• Geomechanics and Engineering
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• 제12권4호
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• pp.611-626
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• 2017

The research reported herein is concerned with the model testing of piles socketed in soft rock which was simulated by cement, plaster, sand, water and concrete hardening accelerator. Model tests on a single pile socketed in simulated soft rock under axial cyclic loading were conducted and the bearing capacity and accumulated deformation characteristics under different static, and cyclic loads were studied by using a device which combined oneself-designed test apparatus with a dynamic triaxial system. The accumulated deformation of the pile head, and the axial force, were measured by LVDT and strain gauges, respectively. Test results show that the static load ratio (SLR), cyclic load ratio (CLR), and the number of cycles affect the accumulated deformation, cyclic secant modulus of pile head, and ultimate bearing capacity. The accumulated deformation increases with increasing numbers of cycles, however, its rate of growth decreases and is asymptotic to zero. The cyclic secant modulus of pile head increases and then decreases with the growth in the number of cycles, and finally remains stable after 50 cycles. The ultimate bearing capacity of the pile is increased by about 30% because of the cyclic loading thereon, and the axial force is changed due to the applied cyclic shear stress. According to the test results, the development of accumulated settlement is analysed. Finally, an empirical formula for accumulated settlement, considering the effects of the number of cycles, the static load ratio, the cyclic load ratio and the uniaxial compressive strength, is proposed which can be used for feasibility studies or preliminary design of pile foundations on soft rock subjected to cyclic loading.

• 한국터널지하공간학회 논문집
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• 제18권2호
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• pp.235-244
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• 2016

해저터널 시공 중 단층, 파쇄대 및 미고결층 등의 취약한 지반조건에서 일어나는 문제점을 극복하기 위해 시공 중 그라우팅을 진행한다. 암반에서 그라우팅은 주로 불연속면을 따라 주입되므로 절리의 분포, 거칠기 또는 폭과 같은 절리 인자들이 그라우팅 보강암반의 물성에 지대한 영향을 미친다. 해저터널 주변의 그라우팅 보강암반은 해저환경에서 정수압을 다 부담하여 장기적인 열화와 미세구조변화 및 균열 등이 발생하며 암반물성이 시간에 따라 변하므로 그라우팅으로 인한 해저터널 주변암반의 장기적인 거동평가가 요구된다. 본 연구에서는 실내실험을 통해 다양한 축 응력, 양생기간 및 절리조건에서 그라우팅 보강암반의 탄성파 전달특성을 분석하였고 국내에서 사용되는 다양한 암반분류법들의 탄성파 기준을 고려하여 그라우팅 보강암반의 보강정도를 탄성파 속도로 추론하였다.

• 대한약침학회지
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• 제18권4호
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• pp.12-19
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• 2015

Objectives: This study was done out to evaluate the effects of Sida rhombifolia methanol extract (SRM) on diabetes in moderately diabetic (MD) and severely diabetic (SD) Sprague-Dawley rats. Methods: SRM was prepared by soaking the powdered plant material in 70% methanol and rota evaporating the methanol from the extract. Effective hypoglycemic doses were established by performing oral glucose tolerance tests (OGTTs) in normal rats. Hourly effects of SRM on glucose were observed in the MD and the SD rats. Rats were grouped, five rats to a group, into normal control 1 (NC1), MD control 1 (MDC1), MD experimental 1 (MDE1), SD control 1 (SDC1), and SD experimental 1 (SDE1) groups. All rats in the control groups were administered 1 mL of distilled water (DW). The rats in the MDE1 and the SDE1 groups were administered SRM orally at 200 and 300 mg/kg body weight (BW), respectively, dissolved in 1 mL of DW. Blood was collected initially and at intervals of 1 hour for 6 hours to measure blood glucose. A similar experimental design was followed for the 30-day long-term trial. Finally, rats were sacrificed, and blood was collected to measure blood glucose, lipid profiles, thiobarbituric acid reactive substances (TBARS) and reduced glutathione (GSH). Results: OGTTs indicated that two doses (200 and 300 mg/kg BW) were effective hypoglycemic doses in normal rats. Both doses reduced glucose levels after 1 hour in the MDE1 and the SDE1 groups. A long-term trial of SRM in the MD group showed a reduced glucose level, a normal lipid profile, and normal GSH and TBARS levels. In SD rats, SRM had no statistically significant effects on these parameters. Normal weight was achieved in the MD rats, but the SD rats showed reduced BW. Conclusion: The study demonstrates that SRM has potential to alleviate the conditions of moderate diabetic, but not severe diabetes.

• 한국산학기술학회논문지
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• 제13권4호
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• pp.1480-1487
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• 2012

최근, 국내 탄광의 안전성이 향상되고 있으나 사고는 꾸준히 발생하고 있다. 대부분의 터널 지보는 I빔과 I빔을 연결하는 이음판 부분에서 지압을 견디지 못하고 파손이 발생한다. XX 탄광의 경우, 터널지보의 아치부가 일반적인 굽힘 거동이 아닌, 위쪽 방향으로 굽힘이 발생하고 있다. 이러한 경우는 터널지보에 수직하중 이외에 수평하중이 과대하게 작용하는 경우로 볼 수 있으며 이러한 수평하중은 지하암반의 급격한 변화에 의한 암반의 이완범위의 증가나 지하수의 누출 등으로 인한 수리학적인 요인 등의 복합적인 문제가 작용하여 나타난다. 따라서 본 연구에서는 위쪽 방향으로 굽힘을 일으키는 수평하중의 크기를 추정하기 위하여 실험계획법과 최적화 알고리듬을 적용하여 터널지보의 굽힘거동을 규명하였다.

• 한국수산과학회지
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• 제26권6호
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• pp.567-579
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• 1993

태풍통과시 동해의 일본북구연안에서의 수위변동을 조사하기 위해 $1966{\sim}1986$년간의 시간별수위자료분석 및 고분해능($5'{\times}5'$)을 갖는 천해파모델상에서의 수치실험을 행하였다. 자료분석의 주결과는 1) 태풍통과시 Simonoseki(SS)와 Maizuru(MZ) 간에 약 4m/s의 위상속도를 갖는 진행파가 존재하나, 2) Sasebo(SB)와 Hakata(HK) 간에는 파속이 매우 느리고(약 1.7 m/s), 3) HK에서는 SS에 비해 약 반나절 늦게 최대수위에 도달하는 점등이었다. 실험결과는 관측결과와 좋은 대응을 보였다. 실험결과로 볼 때, 연안에 전파하는 진행파는 관측결과와 거의 같은 위상속도 약 4 m/s를 갖는 지형성파로서 확인된다. 태풍이 대한해협을 통과하기전에는 일본연안에 평행한 바람에 의해 생성된 남서방향의 연안젯트류에 의해 파의 전파가 영향을 받고, 태풍이 통과한 후에는 연안젯트류가 약해지면서 파가 전파하게 된다.

• The Korean Journal of Physiology and Pharmacology
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• 제17권4호
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• pp.331-338
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• 2013

AMP-activated protein kinase (AMPK), an important regulator of energy metabolism, is activated in response to cellular stress when intracellular levels of AMP increase. We investigated the neuroprotective effects of AMPK against scopolamine-induced memory impairment in vivo and glutamate-induced cytotoxicity in vitro. An adenovirus expressing AMPK wild type alpha subunit (WT) or a dominant negative form (DN) was injected into the hippocampus of rats using a stereotaxic apparatus. The AMPK WT-injected rats showed significant reversal of the scopolamine induced cognitive deficit as evaluated by escape latency in the Morris water maze. In addition, they showed enhanced acetylcholinesterase (AChE)-reactive neurons in the hippocampus, implying increased cholinergic activity in response to AMPK. We also studied the cellular mechanism by which AMPK protects against glutamate-induced cell death in primary cultured rat hippocampal neurons. We further demonstrated that AMPK WT-infected cells increased cell viability and reduced Annexin V positive hippocampal neurons. Western blot analysis indicated that AMPK WT-infected cells reduced the expression of Bax and had no effects on Bcl-2, which resulted in a decreased Bax/Bcl-2 ratio. These data suggest that AMPK is a useful cognitive impairment treatment target, and that its beneficial effects are mediated via the protective capacity of hippocampal neurons.

• 한국재료학회지
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• 제5권1호
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• pp.12-21
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• 1995

본 연구에서는 부식환경하에서 bulging 시험동안 음향방출거동에 미치는 변형률속도에 대한 영향을 알아보았다. 시험에 사용된 변형률속도의 범위는 $4 \times 10^{-6}S^{-1}$에서 $1 \times 10^{-4} \times S^{-1}$까지이며, AE신호 특성을 평가하기 위해 사용된 인자는 AE hit수와 진폭으로 하였다. 시험결과, 변형률속도가 감소함에 따라 등가파괴변형률과 원주방향의 균열 길이는 감소하였으나, 파괴과정동안 총 누적 AE hit수와 평균진폭은 크게 증가하였다. 그리고 AE신호 특성치의 최대점은 시험전분부에 접근하였으며, 단위 등가파괴변형률당 평균진폭이 20dB 이상에서는 뚜렷하게 응력부식륜열 현상을 관찰할 수 있었다. 또한 음향방출시험법은 변형률속도에 따른 재료의 응력부식균열 감수성 정도를 평가하는데 있어 그 적용 가능성이 있음을 알 수 있었다.

• 한국약용작물학회지
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• 제15권5호
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• pp.352-356
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• 2007

The present study was investigated the anti-oxidative effects of aloe vera ingestion on brain and kidney in aged rats by monitoring several oxidative-related parameters. Male specific pathogen-free Fischer 344 rats were randomly divided into four groups of five rat each: Group A was fed test chow without aloe supplementation; Group B was fed a diet containing a 1% freeze-dried aloe filet; Group C was fed a diet containing a 1% charcoal-processed, freeze-dried aloe filet; and Group D was fed a diet containing a charcoal-processed, freeze-dried, whole leaf aloe in drinking water. Analyses of tissues were done at 4 months and 16 months of age. Results showed that a long-term intake of aloe, regardless of the preparation used, enhanced antioxidant defenses against lipid peroxidation, as indicated by reduced phosphatidylcholine hydroperoxide levels in both brain and kidney. The additional benefit of aloe intake on the anti-oxidative action was evidenced by enhanced superoxide dismutase and catalase activity in all aloe-ingested groups. Another beneficial effect of aloe shown in this study, although not an anti-oxidative parameter, was its cholesterol-lowering effect as detected in brain and kidney with significant decreases at age16 months of aloe-fed rats. Based on these findings, we conclude that a long-term dietary aloe supplementation modulated the anti-oxidative defense systems and cholesterol level.

• 한국지반공학회논문집
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• 제27권5호
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• pp.61-74
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• 2011

본 연구는 석탄회와 폐타이어, 그리고 두 재료의 혼합재료 등 경량 폐기물의 성토재 활용을 위한 기본적인 연구로서, 이들 재료의 입도분포, 비중, 다짐밀도, 전단강도, 투수특성 등 기본물성 및 지반공학적 물성 평가를 위한 실험을 수행하였으며, 현장 조건에 따른 함수비와 온도변화를 고려한 1차원 압축 침하특성 등을 평가하였다. 석탄회 재료의 경우 대표적인 성토재료인 풍화토와 유사한 입도분포를 가지면서, 경량의 특정을 확인할 수 있었다. 그러나 강도측면에서는 풍화토와 유사한 수준을 보이고, 투수특성은 입도에 따라 매우 큰 차이를 나타냈다. 폐타이어가 포함된 재료들의 경우에도 강도값은 성토재로 충분한 값을 보였다. 이들 재료의 1차원 수직압축특성 실험 결과에서도 일정 수직응력 수준 하에서는 모래와 유사한, 비교적 압축성이 낮은 재료로 평가할 수 있었으며, 함수비변화와 반복적인 동결융해조건 하에서는 석탄회가 포함된 재료들이 풍화토 및 풍화토-폐타이어 혼합재료에 비해 낮은 압축침하거동을 보였다.

• 한국환경과학회지
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• 제20권9호
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• pp.1141-1149
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• 2011

The three-dimensional hydrodynamic model was simulated to understand coastal sea front of formation and seasonal variation in the Southern Sea of Korea. In this study, we used to concept of stratification factor, to realize seasonal distribution of stratification coefficient which of seasonal residual flow, considered with, tide, wind and density effect. Tidal current tends to flow westward during the flood and eastward during ebb. The current by the wind stress showed to be much stronger the coastal than the offshore area in the surface layer. And the current by the horizontal gradient of water density showed to be relatively weak in the coastal area, with little seasonal differences. On the other hand, the flow in the offshore area showed results similar to that of the Tsushima Warm Current. The stratification factor (SHv) was calculated by taking into account the total flow of tide, wind and density effect. In summer, the calculated SHv distribution ranged from 2.0 to 2.5, similar to that of the coastal sea front. The horizontal temperature gradient showed to be strong during the winter, when the vertical stratification is weak. On the other hand, the horizontal gradient became weak in summer, during which vertical stratification is strong. Therefore, it is presume that the strength of vertical stratification and the horizontal temperature gradient affect the position of the coastal sea front.