• Title/Summary/Keyword: Volume Efficiency

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Intratumoral Administration of Rhenium-188-Labeled Pullulan Acetate Nanoparticles (PAN) in Mice Bearing CT-26 Cancer Cells for Suppression of Tumor Growth

  • Song, Ho-Chun;Na, Kun;Park, Keun-Hong;Shin, Chan-Ho;Bom, Hee-Seung;Kang, Dong-Min;Kim, Sung-Won;Lee, Eun-Seong;Lee, Don-Haeng
    • Journal of Microbiology and Biotechnology
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    • v.16 no.10
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    • pp.1491-1498
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    • 2006
  • The feasibility of pullulan acetate nanoparticles (PAN) with ionic strength (IS) sensitivity as a radioisotope carrier to inhibit tumor growth is demonstrated. PAN was radiolabeled with rhenium 188 (Re-188) without any chelating agents. The labeling efficiency of Re-188 into PAN (Re-188PAN) was $49.3{\pm}4.0%$ as determined by TLC. The tumor volumes of mice treated with 0.45 mCi of Re-188-PAN were measured and compared with that of free Re-188 after 5 days of intratumoral injection. For the histological evaluation of apoptotic nuclei of tumor cells, hematoxylin and eosin (H&E), and terminal deoxynucleotidyl transferase biotinylated deoxyuridine triphosphate nick end labeling (TUNEL) staining were performed. The mean tumor volume of the Re-188-PAN-treated group was decreased by 36% after 5 days, whereas that the free Re-188-treated group was decreased by only 15% (P<0.05). The mean number of TUNEL-positive cells in Re-188-PAN-treated tumors at $144.3{\pm}79.9$ cells/section was significantly greater than the control ($26.7{\pm}7.9$ cells/section, P=0.03). The numbers of leukocyte and lymphocyte were decreased in both free Re-188- and Re-188-PAN-treated mice. These results indicated that the intratumoral injection of Re-188-PAN effectively inhibits the tumor growth by prolonging Re-188 retention time in tumor site induced by the IS sensitivity.

Applicability of Fuel Supply System for HCNG Engine (HCNG 엔진용 연료시스템의 적용성 평가)

  • Lee, Sungwon;Lim, Gihun;Park, Cheolwoong;Choi, Young;Kim, Changgi;Lee, Janghee
    • Transactions of the Korean Society of Automotive Engineers
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    • v.21 no.2
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    • pp.146-153
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    • 2013
  • CNG buses has contributed to improve air quality in cities. But it is difficult to meet the next emission regulations such as EURO-VI without the help of additional post-processing device. Hydorgen has higher flame speed and lower combustion temperature that make it thermal efficiency increase with leaner operation. Using hydrogen natural gas blend (HCNG) fuel is promising technology which can reduce $NO_x$ and $CO_2$ emissions for a natural gas vehicle. However, fuel flow rate of HCNG should be increased since hydrogen's energy density per volume is much smaller than natural gas. In the present study, the characteristics of fuel supply system and its applicability were evaluated in a heavy duty natural gas engine. The results showed that the potential of fuel pressure regulator and fuel metering valve had enough capacity with HCNG. Employed mixer did not affect the distribution characteristics of mixture.

Analytical Study for the Plan of Unit Household in National Housing Scale - Oriented on the cases of Korea housing corporation since 2005 ; Focused on analysing area (국민주택규모 단위세대 평면 분석 연구 - 2005년 이후 대한주택공사 사례를 면적분석 중심으로 -)

  • Lee, Jeong-Ho;Lee, Chan
    • Korean Institute of Interior Design Journal
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    • v.19 no.1
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    • pp.180-189
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    • 2010
  • Since collective houses are started to be supplied, the housing market has been transformed from supplier to demander oriented, and various type with same area of unit households have been deigned and started to be distributed. It can be expected that such transfer phenomenon would be continuously sped-up, and unit household will be more subdivided and varied. Thus, we analysed and studied the planes with subject of unit households in national housing scale ($85m^2$) that is treated as supply standard and has biggest volume in construction by Korean housing corporation. The analysing method is investigating the area of each room within unit household, calculating their minimum, maximum, and average values, studying the efficiency of unit household plane according to the structure of each room by comparative analysis these values, and analysing changing matter by investigating any change of each room area. The analysing results of which are followings. At first, number of BAY on face is increasing. Second, allocation of each room has been vary. Third, area ratio among bedroom1, livingroom, diningroom/kitchen become similar. Fourth, the area of diningroom/kitchen become somewhat bigger. Fifth, the space for passage way is efficiently allocated. Sixth, service area is reduced, Seventh, stereotyped phenomenon Is appeared. Based on many studies so far, any improvements of unit householder in national housing scale are followings. First, in terms of forming style, unit householder in national housing scale is unfolded in various way though, the form of each room is not more than typical style. Second, it shows stereotyped phenomenon. Especially, bathroom 1, 2 show stereotyped feature in terms of their type and area across entire research years, also LDK allocation method is stereotyped, as well as stereotyped trend in bedroom 2, 3, allocation for 4 BAY type.

A Study of Method to Restore Deduplicated Files in Windows Server 2012 (윈도우 서버 2012에서 데이터 중복 제거 기능이 적용된 파일의 복원 방법에 관한 연구)

  • Son, Gwancheol;Han, Jaehyeok;Lee, Sangjin
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.27 no.6
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    • pp.1373-1383
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    • 2017
  • Deduplication is a function to effectively manage data and improve the efficiency of storage space. When the deduplication is applied to the system, it makes it possible to efficiently use the storage space by dividing the stored file into chunks and storing only unique chunk. However, the commercial digital forensic tool do not support the file system analysis, and the original file extracted by the tool can not be executed or opened. Therefore, in this paper, we analyze the process of generating chunks of data for a Windows Server 2012 system that can apply deduplication, and the structure of the resulting file(Chunk Storage). We also analyzed the case where chunks that are not covered in the previous study are compressed. Based on these results, we propose the method to collect deduplicated data and reconstruct the original file for digital forensic investigation.

Integrated Management Middleware for the Servers supporting the terminal-independent (단말기 독립형 서버 통합 관리 미들웨어)

  • Kim Jeong-Hee;Kwak Ho-Young
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.10 no.6
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    • pp.1106-1118
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    • 2006
  • The Internet has become an important instrument for providing many pieces of information to us. And server systems offer the various services after processing a volume of information, it's network topology also has been complex for providing information. Therefore this expansion means the importance of fast and sustained management of server systems. But most of server systems are located in fire-walls to allow only restricted access. Moreover, due to the difference of management based on the different operating system of each server system, management of server system is not to efficiency. That is, sever administrators have to manage by themselves many kinds of servers by using local-based or socket-based single access applications. Therefore, we design and implement a middleware system which allows to manage many kinds of severs integrally ruling XML-based Web Services which have distributed object technology such as CORBA, Java RMI and DCOM, but are free from platforms or development languages. System also provides location transparency and terminal independence and calls a server system management command to manage systems.

Energy-efficient query processing based on partial attribute values in wireless sensor networks (무선 센서 네트워크에서 부분 속성값을 활용한 에너지 효율적인 질의처리)

  • Kim, Sung-Suk;Kim, Hyong-Soon;Yang, Sun-Ok
    • Journal of KIISE:Databases
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    • v.37 no.3
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    • pp.137-145
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    • 2010
  • Wireless sensors play important roles in various areas as ubiquitous computing is generalized. Depending on applications properties, each sensor can be equipped with limited computing power in addition to general function of gathering environment-related information. One of main issues in this environment is to improve energy-efficiency in sensor nodes. In this paper, we devise a new attribute-query processing algorithm. Each sensor has to maintain partial information locally about attributes values gathered at its all descendent nodes. As the volume is higher, however, the maintenance cost also increases. And the update cost also has to be considered in the proposed algorithm. Thus, some bits, AVB(Attribute-Value Bits), are delivered instead of the value itself, where each bit represents a bound of attribute. Thus, the partial information can decrease the number of exchanged messages with a little cost during query processing. Through simulation works, the proposed algorithm is analyzed from several points of view.

An Efficient Knowledge Base Management Using Hybrid SOM (하이브리드 SOM을 이용한 효율적인 지식 베이스 관리)

  • Yoon, Kyung-Bae;Choi, Jun-Hyeog;Wang, Chang-Jong
    • The KIPS Transactions:PartB
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    • v.9B no.5
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    • pp.635-642
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    • 2002
  • There is a rapidly growing demand for the intellectualization of information technology. Especially, in the area of KDD (Knowledge Discovery in Database) which should make an optimal decision of finding knowledge from a large amount of data, the demand is enormous. A large volume of Knowledge Base should be efficiently managed for a more intellectual choice. This study is proposing a Hybrid SOM for an efficient search and renewal of knowledge base, which combines a self-study nerve network, Self-Organization Map with a probable distribution theory in order to get knowledge needed for decision-making management from the Knowledge Base. The efficient knowledge base management through this proposed method is carried out by a stimulation test. This test confirmed that the proposed Hybrid SOM can manage with efficiency Knowledge Base.

Laboratory Performance Evaluation of Alternative Dowel Bar for Jointed Concrete Pavements (콘크리트 포장용 고내구성 대체 다웰바의 실내공용성 평가)

  • Park, Seong Tae;Park, Jun Young;Lee, Jae Hoon;Kim, Hyung Bae
    • International Journal of Highway Engineering
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    • v.15 no.1
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    • pp.23-36
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    • 2013
  • PURPOSES: The problem under this circumstance is that the erosion not only drops strength of the steel dowel bar but also comes with volume expansion of the steel dowel bar which can reduce load transferring efficiency of the steel dowel bar. To avoid this erosion problem, alternative dowers bars are developed. METHODS: In this study, the bearing stresses between the FRP tube dowel bar and concrete slab are calculated and compared with its allowable bearing stress to check its structural stability in the concrete pavement. These comparisons are conducted with several cross-sections of FRP tube dowel bars. Comprehensive laboratory tests including the shear load-deflection test on a full-scale specimen and the full-scale accelerated joint concrete pavement test are conducted and the results were compared with those from the steel dowel bar. RESULTS: In all cross-sections of FRP tube dowel bars, computed bearing stresses between the FRP tube dowel bar and concrete slab are less than their allowable stress levels. The pultrusion FRP-tube dowel bar show better performance on direct shear tests on full-scale specimen and static compression tests at full-scale concrete pavement joints than prepreg and filament-winding FRP-tube dowel bar. CONCLUSIONS: The FRP tube dowel bars as alternative dowel bar are invulnerable to erosion that may be caused by moisture from masonry joint or bottom of the pavement system. Also, the pultrusion FRP-tube dowel bar performed very well on the laboratory evaluation.

A New Circulation Method for Electrokinetic Remediation of Soil Contaminated with Lead (새로운 순환방식을 적용한 동전기 정화기술에 의한 오염토양내의 납제거)

  • 이현호;백기태;양지원
    • Journal of Soil and Groundwater Environment
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    • v.8 no.1
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    • pp.9-16
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    • 2003
  • A new method has been proposed and developed that solves the problem of decreasing electroosmotic flow rate by excess $H^{+}$ and precipitation of heavy metal by $OH^{-}$. An electrolytic solution was circulated between the anode and cathode compartments that enabled the pH at the anode and cathode to be controlled. The change of the soil pH by circulation systems affects the operation time, by lowering the rate of increase of the electric potential gradient, and the removal efficiency of heavy metals, by affecting the soil pH. Since there was no effluent from the cathode compartment in circulation system, there was no need to treat the wastewater after the experiment, which resulted in the reduction of influent electrolyte volume.

Effects of Friction Plate Area and Clearance on the Drag Torque in a Wet Clutch for an Automatic Transmission (클러치 드래그 토크에 미치는 마찰재 면적 및 클리어런스의 영향)

  • Ryu, Jin Seok;Sung, In-Ha
    • Tribology and Lubricants
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    • v.30 no.6
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    • pp.337-342
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    • 2014
  • The reduction of drag torque is an important research issue in terms of improving transmission efficiency. Drag torque in a wet clutch occurs because of the viscous drag generated by the transmission fluid in a narrow gap (clearance) between the friction plate and a separate plate. The objective of this paper is to observe the effects of the friction plate area and the clearance on the drag torque using finite element simulation. The two-phase flow of air and oil fluid is considered and modeled for the simulation. The simulation analysis reveals that as the rotational speed increases, the drag torque generally increases to a critical point and then decreases sharply at a high speed regime. The clearance between the two plates plays an important role in controlling drag torque peak. An increase in the clearance causes a decrease in shear stress; thus, the drag torque also decreases according to Newton's law of viscosity. An observation of the effect of the area of contact between transmission fluid and friction plate shows that the drag torque increases with the contact area. The flow vectors inside the flow channel present clear evidence that the velocity of the fluid flows is faster with a larger friction plate, that is, in the case of a larger contact area. Therefore, the optimum size of the friction plate should be determined carefully, considering both the clutch performance and drag reduction. It is expected that the results from this study can be very useful as a database for clutch design and to predict the drag torque for the initial design with respect to various clutch parameters.