• Bulletin of the Korean Chemical Society
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• v.31 no.5
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• pp.1430-1432
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• 2010

• BMB Reports
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• v.55 no.10
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• pp.500-505
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• 2022

Uncoupling protein 2 (Ucp2) was first introduced as a member of Uncoupling protein family and a regulator of ROS formation; however, its role in adipose tissue is not fully understood. In the present study, we have investigated the role of Ucp2 against high-fat diet (HFD)-induced obesity in epididymal white adipose tissue (eWAT) and browning of inguinal white adipose tissue (iWAT). Diet-induced obesity is closely related to macrophage infiltration and the secretion of pro-inflammatory cytokines. Macrophages surround adipocytes and form a crown-like-structure (CLS). Some reports have suggested that CLS formation requires adipocyte apoptosis. After 12 weeks of HFD challenge, Ucp2 knockout (KO) mice maintained relatively lean phenotypes compared to wild-type (WT) mice. In eWAT, macrophage infiltration, CLS formation, and inflammatory cytokines were reduced in HFD KO mice compared to HFD WT mice. Surprisingly, we found that apoptotic signals were also reduced in the Ucp2 KO mice. Our study suggests that Ucp2 deficiency may prevent diet-induced obesity by regulating adipocyte apoptosis. However, Ucp2 deficiency did not affect the browning capacity of iWAT.

• Bulletin of the Korean Chemical Society
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• v.32 no.1
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• pp.332-334
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• 2011

• BMB Reports
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• v.55 no.7
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• pp.360-360
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• 2022

• BMB Reports
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• v.55 no.4
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• pp.187-191
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• 2022

Obesity is caused by an imbalance between energy intake and energy expenditure. Exercise is attracting attention as one of the ways to treat obesity. Exercise induces 'beige adipogenesis' in white adipose tissue, increasing total energy expenditure via energy dissipation in the form of heat. Also, beige adipogenesis can be induced by treatment with a beta-adrenergic receptor agonist. We developed a Cidea-dual reporter mouse (Cidea-P2A-Luc2-T2A-tdTomato, Luciferase/tdTomato) model to trace and measure beige adipogenesis in vivo. As a result, both exercise and injection of beta-adrenergic receptor agonist induced beige adipogenesis and was detected through fluorescence and luminescence. We confirmed that exercise and beta-adrenergic receptor agonist induce beige adipogenesis in Cidea-dual reporter mouse, which will be widely used for detecting beige adipogenesis in vivo.

• Cross-Cultural Studies
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• v.22
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• pp.29-49
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• 2011

This study is focused on looking into the essence and application in the modem history of 'Martial Art Culture' that is a representative cultural code in the East Asia. Doubting and reconstructing the paradigm of the past and present, Postmodernism in the 21st century has defined marital arts as a new cultural phenomenon. This study begins by doubting whether the essence of martial arts was a cultural conduct to train both bodies and spirits. Practically used as a fighting skill since the primitive age, martial arts has fallen into sports or cultural behaviors due to the invention of the state-of-the-art modern weapons. However modern people misunderstand that martial arts of East Asia is originated a kind of cultural behaviors. It implies there is a fundamental mistake in the wat Western civilization evaluates the orientalism. This study analyzes this mistake through access method based on realities of modern history. This trial will contribute to expanding the thinking range, inquiring into varied cultural phenomena including martial arts which are misunderstood in modern history.

• The Southeast Asian review
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• v.21 no.2
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• pp.43-75
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• 2011

The article focuses on the impact and Acceptance of Hindu culture in Modern Southeast Asian Buddhism. The purpose of this study is to examine critically the influential epic Ramayana on Siam culture, Thai Ramayana version 'Ramakien', reveal instances of Buddhist Modification. The Ramayana by the great sage Valmiki is considered by Indians to be the first great literary work to be produced in India. The influence of this work is to be seen not only through centuries but even in other countries, such as Thailand where there are modified modern versions. In this paper, I have three objectives : (1) I may discuss the epic Ramayana of India gave birth to the Ramakien of Thailand. In modern times Valmiki's epic was made to fit the spiritual trends current in the new Chakri dynasty, which were themselves based on Brahmanic tradition and Theravada buddhism. With regarding to the structure of the Traibhumi cosmography, and the relationship between merit and power implied by this cosmography ranks all beings from demons to deities in a hierarchy of merit which accrues according to karma the actions of past lives. (2) I analyze how to have attempted to dissect the Hindi and Thai version of the Ramayana. The Hindu concept of kingship is also depicted in the life of Rama. The Hindus see in Rama the norm of a true Hindu life characterized by the Caste and Dharma. In Thai transformed version, it does not preach Hindu values of personal or social life. The Ramakien emphasized that the Buddhism were higher than all other laws, and that the King is regarded as the incarnation of Phra Ram, and thus is also the narration of the righteous buddhist ruler. (3) I discuss how cultural or social contexts can influence the structure of the royal Wat. The whole epic was painted by the order of Rama I in the galleries of the Wat Phra Keo. In other words, it is the very centre of the dynastic cult enshrining the Emerald Buddha, the most iconic expression of the Ramakien tradition were officially amalgamated. Rama I was continued the process of elaborating and stabilizing the complex religious pattern, with Buddhism at the pinnacle. My finding will support the idea that the Ramakien is particularly appealing to the Thai people because it presents the image of an ideal king, Rama, who symbolizes the force of virtue or dharma while Thotsakan represents the force of evil. Eventually the force of good prevails. Being Buddhists, the Thai poets bring into the story the Buddhist philosophy(especially, the law of cause and effect, karma). This paper examines the role of the Hindu epic Ramayana in the historical and cultural contact between Hindu India and Buddhist Southeast Asia. It should now be possible to evaluate what elements of Hindu culture were transmitted into Thai through the Rama story.

• Archives of design research
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• v.16 no.3
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• pp.341-350
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• 2003

The topic of 21st century's culture is the appearance of digital media. It made changes as big as the industrial revolution, and our society is now ruled by the digital media. The main objective of this study is to forecast the direction of current visual design education by researching and analyzing how the introduction of digital media is influencing the evolution of visual design's identity, which is an ever changing and developing science. Also, since the rain target of digital media is the young generation, the change in the method of expressing visual language is inevitable In fact, there have been a lot of changes in the methods of creating and distributing visual communication due to the introduction of digital media. In the past, most educational institutions of design had similar objectives, curriculums and teaching methods to provide education that prepares students for practical business. However, in this digital media era, the application and utilization of visual design are uncomparably diversified, and it is generally classified as interaction. The purpose of this study is to find a wat to train visual design professionals in this digital era. For this purpose, this study will identify a new educational system that fulfills the demands of this society by fusing the traditional education and the new digital education, and will suggest what an design education institute that is ahead of the demands of society should be like.

• Journal of the Korean Society for information Management
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• v.33 no.1
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• pp.247-268
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• 2016

Although it has been a long subject of study why researchers prefer some cited documents to others, the existing relative researches have had a variety of perspectives on the nature and complexity of the citation behavior and not provided a complete answer to this question. In particular, Korea researchers mainly used statistical analysis of bibliographic information, which has limitations in revealing dynamic and complex cognitive aspects of the citation process. In this study, I investigate the citer perception of citing motives and bibliographic factors through survey and compared the responses according to the researchers' characteristics. After extracting the 22 motivations and 21 factors through the literature analysis and configuring a 5-point Likert scale questions, I conducted a survey in the wat of an e-mail attachment. From the SPSS 22.0, the frequency analysis, t-test, and one-way ANOVA were performed on the 354 valid samples. As a result, it is found that supporting is considered the most important citing motive and social connection, self-citation have little influence. In the case of bibliographic factors, the journal's reputation was recognized the most influential factor and the number of pages and authors was the least. Significant differences in fields of study and research careers were showed in some parts. These results can substantiate earlier studies, determine whether the factors assumed influential in selecting references were intended, and suggest the search point to the specialty library or academic database.