• Structural Engineering and Mechanics
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• v.55 no.3
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• pp.555-581
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• 2015

Triangular pyramid and Quadrangular pyramid elements for partial double-layer spherical reticulated shells of pyramidal system are investigated in the present study. Macro programs for six typical partial double-layer spherical reticulated shells of pyramidal system are compiled by using the ANSYS Parametric Design Language (APDL). Internal force analysis of six spherical reticulated shells is carried out. Distribution regularity of the stress and displacement are studied. A shape optimization program is proposed by adopting the sequence two-stage algorithm (RDQA) in FORTRAN environment based on the characteristics of partial double-layer spherical reticulated shells of pyramidal system and the ideas of discrete variable optimization design. Shape optimization is achieved by considering the objective function of the minimum total steel consumption, global and locality constraints. The shape optimization of six spherical reticulated shells is calculated with the span of 30m~120m and rise to span ratio of 1/7~1/3. The variations of the total steel consumption along with the span and rise to span ratio are discussed with contrast to the results of shape optimization. The optimal combination of main design parameters for six spherical reticulated shells is investigated, i.e., the number of the optimal grids. The results show that: (1) The Kiewitt and Geodesic partial double-layer spherical reticulated shells of triangular pyramidal system should be preferentially adopted in large and medium-span structures. The range of rise to span ratio is from 1/6 to 1/5. (2) The Ribbed and Schwedler partial double-layer spherical reticulated shells of quadrangular pyramidal system should be preferentially adopted in small-span structures. The rise to span ratio should be 1/4. (3) Grids of the six spherical reticulated shells can be optimized after shape optimization and the total steel consumption is optimized to be the least.

• Journal of Microbiology and Biotechnology
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• v.27 no.4
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• pp.718-724
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• 2017

The combination of rabies immunoglobulin (RIG) with a vaccine is currently effective against rabies infections, but improvements are needed. Genetic engineering antibody technology is an attractive approach for developing novel antibodies to replace RIG. In our previous study, a single-chain variable fragment, scFv57R, against rabies virus glycoprotein was constructed. However, its inherent weak stability and short half-life compared with the parent RIG may limit its diagnostic and therapeutic application. Therefore, an acidic tail of synuclein (ATS) derived from the C-terminal acidic tail of human alpha-synuclein protein was fused to the C-terminus of scFv57R in order to help it resist adverse stress and improve the stability and half-life. The tail showed no apparent effect on the preparation procedure and affinity of the protein, nor did it change the neutralizing potency in vitro. In the ELISA test of molecular stability, the ATS fusion form of the protein, scFv57R-ATS, showed an increase in thermal stability and longer half-life in serum than scFv57R. The protection against fatal rabies virus challenge improved after fusing the tail to the scFv, which may be attributed to the improved stability. Thus, the ATS fusion approach presented here is easily implemented and can be used as a new strategy to improve the stability and half-life of engineered antibody proteins for practical applications.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.24 no.2
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• pp.204-213
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• 2000

This study deals with jet impingement, which is extensively used in the process industries to achieve intense heating, cooling or drying rates and also widely employed as a test flow for turbulent models due to its complex flow configuration, on a flat plate by numerical methods. In this calculation, the finite volume method was employed to solve the Navier-stokes equation based on the non-orthogonal coordinate with non-staggered variable arrangement. To get a better understanding for the fluid flow and heat transfer characteristics of the turbulent jet impingements, $k-{\varepsilon}-{\overline{v^{'2}}}$ turbulent model was adapted and compared with the experimental data and the result of standard $k-{\varepsilon}$ turbulent model. Numerical calculations were carried out with various flow rates, nozzle to plate distances. In the case of the axisymmetric jet impingement on a flat plate, $k-{\varepsilon}-{\overline{v^{'2}}}$ turbulent model showed better agreement with the experimental data than the standard $k-{\varepsilon}$ turbulent model in the prediction of the mean velocity profiles, the turbulent velocity profiles. the turbulent shear stress and the heat transfer rate. The highest heat transfer rate can be obtained when the impingement occurs within the potential core..

• Journal of the Society of Naval Architects of Korea
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• v.46 no.5
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• pp.510-519
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• 2009

Ship structure is composed of the welded mixture members which are plate and stiffeners. Ship structure is also influenced by variable loadings such as wave and inertia load. There have been several fatigue damage problems on the connection between longitudinal and transverse web due to wide usage of high tensile steel and adoption of wide web space to improve shipbuilding productivity. It is impossible to estimate the fatigue lives for all connection details through refined fatigue analysis. It is necessary to use the simplified approach for the fatigue life estimation of the connection details. PLUS analysis, which is suggested by the classification society, is one of the simplified approaches and is widely adopted to get fatigue lives for the connection details along whole cargo hold area. However, ship building yards still have difficulties to get fatigue lives due to large amount of calculation and time even if this approach reduce the time and amount of calculation. This paper treats the computing system developed to reduce efforts of estimating the fatigue lives. The influence factors of mean shear stress and local dynamic pressure are easily calculated and fatigue lives for all hot spots can be estimated automatically by the developed computing system. It is possible to reduce computing time and efforts to get the fatigue lives for the connection details between longitudinals and transverse webs along the ship. This system was applied to get fatigue lives on the connection details of a VLCC and verified the availability.

• Journal of Korean Clinical Health Science
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• v.1 no.3
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• pp.49-61
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• 2013

Purpose. The purpose of this study is to analyze difference in quality of life related to health according to our country's social stratification. Methods. This study had analytical subjects as 7,992 adults(4,557 men, 3,435 women), who are included in a variable by social stratification among 15,691 people in the age group of 20~69 years old as examinees, based on the 4th Korea National Health and Nutrition Examination Survey. Results. This study obtained the following results. First, seeing the score of health-related life quality by social stratification, namely, the distribution of EQ-5D index, the new middle class(class II) was the highest(men with 0.966 point, women with 0.955 point). The agricultural self-employed class(class V) was indicated to be the lowest(men with 0.918 point, women with 0.866 point). In general, the more belonging to low social stratification led to having shown the lower aspect in EQ-5D index value. Second, as for the results of the hierarchical regression analysis, the factors of contributing to difference by social stratification in health-related quality of life were chronic disease, job stress, education, and income level in both men and women. The health behavior was grasped to be a factor of contributing only to women. Conclusions. To reduce difference in health-related quality of life according to social stratification in the future, the continuous investment is needed for supporting socially high-quality education and economic stability. The sphere of health will need to be given priority to the prevention of chronic disease and the development in effective management policy for the lower classes.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.38 no.11
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• pp.1257-1264
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• 2014

Efforts are presently underway for developing an optimal design methodology for GEN-IV nuclear reactors based on target failure probabilities. A typical example is the system-based code, in which the results are represented in the form of partial safety factors (PSFs). Thus, a PSF is one of the crucial elements in either component design or integrity assessment based on target failure probabilities during the operation period. In the present study, a procedure for calculating the PSF of a circumferential through-wall cracked pipe based on the elastic-plastic crack initiation criterion is established, in which the importance of each input variable is assessed. Elastic-plastic J-integrals are calculated using the GE/EPRI and reference stress methods, and the PSF values are calculated using both first- and second-order reliability methods. Moreover, the effect of statistical distributions of assessment variables on the PSF is also evaluated.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.14 no.1
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• pp.56-63
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• 2004

Exact solutions are presented for the free vibration and buckling of rectangular plates haying two opposite edges ( x=0 and a) simply supported and the other two ( y=0 and b) clamped, with the simply supported edges subjected to a linearly varying normal stress $\sigma$$_{x}$=- $N_{0}$[1-a(y/b)]/h, where h is the plate thickness. By assuming the transverse displacement ( w) to vary as sin(m$\pi$x/a), the governing partial differential equation of motion is reduced to an ordinary differential equation in y with variable coefficients. for which an exact solution is obtained as a power series (the method of Frobenius). Applying the clamped boundary conditions at y=0 and byields the frequency determinant. Buckling loads arise as the frequencies approach zero. A careful study of the convergence of the power series is made. Buckling loads are determined for loading parameters a= 0, 0.5, 1, 1.5. 2, for which a=2 is a pure in-plane bending moment. Comparisons are made with published buckling loads for a= 0, 1, 2 obtained by the method of integration of the differential equation (a=0) or the method of energy (a=1, 2). Novel results are presented for the free vibration frequencies of rectangular plates with aspect ratios a/b =0.5, 1, 2 when a=2, with load intensities $N_{0}$ / $N_{cr}$ =0, 0.5, 0.8, 0.95, 1. where $N_{cr}$ is the critical buckling load of the plate. Contour plots of buckling and free vibration mode shapes ate also shown.shown.

• Journal of the Korean Society of Groundwater Environment
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• v.1 no.2
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• pp.90-99
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• 1994

Heterogeneous hydraulic conductivity in a flow domain is generated under the assumption that it is a random variable with a lognormal, spatially-correlated distribution. The hydraulic head and the conductivity in a groundwater flow system are represented as a stochastic process. The method of Monte Carlo Simulation (MCS) and the finite element method (FEM) are used to determine the statistics of the head and the logconductivity. The second moments of the head and the logconductivity indicate that the cross-covariance of the logconductivity with the head has characteristic distribution patterns depending on the properties of sources, boundary conditions, head gradients, and correlation scales. The negative cross-correlation outlines a weak-response zone where the flow system is weakly responding to a stress change in the flow domain. The stochastic approach has a potential to quantitatively delineate the zone of influence through computations of the cross-covariance distribution.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.25 no.8
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• pp.1277-1286
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• 2001

Aluminum 5052/Aramid Fiber Reinforced Plastic(Al5052/AFRP) laminates are applied to the fuselage-wing intersection. The Al5052/AFRP laminates suffer from the cyclic bending moment of variable amplitude during the service. Therefore, the influence of cyclic bending moment on the delamination and the fatigue crack propagation behavior in Al5052/AFRP laminate was investigated in this study. Al5052/AFRP laminate composite consists of three thin sheets of Al5052 and two layers of unidirectional aramid fibers. The cyclic bending moment fatigue tests were performed with five different levels of bending moment. The shape and size of the delamination zone formed along the fatigue crack between Al5052 sheet and aramid fiber-adhesive layer were measured by an ultrasonic C-scan. The relationships between da/dN and ΔK, between the cyclic bending moment and the delamination zone size, and between the fiber bridging mechanism and the delamination zone were studied. Fiber failures were not observed in the delamination zone in this study. It represents that the fiber bridging modification factor should turn out to increase and that the fatigue crack growth rate should decrease. The shape of delamination zone turns out to be semi-elliptic with the contour decreased non-linearly toward the crack tip.

• Tribology and Lubricants
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• v.22 no.4
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• pp.190-195
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• 2006

A simple and effective analysis method is presented for gaining a complete transient temperatures on the internal and external surfaces of a 40 mm gun tube subjected to a series of rapid firings. Two series of temperature data for both Hs and As were measured by using two rapid response k-type surface thermocouples near the firing origin and the muzzle. With other available temperature data, patterns of temperature variations of the gun tube as a function of time variable were driven through complete evaluations of the data. It is found that overall temperature gradients which increase exponentially toward saturation temperature, actually consist of a series of linear temperature gradients corresponding to the firing sequences. Under the similar firing sequences, patterns of temperature variations fur both the surface temperatures near the chamber and those near the muzzle were found to have linear temperature gradients with different values and the same response frequencies, i.e. they had peaks and lows in temperatures at the same time. The resultant complete temperature data can be used as the fundamental bases for analysis of thermoelastic properties of the materials such as thermal strain and stress, and f3r the prediction of cannon tube life-time through calculation of wear rate.