• Toxicological Research
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• 제16권4호
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• pp.269-274
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• 2000

Epoxidised soya bean oil (ESBO, 1000, 2000 or 4000 mg/kg) was orally administered to BALB/c mice daily for 28 consecutive days, and the control mice were exposed to vehicle (corn oil). Mice were immunized and challenged with sheep red blood cells (SRBC) or bovine serum albumin (BSA). In groups exposed to ESBO, the body weight gains and the relative lymphoid organ weights were not significantly changed as compared with control group. Secondary IgG antibody response to BSA was not significantly changed by ESBO, but plaque-forming cell (PFC) response to SRBC was significantly suppressed in mice treated with 4000 mg ESBO/kg/day. The mitogenic response of splenic B cells induced by LPS was not effected by ESBO in any of the groups. These results indicate that ESBO did not induce significant humoral immune response at a dose less than 2000 mg/kg/day in mice.

• Toxicological Research
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• 제34권2호
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• pp.85-95
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• 2018

The term Butterfly tea refers to decoction of Mariposa christia vespertilionis leaves which is widely consumed by cancer patients throughout Malaysia and has gained a huge popularity among Malaysians, not only cancer patients but also researchers to discover the real potential of this plant. Herein, the study is aimed at evaluating the possible toxicity in 28-day subacute oral toxicity of ethanolic extract M. christia vespertilionis in male Sprague Dawley rats. The 28-day subacute toxicity study was conducted to detect the no-observed adverse effect level (NOAEL). In this study, a total of 30 rats were divided into the control, 5% DMSO (vehicle), low dose (75 mg/kg), medium dose (125 mg/kg) and high dose (250 mg/kg) groups. The extract was administered daily from day 1 until day 28. At the end of the study, the animals were humanely sacrificed and assessed for the effect extract of Mariposa christia vespertilionis leaves on body weight and relative organ weights and haematological, biochemical and histopathological parameters. The haematological and serum biochemical parameters for the assessment of kidney and liver injuries were carried out. Results of haematological and serum biochemistry results showed no changes in the control and treated groups. In the histopathology, evaluation of kidney tissues in all treated groups showed no significant (p > 0.05) lesions. In contrast to kidney, liver tissues showed significant differences (p < 0.05) in lesions observed in low dose (430 mg), medium dose (700 mg) and high dose (1480 mg) groups with very mild, mild and mild to moderate lesion of hepatic necrosis, in the respective groups, and very mild hepatic degeneration and hepatitis were scored in all three groups.

• Journal of Biosystems Engineering
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• 제28권2호
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• pp.89-96
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• 2003

This study was aimed to identify how the main body vibration of power tiller will be transmitted to the trailer, and to find out the basic information for demage reducing method of agricultural products during transportation. The vertical vibration acceleration level was measured at 6 positions, i.e. engine, hitch, seal and three parts of trailer (front middle, and rear) for the not driving but at the engine speeds of 1,000rpm and driving at 0.35m/s. The results of this research could be summarized as follows; 1. For not driving, the accumulated acceleration level up to 120Hz was 50% of total accelerations at engine part and those were 28~41% at other parts. Those up to 40Hz were 20~30% at engine and hitch part and 2~8% at trailer part. And those up to 20Hz were 13~20% at engine and hitch part and 1~4% at trailer part 2. For the driving with 0.35m/s at paved road, the average vertical accelerations were in the range of 0.005~0.058m/s$^2$. The lowest value of 0.005m/s$^2$ was showed at engine part and the value of 0.031-0.058m/s$^2$ was showed at trailer part. 3. For the driving with 0.35m/s, the accumulated value of average vertical accelerations showed the lowest value at engine parts md showed 5 times value of engine part at trailer part especially highest value at middle part of trailer. 4. For the driving with 0.35m/s, the accumulated acceleration level up to 120Hz was 75% of total accelerations at engine part and those were 20~42% at other parts. Ant those up to 20Hz and 40Hz were 24~26% at engine part and 0.1~0.6% at trailer part.

• 대한물리치료과학회지
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• 제16권3호
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• pp.55-66
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• 2009

Background: The purpose of this research was to investigate the factors affecting the low back pain of workers in hospital. 214 subjects waking at two general hospitals in Yosu city participated in this survey. Subjects consisted of doctors, nurses, medical engineers, officers and general laborers. The survey data were collected by a written questionnaire which made out by themselves for 25 days, from fourth August to 29th August, 2008. Methods: The questionnaire consisted of four categories, general, occupational, working habitual and the daily living characteristics. The collected data were analyzed by Chi-square test based on the present or absent of low back pain. Results: 1. In the general characteristics, low back pain had no significant relationship to all factors, sex, ago, body mass index, weight and height. 2. In the occupational characteristics, the phase of distribution of low back pain had statistical significant differences in the working hours a week, satisfaction of pay, satisfaction of occupation(p<0.05). However low back pain did not significantly related to the kind of occupation, period of work and degree of stress. 3. In the habitual characteristics, low back pain was significantly influenced by working posture, frequency of using lumbar and heavy material lifting, monotonous repetition of working operation and noise(p<0.05). No significant difference was shown in the factor of convenience of chair. 4. In the daily living characteristics, low back pain shown the significant differences in walking time a day, status of health and smoking pattern(p<0.05). there were, however, no significant differences in the aspect of the kind of house and bed, sleeping attitude, driving, riding time on the vehicle, exercising, frequency of cultural life and drinking alcohol. Conclusion: when I see above resultants totally, it appears a higher incidence caused by working environment rather than living habit and then consequently compared to hospital workers, they also have high incidence like others. In order to reduce incidence of low back pain and enjoy the our life we need to educate ourselves preventing program for low back pain and try to effort for preventing of low back pain on each department and individual.

• 한국재료학회지
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• 제30권4호
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• pp.197-203
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• 2020

Abdominal organs are the most vulnerable body parts under vehicle trauma, and there is high mortality from acute injuries in accidents. There are various ways to reduce this high mortality; one method is Resuscitative Endovascular Balloon Occlusion of the Aorta, which has recently become very popular as a minimally invasive alternative in the emergent management of patients with non-compressible hemorrhages below the diaphragm. However, high safety factor for patients is applied in actual clinical practice because there is no exact standard for the operating time. Therefore, in this study, the effects of the mechanical behavior of organ tissues for the duodenum, kidney, and liver on the operating time of Resuscitative Endovascular Balloon Occlusion of the Aorta is investigated in order to obtain data needed to establish standards of operating time. In characteristic analysis of organ tissues, uniaxial tensile test and compression test are conducted according to the operating time.

• 한국항공우주학회지
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• 제39권7호
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• pp.652-659
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• 2011

항공기 IR(Infrared; 적외선) 피탐지성 감소 연구를 위해 후방동체 주위 열유동장과 IR 신호를 예측하는 시스템을 구축하였다. 아음속 무인전투기(UCAV)를 대상 항공기로 고려하여 가상 임무 설정 및 성능해석을 통해 가상 엔진을 선정하였다. 또한 각 임무를 만족시키는 노즐을 설계한 후, 고속 고온 열유동장 CFD 해석코드를 이용하여 최대 출력에서의 노즐 내부 유동을 해석하였다. 예측된 노즐 표면 및 후방 동체의 온도는 고체표면 복사 열교환 및 신호 예측코드와 연계시키는 시스템과 연동시켜 최종적으로 IR 신호를 계산하였다. IR 밴드 및 관찰 각도에 대한 IR 신호의 변화를 분석하여 IR 감소설계를 위한 정성적 정보를 도출하였다.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2008년도 제30회 춘계학술대회논문집
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• pp.14-17
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• 2008

비교적 단순한 개폐작동을 통해 액체추진기관 연소기로의 극저온 액체산소 공급을 조절하는 산화제 개폐밸브로써, 공압으로 작동하는 포펫 타입의 밸브가 채택되어 관련 연구개발이 진행되고 있다. 일반적인 포펫 타입의 밸브들은 포펫과 피스톤이 연결되어 일체로 움직이면서 유로 개폐를 제어하지만, 개발 중인 산화제 개폐밸브는 밸브 설계의 유연성을 확보하기 위해 포펫과 피스톤 부분이 서로 접촉되어 있을 뿐 독립적으로 분리되어 있다. 포펫과 피스톤 부분이 분리되어 있는 포펫 타입의 밸브 개폐 시, 피스톤 부분이 밸브 몸체와 충돌할 수 있기 때문에 이와 같은 충돌을 피하기 위해 밸브가 닫히는 동안의 힘평형에 대한 분석이 필수적이다. 따라서 본 연구에서는 산화제 개폐밸브가 닫히는 동안의 힘평형에 대한 분석 내용을 소개하고, 결과적으로 안전한 밸브 작동을 확보할 수 있는 힘평형 조절을 위한 주요 설계 변수를 유도하기로 한다.

• Wind and Structures
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• 제20권2호
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• pp.213-236
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• 2015

For high-speed railways (HSR) in wind prone regions, wind barriers are often installed on bridges to ensure the running safety of trains. This paper analyzes the effect of wind barriers on the running safety of a high-speed train to cross winds when it passes on a bridge. Two simply-supported (S-S) PC bridges in China, one with 32 m box beams and the other with 16 m trough beams, are selected to perform the dynamic analyses. The bridges are modeled by 3-D finite elements and each vehicle in a train by a multi-rigid-body system connected with suspension springs and dashpots. The wind excitations on the train vehicles and the bridges are numerically simulated, using the static tri-component coefficients obtained from a wind tunnel test, taking into account the effects of wind barriers, train speed and the spatial correlation with wind forces on the deck. The whole histories of a train passing over the two bridges under strong cross winds are simulated and compared, considering variations of wind velocities, train speeds and without or with wind barriers. The threshold curves of wind velocity for train running safety on the two bridges are compared, from which the windbreak effect of the wind barrier are evaluated, based on which a beam structure with better performance is recommended.

• 한국융합학회논문지
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• 제11권1호
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• pp.169-174
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• 2020

사이드 볼스터는 자동차 시트에서 탑승자가 시트에 착석하였을 때, 더욱 안정성을 줄 수 있도록 옆에서 탑승자의 몸을 잡아주는 부품이다. 본 연구에서는 A, B 두 가지의 모델을 가지고 자동차 시트에서 사이드 볼스터에 대한 구조 및 피로해석을 수행하였다. 하중이 많이 실리는 부분과 자동차 운행 시 피로로 인한 파손 및 구조에 따른 내구성의 차이를 연구하였고 응력, 변형량의 분포 및 피로 수명을 알아보았으며 또한 그 강도 및 내구성을 검토하였다. 본 연구 결과는 사이드 볼스터의 설계에 따라 피로 파손을 줄이고 그 피로 수명 및 내구성을 증가할 수 있는 데 기여가 될 것으로 사료된다. 그리고 본 결과를 자동차 사이드 볼스터의 설계를 실제적으로 적용함으로서 제품을 향상시킬 수 있고 본 연구결과를 미적 감각을 가진 융합 연구에 응용하는 것이 유리하다고 사료된다.

• Advances in Traditional Medicine
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• 제9권1호
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• pp.49-57
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• 2009

The antifertility activity of methanol extract of Cuscuta reflexa Roxb. stem (MECR) and Corchorus olitorius Linn. seed (MECO) were studied on male Swiss albino mice. The extracts were found to decrease sperm count, percentage of motile sperm and testosterone level in treated mice when compared with vehicle control after 17 days of treatment. The weight of gonads, epididymis were decreased whereas no significant changes of the body weight of mice were observed after methanol extract treatments. The fertility test showed 100% negative result in MECR and MECO treated mice at medium and high dose level of treatment. MECR and MECO in low (25 mg/kg and 15 mg/kg, respectively), medium (50 mg/kg and 20 mg/kg, respectively) and high (75 mg/kg and 25 mg/kg, respectively) dose level caused a simultaneous fall in testicular ${\Delta}5$-$3{\beta}$-hydroxy steroid dehydrogenase and glucose-6-phosphate dehydrogenase activities which are involved in testicular steroidogenesis. Total cholesterol and ascorbic acid content in testis were increased significantly in gonads. The activities of lactate dehydrogenase, malic dehydrogenase and ascorbic acid oxidase were reduced whereas that of carbonic anhydrase was increased significantly in the testis of MECR and MECO treated mice. All these observations indicate that the methanol extract of C. reflexa stem and C. olitorius seed produced antifertility activity in sexually matured male mice, which may be due to inhibition of gonadal steroidogenesis. This activity may be attributed due to the presence of flavonoids and steroids, respectively.