• Journal of Chest Surgery
• /
• v.39 no.12 s.269
• /
• pp.879-890
• /
• 2006

Background: The dysfunction of multiple organs is found to be caused by reactive oxygen species as a major modulator of microvascular injury after hemorrhagic shock. Hemorrhagic shock, one of many causes inducing acute lung injury, is associated with increase in alveolocapillary permeability and characterized by edema, neutrophil infiltration, and hemorrhage in the interstitial and alveolar space. Aggressive and rapid fluid resuscitation potentially might increased the risk of pulmonary dysfunction by the interstitial edema. Therefore, in order to improve the pulmonary dysfunction induced by hemorrhagic shock, the present study was attempted to investigate how to reduce the inflammatory responses and edema in lung. Material and Method: Male Sprague-Dawley rats, weight 300 to 350 gm were anesthetized with ketamine(7 mg/kg) intramuscular Hemorrhagic Shock(HS) was induced by withdrawal of 3 mL/100 g over 10 min. through right jugular vein. Mean arterial pressure was then maintained at $35{\sim}40$ mmHg by further blood withdrawal. At 60 min. after HS, the shed blood and Ringer's solution or 5% albumin was infused to restore mean carotid arterial pressure over 80 mmHg. Rats were divided into three groups according to rectal temperature level($37^{\circ}C$[normothermia] vs $33^{\circ}C$[mild hypothermia]) and resuscitation fluid(lactate Ringer's solution vs 5% albumin solution). Group I consisted of rats with the normothermia and lactate Ringer's solution infusion. Group II consisted of rats with the systemic hypothermia and lactate Ringer's solution infusion. Group III consisted of rats with the systemic hypothermia and 5% albumin solution infusion. Hemodynamic parameters(heart rate, mean carotid arterial pressure), metabolism, and pulmonary tissue damage were observed for 4 hours. Result: In all experimental groups including 6 rats in group I, totally 26 rats were alive in 3rd stage. However, bleeding volume of group I in first stage was $3.2{\pm}0.5$ mL/100 g less than those of group II($3.9{\pm}0.8$ mL/100 g) and group III($4.1{\pm}0.7$ mL/100 g). Fluid volume infused in 2nd stage was $28.6{\pm}6.0$ mL(group I), $20.6{\pm}4.0$ mL(group II) and $14.7{\pm}2.7$ mL(group III), retrospectively in which there was statistically a significance between all groups(p<0.05). Plasma potassium level was markedly elevated in comparison with other groups(II and III), whereas glucose level was obviously reduced in 2nd stage of group I. Level of interleukine-8 in group I was obviously higher than that of group II or III(p<0.05). They were $1.834{\pm}437$ pg/mL(group I), $1,006{\pm}532$ pg/mL(group II), and $764{\pm}302$ pg/mL(group III), retrospectively. In histologic score, the score of group III($1.6{\pm}0.6$) was significantly lower than that of group I($2.8{\pm}1.2$)(p<0.05). Conclusion: In pressure-controlled hemorrhagic shock model, it is suggested that hypothermia might inhibit the direct damage of ischemic tissue through reduction of basic metabolic rate in shock state compared to normothermia. It seems that hypothermia should be benefit to recovery pulmonary function by reducing replaced fluid volume, inhibiting anti-inflammatory agent(IL-8) and leukocyte infiltration in state of ischemia-reperfusion injury. However, if is considered that other changes in pulmonary damage and inflammatory responses might induce by not only kinds of fluid solutions but also hypothermia, and that the detailed evaluation should be study.

• Korean Journal of Materials Research
• /
• v.17 no.1
• /
• pp.11-17
• /
• 2007

Turbulent in-situ mixing process is a new material process technology to get dispersed phase in nanometer size by controlling reaction of liquid/solid, liquid/gas, flow ana solidification speed simultaneously. In this study, mixing which is the key technology to this synthesis method was studied by computational fluid dynamics. For the simulation of mixing of liquid metal, static mixers investigated. Two inlets for different liquid metal meet ana merge like 'Y' shape tube having various shapes and radios of curve. The performance of mixer was evaluated with quantitative analysis with coefficient of variance of mass fraction. Also, detailed plots of intersection were presented to understand effect of mixer shape on mixing. The simulations show that the Reynolds number (Re) is the important factor to mixing and dispersion of $TiB_2$ particles. Mixer was designed according to the simulation, and $Cu-TiB_2$ nano composites were evaluated. $TiB_2$ nano particles were uniformly dispersed when Re was 1000, and cluster formation and reduction in volume fraction of $TiB_2$ were found at higher Re.

• Journal of Ship and Ocean Technology
• /
• v.12 no.3
• /
• pp.36-54
• /
• 2008

A jet stream applied tangential to a curved surface in fluid increases lift force by strengthening circulation around the surface and this phenomenon is known as the Coanda effect. Many experimental and numerical studies have been performed on the Coanda effect and the results found to be useful in various fields of aerodynamics. Recently, preliminary studies on Coanda control surface are in progress to look for practical application in marine hydrodynamics since various control surfaces are used to control behaviors of ships and offshore structures. In the present study, the performance of a Coanda control surface with different geometries of the jet injection nozzle was surveyed to assess applicability to ship rudders. A numerical simulation was carried out to study flow characteristics around a section of a horn type rudder subjected to a tangential jet stream. The RANS equations, discretized by a cell-centered finite volume method were used for this computation after verification by comparing to the experimental data available. Special attentions have been given to the sensitivity of the lift performance of a Coanda rudder to the location of the slit (outlet) and intake of the gap between the horn and rudder surface at the various angles of attack. It is found that the location of the water intake is important in enhancing the lift because the gap functions as a conduit of nozzle generating a jet sheet on the rudder surface.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
• /
• v.23 no.7
• /
• pp.528-534
• /
• 2011

In this paper, thermal characteristics of cylindrical grooved wick heat pipes with water-based MWCNT nanofluids as working medium are experimentally investigated. Volume fractions of nanoparticles are varied with 0.1% to 0.5%. Transient hot wire method developed in house is used to measure the thermal conductivity of nanofluids. It is enhanced by up to 29% compared to that of DI water. The thermal resistances and temperature distributions at the surface of the heat pipes are measured at the same evaporation temperature. The experimental results show that the thermal resistance of the heat pipes with water-based MWCNT nanofluids as working fluid is reduced up to 35.2% compared with that of heat pipe using DI water. The reduction rate of thermal resistance is greater than the enhancement rate of thermal conductivity. Finally, based on the experimental results, we present the reduction of the thermal resistances of the heat pipes compared with conventional heat pipes cannot be explained by only the thermal conductivity of water-based MWCNT nanofluids.

• Journal of the Korean Solar Energy Society
• /
• v.31 no.3
• /
• pp.23-28
• /
• 2011

In this study, the ejector design was modeled using Fluent 6.3 of FVM(Finite Volume Method) CFD(Computational Fluid Dynamics) techniques to resolve the flow dynamics in the ejector. A vacuum system with the ejector has been widely used because of its simple construction and easy maintenance. Ejector is the main part of the desalination system, of which designs determine the efficiency of system. The effects of the ejector was investigated geometry and the operating conditions in the hydraulic characteristics. The ejector consists mainly of a nozzle, suction chamber, mixing tube (throat), diffuser and draft tube. Liquid is supplied to the ejector nozzle, the fast liquid jet produced by the nozzle entrains and the non condensable gas was sucked into the mixing tube. The multiphase CFD modeling was carried out to determine the hydrodynamic characteristics of seawater-air ejector. Condition of the simulation was varied in entrance mass flow rate (1kg/s, 1.5kg/s, 2kg/s, 2.5kg/s, 3kg/s), and position of driving nozzle was located from the central axis of the suction at -10mm, 0mm, 10mm, 20mm, 30mm.. Asaresult, suction flow velocity has the highest value in central axis of the suction.

• Current Optics and Photonics
• /
• v.6 no.5
• /
• pp.489-496
• /
• 2022

Our previous study on monitoring cerebral oxygenation with a variation of isoflurane concentration in a rat model showed that near-infrared spectroscopy (NIRS) signals have potential as a new depth of anesthesia (DOA) index. However, that study obtained results from the brain in a completely invasive way, which is inappropriate for clinical application. Therefore, in this follow-up study, it was investigated whether the NIRS signals measured in a minimally invasive model including the skull and cerebrospinal fluid layer (CSFL) are similar to the previous study used as a gold standard. The experimental method was the same as the previous study, and only the subject model was different. We continuously collected NIRS signals before, during, and after isoflurane anesthesia. The isoflurane concentration started at 2.5% (v/v) and decreased to 1.0% by 0.5% every 5 min. The results showed a positive linear correlation between isoflurane concentration and ratio of reflectance intensity (RRI) increase, which is based on NIRS signals. This indicates that the quality of NIRS signals passed through the skull and CSFL in the minimally invasive model is as good as the signal obtained directly from the brain. Therefore, we believe that the results of this study can be easily applied to clinics as a potential indicator to monitor DOA.

• Journal of Advanced Marine Engineering and Technology
• /
• v.39 no.10
• /
• pp.1002-1010
• /
• 2015

Natural gas hydrates are newly emerging as an environment-friendly source of energy to substitute for fossil fuels in the 21stcentury.NGHs are reported to holds much amounts of natural gas (up to 182 standard volumes of gas per volume of hydrate); they are easy to store and safe to carry at about minus 20 degree Celsius under atmospheric pressure because of the self-preservation phenomenon of gas hydrates. The transporting method by gas-ice-hydrate ship carriers has been introduced and developed by a variety of industry and research institutions. Our team has been conducted to develop NGH total systems, including a breakthrough NGH carrier for sea transportation, since 2011. The NGH pellet carrier does not require a separate cooling system for cargo, and the initial temperature is maintained through insulation of the cargo tanks throughout the transport to the final destination. The heat conducted from the exterior and passing through the insulation material of the hull should be cut off as much as possible, but heat inflow inside the cargo tank from an external source is inevitable during transport. In this study, the heat transfer in a cargo tank of a 115K NGH carrier was analyzed through simulation with a commercial CFD code to estimate the boil-off gas/boil-off rate on the developed carrier and understand major hazards that could significantly impact the safety of the vessel.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.13 no.12
• /
• pp.5661-5668
• /
• 2012

In the era of water scarcity, saving toilet water is one of the most effective ways to save water. In this study, two-phase flow for the development of highly-efficient toilet has been analysed with VOF(Volume Of Fluid) method. Since the whole model requires extensive computing time, part of the whole model has also been adopted to reduce the analysis time. Four different rim models were considered for flow distribution analysis and sizes of rim holes were found to become more important rather than locations or numbers of rim holes in achieving flow distribution effectively. In addition, velocity and pressure of two-phase flow due to siphon phenomenon have been studied through the analysis of whole model. Therefore, this study provides a variety of fundamental data for the development of highly-efficient toilet.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.17 no.7
• /
• pp.237-244
• /
• 2016

The workability of mortar determines its construction performance in a structure showing its designed resistance to external loads. Measuring the rheological properties of mortar is one way of quantifying its workability, but its field-applications are limited due to economical and spatial issues. The robustness of the slump flow test allows its use for evaluating the workability of mortar, even though it is a rather qualitative test method. This paper proposes a channel flow test and develops a correlation between its result and the rheological properties of mortar. The volume-of-fluid simulation for the channel flow test was accomplished, and a numerical database for the correlation was composed. A correlation model to estimate the rheological properties of mortar using the results of the channel flow test as inputs is proposed.

• Korean Chemical Engineering Research
• /
• v.53 no.2
• /
• pp.193-198
• /
• 2015

The high-pressure phase behavior of a polycaprolactone (Mw=56,145 g/mol, polydispersity 1.2), dichloromethane, and carbon dioxide ternary system was measured using a variable-volume view cell. The experimental temperatures and pressures ranged from 313.15 K to 353.15 K and up to 300 bar as functions of the $CO_2$/dichloromethane mass ratio and temperature, at poly(D-lactic acid) weight fractions of 1.0, 2.0, and 3.0%. The correlation results were obtained from the hybrid equation of state (Peng-Robinson equation of state + SAFT equation of state) for the $CO_2$-polymer system using the van der Waals one-fluid mixing rule. The three binary interaction parameters were optimized by the simplex method algorithm.