• Journal of Korean Tunnelling and Underground Space Association
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• v.24 no.2
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• pp.153-170
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• 2022

Waterjet has been comprehensively used in urban areas owing to a suitable technique for cutting concrete and rock, and low noise and vibration. Recently, the abrasive waterjet technique has been adopted and applied by the Korea Atomic Energy Research Institute to demolish concrete plugging without disturbing and damaging In-situ Demonstration of Engineered Barrier System in the disposal research tunnel. In this study, the use of abrasive waterjet in the tunnel was evaluated for practical applicability and the existing cutting model was compared with the experimental results. As a variable for waterjet cutting, multi-cutting, water flow rate, abrasive flow rate, and standoff distance were selected for the diversity of analysis. As regarding the practical application, the waterjet facilitated path selection for cutting the concrete plugging and prevented additional disturbances in the periphery. The pump's noise at idling was 64.9 dB which is satisfied with the noise regulatory standard, but it exceeded the standard at ejection to air and target concrete because the experiment was performed in the tunnel space. The experimental result showed that the error between the predicted and measured cutting volume was 12~13% for the first cut and 16% for second cut. The standoff distance had a significant influence on the cutting depth and width, and the error tended to decrease with decrement of standoff distance.

• Journal of the Korean Society of Marine Environment & Safety
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• v.27 no.2
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• pp.308-323
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• 2021

In this study, we aimed to evaluate the environmental changes in Jinhae Bay caused by cooling water using numerical modeling. Cooling water discharge volume from the results of Case 1 (10 m³ sec^-1) showed that the environmental changes in Jinhae Bay were extremely insignificant throughout the study period. In the simulation conditions of Case 2 (100 m³ sec^-1), there was a decrease in water temperature of approximately 1 - 3℃ within a 5 km radius from the discharge outlet. In Case 3 (1000 m³ sec^-1), a decrease in water temperature of up to 4 - 5℃ was observed within a radius of 8 km from the discharge outlet and cooling water discharge spread throughout the Bay. Growth rate of microalgae decreased by up to 15 % in November, whereas it increased by up to 6 % near the Hangam Bay in Case 3. From the above results, we confirmed that the environmental changes in Jinhae Bay due to cooling water discharged from Tongyeong LNG station are extremely insignificant. Moreover, it is expected that cooling water discharge could be utilized as a counter measure for 'red tide bloom' or 'macroalgae growth'.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.36 no.1
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• pp.21-39
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• 2023

Objectives : The purpose of this study was to investigate the anti-inflammatory effect of Goihwa-san water extract(GHS) in vitro & in vivo. Methods : In vitro, we evaluated the anti-inflammatory effect of GHS by comparing the Raw 264.7 cells with 10, 30, 100, 300㎍/㎖ of GHS for 1 hour before Lipopolysaccharide(LPS) to the single LPS treated group. We examined the relative cell viability by MTT assay and the relative level of LPS, Loxoribine(LOX), Peptidoglycan(PGN), Flagellin(FLA)-induced NO production by using Griess reagent and measured relative iNOS protein level and COX-2 protein level by using western blot and Image analyzing system. We measured the production of TNF-α, IL-1β, and IL-6 by each ELISA kits and then measured the relative levels of IκBα, p-IκBα in whole-cell lysate fraction and NF-κB in nuclear fraction by using western blot and Image analyzing system. In vivo, we induced the paw edema by subcutaneous injection of 100㎕/rat CA and measured the swelling volume of paw by using a plethysmometer and then measured the relative iNOS protein level by using western blot. Results : As a result, in vitro, LPS, PGN-induced NO production was significantly inhibited by pretreatment with GHS. GHS reduced LPS, PGN-induced iNOS expression, PGN-induced COX-2 expression and LPS-induced production of cytokine(TNF-α, IL-1β, IL-6). Expression of IκBα was increased by pretreatment with GHS 100㎍/㎖. And the expression of p-IκBα and NF-κB were decreased by pretreatment with GHS 100㎍/㎖. In vivo, CA-induced inflammation rat model was used for the evaluation of the anti-inflammatory effect of GHS. 0.3 or 1.0g/kg of GHS significantly reduced the increases of paw swelling and iNOS expression in paw tissues. Conclusions : These results show that GHS can decrease inflammatory response via inhibition of the NF-κB pathway in vitro. And in vivo, the anti-inflammatory effect suggest the clinical basis of GHS for the treatment of inflammatory diseases.

• Journal of Korean Neurosurgical Society
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• v.65 no.2
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• pp.204-214
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• 2022

Objective : Osteoporosis result from age-related decline in the number of osteoblast progenitors in the bone marrow. Probiotics have beneficial effects on the host, when administered in appropriate amounts. This study investigated the effects of probiotics expressing specific genes, especially the effects of genetically modified bone morphogenetic protein (BMP)-2-expressing Lactobacillus plantarum CJNU 3003 (LP) on ovariectomized rats. Methods : Twenty-eight female Wistar rats (250-300 g, 12 weeks old) were divided into four groups : the sham (control), the ovariectomy (OVX)-induced osteoporosis group (OVX), the OVX and LP (OVX/LP), OVX and genetically modified BMP-2-expressing LP (OVX/LP with BMP) groups. The three groups underwent bilateral OVX and two of these groups were administered two different types of LP via oral gavage daily. At 16 weeks post-OVX, blood was collected from the heart and the bilateral tibiae were extracted and were scanned by ex-vivo micro-computed tomography and stained with hematoxylin-and-eosin (H&E) and Masson's trichrome stain for pathological assessment. The serum levels of osteocalcin (OC), rat C-telopeptide of type I collagen (CTX-I), BMP-2, and receptor activator of nuclear factor-ĸB ligand (RANKL) were measured. Results : The 3D-micro-computed tomography images showed that the trabecular structure in the OVX/LP with BMP group was maintained compared with OVX and OVX/LP groups. No significant differences were detected in trabecular thickness (Tb.Th) between control and OVX/LP with BMP groups (p>0.05). Furthermore, a tendency toward increased BMD, trabecular bone volume, Tb.Th, and trabecular number and decreased trabecular separation was found in rats in the OVX/LP with BMP groups when compared with the OVX and OVX/LP groups (p>0.05). The H&E and Masson's trichrome stained sections showed a thicker trabecular bone in the OVX/LP with BMP group compared with the OVX and OVX/LP groups. There was no difference in serum levels of OC, CTX and RANKL control and OVX/LP with BMP groups (p>0.05). In contrast, significant differences were found in OC and CTX-1 levels between the OVX and OVX/LP with BMP groups (p<0.05). Conclusion : Our results showed that the expression of genetically modified BMP-2 showed inhibition effect for bone loss in a rat model of osteoporosis.

• Journal of the Korean Society of Marine Environment & Safety
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• v.28 no.7
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• pp.1111-1119
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• 2022

Tourism projects through islands in the waters of Sinan-gun became active, and as a result, a total of 13 marine bridges connecting islands were completed. However, the marine bridge constructed in the fairway is dangerous for traffic. Particularly, in the case of the marine bridge connecting two islands, the width of the fairway is extremely narrow, therefore the risk is higher. In this study, we evaluated the risk of collision between marine bridge piers and ships using the IALA Waterway Risk Assessment Program (IWRAP), a risk assessment model for port waterways, based on a maritime traffic survey on the coastal bridge in Sinan-gun. The results, indicated that No.1 Sinan bridge had the highest probability of collision and most of the transit ships were coastal passenger ships. In addition, No.1 Sinan bridge was the place where the most collision accidents occurred among the marine bridge piers in the target sea, and the cause this study was analyzed. An analysis of the satellite images of the sea environment of No.1 Sinan bridge using an image processing method, confirmed that obstacles that could not be seen in the chart existed nearby the bridge. As a result, traffic was observed to be concentrated in one direction, unlike two-way traffic, which is a method of inducing traffic of bridges to avoid obstacles. The risk cause analysis method using the image processing technique of this study is expected to be used as a basic research method for analyzing the risk factors of island bridge in the future.

• Journal of Chest Surgery
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• v.56 no.3
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• pp.155-161
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• 2023

Background: Surgical closure of an atrial septal defect (ASD) is infrequently indicated during infancy. We evaluated the clinical characteristics and outcomes of patients who underwent surgical ASD closure during infancy. Methods: A single-center retrospective review was performed for 39 patients (19 males) who underwent surgical ASD closure during infancy between 1993 and 2020. The median body weight percentile at the time of operation was 9.3. Results: During a median follow-up of 60.9 months, 4 late deaths occurred due to chronic respiratory failure. A preoperative history of bronchopulmonary dysplasia (BPD) was the only risk factor for late mortality identified in Cox regression (hazard ratio, 3.54; 95% confidence interval [CI], 1.75-163.04; p=0.015). The 5-year survival rate was significantly lower in patients with preoperative history of BPD (97.0% vs. 50.0%, p<0.001) and preoperative ventilatory support (97.1% vs. 40.4%, p<0.001). There were significant postoperative increases in left ventricular end-diastolic (p=0.017), end-systolic (p=0.014), and stroke volume (p=0.013) indices. A generalized estimated equation model showed significantly better postoperative improvement in body weight percentiles in patients with lower weight percentiles at the time of operation (<10th percentile, p=0.01) and larger indexed ASD diameter (≥45 mm/m², p=0.025). Conclusion: Patients with ASD necessitating surgical closure during infancy are extremely small preoperatively and remain small even after surgical closure. However, postoperative somatic growth was more prominent in smaller patients with larger defects, which may be attributable to an increase in postoperative cardiac output due to changes in ventricular septal configuration. The benefits of ASD closure in patients with BPD are undetermined.

• Journal of the Korea Society for Simulation
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• v.32 no.3
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• pp.75-91
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• 2023

As the business-to-customer (B2C) online market expands after the COVID-19 pandemic, the logistics industry has been constructing automated warehouses to handle multi-product, low-volume logistics. When constructing a logistics automation warehouse, it is crucial to validate that the facility's performance and operational logic are designed to meet the required throughput of the automated warehouse from the system design phase. This study proposes simulation-based validation and optimal alternatives for an H logistics automation warehouse in Iksan, Jeollabuk-do. Firstly, we focused on the box supply and packing processes, which are related to the release process, among the entire logistic processes. Then, we analyzed the potential bottlenecks in the target process and designed and implemented a discrete-event simulation model based on the analysis results. The simulation experiments showed that the facility parameters and operational logic identified in the system design phase did not satisfy the performance requirements of the entire automated warehouse. Additional experiments were conducted to suggest alternatives to meet the system performance requirements by changing the facility parameters and operational logic. We expect that the proposed study will be utilized in the future, not only in the system design phase but also in the system construction phase, for verification purposes to ensure that the construction proceeds according to the design.

• The Journal of the Convergence on Culture Technology
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• v.9 no.1
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• pp.685-690
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• 2023

It was analyzed that the volume of deep excavation works adjacent to existing underground structures is increasing according to the population growth and density of cities. Currently, many underground structures and tracks are damaged by external factors, and the cause is analyzed based on the measurement results in the tunnel, and measurements are being made for post-processing, not for prevention. The purpose of this study is to analyze the effect on the deformation of the structure due to the excavation work adjacent to the urban railway track in use. In addition, the safety of structures is evaluated through machine learning techniques for displacement of structures before damage and destruction of underground structures and tracks due to external factors. As a result of the analysis, it was analyzed that the model suitable for predicting the structure management standard value time in the analyzed dataset was a polynomial regression machine. Since it may be limited to the data applied in this study, future research is needed to increase the diversity of structural conditions and the amount of data.

• Journal of Navigation and Port Research
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• v.47 no.1
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• pp.37-48
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• 2023

Recently, the increase of international trade volume is leading to risk exposure and safety accidents in the port terminal industry. In addition, as Serious Disaster Punishment Act came into effect on January, 2021, various guidelines and laws to protect safety and life in port terminals are being enacted. However, despite these efforts, medium-to-large safety accidents in the port terminal industry have occurred. According to the Korea Occupational Safety and Health Agency, from 2016 to 2019, the number of casualties in the port handling industry increased by 4.2%. To build some effective follow-up management of port accidents and preparation of related safety laws/systems, a risk analysis in consideration of causes and damage of accidents should be conducted. Therefore, in this study, major risk factors and preventive measures were derived by conducting risk assessment based on 1,039 cases of port terminal accidents collected by the Korea Occupational Safety and Health Agency for five years. Priorities for preventive measures were then determined through IPA analysis, Borich needs analysis, and The Locus For Focus analysis.

• Journal of The Korean Society of Agricultural Engineers
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• v.65 no.2
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• pp.21-33
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• 2023

While the main purpose of irrigation reservoirs is to supply agricultural water, the needs of environmental flow and flood control has been expanded. The agricultural reservoirs have been operated in the form of carry-over system until now. Therefore, the supply of agricultural water is difficult when the storage rate is not sufficiently secured after large volume of irrigation. In addition, there are regulation of the upper storage rate for some large reservoirs during the flood season, but lower storage rate is not regulated. Accordingly, this study aims to evaluate the capacity of agricultural water and environmental flow supply by setting the management lower storage rate of reservoir. The changes in the supply of agricultural and environmental flow was simulated according to the three different regulating lower storage rate scenarios. As a result, it was judged effective in terms of water supply managing the lower storage rate up to 30% when the initial storage rate of farming period is above annual average for the Naju reservoir considering existing water management practice. If the lower storage rate would have been controlled above 30%, the supply of agricultural water might be increased and non-effective discharge amount would be decreased compared to other scenarios during dry period of 2016-2018.