• The Korean Journal of Physiology and Pharmacology
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• 제1권3호
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• pp.275-284
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• 1997

Unilateral labyrinthectorny (ULX) causes autonomic symptoms, ocular and postural asymmetries, which disappear over tune in the process of equilibrium recovery known as vestibular compensation. In the present study in order to elucidate mechanisms responsible for the effects of electrical stimulation on vestibular compensation and investigate the relationship between vestibular compensation and c-Fos expression in the medial vestibular nuclei following ULX, we measured spontaneous nystagmus, eye movement induced by sinusoidal rotation and c-Fos expression or to 72 hs after ULX in Sprague-Dawley rats. Experimental animals were divided into two groups: ULX group with ULX only, and electrical stimulation (ES) group with electrical stimulation of $-2{\sim}-5V$, 1.0ms, 100 Hz to the lesioned vestibular system for 4 hs/day. Spontaneous nystagmus following ULX disappeared by 72 hs in ULX group and 36 hs in ES group. In eye movement induced by sinusoidal rotation, normal pattern of eye movement by rotation toward the lesioned side was recovered 24 hs after ULX at rotation of 0.1 Hz and 6 hs after at 0.2 Hz, 0.5 Hz in ULX group. In ES group, the eye movement recovered after 12 hs at 0.1 Hz, 6 hs at 0.2 Hz, and 4 hs at 0.5 Hz. Directional Preponderance which represents the symmetry of bilateral vestibular functions showed significantly early recovery in ES group compared with that of ULX group. Expression or c-Fos immunoreactive cells in the bilateral medial vestibular nuclei was severely asymmetrical till 36 hs in ULX group, and then it became a symmetry and disappeared after 72 hs. However, ES group showed the symmetry of c-Fos expression after 6 hs, which was significantly early recovery in 25 group. All these findings suggest that electrical stimulation ameliorates recovery of vestibuloocular reflex following ULX by the restoration of the balance of the resting activity between bilateral medial vestibular nuclei. In addition, c-Fos expression in the medial vestibular nuclei could be used as a marker of vestibular compensation since c-Fos expression is closely related to the course of recovery following ULX.

• 대한의용생체공학회:의공학회지
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• 제31권3호
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• pp.210-216
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• 2010

This study is vestibular electric stimulation applied between the mastoids during quiet standing elicits postural sway. The aim of this study was to characterize the postural sway response to continuous sinusoidal vestibular electric stimulation across various stimulus frequencies and amplitudes. Binaural bipolar sinusoidal vestibular electric stimulation was applied to the skin overlying the mastoid processes of 10 subjects while they stood on a force plate. The position of the center of pressure(COP) and signals at the feet are obtained on an force plate, while the head and whole body center of mass(COM) was measured with motion analysis system. The stimulus conditions included eight frequencies (1/64, 1/32, 1/16, 1/8, 1/4, 1/2, 1, and 2Hz) and six peak amplitudes (0.1, 0.25, 0.5, 0.7, 1 and 2mA). Each subject experienced one trial at each amplitude-frequency pair. The stimuli elicited sway in lateral plane in all subjects, as evidenced by changes in the stimulus frequency. Our results demonstrate that the vestibular system is sensitive to vestibular electric stimulation intensity changes and responds by altering the magnitude of the response accordingly.

• The Korean Journal of Physiology and Pharmacology
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• 제1권3호
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• pp.263-273
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• 1997

The purpose of this study was to evaluate the effects of electrical stimulation on vestibular compensation following ULX in rats. Electrical stimulation (ES) with square pulse ($100{\sim}300uA$, 1.0 ms, 100 Hz) was applied to ampullary portion bilaterally for 6 and 24 hours in rats receiving ULX. After ES, animals that showed the recovery of vestibular symptoms by counting and comparing the number of spontaneous nystagmus were selected for recording resting activity of type I, II neurons in the medial vestibular nuclei (MVN) of the lesioned side. And then the dynamic neuronal activities were recorded during sinusoidal rotation at a frequency of 0.1 Hz and 0.2 Hz. The number of spontaneous nystagmus was significantly different 24 hours (p<0.01, n=10), but not 6 hours after ULX+ES. As reported by others, the great reduction of resting activity only in the type I neurons ipsilateral to lesioned side was observed 6, 24 hours after ULX compared to that of intact labyrinthine animal. However, the significant elevation (p<0.01) of type I and reduction (p<0.01) of type II neuronal activity were seen 24 hours after ULX+ES. Interestingly, gain, expressed as maximum neuronal activity(spikes/sec)/maximum rotational velocity(deg/sec), was increased in type I cells and decreased in type II cells 24 hours after ULX+ES in response to sinusoidal rotation at frequencies of both 0.1 Hz and 0.2 Hz. This result suggests that accompanying the behavioral recovery, the electrical stimulation after ULX has beneficial effects on vestibular compensation, especially static symptoms (spontaneous nystagmus), by enhancing resting activity of type I neurons and reducing that of type II neurons.

• The Journal of Korean Physical Therapy
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• 제26권5호
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• pp.365-371
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• 2014

Purpose: The aim of this study is to examine the effects of training in vestibular sensory stimulation on balance and gait of stroke patients. Methods: Twenty patients were randomly assigned to either the experimental group (n=10) or the control group (n=10). Patients in the experimental group received rotational stimulation training, vertical-horizontal stimulation training, gait training on a flat surface with vestibular sensory stimulation, and gait training on soft ground with vestibular sensory stimulation. Patients in the control group received general treadmill gait training. The intervention was applied four times per week, 25 minutes each time, for a period of four weeks. We measured Berg Balance Scale (BBS), Biodex Balance System, Timed up to Go (TUG) test and Dynamic Gait Index (DGI) to evaluate balance and gait ability. Results: BBS differed significantly in both groups between before and after the intervention (p<0.05) and changes in BBS after the intervention differed between the two groups (p<0.05). According to the Biodex Balance System test result, only the experimental group showed significant changes in balance in the conditions of static eyes open (SEC), dynamic eyes open (DEO), and dynamic eyes closed (DEC) (p<0.05). TUG test results differed significantly between prior to and after the training in both the experimental group and the control group (p<0.05) and changes in TUG after the intervention differed significantly between the two groups (p<0.05). DGI results showed significant change after the intervention in the experimental group only (P<0.05). Conclusion: Training in vestibular sensory stimulation was effective in improving static-dynamic balance and gait ability of stroke patients.

• 전력전자학회논문지
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• 제7권6호
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• pp.524-530
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• 2002

일상 생활에서 반사적인 자세 조절은 정전기관, 시각, 고유수용체 등의 감수체에 의한 구심성 신호가 정전 신경핵에 전달되어 안구운동이나 골격근의 수축을 유발하여 이루어진다. 자세조절기능의 부조화는 오심, 구토, 현기증 등을 초래하여 삶의 의욕을 상실하게 만든다. 본 연구의 목적은 정전기관의 반규관과 이석기관을 선별적으로 자극하기 위한 탈수직축 회전자극 시스템과 수평, 수직, 3D 환경에서 시각자극을 할 수 있는 시운동자극시스템을 개발하여 인간의 자세조절 기능을 평가 하는데 있다. 탈수직축 회전자극 시스템은 편안한 의자와 DC 서보모터로 구동되는 기울임 테이블로 구성되고 PMSM에 의해 제어된다. 그리고 속도 궤환 루프와 위치 궤환 루프를 포함하는 이중 피드백 루프가 서보 제어되는 회전자극시스템에 적용된다. HMD를 이용하여 수평, 수직, 3D 시각자극패턴을 구현 하였고 OKN 자극을 위한 무선시스템과 전기안진 기록계를 이용하여 안구운동을 기록하였다. 이득, 위상, 대칭성은 정전 자극과 시각 자극에 의해 유발되는 안구운동의 분석으로부터 얻어진다.

• 한국전문물리치료학회지
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• 제19권2호
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• pp.39-47
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• 2012

The purpose of this study is to examine the influence of a horse riding simulator and galvanic vestibular stimulation on improving the ability to balance posture and proprioception. Thirty healthy adults participated and were randomly assigned to a horse riding simulator group ($n_1$=10), galvanic vestibular stimulation (GVS) group ($n_2$=10), control group ($n_3$=10). Experiment groups were trained 3 times per week over 6 weeks. The ability to balance posture was measured by force plate and proprioception was measured by Joint position sense. The following results were obtained. the changes of balance index were significant interaction in each group in accordance with the experiment time in 0, 3 and 6 weeks (p<.05). All groups showed the most decreasing pattern compared with the control group. But was not statistically significant. Proprioception was significant interaction in each group in accordance with the experiment time (p<.05). All groups showed the most decreasing pattern compared with the control group. The above results indicated that the 6 weeks horse riding simulator and galvanic vestibular stimulation training demonstrated positive effects in the ability to balance posture and proprioception. These results suggest that the horse riding simulator and galvanic vestibular stimulation training could be therapeutic intervention that can improve balance and postural control.

• 대한지역사회작업치료학회지
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• 제7권1호
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• pp.1-8
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• 2017

목적 : 본 연구는 20대 대학생을 대상으로 전정계 자극 활동이 시 지각 과제 수행에 미치는 영향을 알아보았다. 연구방법 : 2016년 3월14일부터 5월20일까지 충청남도 A대학에 재학 중인 대학생 58명을 대상으로 실시하였다. 세 집단을 무작위 선정하여 A는 전정계 자극활동 없이 일반 사무용 의자에 앉아서 시 지각 과제를 수행하였다. 집단 B와 C는 트램폴린에서 뛰기의 전정계자극 활동을 실시한 후 집단 B는 일반사무용 의자, 집단C는 공 의자에서 시 지각 과제 수행 시간을 측정하였다. 결과 : 전정자극 활동을 실시한 집단과 실시하지 않은 집단 간에 시 지각 과제수행시간에 차이가 나타났다. 전정자극 활동을 전혀 하지 않고 사무용의자에 앉은 집단 A는 전정자극 활동을 하고 사무용 의자에 앉아 과제를 수행한 집단 B(p=.037)와 전정자극 활동 후 공 의자에 앉아 과제를 수행한 C와 차이를 나타냈다(p=.000). 그러나 동일한 전정자극 활동을 하고 사무용 의자에 앉은 집단 B와 공 의자에 앉은 집단 C간에는 차이가 없었다. 결론 : 전정감각 자극활동이 시 지각 과제 수행에 긍정적 영향을 미쳤다. 이후 대상자의 범위를 확대하여 연구를 실시할 필요가 있다.

• 대한통합의학회지
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• 제10권2호
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• pp.203-210
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• 2022

Purpose : The purpose of this study was to investigate the effect of vestibular sensory stimulation exercise on the limit of stability, dynamic weight shift, and upper and lower extremities reaction time in adult women. Methods : This study was conducted with 30 female. All subjects were randomly and equally assigned to an experimental group and a control group of 15 each. Subjects assigned to the experimental group received vestibular sensory stimulation training for 6 weeks. For the intervention, vestibular sensory stimulation exercises were conducted by referring to the Hamid exercise method and the Cawthorne-Cooksey exercise method, and the control group did not receive any intervention. All subjects were tested for limit of stability, dynamic weight shift, and upper and lower extremities reaction time before and after the intervention. Results : The results of this study showed significant differences between groups in reaction time, moving velocity, and directional control in the limit of stability test after intervention. In the dynamic weight shift test after intervention, there was a significant difference between the groups in the slow directional control of left and right. And in the upper and lower extremities reaction time test after intervention, both scores and reaction time showed significant differences between groups. Conclusion : As a result, the three vestibular sensory stimulation exercises applied in this study improved the limit of stability, dynamic weight shift, and upper and lower extremities reaction time.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2002년도 전력전자학술대회 논문집
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• pp.661-664
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• 2002

A control of the body posture and movement is maintained by the vestibular system, vision, and proprioceptors. Afferent signals from those receptors are transmitted to the vestibular nuclear complex, and the efferent signals from the vestibular nuclear complex control the eye movement. The postural disturbance caused by loss of the vestibular function results in nausea, vomiting, vertigo and loss of craving for life. The purpose of this study is to develop a off-vertical rotatory system for evaluating the function of semicircular canals and otolith organs, selectively, and visual stimulation system for stimulation with horizontal, vertical and 3D patterns. The Off-vertical axis rotator which stimulates semicircular canals and otolith organs selectively is composed of a comportable chair, a DC servo-motor with reducer and a tilting table controlled by PMSM. And a double feedback loop system containing a velocity feedback loop and a position feedback loop is applied to the servo controlled rotatory chair system. Horizontal, vertical, and 3D patterns of the visual stimulation for applying head mounted display are developed. And wireless portable systems for optokinetic stimulation and recording system of the eye movement is also constructed. The Gain, phase, and symmetry is obtained from analysis of the eye movement induced by vestibular and visual stimulation. Detailed data were described.

• The Korean Journal of Physiology and Pharmacology
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• 제6권4호
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• pp.193-197
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• 2002

In spite of abundant anatomical evidences for the fiber connection between vestibular nuclei and inferior olivary (IO) complex, the transmission of vestibular information through the vestibulo- olivo-cerebellar climbing fiber pathway has not been physiologically established. The aims of the present study were to investigate whether there are IO neurons specifically responding to horizontal rotation and also in which subregions of IO complex these vestibularly-activated neurons are located. The extracellular recording was made in 68 IO neurons and responses of 46 vestibularly-activated cells were analyzed. Most of the vestibularly-activated IO neurons responded to signals of vertical rotation (roll), while a small number (13/46) of recorded cells were activated by horizontal canal signal (yaw). Regardless of yaw-sensitive or roll-sensitive, vestibular IO neurons were excited, when the animal was rotated to the side contralateral to the recording side. The gain and excitation phase were very similar to otolithic or vertical-canal responses. Histologic identification of recording sites showed that most of vestibular IO neurons were located in ${\beta}$ subnucleus. Electrical stimulation of a HSC evoked an inhibitory effect on the excitability of the ipsilateral IO neurons. These results suggest that IO neurons mainly in the ${\beta}$ subnucleus receive vestibular signals from semicircular canals and otolithic organs, encode them, and transmit vestibular information to the cerebellum.