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Bioequivalence of MeloxifenTM Capsule to MobicTM Capsule(Meloxicam 7.5 mg) (모빅캡슐(멜록시캄 7.5mg)에 대한 멜록시펜캡슐의 생물학적 동등성)

  • Lee, Jin-Sung;Tak, Sung-Kwon;Seo, Ji-Hyung;Kang, Jong-Min;Ryu, Ju-Hee;Yim, Sung-Vin;Hong, Seung-Jae;Lee, Kyung-Tae
    • Journal of Pharmaceutical Investigation
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    • v.39 no.6
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    • pp.457-463
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    • 2009
  • The purpose of the present study was to evaluate the bioequivalence of meloxicam capsule, $Mobic^{TM}$ capsule( Boehringer Ingelheim Ltd., Korea) as a reference drug and $Meloxifen^{TM}$ capsule (Kukje Pharma Ind. Co., Ltd., Korea) as a test drug, according to the guidelines of Korea Food and Drug Administration(KFDA). Thirty two healthy male Korean volunteers received capsule containing meloxicam 7.5 mg in a $2{\times}2$ crossover study. There was a one-week above washout period between the doses. Plasma concentrations of meloxicam were monitored for over a period of 72 hr after administration by using a high performance liquid chromatography-tandem mass spectrometer(LC-MS/MS). $AUC_t$(the area under the plasma concentration-time curve from time zero to 72 hr), $C_{max}$(maximum plasma drug concentration) and $T_{max}$(time to reach $C_{max}$) were complied from the plasma concentration-time data. Analysis of variance(ANOVA) test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$ and $C_{max}$. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Meloxifen^{TM}/Mobic^{TM}$ were log 0.8605-log 0.9847 and log 0.9765-log 1.1503, respectively. These values were within the acceptable bioequivalence intervals of log 0.80-log 1.25, recommended by KFDA. In all of these results, we concluded that $Meloxifen^{TM}$ capsule was bioequivalent to $Mobic^{TM}$ capsule, based on the rate and extent of absorption.

A Basic study of Service Design for Optimization of the Public Elderly Recreational Place (최적화된 노인여가시설 구축을 위한 서비스디자인 기초연구)

  • Lim, Beak-Vin;Gim, Hyeong-Chan;Lee, Sung-Pil
    • Science of Emotion and Sensibility
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    • v.13 no.4
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    • pp.753-760
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    • 2010
  • The purpose of this study to prepare for an aging society and older people happy is important to build recreational facilities gwajera recognize and physically old man of leisure facilities as a basis for the destroyers of the current seniors in public institutions that provide recreational facilities for About under utilized factors was investigated. The specific research methods and information, first, at home the most successful public senior leisure facilities as a model for selected Daegu Senior seutawo visit the simple survey and observation through the pros and cons about the elements that organize and KJ Technique and graft technique (Graph Theory) by applying the elements of physical space limitations on the mutual relationship between the priorities and establish guidelines for the priority was extracted. In addition, field-aged feel the satisfaction of their leisure facilities to evaluate the visits to the Busan, Sasang elderly and local leisure facilities for the elderly surveyed had taken Priority Method is based on comparison of results and final was to organize things to improve. Through this study, first, goods and equipment to the leisure space of the elderly efforts to effectively deploy the expertise to deal with and it actually showed that it is also important. Second, using physical devices and programs for the elderly aged recreational facilities are important, but physical and mental characteristics to consider voluntary participation for the type of space could see that it is important.

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In Vitro Antitumor Activity and Nephrotoxicity of the Novel Platinum(II) Coordination Complex Containing Cis-dach/Diphosphine (새로운 Platinum(II)Complex ([Pt(II)(cis-dach)(DPPP)].$(NO_3)_2$의 항암효과 및 신독성)

  • Jung, Jee-Chang;Yim, Sung-Vin;Park, Seung-Joon;Chung, Joo-Ho;Ko, Kye-Chang;Chang, Sung-Goo;Rho, Young-Soo
    • The Korean Journal of Pharmacology
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    • v.32 no.1
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    • pp.93-102
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    • 1996
  • Platinum coordination complexes are currently one of the most compounds used in the treatment of solid tumors. However, its use is limited by severe side effects such as nephrotoxicity. Our platinum-based drug discovery program is aimed at developing drugs capable of diminishing toxicity and broadening the clinical spectrum of activity of cisplatin. We synthesized new Pt(II) complex analogue containing 1,2-diaminocyclohexane (dach) as carrier ligand and 1,3-bis(diphenyl phosphino)propane (DPPP) as a leaving group. Furthermore, nitrate was added to improve the solubility. A new series of PC-1 [Pt(cis-dach) (DPPP)]. $2NO_3_2$ was synthesized and characterized by their elemental analysis and by various spectroscopic techniques [infrared (IR), $^{13}carbon$ nuclear magnetic resonance (NMR)]. PC-1 was demonstrated acceptable antitumor activity aganist SKOV -3, OVCAR-3 human ovarian adenocarcinomacells and significant activity as compared with that of cisplatin. The toxicity of PC-1 was found quite less than that of cisplatin using MTT, $[^3H]thymidine$ uptake and glucose consumption tests in rabbit proximal tubule cells, human kidney cortical cells and human renal cortical tissues. Based on these results, this novel platinum compound represent a valuable lead in the development of a new anticancer chemotherapeutic agent capable of improving antitumor activity and low toxicity.

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Bioequivalence of Etodin Capsule to Kuhnillodin Capsule (Etodolac 200 mg) (건일로딘 캡슐(에토돌락 200mg)에 대한 에토딘 캡슐의 생물학적동등성)

  • Lee, Myung-Jae;Kang, Jong-Min;Choi, Sang-Jun;Lee, Jin-Sung;Tak, Sung-Kwon;Seo, Ji-Hyung;Rew, Jae-Hwan;Yim, Sung-Vin;Lee, Kyung-Tae
    • Journal of Pharmaceutical Investigation
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    • v.38 no.6
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    • pp.421-427
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    • 2008
  • The purpose of the present study was to evaluate the bioequivalence of two etodolac capsules, Kuhnillodin capsule (Kuhnil. Co., Ltd., Seoul, Korea) as reference drug and Etodin capsule (Myungmun Pharm. Co., Ltd., Seoul, Korea) as test drug, according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-three healthy male Korean volunteers received one capsule at the dose of 200 mg etodolac in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of etodolac were monitored by a high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) for over a period of 24 hr after the administration. $AUC_{0-24\;hr}$ was calculated by the linear trapezoidal rule method. $C_{max}$ and $T_{max}$ were compiled from the plasma concentration-time data. Analysis of variance (ANOVA) was carried out using logarithmically transformed $AUC_{0-24\;hr}$ and $C_{max}$. The 90% confidence intervals of the $AUC_{0-24\;hr}$ ratio and the $C_{max}$ ratio for Etodin/Kuhnillodin were $\log\;0.97{\sim}\log\;1.08$ and $\log\;0.89{\sim}\log\;1.19$, respectively. These values were within the acceptable bioequivalence intervals of $\log\;0.80{\sim}\log\;1.25$. Thus, our study demonstrated that Etodin was bioeqiovalent to Kuhnillodin preparation when the rate and extent of absorption between two preparations were compared.

Antioxidant and Alcohol Dehydrogenase Activity of Water Extracts From Abalone Containing Medicinal Plants (전복과 천연 식물류 복합물의 항산화 및 알코올대사 효소 활성)

  • Shin, Jung-Hye;Lee, Soo-Jung;Choi, Duk-Ju;Kang, Min-Jung;Sung, Nak-Ju
    • Korean journal of food and cookery science
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    • v.24 no.2
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    • pp.182-187
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    • 2008
  • This study was performed to evaluate the possible production of a functional beverage derived from abalone and with several plants (AP). Five types of AP composites were prepared having different medicinal plant compositions (AP- I : abalone, garlic, jujube, Chinese matrimony fruit, dried orange peel, licorice root, zinger, honey; AP- II: abalone, garlic, black bean, Chinese matrimony fruit, cornus fruit, licorice root, zinger, honey; AP-III : abalone, jujube, arrow root, milk vetch, dried orange peel, licorice root, zinger, honey; AP-N: abalone, black bean, arrow root, milk vetch, cornus fruit, liquorice root, zinger, honey; AP-V : abalone, garlic, Chinese matrimony fruit, milk vetch, licorice root, zinger, honey). In vitro analysis were performed to examine the antioxidant contents and alcohol dehydrogenase activities of the composites. AP- II had the highest total phenol contents ($28.55{\pm}1.56\;mg/l00\;g$), and AP- V the highest level of flavonoids ($47.61{\pm}1.58\;mg/l00\;g$). At $78.89{\pm}0.16%$, AP- V displayed the strongest electron donating ability followed by AP-II($57.99{\pm}0.21%$) and API ($37.66{\pm}0.20%$). Reducing power was also significantly higher in AP- V. The Hydroxyl radical scavenging and SOD-like activities of all composites were less than 15% and 20%, respectively. At 12.5% alcohol concentration, ADH activity ranged from $114.47{\pm}2.18{\sim}121.39{\pm}4.36%$ and ALDH activity ranged from $100.04{\pm}2.90{\sim}129.54{\pm}4.80%$; AP- I , AP- II, and AP- Vin 12.5% of alcoholic concentration. The composites of AP- I , AP- II, and AP- V, all containing garlic and Chinese matrimony fruit, were significantly stronger than AP-III and AP-N. Finally, also at 12.5% alcoholic concentration, the ALDH activity of AP- V was higher than its ADH activity.

The association of PBX1 polymorphisms with overweight/obesity and metabolic alterations in the Korean population

  • Ban, Ju-Yeon;Kang, Soon-Ah;Jung, Kyung-Hee;Kim, Hak-Jae;Uhm, Yoon-Kyung;Kim, Su-Kang;Yim, Sung-Vin;Choe, Bong-Keun;Hong, Seung-Jae;Seong, Yeon-Hee;Koh, In-Song;Chung, Joo-Ho
    • Nutrition Research and Practice
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    • v.2 no.4
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    • pp.289-294
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    • 2008
  • Pre-B-cell leukemia transcription factor 1 (PBX1), which is located on chromosome 1q23, was recently reported to be associated with type 2 diabetes mellitus. We examined whether single nucleotide polymorphisms (SNPs) of the PBX1 gene are associated with overweight/obesity in a Korean population. We genotyped 66 SNPs in the PBX1 gene and investigated their association with clinical phenotypes found in 214 overweight/obese subjects and 160 control subjects using the Affymetrix Targeted Genotyping chip array. Seven SNPs (g.+75l86C>T, g.+78350C>A, g.+80646C>T, g.+138004C>T, g.+185219G>A, g.+191272A>C, and g.+265317T>A) were associated with the risk of obesity in three models (codominant, dominant, and recessive) (P=0.007-0.05). Haplotype 1 (CAC) and 3 (TAC) of block 3 and haplotype 2 (GGAAT) of block 10 were also strongly associated with the risk of obesity. In the control group, subjects that had homozygote for the major allele for both g.+185219G>A and g.+191272A>C showed lower high density lipoprotein-cholesterol (HDL-C) level compared to those possessing the minor allele, suggesting that the association between the homozygote for the major allele for both g.+185219G>A and g.+191272A>C and HDL-C is attributable to the increased risk of obesity. This study suggests that the PBX1 gene is a possible risk factor in overweight/obese patients.

A Charge Pump Design with Internal Pumping Capacitor for TFT-LCD Driver IC (내장형 펌핑 커패시터를 사용한 TFT-LCD 구동 IC용 전하펌프 설계)

  • Lim, Gyu-Ho;Song, Sung-Young;Park, Jeong-Hun;Li, Long-Zhen;Lee, Cheon-Hyo;Lee, Tae-Yeong;Cho, Gyu-Sam;Park, Mu-Hun;Ha, Pan-Bong;Kim, Young-Hee
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.11 no.10
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    • pp.1899-1909
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    • 2007
  • A cross-coupled charge pump with internal pumping capacitor, witch is advantages from a point of minimizing TFT-LCD driver IC module, is newly proposed in this paper. By using a NMOS and a PMOS diode connected to boosting node from VIN node, the pumping node is precharged to the same value each pumping node at start pumping operation. Since the lust-stage charge pump is designed differently from the other stage pumps, a back current of pumped charge from charge pumping node to input stage is prevented. As a pumping clock driver is located the font side of pumping capacitor, the driving capacity is improved by reducing a voltage drop of the pumping clock line from parasitic resistor. Finally, a layout area is decreased more compared with conventional cross-coupled charge pump by using a stack-MIM capacitors. A proposed charge pump for TFT-LCD driver IC is designed with $0.13{\mu}m$ triple-well DDI process, fabricated, and tested.

Effects of a Horse Riding Simulator, Gym-ball and McKenzie Exercises on Back Pain and Balance in Patients with Chronic Back Pain in Their 20s (승마기구운동과 짐볼 운동 그리고 멕켄지 운동이 20대 만성허리통증환자의 허리통증과 정적균형에 미치는 영향)

  • Choi, Jong-Won;Kim, Min-Young;Kim, Sung-Hwa;Son, Bo-Hyun;Lee, Su-Min;Lee, Yu-Jeong;Jang, Da-Vin;Je, Hyo-Min;Kim, Ki-Hyun
    • Journal of the Korean Society of Physical Medicine
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    • v.14 no.3
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    • pp.117-126
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    • 2019
  • PURPOSE: This study examined the effects of a horse riding simulator, gym ball, and McKenzie exercises on back pain and static balance. METHODS: Among 30 participants with chronic back pain and more than 5 points of ODI, 28 participants were selected. Groups of performing either horse riding, gym ball, or McKenzie were chosen randomly to work out two times a week for six weeks. The static balance was measured using a gym plate and the degree of pain was measured by the VAS and K-ODI. RESULTS: When each exercise was applied to back pain patients, the VAS was changed in all three groups but only in the gym-ball exercise group. The K-ODI varied in all three groups but not in the gym-ball exercise group, In the anterior - posterior static balance, all three groups showed changes, but only the riding exercise group was not significant. In the left-right static balance, all three groups were significant. CONCLUSION: This study showed that six-week exercise for back pain patients was effective in improving back pain and balance ability. Continuous exercise minimizes the risk of recurrence and is effective in preventing and treating back pain.

Effects of Depression and Anxiety Symptoms on Specific Cognitive Function by Evaluating Healthy Subjects (정상인을 통해 알아본 우울 증상과 불안 증상이 특정 인지 기능에 미치는 영향)

  • Kim, Kyuho;Nam, Yoon-Young;Han, Jiyeon;Yu, Rina;Ryu, Vin
    • Korean Journal of Psychosomatic Medicine
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    • v.29 no.1
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    • pp.42-48
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    • 2021
  • Objectives : Based on the fact that cognitive functions decline known as comorbid symptoms of depression can precede depression, this study seeks to observe the effects of depressive symptoms and anxiety symptoms on cognitive function in healthy subjects. Methods : To recruit 50 general populations to evaluate cognitive and clinical symptoms and to find out the effects of clinical symptoms on cognitive functions, Pearson correlation and multivariate regression were conducted. Correlation analysis of subdomain cognitive function was conducted for reliability analysis. Results : Trail making test-B that evaluates the execution function correlates with depressive symptoms (r=0.300, p=0.03) and age (r=0.323, p=0.02). Depressive symptoms (β=0.304, p=0.03) and age (β=0.335, p=0.01) were significantly related to Trail making test -B (Adjusted R2=0.148). Subjective cognitive tests correlates with anxiety symptoms (r=0.434, p=0.002). In the correlation between cognitive functional items, Subjective cognitive tests was found to be correlated with other test except Spotter. Conclusions : In this study, depressive symptoms contribute independently to executive functions in addition to demographic characteristics such as age and duration of education. Given that cognitive decline is a common long-term clinical outcome in depression, we expect active early intervention and evaluation of cognitive function to be helpful.

Spatial Usage and Patterns of Corvus frugilegus after Sunrise and Sunset in Suwon Using Citizen Science (시민과학을 활용한 수원시에 출몰하는 떼까마귀(Corvus frugilegus)의 일출 및 일몰시 선호 서식지 분석)

  • Yun, Ji-Weon;Shin, Won-Hyeop;Kim, Ji-Hwan;Yi, Sok-Young;Kim, Do-Hee;Kim, Yu-Vin;Ryu, Young-Ryel;Song, Young-Keun
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.24 no.6
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    • pp.35-48
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    • 2021
  • In Suwon, the overall hygiene of the city is threatened by the emergence of the rook(Corvus fugilegus) in the city. Rooks began to appear in November of 2016 and has continued to appear from November to March every year. In order to eradicate or to prepare an alternative habitat for rooks, this study aimed to identify the preferred habitat and specific environmental variables. Therefore, in this work, we aim to understand the predicted distribution of rooks in Suwon City with citizen science and through MaxENT, the most widely utilized habitat modeling using citizen science to analyze the preferred habitat of harmful tides appearing in urban areas. In this study, seven environmental variables were chosen: biotope group complex, building floor, vegetation, euclidean distance from farmland, euclidean distance from streetlamp, and euclidean distance from pole and DEM. Among the estimated models, after the time period of sunrise (08:00~18:00) the contribution percentage were as following: euclidean distance from arable land(39.2%), DEM(25.5%), euclidean distance from streetlamp(22.3%), euclidean distance from pole(7.1%), biotope group complex(4.9%), building floor(1%), vegetation(0%). In the time period after sunset(18:00~08:00) the contribution percentage were as following: biotope group complex(437.4%), euclidean distance from pole(26.8%), DEM(13.4%), euclidean distance from streetlamp(11.8%), euclidean distance from farmland(7.9%), building floor(1.4%), vegetation(1.3%).