• 제목/요약/키워드: Validation Region

검색결과 291건 처리시간 0.026초

Development and Validation of a Perfect KASP Marker for Fusarium Head Blight Resistance Gene Fhb1 in Wheat

  • Singh, Lovepreet;Anderson, James A;Chen, Jianli;Gill, Bikram S;Tiwari, Vijay K;Rawat, Nidhi
    • The Plant Pathology Journal
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    • 제35권3호
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    • pp.200-207
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    • 2019
  • Fusarium head blight (FHB) is a devastating wheat disease with a significant economic impact. Fhb1 is the most important large effect and stable QTL for FHB resistance. A pore-forming toxin-like (PFT) gene was recently identified as an underlying gene for Fhb1 resistance. In this study, we developed and validated a PFT-based Kompetitive allele specific PCR (KASP) marker for Fhb1. The KASP marker, PFT_KASP, was used to screen 298 diverse wheat breeding lines and cultivars. The KASP clustering results were compared with gelbased gene specific markers and the widely used linked STS marker, UMN10. Eight disagreements were found between PFT_KASP and UMN10 assays among the tested lines. Based on the genotyping and sequencing of genes in the Fhb1 region, these genotypes were found to be common with a previously characterized susceptible haplotype. Therefore, our results indicate that PFT_KASP is a perfect diagnostic marker for Fhb1 and would be a valuable tool for introgression and pyramiding of FHB resistance in wheat cultivars.

Convolutional Neural Network-Based Automatic Segmentation of Substantia Nigra on Nigrosome and Neuromelanin Sensitive MR Images

  • Kang, Junghwa;Kim, Hyeonha;Kim, Eunjin;Kim, Eunbi;Lee, Hyebin;Shin, Na-young;Nam, Yoonho
    • Investigative Magnetic Resonance Imaging
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    • 제25권3호
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    • pp.156-163
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    • 2021
  • Recently, neuromelanin and nigrosome imaging techniques have been developed to evaluate the substantia nigra in Parkinson's disease. Previous studies have shown potential benefits of quantitative analysis of neuromelanin and nigrosome images in the substantia nigra, although visual assessments have been performed to evaluate structures in most studies. In this study, we investigate the potential of using deep learning based automatic region segmentation techniques for quantitative analysis of the substantia nigra. The deep convolutional neural network was trained to automatically segment substantia nigra regions on 3D nigrosome and neuromelanin sensitive MR images obtained from 30 subjects. With a 5-fold cross-validation, the mean calculated dice similarity coefficient between manual and deep learning was 0.70 ± 0.11. Although calculated dice similarity coefficients were relatively low due to empirically drawn margins, selected slices were overlapped for more than two slices of all subjects. Our results demonstrate that deep convolutional neural network-based method could provide reliable localization of substantia nigra regions on neuromelanin and nigrosome sensitive MR images.

On the validation of ATHLET 3-D features for the simulation of multidimensional flows in horizontal geometries under single-phase subcooled conditions

  • Diaz-Pescador, E.;Schafer, F.;Kliem, S.
    • Nuclear Engineering and Technology
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    • 제54권9호
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    • pp.3567-3579
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    • 2022
  • This paper provides an assessment of fluid transport and mixing processes inside the primary circuit of the test facility ROCOM through the numerical simulation of Test 2.1 with the system code ATHLET. The experiment represents an asymmetric injection of cold and non-borated water into the reactor coolant system (RCS) of a pressurized water reactor (PWR) to restore core cooling, an emergency procedure which may subsequently trigger a core re-criticality. The injection takes place at low velocity under single-phase subcooled conditions and presents a major challenge for the simulation in lumped parameter codes, due to multidimensional effects in horizontal piping and vessel arising from density gradients and gravity forces. Aiming at further validating ATHLET 3-D capabilities against horizontal geometries, the experiment conditions are applied to a ROCOM model, which includes a newly developed horizontal pipe object to enhance code prediction inside coolant loops. The obtained results show code strong simulation capabilities to represent multidimensional flows. Enhanced prediction is observed at the vessel inlet compared to traditional 1-D approach, whereas mixing overprediction from the descending denser plume is observed at the upper-half downcomer region, which leads to eventual deviations at the core inlet.

Development and validation of fuel stub motion model for the disrupted core of a sodium-cooled fast reactor

  • Kawada, Kenichi;Suzuki, Tohru
    • Nuclear Engineering and Technology
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    • 제53권12호
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    • pp.3930-3943
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    • 2021
  • To improve the capability of the SAS4A code, which simulates the initiating phase of core disruptive accidents for MOX-fueled Sodium-cooled Fast Reactors (SFRs), the authors have investigated in detail the physical phenomena under unprotected loss-of-flow (ULOF) conditions in a previous paper (Kawada and Suzuki, 2020) [1]. As the conclusion of the last article, fuel stub motion, in which the residual fuel pellets would move toward the core central region after fuel pin disruption, was identified as one of the key phenomena to be appropriately simulated for the initiating phase of ULOF. In the present paper, based on the analysis of the experimental data, the behaviors related to the stub motion were evaluated and quantified by the author from scratch. A simple model describing fuel stub motion, which was not modeled in the previous SAS4A code, was newly proposed. The applicability of the proposed model was validated through a series of analyses for the CABRI experiments, by which the stub motion would be represented with reasonable conservativeness for the reactivity evaluation of disrupted core.

Numerical investigation of effect of geotextile and pipe stiffness on buried pipe behavior

  • Candas Oner;Selcuk Bildik;J. David Frost
    • Geomechanics and Engineering
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    • 제34권6호
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    • pp.611-621
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    • 2023
  • This paper presents the results of a numerical investigation of the effect of geotextile reinforcement on underlying buried pipe behavior using PLAXIS 3D. In this study, variable parameters such as the in-plane stiffness of the geotextile, the pipe stiffness, the soil stiffness, the footing width, the geotextile width, and the location of the geotextile reinforcement layer are investigated. Deflections and bending moments acting on the pipe are evaluated for different combinations of variables and are presented graphically. It is observed that with an increase in the in-plane stiffness of the geotextile reinforcement, there is a tendency for a decrease in both deflections in the pipe and bending moments acting on the pipe. Conversely, with an increase in the pipe stiffness, geotextile reinforcement efficiency decreases. In the investigated region of soil stiffness, for the given pipe and geotextile stiffness, an optimum efficiency of geotextile is observed in medium dense soils. Further, it is shown that relative lengths of geotextile and footing has an important role on geotextile efficiency. Lastly, it is also demonstrated that relative location of geotextile layer with respect to the buried pipe plays an important role on the geotextile efficiency in reducing the bending moments acting on the pipe and deflections in the pipe. In general, geotextiles are more efficient in reducing the bending moments as opposed to reducing deflections of the pipe. Numerical validation is done with an experimental study from the literature to observe the applicability of the numerical model used.

Benchmarking of the CUPID code to the ASSERT code in a CANDU channel

  • Eun Hyun Ryu;Joo Hwan Park;Yun Je Cho;Dong Hun Lee;Jong Yeob Jung
    • Nuclear Engineering and Technology
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    • 제54권11호
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    • pp.4338-4347
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    • 2022
  • The CUPID code was developed and is continuously updated in KAERI. Verification and validation (V&V) is mainly done for light water reactors (LWRs). This paper describes a benchmarking of the detailed mesh level compared with sub-channel level for application to pressurized heavy water reactors (PHWRs), even though component scale comparison for the PHWR moderator system was done once before. We completed a sub-channel level comparison between the CUPID code and the ASSERT code and a CUPID code analysis. Because the ASSERT code has already been validated with numerous experiments, benchmarking with the ASSERT code will offer us more trust on the CUPID code. The target channel has high power and thus high pressure deformation. The high power channel tends to have a high possibility of critical heat flux (CHF), because a high void fraction and quality in channel exit region appear. In this research, after determining the reference grid and T/H model, we compared the sub-channel level results of the CUPID code with those of the ASSERT code.

Investigation of decontamination characteristics of a serial multiple pool scrubber system for consequence mitigation of severe accidents

  • Hyeon Ho Byun;Man-Sung Yim
    • Nuclear Engineering and Technology
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    • 제54권12호
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    • pp.4585-4600
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    • 2022
  • A pool scrubber is often used as a wet-type design to mitigate the consequence of a severe nuclear accident. While studies indicated higher decontamination performance of a deeper pool, utilizing a very tall pool can be problematic due to potential structural stability and water backflow issues. This study proposes, as an alternative to a single pool system, a pool scrubber system composed of serially connected multiple pools with lower heights. Since large fraction of aerosol removal takes place in the injection region, serially connected pool scrubber system is expected to enhance the overall decontamination capability of a pool scrubber system. To support the analysis of the proposed system's decontamination capability, a new computer model was developed in the study to describe the bubble size dependent effect on aerosol removal including the effect of pool residence time. The accuracy of the new model was examined against experimental data for its validation. The proposed scrubber system composed of serially connected multiple shorter pools is found to have much improved decontamination performance over the current single pool system design.

Large-eddy simulation on gas mixing induced by the high-buoyancy flow in the CIGMAfacility

  • Satoshi Abe;Yasuteru Sibamoto
    • Nuclear Engineering and Technology
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    • 제55권5호
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    • pp.1742-1756
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    • 2023
  • The hydrogen behavior in a nuclear containment vessel is a significant issue when discussing the potential of hydrogen combustion during a severe accident. After the Fukushima-Daiichi accident in Japan, we have investigated in-depth the hydrogen transport mechanisms by utilizing experimental and numerical approaches. Computational fluid dynamics is a powerful tool for better understanding the transport behavior of gas mixtures, including hydrogen. This paper describes a Large-eddy simulation of gas mixing driven by a high-buoyancy flow. We focused on the interaction behavior of heat and mass transfers driven by the horizontal high-buoyant flow during density stratification. For validation, the experimental data of the Containment InteGral effects Measurement Apparatus (CIGMA) facility were used. With a high-power heater for the gas-injection line in the CIGMA facility, a high-temperature flow of approximately 390 ℃ was injected into the test vessel. By using the CIGMA facility, we can extend the experimental data to the high-temperature region. The phenomenological discussion in this paper helps understand the heat and mass transfer induced by the high-buoyancy flow in the containment vessel during a severe accident.

1D와 CFD(Computational fluid dynamic) 시뮬레이션을 통한 PEMFC(Polymer Electrolyte Membrane Fuel Cell) 성능 비교 (Comparison of Polymer Electrolyte Membrane Fuel Cell performance obtained by 1D and CFD simulations)

  • 전원우;안세현;양재완;이지원;조현빈;염은섭
    • 한국가시화정보학회지
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    • 제21권3호
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    • pp.49-56
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    • 2023
  • The Polymer electrolyte membrane fuel cell (PEMFC) operates at ambient temperature as a low-temperature fuel cell. During its operation, voltage losses arise due to factors such as operating conditions and material properties, effecting its performance. Computational simulations of fuel cells can be categorized into 1D simulation and CFD, chosen based on their specific application purposes. In this study, we carried out an analysis validation using 1D geometry and compared its performance with the results from 2D geometry analysis. CFD allows for the representation of pressure, velocity distribution, and fuel mass fraction according to the geometry, enabling the analysis of current density. However, the 1D simulation, simplifying governing equations to reduce time cost, failed to accurately account for fuel distribution and changes in fuel concentration due to fuel cell operations. As a result, it showed unrealistic results in the cell voltage region dominated by concentration loss compared to CFD.

중·상층 항공난류 예측모델의 성능 평가와 개선 (Performance Evaluation and Improvement of Operational Aviation Turbulence Prediction Model for Middle- and Upper- Levels)

  • 강유정;최희욱;최유나;이상삼;황혜원;이혁제;이용희
    • 한국항공운항학회지
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    • 제31권3호
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    • pp.30-41
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    • 2023
  • Aviation turbulence, caused by atmospheric eddies, is a disruptive phenomenon that leads to abrupt aircraft movements during flight. To minimize the damages caused by such aviation turbulence, the Aviation Meteorological Office provides turbulence information through the Korea aviation Turbulence Guidance (KTG) and the Global-Korean aviation Turbulence Guidance (GKTG). In this study, we evaluated the performance of the KTG and GKTG models by comparing the in-situ EDR observation data and the generated aviation turbulence prediction data collected from the mid-level Korean Peninsula region from January 2019 to December 2021. Through objective validation, we confirmed the level of prediction performance and proposed improvement measures based on it. As a result of the improvements, the KTG model showed minimal difference in performance before and after the changes, while the GKTG model exhibited an increase of TSS after the improvements.