• Journal of The Korean Association For Science Education
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• v.19 no.1
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• pp.29-40
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• 1999

The purpose of the present study was to test hypothesis that, because it uses tri-dimensional sensory pathway which have been showed a higher rate of neural activities than uni- or bi-dimensional's, lab-activity-based instruction is more effective teaching strategy in learning science than verbal-based instruction. In the present study, manipulative teaching strategy that uses visual, somatosensory and auditory information pathway was regarded as a mode of tri-dimensional sensory inputs. In addition, verbal teaching strategy that uses mainly auditory and a little visual information pathway was used as a mode of bi-dimensional sensory inputs. Fifty-six students who failed to successfully solve two proportional reasoning tasks (i.e., pouring water tasks) were sampled for this research from a junior high school. The subjects were randomly divided into a manipulative or a verbal teaching group, and given manipulative or verbal tutoring on the use of proportional reasoning strategies and a test of proportional reasoning during instruction. The results showed that manipulative group's performance on the test of proportional reasoning during instruction showed significantly higher performance than verbal group's (t=2.45, p<0.02). The present study also discussed some educational implications of the results.

• Journal of The Korean Society of Integrative Medicine
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• v.7 no.4
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• pp.131-140
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• 2019

Purpose : The purpose of this study was to investigate the interrelationship between eye movement and auditory function through the effects of eye lateralization on transient evoked otoacoustic emissions of auditory function. Methods : 25 subjects with complete set of ears were used in this study, which composed of 12 males and 13 females with pure tone threshold of below 25 dB without otolaryngology were evaluated. Each of the patient has a visual acuity of greater than 1.0 after correction, and has no problems with eye disease, eye movement, and human parallel system. In a dark silent room, the subjects sat on a chair with their heads fixed on a headrest. The tests were performed by asking the patients to look at a fixed red light dot on a light bar in front of them. This light was directed to the front, right and left sides of the subject at an angle of 40 ° In the presence of the stimulus sound in the ipsilateral ear, the transient evoked otoacoustic emissions of the ipsilateral ear was measured at the straight, right and left fixation. In order to evaluate the transient evoked otoacoustic emissions through the efferent auditory pathway, the transient evoked otoacoustic emission values of the contralateral ear were measured at the straight, right and left fixation. These measurements were taken at frequencies of 1 kHz, 1.4 kHz, 2.0 kHz, 2.8 kHz and 4 kHz, respectively. Results : Transient evoked otoacoustic emissions caused by lateral movement of the eye showed significant changes at 1.4 KHz and 2 KHz of the afferent pathway of the ipsilateral ear. Also, significant changes were observed at 1.4 KHz and 4 KHz of the efferent pathway of the contralateral ear. Conclusion : These results indicated that there is a close relationship between eye movement and auditory cochlea. In the future, further studies considering more diverse subjects and age groups will be needed.

• Food Science of Animal Resources
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• v.43 no.5
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• pp.859-876
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• 2023

It is known that animal-origin medicine could be one of effective treatment to remedy atopic dermatitis (AD) by controlling the cytokines. Cicadidae Periostracum (CP), the slough of Cryptotympana pustulata, has been frequently used for treating AD and skin affliction in traditional Korean Medicine. This study is aimed at investigating the ameliorating effects of CP on AD and its potential mechanism. The dinitrochlorobenzene sensitized mice were treated with CP for 2 weeks. The various biomarkers and the dermatitis scores presented that CP treatment can induce the visual and biological improvements of AD model. Pruritus, the most serious symptom of AD, which can cause repeated scratching behaviors and finally lead to lichenification, was reduced with CP treatment by regulating the inflammatory reactions. In addition, CP treatment diminished the number of mast cells that are known for causing inflammatory reactions. Moreover, it is proven that CP can decline secretion of interleukin-22, which means CP treatment has anti-inflammatory effects. CP treatment can correct the imbalance of helper T (Th)1 and Th2, downregulating thymic stromal lymphopoietin that leads to decrease of mRNA level of inflammatory cytokines. The crucial role of CP treatment is controlling of the Janus kinase 1/signal transducer and activator of transcription 3 pathway. In addition, CP treatment has the inhibitory effects on kallikrein related peptidase (KLK) 5 and KLK7. Taken together, CP treatment can ameliorate most symptoms and problems caused by AD disease, improving the AD patients' life quality.

• Progress in Medical Physics
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• v.18 no.1
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• pp.42-47
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• 2007

Purpose: To evaluate the tracing of optic nerve tract using manganese enhanced magnetic resonance Imaging. Materials and Methods: After injecting $30{\mu}l$ of $MnCl_2(1mol)$ (1 mol) Into the retina of female New Zealand white rabbit, the contrast enhancements at major anatomical structures of optic nerve tract were evaluated by high resolution T1-weighted Images 12 hours, 24 hours, and 48 hours after $MnCl_2(1mol)$ Injection using 3D FSPGR (Fast Speiled Gradient Recalled echo) pulse sequence at 1.5T clinical MR scanner with high performance gradient system. Also, for quantitative evaluation, the signal-to-noise ratios of circular ROI on anatomical locations were measured. Results: The major structures on the optic nerve tract were enhanced after injecting $MnCl_2(1mol)$. The structures, which showed enhancement, were right optic nerve, optic chiasm, left optic tract, left lateral geniculate nucleus, left superior colliculus. The structures on the contralateral optic pathway to the right retina were enhanced whereas the structures on the ipsilateral pathway did not show enhancement. Conclusion: The Mn transport through axonal pathway of optic nerve sys)em was non- invasively observed after injecting injecting $MnCl_2$ at the retina, which is the end terminal of optic nerve system. This Mn transport seems to occur by voltage gated calcium $(Ca^{2+})$ channel and In case of direct Injection Into the retina, the fast transpori pathway of voltage gated calcium channel seems to be responsible for Mn transport.

• Clinical and Experimental Pediatrics
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• v.64 no.10
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• pp.497-503
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• 2021

Reading disability (dyslexia) refers to an unexpected difficulty with reading for an individual who has the intelligence to be a much better reader. Dyslexia is most commonly caused by a difficulty in phonological processing (the appreciation of the individual sounds of spoken language), which affects the ability of an individual to speak, read, and spell. In this paper, I describe reading disabilities by focusing on their underlying neurobiological mechanisms. Neurobiological studies using functional brain imaging have uncovered the reading pathways, brain regions involved in reading, and neurobiological abnormalities of dyslexia. The reading pathway is in the order of visual analysis, letter recognition, word recognition, meaning (semantics), phonological processing, and speech production. According to functional neuroimaging studies, the important areas of the brain related to reading include the inferior frontal cortex (Broca's area), the midtemporal lobe region, the inferior parieto-temporal area, and the left occipitotemporal region (visual word form area). Interventions for dyslexia can affect reading ability by causing changes in brain function and structure. An accurate diagnosis and timely specialized intervention are important in children with dyslexia. In cases in which national infant development screening tests have been conducted, as in Korea, if language developmental delay and early predictors of dyslexia are detected, careful observation of the progression to dyslexia and early intervention should be made.

• Science of Emotion and Sensibility
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• v.23 no.3
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• pp.47-62
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• 2020

The snake detection theory posits that, due to competition with snakes, the primate visual system has been evolved to detect camouflaged snakes. Specifically, one of its hypotheses states that the subcortical visual pathway mainly consisting of koniocellular cells enables humans to automatically detect the threat of snakes without consuming mental resources. Here we tested the hypothesis by comparing human participants' responses to snakes with those to fearful faces and flowers. Participants viewed either original images or converted ones, which lacked the differences in color, luminance, contrast, and spatial frequency energies between categories. While participants in Experiment 1 produced valence and arousal ratings to each image, those in Experiment 2 detected target images in the breaking continuous flash suppression (bCFS) paradigm. As a result, visual factors influenced the responses to snakes most strongly. After minimizing visual differences, snakes were rated as being less negative and less arousing, and detected more slowly from suppression. In contrast, the images of the other categories were less affected by image conversion. In particular, fearful faces were rated as greater threats and detected more quickly than other categories. In addition, for snakes, changes in arousal ratings and those in bCFS response times were negatively correlated: Those snake images, the arousal ratings of which decreased, produced increased detection latency. These findings suggest that the influence of snakes on human responses to threat is limited relative to fearful faces, and that detection responses in bCFS share common processing mechanisms with conscious ratings. In conclusion, the current study calls into question the assumption that snake detection in humans is a product of unconscious subcortical visual processing.

• Proceedings of the KOSOMBE Conference
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• v.1994 no.05
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• pp.65-68
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• 1994

시각자극에 의해 머리표면에서 발생하는 Transient Evoked Potential을 검출하여 Source Tracing Method를 이용하여 뇌의 시각인지영역을 추정하였다. 본 과정에서 TEP검출방식은 average method를 이용하였고, 신경흥분에 대한 물리적 모델로 Single Current Dipole Model을 이용하고, 머리기하에 대한 3중구각모델을 이용하여 Forward Problem을 풀었다. Inverse Problem은 current dipole의 6개의 parameter에 대한 Least Square Error Method를 이용하여 신경흥분의 위치를 추정하였다. 이러한 결과와 생리학적으로 밝혀진 시각경로와의 비교결과 유사성이 확인되었다.

• Journal of The Korean Radiological Technologist Association
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• v.30 no.1
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• pp.95-101
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• 2004

Purpose : In this study, we demonstrates technical approach to high resolution T1-weighted 3D gradient-echo (256$\ast$128$\ast$125 ${\mu}mm^3$) of neuroaxonal structure of the rabbit brain in vivo by injecting $Mn^{2+

• Biomolecules & Therapeutics
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• v.12 no.3
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• pp.185-188
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• 2004

The purpose of this study is to evaluate the effect of cigarette smoke condensate (CSC) on toxification/detoxification metabolic pathway in primary cultured rat hepatocytes. We measured the activities of cytochrome P450 monooxygenases (CYP450s) and UDP-glucuronyltransferase, sulfotransferase and glutathione-S-transferase in CSC-treated rat hepatocytes. CSC significantly increased the activities of hepatic CYP4501A1 and CYP4501A2 to 7.5 fold and 1.6 fold respectively, compared with control level. However, CSC did not affect the activities of conjugation enzymes. We a1so examined if treatment of CSC could change thc cytotoxicity of acetaminophen (AA) through modulation of metabolizing enzymes. In rat hepatocytes, pretreatment with CSC potentiated the cytotoxicity of AA. This result indicates that potentiation of AA toxicity by CSC pretreatment may be related to induction of CYP4501A1 and CYP4501A2.

• Korean Journal of Child Studies
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• v.30 no.3
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• pp.55-69
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• 2009

The purpose of this study was to describe preschoolers' perceptions of fear from their own perspective. Qualitative data from 213 preschoolers 4 to 6 years of age were obtained by semi-structured interviews. The fear inventory was analyzed by content analysis and frequency. The most common fears of preschoolers in this study were fear of ferocious animals and imaginary figures, such as tigers, lions, snakes, spirits and ghosts. Fear of ghosts was the primary fear of both boys and girls. Results showed that most fears were caused by disgust-related visual images. Worry about injury and pain was another common pathway to fear. At-risk preschoolers scored significantly higher than normal preschoolers on fears of criticism and getting an injection.