DOI QR코드

DOI QR Code

Recent update on reading disability (dyslexia) focused on neurobiology

  • Kim, Sung Koo (Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine)
  • Received : 2020.09.09
  • Accepted : 2021.01.21
  • Published : 2021.10.15

Abstract

Reading disability (dyslexia) refers to an unexpected difficulty with reading for an individual who has the intelligence to be a much better reader. Dyslexia is most commonly caused by a difficulty in phonological processing (the appreciation of the individual sounds of spoken language), which affects the ability of an individual to speak, read, and spell. In this paper, I describe reading disabilities by focusing on their underlying neurobiological mechanisms. Neurobiological studies using functional brain imaging have uncovered the reading pathways, brain regions involved in reading, and neurobiological abnormalities of dyslexia. The reading pathway is in the order of visual analysis, letter recognition, word recognition, meaning (semantics), phonological processing, and speech production. According to functional neuroimaging studies, the important areas of the brain related to reading include the inferior frontal cortex (Broca's area), the midtemporal lobe region, the inferior parieto-temporal area, and the left occipitotemporal region (visual word form area). Interventions for dyslexia can affect reading ability by causing changes in brain function and structure. An accurate diagnosis and timely specialized intervention are important in children with dyslexia. In cases in which national infant development screening tests have been conducted, as in Korea, if language developmental delay and early predictors of dyslexia are detected, careful observation of the progression to dyslexia and early intervention should be made.

Keywords

References

  1. Yell ML, Shriner JG, Katsiyannis A. Individuals with disabilities education improvement act of 2004 and IDEA regulations of 2006: implications for educators, administrators, and teacher trainers. Focus Except Child 2006;39:1-24.
  2. American Psychiatric Association. Neurodevelopmental disorders: DSM5® selections. Washington, DC: American Psychiatric Pub, 2015.
  3. Rehnberg V, Walters E. The life and work of Adolph Kussmaul 1822-1902: 'Sword swallowers in modern medicine'. J Intensive Care Soc 2017;18:71-2. https://doi.org/10.1177/1751143716676822
  4. Wagner RF. 5. Rudolf Berlin: originator of the term dyslexia. Bull Orton Soc 1973;23:57-63. https://doi.org/10.1007/BF02653841
  5. Kliegman RM, Stanton BF, St. Geme JW III, Schor NF, Behrman RE, editors. Nelson textbook of pediatrics. 21st ed. Philadelphia (PA): Elsevier, 2020.
  6. LaBuda MC, DeFries JC. Cognitive abilities in children with reading disabilities and controls: a follow-up study. J Learn Disabil 1988;21:5626.
  7. Schumacher J, Hoffmann P, Schmal C, Schulte-Korne G, Nothen MM. Genetics of dyslexia: the evolving landscape. J Med Genet 2007;44:28997.
  8. Shaywitz BA, Shaywitz SE, Pugh KR, Mencl WE, Fulbright RK, Skudlarski P, et al. Disruption of posterior brain systems for reading in children with developmental dyslexia. Biol Psychiatry 2002;52:101-10. https://doi.org/10.1016/S0006-3223(02)01365-3
  9. Shaywitz SE. Overcoming dyslexia: a new and complete science-based program for reading problems at any level. New York: Alfred A. Knopf, 2003.
  10. Fiez JA, Tranel D, Seager-Frerichs D, Damasio H. Specific reading and phonological processing deficits are associated with damage to the left frontal operculum. Cortex 2006;42:624-43. https://doi.org/10.1016/S0010-9452(08)70399-X
  11. Fiebach CJ, Friederici AD, Muller K, von Cramon DY. fMRI evidence for dual routes to the mental lexicon in visual word recognition. J Cogn Neurosci 2002;14:11-23. https://doi.org/10.1162/089892902317205285
  12. Jobard G, Crivello F, Tzourio-Mazoyer N. Evaluation of the dual route theory of reading: a metanalysis of 35 neuroimaging studies. NeuroImage 2003;20:693-712. https://doi.org/10.1016/S1053-8119(03)00343-4
  13. Heim S, Eickhoff SB, Amunts K. Different roles of cytoarchitectonic BA 44 and BA 45 in phonological and semantic verbal fluency as revealed by dynamic causal modelling. NeuroImage 2009;48:616-24. https://doi.org/10.1016/j.neuroimage.2009.06.044
  14. Paulesu E, Frith CD, Frackowiak RS. The neural correlates of the verbal component of working memory. Nature 1993;362:342-5. https://doi.org/10.1038/362342a0
  15. Binder JR, Desai RH. The neurobiology of semantic memory. Trends Cogn Sci 2011;15:527-36. https://doi.org/10.1016/j.tics.2011.10.001
  16. Costanzo F, Menghini D, Caltagirone C, Oliveri M, Vicari S. High frequency rTMS over the left parietal lobule increases non-word reading accuracy. Neuropsychologia 2012;50:2645-51. https://doi.org/10.1016/j.neuropsychologia.2012.07.017
  17. Sliwinska MW, Khadilkar M, Campbell-Ratcliffe J, Quevenco F, Devlin JT. Early and sustained supramarginal gyrus contributions to phonological processing. Front Psychol 2012;3:161. https://doi.org/10.3389/fpsyg.2012.00161
  18. Mechelli A, Josephs O, Lambon Ralph MA, McClelland JL, Price CJ. Dissociating stimulus-driven semantic and phonological effect during reading and naming. Hum Brain Mapp 2007;28:205-17. https://doi.org/10.1002/hbm.20272
  19. Wilson SM, Brambati SM, Henry RG, Handwerker DA, Agosta F, Miller BL, et al. The neural basis of surface dyslexia in semantic dementia. Brain 2009;132:71-86. https://doi.org/10.1093/brain/awn300
  20. McCandliss BD, Cohen L, Dehaene S. The visual word form area: Expertise for reading in the fusiform gyrus. Trends Cogn Sci 2003;7:2939.
  21. Dehaene S, Cohen L. The unique role of the visual word form area in reading. Trends Cogn Sci 2011;15:254-62. https://doi.org/10.1016/j.tics.2011.04.003
  22. Peterson RL, Pennington BF. Developmental dyslexia. Lancet 2012;379:1997-2007. https://doi.org/10.1016/S0140-6736(12)60198-6
  23. Lindgren S, De Renzi E, Richman L. Cross-national comparisons of developmental dyslexia in Italy and the United States. Child Dev 1985;56:1404-17. https://doi.org/10.1111/j.1467-8624.1985.tb00206.x
  24. Shaywitz SE, Shaywitz BA, Fletcher JM, Escobar MD. Prevalence of reading disability in boys and girls. Results of the Connecticut longitudinal study. JAMA 1990;264:998-1002. https://doi.org/10.1001/jama.1990.03450080084036
  25. Hulme C, Snowling MJ. Children's reading comprehension difficulties: nature, causes, and treatments. Curr Dir Psychol Sci 2011;20:139-42. https://doi.org/10.1177/0963721411408673
  26. Wilcke A, Muller B, Schaadt G, Kirsten H, Boltze J, Members of the Legascreen Consortium. High acceptance of an early dyslexia screening test involving genetic analyses in Germany. Eur J Hum Genet 2016;24:178-82. https://doi.org/10.1038/ejhg.2015.103
  27. Kim AH, Kim EJ, Kim JK, Jung DY. Who are the students with learning disabilities, dyslexia, poor learning (including borderline intelligence) and learning support, and is the educational support okay? Notes on the role and challenges of special education. Korean J Spec Educ 2018;53:1-21
  28. Verpalen A, Van de Vijver F, Backus A. Bias in dyslexia screening in a Dutch multicultural population. Ann Dyslexia 2018;68:43-68. https://doi.org/10.1007/s11881-018-0155-0
  29. Kita Y, Ashizawa F, Inagaki M. Prevalence estimates of neurodevelopmental disorders in Japan: A community sample questionnaire study. Psychiatry Clin Neurosci 2020;74:118-23. https://doi.org/10.1111/pcn.12950
  30. Lin Y, Zhang X, Huang Q, Lv L, Huang A, Li A, et al. The prevalence of dyslexia in primary school children and their Chinese literacy assessment in Shantou, China. Int J Environ Res Public Health 2020;17:7140. https://doi.org/10.3390/ijerph17197140
  31. Shaywitz SE, Shaywitz BA. Dyslexia (specific reading disability). Pediatr Rev 2003;24:147-53. https://doi.org/10.1542/pir.24-5-147
  32. Lyon GR, Shaywitz SE, Shaywitz BA. A definition of dyslexia. Ann Dyslexia 2003;53:1-14. https://doi.org/10.1007/s11881-003-0001-9
  33. Scarborough HS. Early syntactic development of dyslexic children. Ann Dyslexia 1991;41:207-20. https://doi.org/10.1007/BF02648087
  34. McCardle P, Scarborough HS, Catts HW. Predicting, explaining, and preventing children's reading difficulties. Learn Disabil Res Pract 2001;16:230-9. https://doi.org/10.1111/0938-8982.00023
  35. Blackburne LK, Eddy MD, Kalra P, Yee D, Sinha P, Gabrieli JD. Neural correlates of letter reversal in children and adults. PLoS One 2014;9:e98386. https://doi.org/10.1371/journal.pone.0098386
  36. Vellutino FR, Fletcher JM, Snowling MJ, Scanlon DM. Specific reading disability (dyslexia): What have we learned in the past four decades? J Child Psychol Psychiatry 2004;45:2-40. https://doi.org/10.1046/j.0021-9630.2003.00305.x
  37. Shaywitz SE, Gruen JR, Shaywitz BA. Management of dyslexia, its rationale, and underlying neurobiology. Pediatr Clin North Am 2007;54:609-23. https://doi.org/10.1016/j.pcl.2007.02.013
  38. Shaywitz SE, Fletcher JM, Holahan JM, Shneider AE, Marchione KE, Stuebing KK, et al. Persistence of dyslexia: the Connecticut longitudinal study at adolescence. Pediatrics 1999;104:1351-9. https://doi.org/10.1542/peds.104.6.1351
  39. Scarborough HS. Predicting the future achievement of second graders with reading disabilities: Contributions of phonemic awareness, verbal memory, rapid naming, and IQ. Ann Dyslexia 1998;48:115-36. https://doi.org/10.1007/s11881-998-0006-5
  40. Yell ML, Shriner JG. Katsiyannis A. Individuals with disabilities education improvement act of 2004 and IDEA regulations of 2006: Implications for educators, administrators, and teacher trainers. Focus Except Child 2006;39:1-24.
  41. Hendren RL, Haft SL, Black JM, White NC. Hoeft F. Recognizing psychiatric comorbidity with reading disorders. Front Psychiatry 2018;9:101. https://doi.org/10.3389/fpsyt.2018.00101
  42. Torgesen JK, Wagner RK, Rashotte CA, Rose E, Lindamood P, Conway T, et al. Preventing reading failure in young children with phonological processing disabilities: Group and individual responses to instruction. J Educ Psychol 1999;91:579-93. https://doi.org/10.1037/0022-0663.91.4.579
  43. Torgesen JK, Alexander AW, Wagner RK, Rashotte CA, Voeller KK, Conway T. Intensive remedial instruction for children with severe reading disabilities: immediate and long-term outcomes from two instructional approaches. J Learn Disabil 2001;34:33-58. https://doi.org/10.1177/002221940103400104
  44. Siegel LS. Perspectives on dyslexia. Paediatr Child Health 2006;11:581-7. https://doi.org/10.1093/pch/11.9.581
  45. American Academy of Pediatrics. Learning disabilities, dyslexia, and vision. Pediatrics 2009;124:837-44. https://doi.org/10.1542/peds.2009-1445
  46. Germano E, Gagliano A, Curatolo P. Comorbidity of ADHD and dyslexia. Dev Neuropsychol 2010;35:475-93. https://doi.org/10.1080/87565641.2010.494748
  47. Breaux KC, Lichtenberger EO. Essentials of KTEA-3 and WIAT-III Assessment. Hoboken (NJ): John Wiley & Sons, 2016.
  48. Galuschka K, Ise E, Krick K, Schulte-Korne G. Effectiveness of treatment approaches for children and adolescents with reading disabilities: A metaanalysis of randomized controlled trials. PLoS One 2014;9:e89900. https://doi.org/10.1371/journal.pone.0089900
  49. Chard DJ, Vaughn S, Tyler BJ. A synthesis of research on effective interventions for building reading fluency with elementary students with learning disabilities. J Learn Disabil 2002;35:386-406. https://doi.org/10.1177/00222194020350050101
  50. Wolf M. Katzir-Cohen T. Reading fluency and its intervention. Sci Stud Read 2001;5:211-39. https://doi.org/10.1207/S1532799XSSR0503_2
  51. Tressoldi PE, Lorusso ML, Brenbati F, Donini R. Fluency remediation in dyslexic children: Does age make a difference? Dyslexia 2008;14:14252.
  52. Munzer T, Hussain K, Soares N. Dyslexia: neurobiology, clinical features, evaluation and management. Transl Pediatr 2020;9:S36. https://doi.org/10.21037/tp.2019.09.07