• Journal of Industrial Convergence
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• v.17 no.4
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• pp.77-86
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• 2019

The purpose of this study was to identify the effect of Home Health Nursing based Respiratory Management Program (HHNbRMP) on unmet healthcare need and healthcare resource utilizations of patients applying the home mechanical ventilator in the home with amyotrophic lateral sclerosis. The subjects of this study were 40 patients placed in an experimental group(n=19) and a control group(n=21), respectively. This HHNbRMP based on Cox's interaction model was consisted of cognitive assent (education, specialized medical care, case management), internal motivation (airway clearance, thoracic and air accumulated exercise) and psychological response (meditation & active listening). The intervention was applied to experimental group during 12 weeks. As variables was measured at baseline, twelve, twenty-four weeks and healthcare unmet need, resource utilizations (admission, out patient department, emergency room) was measured at 24 weeks. The data were analyzed by t-test, ANOVA and Repeated Measures ANCOVA. This intervention was not effective the unmet healthcare need. But the admission in to the hospital among the healthcare resource utilizations variables showed a significant difference at twenty-four weeks(t=4.17, p=.049). This results suggest that applying this program tailored to patients condition, utility of medical resource would be decreased, specially admission.

• Journal of Gastric Cancer
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• v.20 no.1
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• pp.60-71
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• 2020

Purpose: The utility of 18-fluordesoxyglucose positron emission tomography ([¹⁸F]-FDG-PET) combined with computer tomography or magnetic resonance imaging (MRI) in gastric cancer remains controversial and a rationale for patient selection is desired. This study aims to establish a preclinical patient-derived xenograft (PDX) based [¹⁸F]-FDG-PET/MRI protocol for gastric cancer and compare different PDX models regarding tumor growth and FDG uptake. Materials and Methods: Female BALB/c nu/nu mice were implanted orthotopically and subcutaneously with gastric cancer PDX. [¹⁸F]-FDG-PET/MRI scanning protocol evaluation included different tumor sizes, FDG doses, scanning intervals, and organ-specific uptake. FDG avidity of similar PDX cases were compared between ortho- and heterotopic tumor implantation methods. Microscopic and immunohistochemical investigations were performed to confirm tumor growth and correlate the glycolysis markers glucose transporter 1 (GLUT1) and hexokinase 2 (HK2) with FDG uptake. Results: Organ-specific uptake analysis showed specific FDG avidity of the tumor tissue. Standard scanning protocol was determined to include 150 μCi FDG injection dose and scanning after one hour. Comparison of heterotopic and orthotopic implanted mice revealed a long growth interval for orthotopic models with a high uptake in similar PDX tissues. The H-score of GLUT1 and HK2 expression in tumor cells correlated with the measured maximal standardized uptake value values (GLUT1: Pearson r=0.743, P=0.009; HK2: Pearson r=0.605, P=0.049). Conclusions: This preclinical gastric cancer PDX based [¹⁸F]-FDG-PET/MRI protocol reveals tumor specific FDG uptake and shows correlation to glucose metabolic proteins. Our findings provide a PET/MRI PDX model that can be applicable for translational gastric cancer research.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.6
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• pp.88-97
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• 2018

Computer modeling and optimization works have been performed for the separation of the binary mixture of 1-propanol and benzene through a pressure-swing distillation. PRO/II with PRIVISION V10.0 at Schneider Electric company and NRTL liquid activity coefficient model were utilized. The sum of the total reboiler heat duties of the low-high and high-low pressure column configurations were compared. To minimize the utility consumptions, low column, and high column to obtain pure benzene at the top, the number of theoretical stages and optimal feed tray locations for each distillation column were determined and the reflux ratios for each distillation column were also adjusted. As a result of the optimization works, the sum of the total reboiler heat duties for the high-low and low-high pressure configurations were $3.10{\times}10^6kcal/h$ and $2.75{\times}10^6kcal/h$, respectively. In the case where heat integration was applied to low-high pressure configurations, 57.36 % of the total reboiler heat duties could be saved compared to the high-low pressure configurations.

• Journal of Wetlands Research
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• v.19 no.2
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• pp.202-210
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• 2017

Shear stress is one of the most important mechanical factors used in various fields and is important for the design of artificial channels. Current shear stresses have been used in the past, but there are factors that are difficult to actually measure or calculate, such as bed shear stress and energy slope in the equation used. In particular, the energy slope is a very difficult factor to estimate, and it is difficult to estimate the slope and flow velocity of the boundary layer although the energy slope can be used to obtain the shear stress distribution. In addition, the bed shear stress among the shear stress distribution is very difficult to measure directly, and the research is somewhat slower than the velocity. In this study, we have studied the simple calculation of the average flow velocity and the shear stress distribution using entropy M without reflecting the energy gradient, and we used existing laboratory data to demonstrate the utility of the applied equation. The stress distribution in the graphs was comparatively analyzed. In the case of the uniform flow and the non-uniform flow, the correlation coefficient was almost identical to 0.930-0.998.

• Journal of Korea Water Resources Association
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• v.49 no.5
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• pp.361-372
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• 2016

Reliable long-term dam inflow prediction is necessary for efficient multi-purpose dam operation in changing climate. Since 2000s the teleconnection between global climate indices (e.g., ENSO) and local hydroclimate regimes have been widely recognized throughout the world. To date many hydrologists focus on predicting future hydrologic conditions using lag teleconnection between streamflow and climate indices. This study investigated the utility of teleconneciton for predicting dam inflow with 1-month lead time at Andong dam basin. To this end 40 global climate indices from NOAA were employed to identify potential predictors of dam inflow, areal averaged precipitation, temperature of Andong dam basin. This study compared three different approaches; 1) dam inflow prediction using SWAT model based on teleconneciton-based precipitation and temperature forecast (SWAT-Forecasted), 2) dam inflow prediction using teleconneciton between dam inflow and climate indices (CIR-Forecasted), and 3) dam inflow prediction based on the rank of current observation in the historical dam inflow (Rank-Observed). Our results demonstrated that CIR-Forecasted showed better predictability than the other approaches, except in December. This is because uncertainties attributed to temporal downscaling from monthly to daily for precipitation and temperature forecasts and hydrologic modeling using SWAT can be ignored from dam inflow forecast through CIR-Forecasted approach. This study indicates that 1-month lead dam inflow forecast based on teleconneciton could provide useful information on Andong dam operation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.9
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• pp.25-31
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• 2020

In this study, for the safe use of a portable ultrasonic skin-beauty device, an android app was developed to show the irradiation locations of focused ultrasound to a user through augmented reality (AR) and enable stable self-surgery. The utility of the app was assessed through testing. While the user is making a facial treatment with the beauty device, the user's face and the ultrasonic irradiation location on the face are detected in real-time with a smart-phone camera. The irradiation location is then indicated on the face image and shown to the user so that excessive ultrasound is not irradiated to the same area during treatment. To this end, ML-Kit is used to detect the user's face landmarks in real-time, and they are compared with a reference face model to estimate the pose of the face, such as rotation and movement. After mounting a LED on the ultrasonic irradiation part of the device and operating the LED during irradiation, the LED light was searched to find the position of the ultrasonic irradiation on the smart-phone screen, and the irradiation position was registered and displayed on the face image based on the estimated face pose. Each task performed in the app was implemented through the thread and the timer, and all tasks were executed within 75 ms. The test results showed that the time taken to register and display 120 ultrasound irradiation positions was less than 25ms, and the display accuracy was within 20mm when the face did not rotate significantly.

• Environmental and Resource Economics Review
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• v.13 no.3
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• pp.337-366
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• 2004

Contingent Valuation Method (CVM), as non-market valuation approach, has been criticized on that respondents may not realistically reflect their budget constraints in answering willingness to pay (WTP) for hypothetical CV questions. This paper empirically estimates the income calibration factor associated with CV responses through combining travel cost method and contingent valuation method in a utility-theoretic framework. The joint model of recreation demand function and contingent WTP function was applied to an important case study on the Man Kyoung River system, whose water quality is at issue because of the Sae Alan Kum reclamation project. Relevant economic variables such as price, income and water quality had significant influence as anticipated by the economic theory. Equally important, the income calibration factor was not significantly different from one, suggesting that the systematic discrepancies of CV responses relative to the actual behavior was not detected at least in terms of budget exaggeration. Overall, this study supports the notion that carefully designed CVM studies can provide informative data on individuals' willingness to pay for environmental quality changes.

• Biomolecules & Therapeutics
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• v.19 no.1
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• pp.38-44
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• 2011

Cisplatin is widely used for various types of cancers. However, its side effects, most notably, renal toxicity often limit its clinical utility. Although previous metabolomic studies reported possible toxicity markers, they used small number of animals and statistical approaches that may not perform best in the presence of intra-group variation. Here, we identified urinary biomarkers associated with renal toxicity induced by cisplatin using NMR-based metabolomics combined with Orthogonal Projections to Latent Structures-Discriminant Analysis (OPLS-DA). Male Sprague-Dawley rats (n=22) were treated with cisplatin (10 mg/kg single dose), and the urines obtained before and after treatment were analyzed by NMR. Multivariable analysis of NMR data presented clear separation between non-treated and treated groups. The OPLS-DA statistical results revealed that 1,3-dimethylurate, taurine, glucose, glycine and branched-chain amino acid (isoleucine, leucine and valine) were significantly elevated in the treated group and that phenylacetylglycine and sarcosine levels were decreased in the treated group. To test the robustness of the approach, we built a prediction model for the toxicity and were able to predict all the unknown samples (n=14) correctly. We believe the proposed NMR-based metabolomics with OPLS-DA approach and the resulting urine markers can be used to augment the currently available blood markers.

• Journal of Korean Society of Disaster and Security
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• v.10 no.1
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• pp.1-10
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• 2017

Recently, increasing cases of ground subsidence in the urban area has become social issue, and related bill has been passed. Ground subsidence occurs through complex combination of various factors, and numerical analysis of this problem is limited thereby. This is why verification of ground subsidence mechanism has been conducted through physical modelling. Previous researches has been focused on modelling ground subsidence caused by utility pipe defects, and there has been insufficient physical modelling study on ground subsidence caused by various reasons such as groundwater flow and excavation activity. Also, most previous physical modelling studies were performed in 1g condition, which cannot take the in-situ stress condition into the evaluation of the ground subsidence mechanism. Therefore, in this study, physical modelling techniques to simulate various conditions is discussed by studying the previous researches on the ground subsidence mechanism through physical modelling. Also, centrifuge modelling test is suggested in this study as the technique to perform more reliable evaluation of ground subsidence mechanism. Lastly, this study suggests to apply the techniques used in the evaluation of ground subsidence mechanism into Ground Stability Assessment.

• Journal of Korean Society of Forest Science
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• v.102 no.1
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• pp.15-23
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• 2013

This study aims to analyze factors affecting villagers' participation in conservation of village woodlands. We postulated that socio-economic characteristics such as gender, age, place of birth, wealth level, frequency of use and leader experience could contribute to decision-making of participation in the village woodland conservation. Data were collected by interviewing 52 villagers in village A and 41 villagers in village B and were used to estimate the probability function of villager's participation in village woodland conservation using ordered logit model. The results indicate that frequent use of village woodlands increases the probability of villagers' participation in conservation of village woodlands in the case of village A. In the case of village B, people who were born in the village and have experiences of serving the village as a village leader are more likely to participate in the village woodland conservation activities. Considering the fact that the village woodland of village A is owned by the community as a village common, and that cultural activities remain in the village woodland of village A, the utility of village woodlands to the residents and their common understanding of village woodlands seem to influence the likelihood of villagers' participation in conservation of village woodlands. In order to induce villagers' participation in the village woodland conservation, it is necessary to recognize the right of villager's access and provide villagers with common understanding of village woodlands through cultural activities and education programs.