• Management Science and Financial Engineering
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• 제5권1호
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• pp.51-71
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• 1999

Performance of the group cumulative sum (CUSUM) control scheme using multiple univariate CUSUM charts is more sensitive to the change of quality control (QC) characteristics than the control chart schemes based on the Hotelling statistic We vexamine three group charts for multivariate normal data sets simulated with various correlation structures and shift directions in the mean vector. These group schemes apply the original measurement vectors, the scaled residual vectors from the re-gression of each variable on all others and the principal component vectors respectively to calculat-ing the CUSUM statistics. They are also compared to the multivariate QC charts based on the Ho-telling statistic by estimating average run lengths, coefficients of variation of run length and ranks in signaling order. On the basis of simulation results, we suggest a control chart scheme appropriate for specific quality control environment.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2004년도 추계학술발표대회 논문집
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• pp.272-277
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• 2004

The elastic waves in the plate are dispersive waves with the characteristics of Lamb waves. However, $S_0$ symmetric mode is less dispersive in the frequency region less than first cut-off frequency. And, in anisotropic plates such as CFRP plates, the propagation velocities vary with the direction. So, the wave vector direction to be the phase velocity direction is not accord with the energy flow direction to be the group velocity direction. In this work, the group velocities of the $S_0$ symmetric mode less than the first cut-off frequency was analyzed with the group velocity dispersion curves in unidirectional CFRP plate. And, the group velocity curve obtained by the group velocity dispersion curves are compared with the measured velocities as varied the propagation direction of the Lamb wave. The measured velocities are good agreement with the corrected group velocity curve except near the fiber direction which is called the cusp region. When the propagation direction is not accorded with the principal axis, the direction of the group velocities declines to the fiber direction in the unidirectional CFRP plates. This implies that the energy propagates preferentially toward fiber direction.

• Genomics & Informatics
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• 제6권2호
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• pp.84-86
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• 2008

The Tetrahymena group I intron has been shown to employ a trans-splicing reaction and has been modified to specifically target and replace human telomerase reverse transcriptase (hTERT) RNA with a suicide gene transcript, resulting in the induction of selective cytotoxicity in cancer cells that express the target RNA, in animal models as well as in cell cultures. In this study, we evaluated the target RNA specificity of trans-splicing phenomena by the group I intron in mice that were intraperitoneally inoculated with hTERT-expressing human cancer cells to validate the anti-cancer therapeutic applicability of the group I intron. To this end, an adenoviral vector that encoded for the hTERT-targeting group I intron was constructed and systemically injected into the animal. 5'-end RACE-PCR and sequencing analyses of the trans-spliced cDNA clones revealed that all of the analyzed products in the tumor tissue of the virus-infected mice resulted from reactions that were generated only with the targeted hTERT RNA. This study implies the in vivo target specificity of the trans-splicing group I intron and hence suggests that RNA replacement via a trans-splicing reaction by the group I intron is a potent anti-cancer genetic approach.

• Korean Chemical Engineering Research
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• 제59권2호
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• pp.191-199
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• 2021

화학 공정의 주요 설비 중 하나인 증류탑은 물질들의 끓는점 차이를 이용하여 혼합물에서 원하는 생산물을 분리하는 설비이며 증류 공정은 많은 에너지가 소비되기 때문에 최적화 및 운전 예측이 필요하다. 본 연구의 대상 공정은 공급처에 따라 원료의 조성이 일정하지 않아 정상 상태로 운전이 어려워 효율적인 운전이 어렵다. 이를 해결하기 위해 데이터 기반 예측 모델을 이용하여 운전 조건을 예측 할 수 있다. 하지만 미가공 공정 데이터에는 이상치 및 노이즈가 포함되어 있어 예측 성능을 향상시키기 위해 데이터 전처리가 필요하다. 본 연구에서는 인공 신경망 모델인 Long short-term memory (LSTM)과 Random forest (RF)를 사용하여 모델을 최적화한 후, 데이터 전처리 방법으로 Low-pass filter와 One-class support vector machine을 사용하여 데이터 전처리 방법 및 범위에 따른 예측 성능을 비교하였다. 각 모델의 예측 성능과 데이터 전처리의 영향은 R2과 RMSE를 사용하여 비교하였다. 본 연구의 결과, 전처리를 통해 LSTM의 경우 R2은 0.791에서 0.977으로 RMSE는 0.132에서 0.029로 각각 23.5%, 78.0% 향상되었고, RF의 경우 R2은 0.767에서 0.938으로 RMSE는 0.140에서 0.050으로 각각 22.3%, 64.3% 향상되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8533-8539
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• 2016

Background: B-cell chronic lymphocytic leukemia B (B-CLL), the most common type of leukemia, may be caused by apoptosis deficiency in the body. Adipose tissue-derived mesenchymal stem cells (AD-MSCs) as providers of pro-apoptotic molecules such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), can be considered as an effective anti-cancer therapy candidate. Therefore, in this study we assessed the role of tumor necrosis factor-producing mesenchymal stem cells oin apoptosis of B-CLL cells resistant to fludarabine-based chemotherapy. Materials and Methods: In this study, after isolation and culture of AD-MSCs, a lentiviral LeGO-iG2-TRAIL-GFP vector containing a gene producing the ligand pro-apoptotic with plasmid PsPAX2 and PMDG2 virus were transfected into cell-lines to generate T293HEK. Then, T293HEK cell supernatant containing the virus produced after 48 and 72 hours was collected, and these viruses were transduced to reprogram AD-MSCs. Apoptosis rates were separately studied in four groups: group 1, AD-MSCs-TRAIL; group 2, AD-MSCs-GFP; group 3, AD-MSCs; and group 4, CLL. Results: Observed apoptosis rates were: group 1, $42{\pm}1.04%$; group 2, $21{\pm}0.57%$; group 3, $19{\pm}2.6%$; and group 4, % $0.01{\pm}0.01$. The highest rate of apoptosis thus occurred ingroup 1 (transduced TRAIL encoding vector). In this group, the average medium-soluble TRAIL was 72.7pg/m and flow cytometry analysis showed a pro-apoptosis rate of $63{\pm}1.6%$, which was again higher than in other groups. Conclusions: In this study we have shown that tumor necrosis factor (TNF) secreted by AD-MSCs may play an effective role in inducing B-CLL cell apoptosis.

• International Journal of Automotive Technology
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• 제8권4호
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• pp.505-512
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• 2007

This paper presents the quantitative evaluation of the fearfulness of the human driver in the case of the short range (time) on the highway. The driving situation is realized by using the driving simulator based on CAVE, which provides three-dimensional stereoscopic immersive visual information. The examinees' responses and personal information are categorized reasonably by applying the competitive learning algorithm. The characteristics of each group are analyzed. The following two situations are also compared: (1) the active approaching situation where the examinee drives the vehicle near the preceding vehicle, and (2) the passive approaching situation where the preceding vehicle nears the examinee's vehicle by gradually decelerating. The range time that the examinee feels fear in the active approaching case tends to be shorter than that in the passive approaching case.

• 대한수학회논문집
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• 제9권4호
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• pp.927-931
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• 1994

Let G be a cyclic group of order 2 and let $S^1$ denote the unit circle in $R^2$ with the standard metric. We consider smooth G-vector bundles over $S^1$ when G acts on $S^1$ by reflection. Then the fixed point set of G on $S^1$ is two points ${z_0, z_1}$. Let $E$\mid$_{z_0} and E$\mid$_{z_1}$ be the fiber G-representation spaces at $z_0$ and $z_1$ respectively. We associate an orthogonal G-representation $\rho_i : G \to O(n)$ to $E$\mid$_{z_i}, i = 0, 1$. Let det $p\rho_i(g), g \neq 1$, be denoted by det $E$\mid$_{z_i}$ since det $\rho_i(g)$ is independent of choice of $\rho_i$.

• 한국컴퓨터그래픽스학회논문지
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• 제12권3호
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• pp.7-11
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• 2006

최근 임베디드 환경에서 2차인 Vector Graphics에 대한 요구는 크게 증가하고 있으며, Flash Lite, SVG등의 응용이 이미 널리 사용되고 있다. 반면 이러한 응용을 지원하기 위한 API의 표준은 전무한 실정이었다. OpenVG 1.0은 임베디드 시스템을 위한 미디어 표준 제정 기관인 Khronos Group에서 제정한 2차원 벡터 그래픽스를 위한 API (Application Programming Interface)로 2005년 8월 발표되었다. 본 논문에서는 OpenVG 표준에 대해 간략히 소개하고 (주)휴원에서 세계최초로 상용화 개발에 성공한 AlexVG Engine의 개발과정과 결과에 대하여 설명한다.

• 대한음성학회:학술대회논문집
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• 대한음성학회 2007년도 한국음성과학회 공동학술대회 발표논문집
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• pp.33-36
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• 2007

In this paper, we investigate a fast speaker adaptation method based on eigenvoice in several noisy environments. In order to overcome its weakness against noise, we propose a noisy environment clustering method which divides the noisy adaptation utterances into utterance groups with similar environments by the vector quantization based clustering using a cepstral mean as a feature vector. Then each utterance group is used for adaptation to make an environment dependent model. According to our experiment, we obtained 19-37 % relative improvement in error rate compared with the simultaneous speaker adaptation and environmental compensation method

• 한국품질경영학회:학술대회논문집
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• 한국품질경영학회 2004년도 품질경영모델을 통한 가치 창출
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• pp.70-75
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• 2004

In actual manufacturing industries, process capability indices(PCI) are used to determine whether a production process is capable of producing items within a specified specification limits. We study some vector-valued PCIs $C_p=(C_{px},\;C_{py})$ and $C_{pk}=(C_{pkx},\; C_{pky})$ in this article. We propose some asymptotic confidence regions of PCIs with bootstrapping and examine the performance of those asymptotic confidence regions under the assumption of bivariate normal distribution.