• 제목/요약/키워드: V-I slope

검색결과 119건 처리시간 0.021초

토끼 단일 심근세포에서 대사억제시 Inward Rectifier$(I_{K1})$의 변화 (Effect of Metabolic Inhibition on Inward Rectifier K Current in Single Rabbit Ventricular Myocytes)

  • 정유정;호원경;엄융의
    • The Korean Journal of Physiology and Pharmacology
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    • 제1권6호
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    • pp.741-748
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    • 1997
  • In the present study, we have investigated the effect of metabolic inhibition on the inward rectifier K current ($I_{K1}$). Using whole cell patch clamp technique we applied voltage ramp from +80 mV to -140 mV at a holding potential of -30 mV and recorded the whole cell current in single ventricular myocytes isolated from the rabbit heart. The current-voltage relationship showed N-shape (a large inward current and little outward current with a negative slope) which is a characteristic of $I_{K1}$. Application of 0.2 mM dinitrophenol (DNP, an uncoupler of oxidative phosphorylation as a tool for chemical hypoxia) to the bathing solution with the pipette solution containing 5 mM ATP, produced a gradual increase of outward current followed by a gradual decrease of inward current with little change in the reversal potential (-80 mV). The increase of outward current was reversed by glibenclamide ($10\;{\mu}M$), suggesting that it is caused by the activation of $K_{ATP}$. When DNP and glibenclamide were applied at the same time or glibenclamide was pretreated, DNP produced same degree of reduction in the magnitude of the inward current. These results show that metabolic inhibition induces not only the increase of $K_{ATP}$ channel but also the decrease of $I_{K1}$. Perfusing the cell with ATP-free pipette solution induced the changes very similar to those observed using DNP. Long exposure of DNP (30 min) or ATP-free pipette solution produced a marked decrease of both inward and outward current with a significant change in the reversal potential. Above results suggest that the decrease of $I_{K1}$ may contribute to the depolarisation of membrane potential during metabolic inhibition.

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수위유량곡선보정방법에 대하여 (A Method of Rating Curve Adjustment)

  • 박정근
    • 한국농공학회지
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    • 제18권2호
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    • pp.4116-4120
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    • 1976
  • With the use of many rivers increased nearly to the capacity, the need for information concerning daily quantities of water and the total annual or seasonal runoff has became increased. A systematic record of the flow of a river is commonly made in terms of the mean daily discharge Since. a single observation of stage is converted into discharge by means of rating curve, it is essential that the stage discharge relations shall be accurately established. All rating curves have the looping effect due chiefly to channel storage and variation in surface slope. Loop rating curves are most characteristic on streams with somewhat flatter gradients and more constricted channels. The great majority of gauge readings are taken by unskilled observers once a day without any indication of whether the stage is rising or falling. Therefore, normal rating curves shall show one discharge for one gauge height, regardless of falling or rising stage. The above reasons call for the correction of the discharge measurements taken on either side of flood waves to the theoretical steady-state condition. The correction of the discharge measurement is to consider channel storage and variation in surface slope. (1) Channel storage As the surface elevation of a river rises, water is temporarily stored in the river channel. There fore, the actual discharge at the control section can be attained by substracting the rate of change of storage from the measured discharge. (2) Variation in surface slope From the Manning equation, the steady state discharge Q in a channel of given roughness and cross-section, is given as {{{{Q PROPTO SQRT { 1} }}}} When the slope is not equal, the actual discharge will be {{{{ { Q}_{r CDOT f } PROPTO SQRT { 1 +- TRIANGLE I} CDOT TRIANGLE I }}}} may be expressed in the form of {{{{ TRIANGLE I= { dh/dt} over {c } }}}} and the celerity is approximately equal to 1.3 times the mean watrr velocity. Therefore, The steady-state discharge can be estimated from the following equation. {{{{Q= { { Q}_{r CDOT f } } over { SQRT { (1 +- { A CDOT dh/dt} over {1.3 { Q}_{r CDOT f }I } )} } }}}} If a sufficient number of observations are available, an alternative procedure can be applied. A rating curve may be drawn as a median line through the uncorrected values. The values of {{{{ { 1} over {cI } }}}} can be yielded from the measured quantities of Qr$.$f and dh/dt by use of Eq. (7) and (8). From the 1/cI v. stage relationship, new vlues of 1/cI are obtained and inserted in Eq. (7) and (8) to yield the steady-state discharge Q. The new values of Q are then plotted against stage as the corrected steadystate curve.

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고상 결정화로 제작한 다결성 실리콘 박막 트랜지스터에서의 열화특성 분석 (The Analysis of Degradation Characteristics in Poly-Silicon Thin film Transistor Formed by Solid Phase Crystallization)

  • 정은식;이용재
    • 한국전기전자재료학회논문지
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    • 제16권1호
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    • pp.26-32
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    • 2003
  • Then-channel poly-Si thin-film transistors (poly-Si TFT's) formed by solid phase crystallization (SPC) method on glass were measured to obtain the electrical parameters such as of I-V characteristics, mobility, leakage current, threshold voltage, and subthreshold slope. Then, devices were analyzed to obtain the reliability and appliability on TFT-LCD with large-size and high density. In n-channel poly-Si TFT with 5$\mu\textrm{m}$/2$\mu\textrm{m}$, 8$\mu\textrm{m}$, 30$\mu\textrm{m}$ devices of channel width/length, the field effect mobilities are 111, 116, 125 $\textrm{cm}^2$/V-s and leakage currents are 0.6, 0.1, and 0.02 pA/$\mu\textrm{m}$, respectively. Low threshold voltage and subthreshold slope, and good ON-OFF ratio are shown, as well. Thus. the poly-Si TFT's used by SPC are expected to be applied on TFT-LCD with large-size and high density, which can integrate the display panel and peripheral circuit on a targe glass substrate.

V자형 배치 외부강선을 이용한 PSC I거더교의 보강 효과 (Reinforcement Effects using V Type External Strands on PSC I Girder Bridges)

  • 백승철;송재호;김행배;김석수
    • 한국구조물진단유지관리공학회 논문집
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    • 제20권3호
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    • pp.49-57
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    • 2016
  • 본 연구에서는 PSC I거더교에 대한 외부강선을 이용한 보강 방법 중 V자형 보강방식의 효용성을 검증하기 위하여 공용중인 교량을 대상으로 보강장치를 시공하여 보강효과를 분석하였다. 따라서 PSC I거더교의 보강 전과 후 각각의 경우에 대하여 정적 및 동적 재하실험을 실시하였다. 그리고 재하실험에서 측정된 결과를 면밀히 분석하고, 구조해석을 통해 얻은 결과와도 비교분석하여 외부 프리스트레스 도입을 통한 보강효과를 검증하였다. 본 연구에서 외부강선을 이용한 보강방법을 적용하여 보강효과를 검토한 결과, 본 연구에서의 V자형 외부강선 보강방법을 적용할 때 횡방향 하중분배계수 곡선이 완만해져 상부구조의 건전성이 증진됨을 알 수 있었으며, PSC I거더교의 휨 성능 및 전단 성능개선뿐만 아니라 동적구조거동에도 크게 도움을 줄 수 있는 것으로 판단되고, 본 연구에서의 탄성패드를 적용할 때 동적보강효과가 극대화 된다는 것을 확인하였다.

STUDY OF THE MARINE CLOUD STRUCTURE WITH AQUA AMSR-E

  • Shoom, Mariya Yu.
    • 대한원격탐사학회:학술대회논문집
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    • 대한원격탐사학회 2006년도 Proceedings of ISRS 2006 PORSEC Volume II
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    • pp.1007-1010
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    • 2006
  • This study investigates the spatial structure of the total cloud liquid water content Q fields over the Northwest Pacific Ocean during winter monsoon. The distributions of Q have been estimated from the brightness temperatures of the ocean - atmosphere system $T_B(f)$, where f is frequency, measured by AQUA AMSR-E in January -March 2003. Marine strati (St) and stratocumuli (Sc) are typical for winter monsoon season. They were analysed using mainly high-frequency channel at f = 36.5 GHz, vertical polarisation. $T_B$ data were accompanied by the data on near surface wind speed, air temperature and humidity from the nearest meteorological stations. Tow one-dimensional spectra were computed for downwind and crosswind sections of Q fields. The AMSR-E antenna field of view (14-8 km) and the cloud field sizes (100-1000 km) restricted the spatial scales. The results of case study Jan 31 2003 are presented. Scale-invariant spectrum is typical. In the cases of extended St levels a spectral slope equals about -1.7, conforming to classical -5/3 of turbulence theory. For Sc cases the absolute magnitude of spectral slope is rather higher, as a rule. The value is about -2. In the case when cloud streets are presented, a strait line form of spectrum is less reliable with a slope being rather lower (about -1.4).

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나노 Ruthenium Oxide 고분자 복합재료 pH전극 (Nano-Ruthenium Oxide Polymeric Composite pH Electrodes)

  • 박종만
    • 대한화학회지
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    • 제62권4호
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    • pp.269-274
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    • 2018
  • 금속산화물 고분자 복합재료전극 제조기법을 수소이온 감응성이 높은 $RuO_2$에 적용하여 표면연마가 가능한 나노 $RuO_2$ 복합재료 pH전극을 제조하였다. $RuO_2$ 함량 53 wt%을 가지는 나노 $RuO_2$ 복합재료 전극의 경우 나노 $IrO_2$ 복합재료 전극과 비슷한 수소이온 감응특성을 나타내었다. pH 1~9의 범위에서 이론치에 가까운 -58.7 mV/pH의 감응기울기, 1초 이하의 감응속도, 평균 $-57.0{\pm}0.3mV/pH$ (n=5)의 표면재생성, 장기 안정성 등 제반 특성과 전기화학적으로 활성이 높은 화학종에 의한 방해효과도 비슷하게 나타났다. 그러나 pH 10 이상의 염기성 용액에서의 감응기울기와 감응속도는 나노 $IrO_2$ 복합재료전극에 비하여 현저히 떨어지는 결과를 보였으며 이는 복합재료 매질 속의 금속산화물 함량에 따른 물리적 성질 차이에 따른 것으로 추측된다.

Polymeric Acetate-Selective Electrodes Based on meso-(α,α,α,α)-Tetrakis-[(2-arylphenylurea)phenyl]porphyrins: Electormic and pH Effects

  • Lee, Hyo-Kyoung;Song, Ki-ju;Seo, Hyung-Ran;Jeon, Seung-won
    • Bulletin of the Korean Chemical Society
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    • 제23권10호
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    • pp.1409-1412
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    • 2002
  • Polymeric membrane electrodes for acetate anion based on meso-(${\alpha}$,${\alpha}$,${\alpha}$,${\alpha}$)-5,10,15,20-tetrakis[2-(penta-fluorophenylurea) phenyl]porphyrin I and similar urea-functionalized porphyrins Ⅱ-Ⅳ as neutral ionophores were prepared. The membrane based on porphyrin I exhibits the best potentiometric properties in pH 6.0 rather than pH 7.0: linear stable response over a wide concentration range (6.0 ${\times}$$10^{-5}$-1.0 ${\times}$$10^{-2}$) with a slope of -59.6 mV/decade and a detection limit of log[CH3CO$O^-$] = -5.32. Selectivity coefficients obtained from the matched potential method (MPM) in pH 6.0 indicate that interferences of hydrophobic anions are very small for the membranes of porphyrins I and II having the strong withdrawing group. The electronic effect of urea-functionalized porphyrins and pH effect of buffer solutions are discussed on the potentiometric response.

Polymeric Iodide-ion Selective Electrodes Based on Urea Derivative as an Ionophore

  • Jeong, Dae-Cheol;Lee, Hyo-Kyoung;Jeon, Seung-Won
    • Bulletin of the Korean Chemical Society
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    • 제27권12호
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    • pp.1985-1988
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    • 2006
  • The polymeric membrane electrodes based on urea derivative as an ionophore were prepared and studied for the iodide-ion selective electrode. This membrane exhibits a linear stable response over a wide concentration range ($1.0\;{\times}\;10^{-5}\sim1.0\;{\times}\;10^{-2}$) with a slope of -57.7 mV/decade, a detection limit of log[$I^-$] = -5.63, and a selectivity coefficient for iodide against perchlorate anion (log$K^{pot}_{I^-,j}$ = -1.42). The selectivity series of the membrane gives the follow as $I^-$ > $SCN^-$, $Sal^-$ > $ClO_4^-$ > $NO_3^-$ > $Br^-$ > $NO_2^-$ > $Cl^-$ > $F^-$. The proposed electrode showed good selectivity and response for iodide anion over a wide variety of other anions in pH 5.0 buffer solutions.

Polymeric Membrane Cesium-Selective Electrodes Based on Quadruply-bridged Calix[6]arenes

  • 최은미;오혜진;고승화;최용국;남계춘;전승원
    • Bulletin of the Korean Chemical Society
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    • 제22권12호
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    • pp.1345-1349
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    • 2001
  • New quadruply-bridged calix[6]arenes (I-V) have been studied as cesium selective ionophores in poly(vinyl chloride) (PVC) membrane electrodes. PVC membranes were prepared with dioctyl sebacate (DOS) or 2-nitrophenyl octyl ether (o-NPOE) as the sol vent mediator and potassium tetrakis(p-chlorophenyl)borate as the lipophilic salt additive. These ionophores produced electrodes with near-Nernstian slope. The selectivity coefficients for cesium ion with respect to alkali, alkaline earth and ammonium ions have been determined. The lowest detection limit (logaCs+ = -6.3) and the higher selectivity coefficient (logkpotCs+,Rb+ = -2.1 by SSM, -2.3 by FIM for calix[6]arene I) for Cs+ have been obtained for membranes containing quadruply-bridged calix[6]arenes (I, Ⅱ, Ⅲ), which have no para t-butyl substituents on the bridging benzene ring.

경사지에서 운용 가능한 대형 차량형 플랫폼 장비 자동수평조절장치의 동적 거동 (Dynamic Behavior Analysis of the Auto-leveling System for Large Scale Transporter Type Platform Equipment on the Ground Slope)

  • 하태완;박정수
    • 한국군사과학기술학회지
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    • 제23권5호
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    • pp.502-515
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    • 2020
  • To identify the dynamic characteristics of the Auto-leveling system applied to the Tractor-Trailer type Transporter for mounting a large scale precision equipment, Dynamics Modeling & Simulation were performed using general Dynamics Analysis Program - RecurDyn(V9R2). The axial load data, transverse load data and pad trace data of leveling actuators were obtained from M&S. And they were analyzed and compared with each other by parameters, i.e. friction coefficients on the ground, landing ram speed of actuators, and direction & quantity of ground slope. It was observed that ground contact friction coefficients affected to transverse load and pad trace; the landing ram speed of actuators to both amplitude of axial & transverse load, and this phenomena was able to explain from the frequency analysis of the axial load data; the direction of ground slope to driving sequence of landing ram of actuators. But the dynamic behaviors on the two-directional slope were very different from them on the one-directional slope and more complex.