• Transactions of the Korean Society of Mechanical Engineers
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• v.15 no.1
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• pp.355-365
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• 1991

New definition for the interaction of flames is introduced and interacting turbulent diffusion flames issuing from two rectangular nozzles are investigated on the basis of the definition. Theoretical study through numerical model is carried out and experiment for validation is conducted. The characteristics of interaction due to the variation of major parameters such as nozzle spacing, Reynolds number and nozzle aspect ratio are studied. Results show that strong interaction occurs for small nozzle spacing, small Reynolds number and large aspect ratio. In order of their magnitude, the intensity of interactions on the individual transport mechanism is momentum, heat and mass. It is also found that interaction makes flames longer, tilted and finally merged. Increase of velocities and temperature, decrease of oxygen concentration and depression of turbulence are occurred in the region between flames.

• Genomics & Informatics
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• v.13 no.1
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• pp.15-24
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• 2015

Fatty acid synthase (FASN, EC 2.3.1.85), is a multi-enzyme dimer complex that plays a critical role in lipogenesis. This lipogenic enzyme has gained importance beyond its physiological role due to its implications in several clinical conditions-cancers, obesity, and diabetes. This has made FASN an attractive pharmacological target. Here, we have attempted to predict the theoretical models for the human enoyl reductase (ER) and ${\beta}$-ketoacyl reductase (KR) domains based on the porcine FASN crystal structure, which was the structurally closest template available at the time of this study. Comparative modeling methods were used for studying the structure-function relationships. Different validation studies revealed the predicted structures to be highly plausible. The respective substrates of ER and KR domains-namely, trans-butenoyl and ${\beta}$-ketobutyryl-were computationally docked into active sites using Glide in order to understand the probable binding mode. The molecular dynamics simulations of the apo and holo states of ER and KR showed stable backbone root mean square deviation trajectories with minimal deviation. Ramachandran plot analysis showed 96.0% of residues in the most favorable region for ER and 90.3% for the KR domain, respectively. Thus, the predicted models yielded significant insights into the substrate binding modes of the ER and KR catalytic domains and will aid in identifying novel chemical inhibitors of human FASN that target these domains.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.32 no.6D
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• pp.673-678
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• 2012

Accurate demand estimating process in the construction of urban railway is very important, and precise validation is required. Existing model formula in the 4 phase model is limited in the estimation of the demand the administrative boundary-based zone system reflects no spatial railway demand characteristics around railway stations. The purpose of this study is improving the accuracy of urban rail demand estimation through segmentations of station influence areas and modal split characteristics within the areas. According to the case analysis, it is possible to set up the ststion influence area with a radius of 500m in the urban region and 1,000m in the suburban. And eastablishing proper segmentations of the ststion influence area shows more accurate results to the real demand of railway stations.

• Journal of the Korean Wood Science and Technology
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• v.44 no.6
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• pp.852-863
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• 2016

Wood-plastic composite (WPC) is a promising and sustainable material, and refers to a combination of wood and plastic along with some binding (adhesive) materials. In comparison to pure wood material, WPCs are in general have advantages of being cost effective, high durability, moisture resistance, and microbial resistance. The properties of WPCs come directly from the concentration of different components in composite; such as wood flour concentration directly affect mechanical and physical properties of WPCs. In this study, wood powder concentration in WPC was determined by Fourier transform near-infrared (FT-NIR) and Fourier transform infrared (FT-IR) spectroscopy. The reflectance spectra from WPC in both powdered and tableted form with five different concentrations of wood powder were collected and preprocessed to remove noise caused by several factors. To correlate the collected spectra with wood powder concentration, multivariate calibration method of partial least squares (PLS) was applied. During validation with an independent set of samples, good correlations with reference values were demonstrated for both FT-NIR and FT-IR data sets. In addition, high coefficient of determination (${R^2}_p$) and lower standard error of prediction (SEP) was yielded for tableted WPC than powdered WPC. The combination of FT-NIR and FT-IR spectral region was also studied. The results presented here showed that the use of both zones improved the determination accuracy for powdered WPC; however, no improvement in prediction result was achieved for tableted WPCs. The results obtained suggest that these spectroscopic techniques are a useful tool for fast and nondestructive determination of wood concentration in WPCs and have potential to replace conventional methods.

• Proceedings of the Korean Society of Near Infrared Spectroscopy Conference
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• 2001.06a
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• pp.4104-4104
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• 2001

Milk somatic cell count (SCC) is a recognized indicator of cow health and milk quality. The potential of near infrared (NIR) spectroscopy in the region from 1100 to 2500nm to measure SCC content of cow milk was investigated. A total of 196 milk samples from 7 Holstein cows were collected for 28 days, consecutively, and analyzed for fat, protein, lactose and SCC. Three of the cows were healthy, and the rest had mastitis periods during the experiment. NIR transflectance milk spectra were obtained by the InfraAlyzer 500 spectrophotometer in a wavelength range from 1100 to 2500 nm. The calibration for logSCC was performed using partial least square (PLS) regression and different spectral data pretreatment. The best accuracy of determination was found for equation, obtained using smoothed absorbance data and 10 PLS factors. The standard error of calibration was 0.361, calibration coefficient of multiple correlation 0.868, standard error of prediction for independent validation set of samples 0.382, correlation coefficient 0.854 and the variation coefficient 7.63%. The accuracy of logSCC determination by NIR spectroscopy would allow health screening of cows, and differentiation between healthy and mastitic milk samples. When the spectral information was studied it has been found that SCC determination by NIR milk spectra was indirect and based on the related changes in milk composition. In the case of mastitis, when the disease occurred, the most significant factors that simultaneously influenced milk spectra were alteration of milk proteins and changes in ionic concentration of milk.

• Proceedings of the Korean Society of Near Infrared Spectroscopy Conference
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• 2001.06a
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• pp.4102-4102
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• 2001

In multivariate analysis, absorbance spectrum is measured over a band of wavelengths. One does not often pay attention to the size of this wavelength band. However, it is desirable that spectrum is measured at only necessary wavelengths as long as the acceptable accuracy of prediction can be met. In this paper, the method of selecting an optimal band of wavelengths based on the loading vector analysis was proposed and applied for determining total protein in human serum using near-infrared transmission spectroscopy and PLSR. Loading vectors in the full spectrum PLSR were used as reference in selecting wavelengths, but only the first loading vector was used since it explains the spectrum best. Absorbance spectra of sera from 97 outpatients were measured at 1530∼1850 nm with an interval of 2 nm. Total protein concentrations of sera were ranged from 5.1 to 7.7 g/㎗. Spectra were measured by Cary 5E spectrophotometer (Varian, Australia). Serum in the 5 mm-pathlength cuvette was put in the sample beam and air in the reference beam. Full spectrum PLSR was applied to determine total protein from sera. Next, the wavelength region of 1672∼1754 nm was selected based on the first loading vector analysis. Standard Error of Cross Validation (SECV) of full spectrum (1530∼l850 nm) PLSR and selected wavelength PLSR (1672∼1754 nm) was respectively 0.28 and 0.27 g/㎗. The prediction accuracy between the two bands was equal. Wavelength selection based on loading vector in PLSR seemed to be simple and robust in comparison to other methods based on correlation plot, regression vector and genetic algorithm. As a reference of wavelength selection for PLSR, the loading vector has the advantage over the correlation plot since the former is based on multivariate model whereas the latter, on univariate model. Wavelength selection by the first loading vector analysis requires shorter computation time than that by genetic algorithm and needs not smoothing.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.46 no.8
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• pp.652-661
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• 2018

It is necessary to resolve the absolute velocity as well as Mach number to reflect the high temperature effect in high speed flow. So this region is classified as high enthalpy flows distinguished from high speed flows. Many facilities, such as arc-jet, shock tunnel, etc. has been used to obtain the high enthalpy flows at the ground level. However, it is difficult to define the exact test condition in this type of facilities, because some chemical reactions and energy transfer take place during the experiments. In the present study, a quasi 1D code considering the thermochemical non-equilibrium effect is developed to effectively estimate the test condition of a shock tunnel. Results show that the code gives reasonable solution compared with the results from the known experiments and 2D axisymmetric simulations.

• Interdisciplinary Bio Central
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• v.2 no.3
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• pp.8.1-8.5
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• 2010

Introduction: Recently identified human homologues of ALKB protein have shown the activity of DNA damaging drugs, used for cancer therapy. Bioinformatics study of hABH2 and hABH3 had led to the discovery of a novel DNA repair mechanism. Very little is known about structure and function of hABH4, one of the members of this superfamily. Therefore, in present study we are intended to predict its structure and function through various bioinformatics tools. Materials and Methods: Modeling was done with modeler 9v7 to predict the 3D structure of the hABH4 protein. This model was validated with the program Procheck using Ramachandran plot statistics and was submitted to PMDB with ID PM0076284. The 3d2GO server was used to predict the functions. Residues at protein ligand and protein RNA binding sites were predicted with 3dLigandSite and KYG programs respectively. Results and Discussion: 3-D model of hABH4, ALKBH4.B99990003.pdb was predicted and evaluated. Validation result showed that 96.4 % residues lies in favored and additional allowed region of Ramachandran plot. Ligand binding residues prediction showed four Ligand clusters, having 24 ligands in cluster 1. Importantly, conserved pattern of Glu196-X-Pro198- Xn-His254 in the functional domain was detected. DNA and RNA binding sites were also predicted in the model. Conclusion and Prospects: The predicted and validated model of human homologue hABH4 resulted from this study may unveil the mechanism of DNA damage repair in human and accelerate the research on designing of appropriate inhibitors aiding in chemotherapy and cancer related diseases.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.20 no.5
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• pp.429-438
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• 2008

The present study is to predict the multidiretional random wave height at the front face and concave corner of a refracted breakwater which is not straight. The numerical simulation on wave height at the front face of an insular breakwater is performed by using the boundary element method, and obtained results have been compared with those of exact- and analytical solutions of the eigenfunction presented by Goda et al. (1971) and the other existing numerical solution. Also, the results of wave-height distribution due to the refracted breakwater have been validated through comparisons with previous results of analytical solution. Based on the validation through these comparisons, several wave-height distributions at the interested region have been illustrated for various conditions related with concave corner angles and the wave incidence, and then the prediction of wave height are simulated at the front face and concave corner of a refracted breakwater under construction currently. Excellent agreements have been obtained in all cases, and this study can effectively be utilized for predicting random waves for various breakwater system.

• The Korean Journal of Health Service Management
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• v.6 no.1
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• pp.39-51
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• 2012

The purpose of this study is to provide a set of fundamental data for the oral hygiene education for the elderly as a result of the survey on the oral hygiene and subjective oral health of the elderly in an aged society. For this purpose, 269 elders who dwelled in Gyeongsangbuk-do region were randomly selected in an arbitrary selection process, followed by a survey on their oral hygiene and health. The collected data were coded and processed by using SPSS 15.0 software. As for the analysis of the data, the general characteristics and the basic items concerning the management of the oral health were analyzed for their frequency and percentages, while the general characteristics and the awareness on the oral health were processed with Chi-square validation to show a set of results as follows; Firstly, among the items on the oral health, the satisfaction on the current condition of their oral health was below average. Secondly, concerning the oral hygienic behaviors, the majority of the samples answered that they were brushing their teeth twice a day. And, as for the brushing methods, the largest number of the samples answered that they were brushing their teeth in a 'horizontal direction'. Thirdly, they reported they were having difficulties in getting dental treatments. The implications of this study are that it is necessary to provide sound oral health education to them to correct the inappropriate oral hygienic behaviors.