• BMB Reports
• /
• v.43 no.8
• /
• pp.524-529
• /
• 2010

Glucocorticoids (GCs) are useful drugs for the treatment of various diseases, but their use for prolonged periods can cause severe side effects such as osteoporosis. GCs have a direct effect on bone cells, where they can arrest bone formation, in part through the inhibition of osteoblast. On the other hand, GCs potently suppress osteoclast resorptive activity by disrupting its cytoskeleton based on the inhibition of RhoA, Rac and Vav3 in response to macrophage colony-stimulating factor. GCs also interfere with microtubule distribution and stability, which are critical for cytoskeletal organization in osteoclasts. Thus, GCs inhibit microtubule-dependent cytoskeletal organization in osteoclasts, which, in the context of bone remodeling, further dampens bone formation.

• Annals of Clinical Neurophysiology
• /
• v.6 no.1
• /
• pp.1-13
• /
• 2004

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that primarily affects motor neurons. The characteristic features of this devastating disorder are the simultaneous presence of upper and lower motor neuron (LMN) signs with progression from one region of the neuraxis to the next and eventual death, typically from respiratory compromise. Electrophysiological studies are an indispensible part of the ALS evaluation, especially serving as an extension of the clinical examination, and most useful in identifying LMN dysfunction. Not only may electrodiagnostic studies reveal characteristic changes in those regions clinically manifesting signs, but it also serves to disclose asymptomatic areas of involvement.

• Transactions of the Korean Society of Mechanical Engineers
• /
• v.15 no.2
• /
• pp.596-603
• /
• 1991

Fatigue life prediction of pressure vessel is studied analytically using cumulative damage models and linear elastic fracture mechanics method. The stresses are analyzed by finite element method. During operation, the maximum stress occurs at the outside of neck region while fatigue analysis indicates that the bottom of nozzle part has the shortest fatigue life. Previously proposed fatigue life prediction equation and cumulative damage model are modified successfully by introducing reference fatigue modulus. It is found that the modified life prediction equation and damage model are useful for lower stress level application.

• Proceedings of the KSME Conference
• /
• 2004.11a
• /
• pp.441-446
• /
• 2004

Mechanical systems with rubber parts have been used widely in industry fields. The evaluation of the physical characteristics of rubber is important in rubber application. Rubber material is useful to machine component for excellent shock absorbing characteristics. The impact characteristics of rubber were examined by experimental and finite element method. The impact test was conducted with a free-drop type impact tester. The ABAQUS/Explicit was used for finite element analysis. The effects of thickness and diameter of the cylindrical rubber structures were investigated. The impact absorbing ratio of the rubber material was studied order to compare the peak reaction force of the specimen which only contained aluminum against the specimen with the inserted rubber part.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
• /
• 2002.04a
• /
• pp.215-220
• /
• 2002

Recently, linear motor has been developed for linear motion of machine tools. Linear motor is useful to design the linear motion, high speed and high accuracy, because of the simple system not required the additional mechanical part such as coupling and ballscrew. This paper tested performance of linear motor relevant to motioning and positioning table such as F.R.F., step response and positional accuracy Linear motion system using linear motor requires the effective cooling system because it cause to decrease the positional error and to protect the motor coil. Therefore the positional error measurement was made to evaluate the effect of the temperature variation.

• Journal of the Korean Society of Environmental Restoration Technology
• /
• v.19 no.5
• /
• pp.29-45
• /
• 2016

This study identified vulnerable regions in the national parks of the Republic of Korea (ROK). The potential vulnerable regions were defined as areas showing a decline in forest productivity, low resilience, and high sensitivity to climate variations. Those regions were analyzed with a regression model and trend analysis using the Enhanced Vegetation Index (EVI) data obtained from long-term observed Moderate Resolution Imaging Spectroradiometer (MODIS) and gridded meteorological data. Results showed the area with the highest vulnerability was Naejangsan National Park in the southern part of ROK where 32.5% ($26.0km^2$) of the total area was vulnerable. This result will be useful information for future conservation planning of forest ecosystem in ROK under environmental changes, especially climate change.

• Korean Journal of Biological Psychiatry
• /
• v.4 no.1
• /
• pp.36-42
• /
• 1997

Higher cognitive functions refer to the highest level of human intellectual functioning, including concept formation, reasoning, and executive functions. The executive functions can be conceptualized as having four components : volition, planning, purposive action, and effective performance. Because higher cognitive functions represent the most advanced stages of intellectual development, they are often highly susceptible to the effects of brain injuries and mental disorders. The ability to perform effectively within the environment is determined in large part by an individual's adequacy in performing such higher-order functions. Especially executive functions are necessary for appropriate, socially responsible, and effectively self-serving adult conduct. Threfore, an assessment of the psychiatric patient's performance in these areas will provide useful diagnostic information, as well as information concerning social and vocational prognosis.

• Journal of the Korean Society for Precision Engineering
• /
• v.22 no.9 s.174
• /
• pp.202-211
• /
• 2005

This paper introduces and illustrates the results of a new method fer offsetting triangular mesh by moving all vertices along the multiple normal vectors of a vertex. The multiple normal vectors of a vertex are set the same as the normal vectors of the faces surrounding the vertex, while the two vectors with the smallest difference are joined repeatedly until the difference is smaller than allowance. Offsetting with the multiple normal vectors of a vertex does not create a gap or overlap at the smooth edges, thereby making the mesh size uniform and the computation time short. In addition, this offsetting method is accurate at the sharp edges because the vertices are moved to the normal directions of faces and joined by the blend surface. The method is also useful for rapid prototyping and tool path generation if the triangular mesh is tessellated part of the solid models with curved surfaces and sharp edges. The suggested method and previous methods are implemented on a PC using C++ and illustrated using an OpenGL library.

• Journal of the Korean Society for Precision Engineering
• /
• v.19 no.6
• /
• pp.160-165
• /
• 2002

A study on digital processes of injection mold in reverse engineering are presented. Reverse engineering is useful fur several cases, where user has no geometry information of object. Laser scanner is used to obtaining 3D coordinates of object. Sequences to process cloud data are described; sampling to reduce number of points, sorting to adjust the point order, and fitting to curve and surface, and so on. Split slide structure of mold is used fur undercut part and high viscosity material. Flow of injection molding are analysed to correct cooling channel and simulate molding conditions. NC tool paths are generated to carve core and cavity. The processes are performed in digital data for reduction of lead time and consecutive geometry data.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 2005.06a
• /
• pp.305-308
• /
• 2005

Linear motor has been developed for linear motion of machine tools. Linear motor is useful to design the linear motion, high speed and high accuracy, because of the simple system not required the additional mechanical part such as coupling and ballscrew. This paper tested performance of linear motor such as velocity response, position tracing performance, subordinate Traction force change and positional accuracy.