건근수량은 생산력 검정시험, 지역적응시험 및 농가실증시험 결과 모두 봉화 식방풍보다 ha당 $10\sim28%$ 증수되었다.

• Archives of Pharmacal Research
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• 제21권3호
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• pp.241-247
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• 1998

This study was designed to determine biochemical and pharmacological properties of a newly synthesized benzimidazole derivative, 2-amino-4, 5-dihydropyrido [1, 2-a] thiazolo [5, 4-g] benzimidazole (YJA20379-5) in vitro and in vivo. In the leaky membrane vesicles of pig gastric mucosa, YJA20379-5 inhibited the $K^+$-stimulated $H^+$, $K^+$-ATPase activity in a concentration- and time-dependent manner, with $IC_{50}$ values being $43{\mu}\textrm{M}$ and $43{\mu}\textrm{M}$ at pH 6.4 and 7.4, respectively. YJA20379-5, given intraduodenally, had a potent inhibitory effect on the gastric acid secretion in pylorus-ligated rats. The $ED_{50}$ value for acid secretion was 15.4 mg/kg. YJA20379-5, administered orally, also suppressed gastric damages induced by water-immersion stress, indomethacin and ethanol, and duodenal damage induced by mepirizole in rats; the $ED_{50}$ values were 17.6, 4.7, 3.0 and 18.7 mg/kg, respectively. Furthermore, repeated oral administration of YJA20379-5 accelerated the spontaneous healing of acetic acid-induced gastric ulcers in rats. It is concluded that the a-ntisecretory activity of YJA20379-5 appears to be associated with inhibition of $H^+$, $K^+$-ATPase, while its antigastric and antiduodenal lesion activities are primarily related to the antisecretory effect.

• Nuclear Engineering and Technology
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• 제24권3호
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• pp.263-273
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• 1992

핵연료 집합체의 속도분포, 압력강하는 열수력 설계와 안전해석에 중요하다. 본 실험적 연구의 목적은 봉다발 지지 격자 하류에서의 수력학적 혼합을 고찰하는데 있다. 이 연구에서 가압경수로형 5X5 봉다발 부수로의 상세한 수력학적 특성들을 1차익 He-Ne LDV를 이용하여 측정하였다. 축방향 유속, 난류강도와 압력강하를 주로 측정하였고 LDV의 정렬을 조정하여 측방향의 유속, 난류강도, Reynolds 전단응력 등도 역시 측정하였다. 봉다발의 마찰계수와 지지 격자의 손실계수는 측정된 압력 강하로부터 평가하였다. 서로 다른 종류의 지지 격자의 수력학적 혼합성능을 이웃하는 부수로 간에서의 난류 횡류 혼합률을 예측함으로써 고찰할 수 있었다.

• 한국식품저장유통학회지
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• 제13권4호
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• pp.495-500
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• 2006

항산화물에 의한 천식 억제 효과를 확인하기 위하여 항산화정도를 알아볼 수 있는 DPPH, FRAP, hydroxyl radical 소거활성 실험을 high throughput-compatible chemical assay로 디자인하여 해바라기씨 추출물에 적용하여 보았다. 해바라기씨 추출물의 용매에 따른 항산화 효과 중 $H_2O_2$에 의한 산화스트레스에 의한 세포사멸을 DW추출물에서 강한 억제능력을 보였다. 이를 이용하여 마우스를 이용한 천식 동물모델에 적용하여 탁월한 천식 억제효과를 $CD4^+$세포, IL-4와 IL-13의 발현정도를 통해 알수 있었다. 해바라기씨 추출물은 천식에 탁월한 효과가 있는 것으로 in vitro 및 in vivo 실험으로 증명하였다.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.272-272
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• 2017

Recently, consumer's demands are increasing for new natural functional and healthful food. These demands have encouraged a better understanding of the biochemical, chemical and nutritional composition of plant products. Superhongmi rice variety was derived from a cross between CG2-3-5-2-6-2 (Heugjinju/Suwon 425) having reddish brown color and Daeribbyeo 1 having a large grain size. Superhongmi rice headed on Sep. 5th and has 94.7 cm culm length. Taxifolin, a phenolic compound in superhongmi rice extract had high ${\alpha}-glucosidase$ inhibitory activity. The ${\alpha}-glucosidase$ inhibitory activity of the superhongmi rice extracts correlated to the taxifolin content and antioxidant activity of the extracts. A new method for quantitative determination of taxifolin in superhongmi rice variety by high performance liquid chromatography was established. A reversed-phase system with Tosoh TSK-gel $C_{18}$ column using 60% methanol in water(pH 2.4) as a mobile phase was developed. Taxifolin was detected at 280 nm and the analysis was successfully carried out within 40 min. In ripening phase, the amount of taxifolin showed a mild decreasing slope. The highest contents was 59.27mg in 100g seed on the 30 days after heading(DAH). The optimum harvesting time, considering taxifolin content, maturity rate and thousand seed weight(TSW) was DAH 50. These results suggest that superhongmi rice which has high taxifolin content has the potential to contribute as a dietary supplement for controlling hyperglycemia and oxidative stress-linked diabetes complications.

• 생약학회지
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• 제44권1호
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• pp.41-46
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• 2013

Alzheimer's disease (AD), most common form of dementia is characterized that memory deficit and loss of cognitive function. The Codonopsis lanceolata (C.lanceolata) was treated by high hydrostatic pressure process and fermentation. This study was evaluated cognitive enhancing effect C.lanceolata extract by high hydrostatic pressure process and fermentation and compared with common C.lanceolata extract using Morris water maze and passive avoidance test. And their neuroprotective effect on glutamate induced oxidative stress in HT22 cell was investigated by MTT assay. High hydrostatic pressure process and fermented C.lanceolata extract (HFCE) and common C.lanceolata extract (CCE) (100 and 300 mg/kg) were administered to mice. Results showed HFCE enhanced cognitive function than CCE as shown by decrease in escape latency time. HFCE increased the latency time of the passive avoidance test compared to CCE. Furthermore, HFCE showed significant neuroprotective effect against glutamate cytotoxicity in HT22 cells. These results indicate that high hydrostatic pressure process and fermented more improve spatial cognitive ability of C. laanceolata.

• 동의생리병리학회지
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• 제25권1호
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• pp.37-47
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• 2011

This study was aimed to investigate the memory enhancing effect of Jeongjihwan against scopolamine-induced amnesia in C57BL/6 mice. To determine the effect of Jeongjihwan on the memory and cognitive function, we have injected scopolamine (1 mg/kg, i.p.) into C57BL/6 mice 30 min before beginning of behavior tests. We have conducted Y-maze, Morris water-maze, passive avoidance and fear conditioning tests to compare learning and memory functions. Scopolamine-induced behavior changes of memory impairment were significantly restored by oral administration of Jeongjihwan (100 or 200 mg/kg/day). To elucidate the molecular mechanism underlying the memory enhancing effect of Jeongjihwan, we have examined the antioxidant defense system and neurotrophic factors. Jeongjihwan treatment attenuated intracellular accumulation of reactive oxygen species and up-regulated mRNA and protein expression of antioxidant enzymes as assessed by RT-PCR and western blot analysis, respectively. Jeongjihwan also increased protein levels of brain-derived neurotrophic factor (BDNF) compared with those in the scopolamine-treated group. Furthermore, as an upstream regulator, the activation of cAMP response element-binding protein (CREB) via phosphorylation was assessed by Western blot analysis. Jeongjihwan elevated the phosphorylation of CREB (p-CREB), which seemed to be mediated partly by extracellular signal-regulated kinase1/2 (ERK1/2) and protein kinase B/Akt. These findings suggest that Jeongjihwan may have preventive and therapeutic potential in the management of amnesia.