• 한국식품영양과학회지
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• 제14권1호
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• pp.33-38
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• 1985

지질(脂質)의 항산화제(抗酸化制)인 vitamin E와 selenium이 백서(白鼠)의 혈청(血淸) 및 간(肝)의 지질성분(脂質成分)에 미치는 영향(影響)을 조사(調査)하고 이를 서로 비교(比較)하기 위하여 본(本) 실험(實驗)에서는 vitamin E와 selenium이 결핍(缺乏)한 기본식이(基本食餌)에 dl-${\alpha}$-tocopheryl acetate 200 mg 과 sodium selenite 0.5 ppm 을 rkr(各) 군(群)에 따라 급여(給與)하고 6주간(週間) 사육(飼育)한 후(後) 백서(白鼠)의 체중증가량(體重增加量), 사료효율(飼料效率), 각종(各種) 장기(臟器) 중량(重量), 혈청(血淸) 및 간(肝)의 지질성분(脂質成分)을 측정(測定), 고안(考案)한 결과(結果) 다음과 같았다. 1. 체중증가량(體重增加量)과 사료효율(飼料效率)은 vitamin E나 selenium을 공급(供給)한 군(群)이 결핍(缺乏)한 군(群)보다 높았고 함께 공급(供給)한 군(群)이 가장 높았다. 2. 각종(各種) 장기(臟器)의 중량(重量)에서 신장(腎臟), 심장(心臟), 폐장(肺臟)은 실험군간(實驗群間)에 별다른 차이(差異)가 없었고 간장(肝臟)의 중량(重量)은 vitamin E나 selenium을 공급(供給)함에 따라 감소(減少)하였고 간장(肝臟)의 중량(重量)은 vitamin E의 공급(供給)에 의해 유의(有意)하게 감소(減少)하였다. 3. 혈청(血淸)중의 total lipid량(量)은 유의성(有意性)이 없으며 vitamin E의 공급(供給)에 의해 cholesterol량(量)은 감소(減少)하였고 triglyceride와 free fatty acid의 함량(含量)은 증가(增加)하였으나 selenium의 공급(供給)은 아무런 변화(變化)가 없었다. 4. 간장(肝臟)중의 crude lipid, cholesterol, triglyceride 및 free fatty acide의 함량(含量)은 vitamin E나 selenium의 공급(供給)에 으ㅢ해 유의(有意)하게 감소(減少)하였다. 5. 간장(肝臟)중의 지방산(脂肪酸) 조성(組成)은 포화지방산(飽和脂肪酸)과 oleic acid의 경우 유의성(有意性)이 없었고 oleic acid은 대체로 높은 비율(比率)이었으며 linoleic acid은 selenium공급(供給)에 의해, arachidonic acid은 vitamin E나 selenium의 공급(供給)에 의해 유의(有意)하게 감소(減少)하였다.

• 한국수정란이식학회지
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• 제22권2호
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• pp.127-135
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• 2007

본 연구에서 Holstein 유우 78두로부터 분만 후 9주까지 1주 간격으로 혈액과 우유를 채취하여 cholesterol, glucose, 광물질(selenium, Ca, p), vitamin E 및 혈장내 progesterone을 분석하여, 이들 성분의 변화와 성분간의 상관 관계 및 변화 요인에 관하여 조사하였으며, 결과는 다음과 같다. 1. 분만 후 9주까지의 각 성분별 평균 수준은 혈액에서 cholesterol, glucose, selenium, Ca, P, vitamin E 및 BUN이 각각 78.8 mg/dl, 62.3 mg/dl, 8.9mg/dl, 7.4 mg/dl, 52.2 ng/ml, $10.3{\mu}g/l$ 및 16.3 mg/dl이었으며, MSe와 MUN은 15.3 ng/ml과 15.8 mg/dl이었다. 2. 혈액내 cholesterol, glucose, selenium, Vitamin E 및 MSe는 분만 후 시일 경과에 따라 증가되었다. 3. 성분간의 유의적 상관관계를 보면 cholesterol은 P와 부(-), selenium과 U과는 정(+)의 상관이 었고, glucose는 P, MSe와 정(+), P는 selenium 와 부(-) 상관이었으며 그리고 BUN과 MUN은 정(+) 상관을 나타내었다. 4. 성분 변화의 요인으로서 유우 나이는 glucose와 selenium, 산차는 selenium과 vitamin E, 유량은 glucose와 MSe 수준에 차이가 나타났으며 청초와 건초 급여간에는 혈액내 Ca와 selenium를 제외 한 성분에서 차이를 보였다. 요소태 질소에서는 MUN에서만 나이와 산차간에 차이가 있었다. 이상의 결과로 분만 후 급여 사료에 따라 혈액 및 우유의 성분에 차이를 보이며, 특히 혈액 및 우유내의 selenium은 분만 후 젖소에는 중요한 요소임을 확인할 수 있었다.

• Asian-Australasian Journal of Animal Sciences
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• 제10권3호
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• pp.308-312
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• 1997

Incidence of retained placenta in dairy cows was investigated in 120 parturitions. Prior to calving, cows were allotted into four groups; 1) control, 2) the infection of Vitamin E (500 IU), 3) the injection of selenium (40 mg), and 4) the infection of Vitamin E (500 IU) and selenium (40 mg). Selenium (Se) and Vitamin E were injected intramusculary 20 d prior to the estimated calving date. No effects of Se or Vitamin E administration alone was observed for number of service per conception, conception rate, and estrus rate (p > 0.05). But the Vitamin E administration with Se significantly (p < 0.05) reduced the incidence of retained placenta and the days required for calving the first service. Incidence of retained placenta was not significantly (p > 0.05) influenced by parity, but it was significantly (p < 0.01) influenced by season, especially, increased during July and August. Concentration of Se in plasma was not significantly (p > 0.05) changed during peripartum period whether the treatment. The results of this study on retained placenta suggest that this disorder will be reduced by the administration of Se and Vitamin E prior to calving in dairy cows.

• Toxicological Research
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• 제32권4호
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• pp.301-309
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• 2016

Due to undesirable hazardous interactions with biological systems, this investigation was undertaken to evaluate the effect of chronic exposure to silver on certain biochemical and some oxidative stress parameters with histopathological examination of brain, as well as the possible protective role of selenium and/or vitamin E as nutritional supplements. Thirty six male rats were divided into six groups of six each: the first group used as a control group. Group II given both vitamin E (400 mg/kg) of diet and selenium (Se) (1 mg/L) in their drinking water. Group III given silver as silver nitrate ($AgNO_3$) (20 mg/L). Group IV given vitamin E and $AgNO_3$. Group V given both $AgNO_3$ and selenium. Group VI given $AgNO_3$, vitamin E and Se. The animals were in the same exposure conditions for 3 months. According to the results which have been obtained; there was an increase in serum lactate dehydrogenase (LDH), lipase activities and cholesterol level, a decrease in serum total protein, calcium and alkaline phosphatase (ALP) activity in Ag-intoxicated rats. Moreover, the findings showed that $Ag^+$ ions affected antioxidant defense system by decreasing superoxide dismutase (SOD) activity and increasing vitamin E concentration with a high level of malondialdehyde (MDA) in brain tissue. The histological examination also exhibited some nervous tissue alterations including hemorrhage and cytoplasm vacuolization. However, the co-administration of selenium and/or vitamin E ameliorated the biochemical parameters and restored the histological alterations. In conclusion, this study indicated that silver could cause harmful effects in animal body and these effects can be more toxic in high concentrations or prolonged time exposure to this metal. However, selenium and vitamin E act as powerful antioxidants which may exercise adverse effect against the toxicity of this metal.

• Asian-Australasian Journal of Animal Sciences
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• 제1권1호
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• pp.13-19
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• 1988

Effect of vitamin E and selenium supplementation on immunity was studied in newborn Jersey and buffalo calves. The supplement contained 500 mg vitamin E and $200\;{\mu}g$ selenium; and was fed daily from birth to day 30. Differences in weight gain, total leucocytic count, differential leucocytic count, antibody titre and susceptibility to disease were found to be nonsignificant between supplemented and control calves during the study period of 3 months. Vitamin E seemed to enhance the recovery from disease in buffalo calves. Buffalo calves were found to be more sensitive to selenium toxicity than Jersey calves.

• Journal of Nutrition and Health
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• 제29권1호
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• pp.22-31
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• 1996

The purpose of this study was to investigate the effect of vitamin E and selenium on the antioxidative defense mechanism in the liver of streptozotocin(STZ)-induced diabetic rats. Sprague-Dawley male rats(120$\pm$10gm) were randomly assigned to one control and five STZ-diabetic groups. Diabetic groups were classified to STZ-0E (vitamin E free diet), STZ-40E(40mg vitamin E/kg of diet), STZ-400E(400mg vitamin E/kg of diet), STZ-S(0.5ppm Se/kg of diet) and STZ-400ES(400mg vitamin E and 0.5ppm Se/kg of diet) according to the level of vitamin E and selenium supplementation. Diabetes was experimentally induced by intravenous adminstration of 55mg/kg of STZ in citrate buffer(pH 4.3) after 4-weeks feedng of six experimental diets. Animals were sacrificed at the 4th day of diabetic states. Activities of the serum glutamic oxaloacetate transaminase(GOT) and the glutaminc pyruvate transaminase(GPT) in STZ-0E, STZ-40E and STZ-S rats were higher than those of control. Liver xanthine oxidase activities were similar to serum GOT and GPT. Liver superoxide dismutase(SOD) activities were higher in STZ-0E and STZ-40E groups by 33%, 22%, respectively than that of control. Glutathione S-transferase(GST) activities of liver were similar to GSH-Px activities. The contents of vitamin E in liver tissue were significantly lower STZ-0E, STZ-40E and STZ-S groups by 50%, 36%, 45% than that of control. Reduced glutathione(GSH) contents of liver were lower STZ-0E, STZ-40E, STZ-400E, STZ-S and STZ-400ES groups by 57%, 51%, 19%, 18%, 12% than that of control. Lipid peroxide values (LPO) in liver were higher 5.6, 2.3 and 2.3 times in STZ-0E, STZ-40E and STZ-S group than that of control. The present results indicate that STZ-induced diabetic rats are more sensitive to oxidative stress, leading to the acceleration of lipid peroxidation process, which can be more accelerated by feeding the low level of dietary vitamin E. In the coincident supplementation of high dietary vitamin E and selenium antioxidative enzymes activities and physiolosical antioxidants were increased more than those of the separate supplementation of vitamin E or selenium. Therefore, dietary vitamin E and selenium reduced peroxidative damage of tissue, promoting antioxidative defense mechanism against lipid peroxidation by diabetes.

• 한국가금학회지
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• 제34권2호
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• pp.143-149
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• 2007

비타민 E 150 IU, selenium yeast로 셀레늄 1.2 ppm에 비타민 E를 100, 150, 200 및 300 IU로 복합 첨가하였을 때 육계의 사료 섭취량, 증체량, 사료 요구율, 계육 품질 및 selenium 축적에 미치는 영향을 조사한 결과를 요약하면 다음과 같다. 1. $1{\sim}21$일의 증체량은 대조구와 비타민 E 150 IU 첨가구가 높았으며(P<0.05), 사료 섭취량은 비타민 E 150 IU 첨가구가 유기태 셀레늄 1.2 ppm에 비타민 E 150 IU와 200 IU를 복합 첨가한 구에 비하여 증가하였다(P<0.05). $21{\sim}35$일의 사료 섭취량은 대조구가 유기태 셀레늄 1.2 ppm에 비타민 E 200 IU를 복합 첨가한 구에 비하여 증가하였다(P<0.05). 그러나 시험 전기간의 사료 요구율은 대조구를 포함한 모든 처리구에서 차이가 없었다. 2. 가슴 근육의 셀레늄 함량은 대조구와 비타민 E 150 IU 첨가구에 비하여 유기태 셀레늄과 비타민 E를 복합 첨가함으로서 유의적으로 높게 나타났으며(P<0.05), 간조직의 셀레늄 함량 역시 대조구와 비타민 E 150 IU 첨가구에 비하여 유기태 셀레늄과 비타민 E를 복합 첨가함으로서 높게 나타났다(P<0.05). 3. 저장 기간별로 TBARS는 대조구와 비타민 E 150 IU 첨가구는 1일보다 3일차가 높게 나타났으나(P<0.05), 셀레늄 1.2 ppm에 비타민 E 100, 150, 200 및 300 IU 복합 첨가구는 1일과 3일간에서 차이가 없었으며, 3일차에는 대조구보다 비타민 E와 셀레늄 복합 첨가구가 낮게 나타났다(P<0.05). 이상의 결과를 종합하면, 육계 사료에 유기태 셀레늄 1.2 ppm에 비타민 E를 100, 150, 200 및 300 IU를 복합 첨가시 생산성에는 차이가 없으나 계육 내 selenium 함량과 저장성은 향상되었다.

• Asian-Australasian Journal of Animal Sciences
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• 제17권7호
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• pp.1000-1006
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• 2004

Selenium and vitamin E are micronutrients essential for normal health and maintenance in poultry. They are necessary in preventing free radical damage to phospholipid membranes, enzymes and other important molecules. Two experiments were conducted in a semi-commercial environment to examine the effect of Se source and vitamin E level in diet on broiler performance and meat quality. Increasing vitamin E from 50 IU to 100 IU did not affect growth performance of broilers although the 24 h drip-loss was tended to be reduced (p=0.06). There was an interaction between vitamin E and the source of Se in glutathione peroxidase activity (GSH-Px) and Se concentration in excreta. Increasing vitamin E from 50 IU to 100 IU elevated GSH-Px and Se concentration in excreta by 42 IU/g Hb and 0.9 ppm for the organic Se group, respectively, but reduced GSH-Px and Se concentration in excreta by 16 IU/g Hb and 1.3 ppm for inorganic group, respectively. Vitamin E played no role in the feather coverage of the birds when scored on day 37. Organic Se is more effective in improving feather score and 24 h drip-loss, with a markedly higher deposition rate in breast muscle and a lower excretion rate in the excreta (p<0.05) compared to the inorganic Se source. Both vitamin E and the source of Se did not affect (p>0.05) the energy utilisation by birds.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2619-2627
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• 2015

There are several studies that relate oxidative damage as possible mechanism for many cancers. Many studies have also shown that anti-oxidants like selenium and vitamin E decrease the risk for prostate cancer. The main objective of the Selenium and Vitamin E Cancer Prevention Trial (SELECT) study was to look for the benefits of selenium and vitamin E supplementation on prostate cancer. The study had a large sample size, stringent experimental conditions, very long duration, standardized laboratories for biochemical analyses and other factors that contribute to high external validity. The SELECT study failed to show any significant risk reduction for prostate cancers ascribable to selenium and vitamin E supplementations. Because of these conflicting results, many researchers argue about the methods used, supplementations administered (selenium and vitamin E) and indicators used for assessing levels of supplementations. We reviewed many epidemiological studies, clinical trials, and pre-clinical studies. With corroborative evidences we justify that SELECT study has a sound methodology and rationale. In lieu of the contrary results of the select study, researchers should focus on the probable mechanisms for these contrary findings and continue their search for newer and effective agents for prevention of prostate cancer.

• 한국축산식품학회지
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• 제22권2호
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• pp.108-114
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• 2002

Vitamin E와 selenium의 급여가 거세한우육의 진열저장중 (5$^{\circ}C$, 1,200 lux) 육색안정성에 미치는 영향을 조사하였다. 실험처리구는 대조구(Vit E 27 IU/head/day, Se 0.09 mg/head/day), Vitamin E 급여구(2,500 IU/head/day), Selenium 급여구(20 mg/head/day), Vitamin E와 Selenium 복합 급여구 (Vit E 2,500 IU/head/day, Se 20 mg/head/day)로 나누어 실험하였다. CIE a*값, chroma값, oxymyoglobin함량(%) 및 R630-R580간은 모든 처리구에서 저장기간이 길어질수록 유의적으로 감소하는 경향을 나타내었으며(p<0.05), 특히 대조구가 저장기간이 길어질수록 현저한 감소현상을 보였다. Metmyoglobin(%)의 함량은 저장 전(0일)에는 처리구간에 유의적인 차이를 나타내지 않았으나(p>0.05) 저장기간이 경과 함으로써 대조구의 metmyoglobin 형성율이 현저하게 증가하여 다른 처리구에 비해 변색이 가속화됨을 알 수 있었다. 지질의 산패 정도를 나타내는 TBARS는 Se구와 Vit E+Se구가 대조구와 Vit E구보다 유의적으로 낮은 값을 나타내었다. 환원력은 저장 전에는 대조구가 유의적으로 낮게 나타났으며 3일 저장시 대조구가 다른 처리구에 비해 현저히 낮아짐을 알 수 있었다. 결과적으로 selenium 급여구들(Se구, Vit E+Se 구)의 경우 대조구와 vitamin E급여구에 비해 지질산화에 대해 안정성을 가졌으며, 육색이나 육색소에 있어서는 Vit E구, Se구, Vit E+Se구가 대조구보다 저장안정성을 보였으나 이 3가지 처리구간에는 유의적인 차이가 나타나지 않았다.