• 한국환경성돌연변이발암원학회지
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• 제25권1호
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• pp.6-12
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• 2005

Many compounds might become activated after absorption of UV light energy. In some cases, the resulting molecule may undergo further biological reaction of toxicological relevance related especially to the photo-carcinogenicity resulting from photo-genotoxicity. However, no regulatory requirements have been issued with the exception of guideline issued by the Scientific Committee of Cosmetology, Commission of the European Communities (SCC/EEC) on the testing of sunscreens for their photo-genotoxicity. Thus, the objectives of this study are to investigate the utility of photo-Ames assay for detecting photo-mutagens, and to evaluate its ability to predict rodent photo-carcinogenicity. Photo-Ames assay was performed on five test substances that demonstrated positive results in photo-carcinogenicity tests: 8-methoxypsoralen (photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation), chlorpromazine (an aliphatic phenothiazine an a-adr-energic blocking agent), lomefloxacin (an antibiotic in a class of drugs called fluoroquinolones), anthracene (a tricyclic aromatic hydrocarbon a basic substance for production of anthraquinone, dyes, pigments, insecticides, wood preservatives and coating materials) and retinoic acid (a retinoid compound closely related to vitamin A). Out of 5 test substances, 3 showed a positive outcome in photo-Ames assay. With this limited data set, an investigation into the predictive value of this photo-Ames test for determining the photo-carcinogenicity showed that photo-Ames assay has relatively low sensitivity (the ability of a test to predict carcinogenicity). Thus, to determine the use of in vitro genotoxicity tests for prediction of carcinogenicity,' several standard photo-genotoxicity assays should be compared for their suitability in detecting photo-genotoxic compounds.

• 한국정보처리학회논문지
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• 제6권9호
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• pp.2422-2430
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• 1999

본 논문에서는 단어들 사이의 연관성을 이용하여 문서들을 사용자의 관심분야 만큼 자동으로 분류하는 다음과 같은 방법을 제안한다. 첫째, TF*IDF 알고리즘을 이용하여 각 문서를 대표할 수 있는 단어들을 찾아내고, 본 논문에서 제안한 연관성 계산을 위한 확률 모델을 이용하여 각 문서를 대표할 수 있는 단어들을 찾아내고, 본 논문에서 제안한 연관성 계산을 위한 확률 모델을 이용하여 각 문서를 대표하는 각각의 단어들이 문서 전체집합에서 서로 어느 정도 연관성을 갖고 있는가를 계산한다. 둘째, 연관성이 가장 높은 두 단어를 중심으로 그 단어들에 밀접하게 연결되어 있는 단어들을 하나의 집합으로 구성하고, 그 집합을 이용하여 하나의 클래스와 프로파일을 생성한다. 연관성이 다음으로 높은 두 단어를 중심으로 위와 같은 과정을 임계 값 보다 낮은 값이 나올 때까지 계속적으로 반복함으로써, 사용자가 관심 있는 분야만큼의 프로파일을 생성한다. 또한, 본 논문에서는 생성된 각각의 프로파일이 각 문서들에 어느 정도의 영향력을 갖고 있는지를 평가하여 문서들을 분류하고, 기존의 자동문서 분류 방법과의 비교를 통하여 본 논문에서 제시한 방법의 타당성을 입증한다.

• 시큐리티연구
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• 제28호
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• pp.79-102
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• 2011

본 연구는 오재환(2010)의 후속연구로 개선된 교육 프로그램이 민간경비원의 직무만족 및 직무성과에 미치는 영향을 확인하는 것이 목적이다. 이를 위해 오재환(2010) 연구에서 선정된 서울, 경기 지역에 거주하고 있는 민간경비원 170명을 대상으로 유의 표집하여 설문조사를 실시하였다. 수집된 자료는 SPSS 15.0를 활용하여 빈도분석, 상관분석, 다중 회귀분석을 실시하였다. 설문지의 신뢰도 Cronbach's ${\alpha}$ 값은 0.800 이상으로 나타났다. 본 연구의 분석 결과는 다음과 같다. 해당 프로그램의 교육훈련 내용이 증가하면 직무만족 및 직무성과가 증가되는 것으로 나타났다. 이는 개선된 교육프로그램의 내용이 METT, 행동촉발질문과 같은 과학적이고 체계적인 기법이 포함되어 있고, 실무교육이 적절하게 구성되어 있어 민간경비원으로 하여금 자신감 있는 근무를 할 수 있게 하고, 시대의 흐름을 적절하게 반영하였으며, 민간경비원의 업무와도 직접적으로 관련성이 높아 업무에 활용될 수 있는 가능성이 높다는 것을 의미한다.

• Journal of Veterinary Science
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• 제22권2호
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• pp.27.1-27.13
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• 2021

Background: Ozone is an antimicrobial agent that in experimental and case-control studies has been found to exert a positive effect on wound healing. Wild and pet chelonians frequently present insidious wounds exhibiting secondary infections and/or delayed healing. Objectives: Evaluate the effects of topical ozonated sunflower oil on second-intention healing of acute experimental skin wounds in red-eared sliders (Trachemys scripta elegans). Methods: Randomised within-subject controlled study; Group 1 (n = 24) was used to assess clinical healing features; Group 2 (n = 12) was used for histological evaluation in which two sets of wounds were biopsied at 2, 7, 14, 21, 28 and 42 days over the course of the cicatrisation process. A single 6 mm diameter wound was made on each rear limb and topical ozonated (950 peroxide value) and non-ozonated sunflower oil were applied daily for one week on treated and contralateral control wounds, respectively. Results: Mean wound size was significantly lower in the ozone-treated group at day 28 (p < 0.0001) with differences of clinical relevance (74.04% vs. 93.05% reduction of initial wound size). Histologically, the acute inflammatory reaction was enhanced in treated wounds, with significantly higher numbers of heterophils (p = 0.0016), lymphocytes (p < 0.001) and fibroblasts (p < 0.001). Conclusions: Daily topical application of ozonated sunflower oil over the course of one week improved the healing of acute, full-thickness skin wounds in chelonians. This clinical outcome was histologically correlated with an enhanced acute inflammatory reaction, as well as the production and remodelling of collagen fibres.

• Journal of Korea Trade
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• 제25권5호
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• pp.93-109
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• 2021

Purpose - The logistics industry is often featured by its location relevance and industrial concentration. Industrial concentration is conducive to the effective transmission of information by reducing transaction costs and improving transaction efficiency, thus promoting the development of trade. The main purpose of this paper is to measure the spatial total factor productivity and location quotient of the logistics industry in Korea, and to study the impact of the logistics industry efficiency and agglomeration effect on import and export trade in Korea. Design/methodology - First, used the spatial stochastic frontier method to measure the spatial total factor productivity of the logistics industry in Korea, this serves as the efficiency index of the logistics industry in various regions of Korea. Second, calculated the location quotient (LQ) of the logistics industry to measure the industry's concentration degree. Third, employed a spatial econometric model to analyze the impacts of factors such as the efficiency and concentration levels of the logistics industry on import and export trade in Korea. Findings - This study's main findings can be summarized as follows: this study found that the overall efficiency of the logistics industry in Korea needs to be improved, even though it showed an upward trend in all regions of the country; Moreover, the agglomeration level of Korea's logistics industry needs to be improved; Finally, the positive spatial correlation and industrial agglomeration effect of Korea's logistics industry had a positive impact on the country's import and export trade. Originality/value - This study is innovative in terms of research perspective and methods. Most of the previous studies have measured the development level of the logistics industry using the logistics performance index (LPI), Fewer studies have assessed through the spatial total factor productivity and location quotient of the logistics industry in Korea to measure the efficiency index of the logistics industry in various regions of Korea and concentration degree, as well as there was almost no study on the impact of logistics industry efficiency and agglomeration effect on import and export trade in Korea. This study addresses this limitation by analyzing the impacts of the efficiency and agglomeration effect of the logistics industry on import and export trade in Korea.

• 대한종양외과학회지
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• 제14권2호
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• pp.76-82
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• 2018

Purpose: Lgr5 is a well-known stem cell marker in colorectal cancer (CRC). This retrospective study evaluated the expressions of Lgr5 in CRC specimens, and examined whether these expressions were associated with survival outcomes. Methods: We used immunohistochemistry to retrospectively examine expressions of Lgr5 in paraffin-embedded specimens from 337 patients with CRC between January 2009 and December 2013. All clinicopathologic data were collected by retrospective review based on medical records. The correlation between its expression and clinicopathological data as well as clinical outcomes of patients was analyzed. Results: Low expression and high expression of Lgr5 in 337 patients were 175 (51.9%) and 162 (48.1%), respectively. There was no statistically significant difference in the association of Lgr5 expression with clinicopathologic factors (age, tumor location, lymphatic invasion, vascular invasion, perineural invasion, TNM stage, and differentiation). In the survival analysis, the high expression group of Lgr5 showed a better prognosis than the low expression group in disease-free survival (P=0.044). However, overall survival was not significantly different between the two groups (P=0.087). In multivariate analysis, we found that high expression of Lgr5 was independent prognostic factor for tumor relapse (hazard ratio, 0.601; 95% confidence interval, 0.388-0.929; P=0.022). Conclusion: In present study, high expression of Lgr5 is an independent predictor of favorable prognosis in patients with CRC. So, further well designed, prospective, large scale studies are needed to examine the value of Lgr5 as a prognostic biomarker for CRC.

• 한국방사선학회논문지
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• 제13권4호
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• pp.531-537
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• 2019

본 연구는 복부 초음파 검사를 통해 확인된 지방간 환자의 지방간 정도에 따른 혈액학적 고지혈증 지표와의 관련성을 분석하여 관련 연구에 기초자료를 제공하고자 시행되었다. 2017년 1월 1일부터 2017년 12월 31일까지 총 412명의 성인을 대상으로 하였으며, 복부초음파 검사를 진행하여 지방간이 확인된 환자 중 초음파 검사 시행일 기준 3개월 이내의 혈액학적 데이터가 있는 환자를 대상으로 후향적 분석을 실시하였다. 연구결과, 지방간 정도에 따른 혈액학적 수치는 중성지방, AST, ALT에서 통계적으로 유의한 차이가 있었고(p<.05), 지방간은 전체 변수 중 성별, 중성지방, AST, ALT와 관련성이 있었다(p<.05). 결론적으로 지방간 정도는 고지혈증의 혈액학적 수치와 직접적인 영향인자는 아니었지만 그 관련성 확인을 통해 지방간과 고지혈증 동반 관리의 필요성을 확인했다.

• 한국프랜차이즈경영연구
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• 제10권4호
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• pp.43-52
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• 2019

Purpose: As a research on the effects of the characteristics of franchise educational institution and contents on the educational transition, commitment, and recommendation intention, this study aimed to suggest the basic data that could be used for the performance of educational training of franchise headquarters, and also to suggest an empirical research helpful for the development of actual educational system and the operation of curriculum for franchise educational institutions. Research design, data, and methodology: This study selected the trainees who recently completed the training in a franchise educational institution as the samples. The survey was conducted for 20 days from October 1st to October 20th 2018, targeting total 230 people, and total 207 questionnaires were collected (Missing value 23). To verify the validity of the measurement tool used for this study, this study reviewed the factor loading of each factor by conducting the confirmatory factor analysis(CFA), and then verified the average variance extracted(AVE) and the composite construct reliability(CCR). Lastly, the structural equation model(SEM) was verified based on the research hypotheses and research model. The SPSS Win Ver. 20.0 & AMOS 20.0 were used for every analysis of this study. Results: The results of this study could be summarized as follows. First, the reputation and interaction of the characteristics of franchise educational institution had significantly positive(+) effects on the educational transition. Second, all the sub - variables of educational contents such as job relevance, education method, and instructors' professionalism had positive(+) effects on the educational transition while the educational transition had positive effects on the organizational commitment, career commitment, and job commitment. Lastly, the organizational commitment and job commitment had positive(+) effects on the recommendation intention. Thus, the trainees with higher organizational commitment and job commitment in a franchise educational institution, showed higher intention to recommend the educational institution to others. Conclusions: The results of this study imply that the franchise educational institutions could increase the actual performance of education such as educational transition, commitment, and recommendation intention by increasing interactions within educational institutions and also designing effective educational contents, so that the trainees could highly perceive the educational transition of education.

• 한국의류산업학회지
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• 제23권6호
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• pp.770-780
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• 2021

The purpose of this study is to classify customer experience components using Bernd H. Schmitt's Strategic Experiential Modules and explore the relevance between fashion lifestyle and customer experience components. A survey was conducted on 400 adults between the ages of 20s to 50s who had experience in sportswear stores. The results obtained are as follows. First, according to fashion lifestyle, the respondents were divided into an individuality-valued pragmatic group, a trend-oriented brand-seeking group, a fashion-interested group, and a conservative pragmatic group. Second, customer experience components were divided into sensory experience, emotional experience, cognitive experience, behavioral experience, and relational experience. Third, on analyzing the relationship between customer experience and fashion lifestyle, it was found that a fashion-interested group has the highest value in all experiences; therefore, it can be considered that the higher the interest in fashion, the more important is the customer experience. On the other hand, the conservative pragmatic group represented generally smaller values than the other three groups in all customer experiences. Fourth, there were significant differences in the customer experience components that were considered to be important depending on the fashion lifestyle type. An individuality-valued pragmatic group valued cognitive experiences, a fashion-interested group valued all experiences, and a conservative pragmatic group showed low scores in all customer experiences. The results of this study will allow companies to build more customer-friendly experiences and enable consumers to engage in satisfactory purchasing activities through better customer experiences.

• 한국축산식품학회지
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• 제42권3호
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• pp.536-555
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• 2022

The most abundant Orthoptera in Mexico is a small grasshopper (Sphenarium purpurascens) which is considered a food source with increased nutritional value due to its high protein content. Insect proteins have gained relevance because of their high potential as gelling, texturing, and extender agents in the food industry. The objective of this study was to evaluate the effect of substituting meat with a soluble protein extract from grasshopper obtained by alkalisation or alkalisation-piezoelectric ultrasound, on the techno-functional, physicochemical, and sensory characteristics of cooked meat models (sausages). The soluble protein was extracted in NaHCO₃ pH 8 and a piezoelectric ultrasound 5-mm sonotrode at 20 kHz with 99% amplitude. Different formulations with meat substitution: 0%, 5%, 10%, and 15% were prepared and characterised for their rheological behaviour, emulsion stability, weight loss by cooking, total protein content, colour, and texture. Sensory evaluation was conducted with consumers using a test involving check-all-that-apply and overall liking. The alkalisation-piezoelectric ultrasound method improved the solubility and the techno-functional properties of the soluble grasshopper protein when applied in sausages at maximum levels of 10% meat substitution. The sensory evaluation indicated that the formulation with 5% meat substitution exhibited the same acceptability as the control sample. Given these results, the soluble protein treated with alkalisation and piezoelectric ultrasound could be used as an extender in meat products.