• BMB Reports
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• 제40권1호
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• pp.119-124
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• 2007

Adenoviral vectors are among the most promising vectors available for human gene therapy. However, the use of recombinant adenoviral vectors, including replicationcompetent adenovirus (RCA), raises a variety of safety concerns in relation to the development of new therapies based on gene therapy. To examine how organic compounds change in rat plasma following the injection of adenovirus, $\beta$-galactosidase expressing recombinant adenovirus (designated rAdLacZ) or RCA, we investigated the content of fatty acids (FAs), which are important biochemical indicators in pathological conditions. Pattern recognition analysis on the level of FAs in rat plasma is described for the visual discrimination of adenovirus infection groups from normal controls. Plasma FAs from four control rats (normal group), and from four rats with rAdLacZ infection and six rats with RCA infection (the two abnormal groups), were examined by gas chromatography-mass spectrometry in selected ion monitoring modes as their tert-butyldimethylsilyl derivatives. In total, 20 FAs were positively detected and quantified. The results of the Student's t-test on the normal mean of two abnormal groups, the levels of three FAs (p<0.05) from rAdLacZ group and eleven FAs (p<0.05) from RCA group were significantly different. When star symbol plotting was applied to the group mean values of 20 FAs after normalization to the corresponding normal mean values, the resulting eicosagonal star patterns of the two infected groups were distorted into similar shapes, but were distinguishable from each other. Thus, these approaches will be useful for screening and monitoring of diagnostic markers for the effects of infection following the use of adenoviral vectors in gene therapy.

• Journal of Preventive Medicine and Public Health
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• 제37권3호
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• pp.267-273
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• 2004

Objectives : This study was aimed at investigating the medical service utilization pattern of patients who use public medical aid compared to those who have health insurance. Methods : We selected every patient between the age of 18 and 69 who used public medical aid from January 1, 1999, to December 31, 2001, in Gwangju metropolitan city, South Korea. For comparison, a list of patients with health insurance was gathered for same period. Then the medical records of those who had been hospitalized for acute appendicitis were selected among both groups. Of those records, we compared the number of cases of ruptured appendicitis to cases of whole acute appendicitis in both groups. Regarding coding for ruptured appendicitis, International Classification of Diseases - 10 (ICD-10) was used. Multiple logistic regression was used as a statistical tool to determine the effectiveness of risk factors. Results : Even after adjusting for risk factors, such as age and sex, the proportion of perforation of acute appendicitis among public medical aid patients was found to be significantly higher than among insured patients. Conclusions : This comparative study on ruptured appendicitis among public medical aid patients and insured patients, indicates that the proportion of perforation of acute appendicitis could be an index showing that these types of patients utilize medical services differently than insured patients. We know that when abdominal pain is not properly treated at the outset, it easily develops into ruptured appendicitis complicated with peritonitis. Considering this data analysis, we guess the public medical aid system to have significant problem with medical accessibility. So additional and systematic research on the pattern of utilization of medical services of public medical aid patients is needed.

• 사상체질의학회지
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• 제24권3호
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• pp.17-33
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• 2012

Objectives We aimed to analyze the meanings of ordinary symptoms and the developing aspects of present symptoms according to the ordinary symptoms based on the Soeumin pathology, and present the new methodology to make use of the ordinary symptoms in the clinical field. Methods The Soeumin symptomatology and pathology of the Sinchuk Edition (the upgraded and revised edition) of "Donguisusebowon" were reviewed and examined for relevant information on the ordinary symptoms. Results and Conclusions 1) In the Soeumin symptomatology, the representative symptoms, by which the aspects of whole physio-pathological conditions can be decided, were showed as ordinary symptoms, and especially the aggravated state of the deflection of Seong-Jeong are presented additionally in the ordinary symptoms of the unfavorable patterns of Exterior and Interior symptomatologies. 2) In the Soeumin symptomatology, the ordinary symptoms have the clinical meanings as 'pathological predisposition', and can be estimated as one symptomatology in the whole schemes of symptomatology. 3) In the Soeumin symptomatology, the ordinary symptoms can affect the present symptoms, and can be the principal factors in the pattern identifications of the present symptoms and the determinations of therapeutical prescriptions. 4) In the Soeumin symptomatology, the ordinary symptoms can develop to the present symptoms across the Interior or the Exterior symptomatologies within the categories of the favorable and unfavorable patterns, and this developing aspects can be explained from the Soeumin pathological perspective.

• 대한의용생체공학회:의공학회지
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• 제26권1호
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• pp.9-16
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• 2005

One of the most important roles of a brain atlas is providing a spatial reference system in which multiple images can be interpreted in a consistent way. The brain atlase based on Western populations such as the International Consortium for Brain Mapping's 452 T-1 Weighted Average Atlas was widely used; however, they may not be the optimal choice for use with brain images from other ethnic groups, because structural differences between occidental and oriental brains have been reported. Therefore, in this study, we created an average brain atlas from 100 healthy Koreans (100 cases (M/F=53/47), 39.0±17.0 years). The purpose of this study was to make a Korean average-brain atlas and to measure its differences from a widely accepted average brain atlas built on an occidental population. The average brain atlas for Koreans was developed using widely accepted tools and procedures. The comparison between the Korean and occidental averages was performed using tissue probability maps and a registration tool, and it was shown that the global pattern of differences between the two average brains found in this work agreed with previously reported differences: Korean brains are wider and shorter in size, and smaller in volume, yet no hemispheric volume asymmetry was found.

• Archives of Plastic Surgery
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• 제32권1호
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• pp.105-109
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• 2005

Perineal area is composed of compact structures of urogenital organs and anus requiring a more sophisticated selection of flap and reconstruction. For achieving better outcome then conventional flap surgery, we use the perineal perforator based island flap for its reconstruction. After locating the perforator by Doppler, the flaps were designed according to the defect or expected vaginal orifice. The flaps were elevated bilaterally as island pattern. Finally defect or neovagina was reconstructed with inconspicious linear scar hidden in the inguinal crease. Five cases were performed with the perineal perforator based island flap. There were 3 cases of vulvar cancer, 1 case of transsexualism, and 1 case of ambiguous genitalia because of congenital adrenal hyperplasia. Operative results were satisfactory with good contouring and less prominent donor scar, when they were compared with other flap reconstructions such as latissimus dorsi perforator flap, groin flap, gracilis myocutaneous flap etc. The perineal perforator based island flap is highly recommended with the advantages of easy flap elevation, good rotation arc, and appropriate flap thickness for contouring. Compared with other conventional flaps, it can be selected as a good option for moderate defect of perineal area.

• Journal of Oral Medicine and Pain
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• 제31권2호
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• pp.167-176
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• 2006

최근에 안모에 관심이 증가하면서 안모비대칭에의 불편을 호소하는 환자가 증가하고 있으며 안모 비대칭 평가에는 고가의 3차원적인 영상이 많이 이용되었다. 본 연구에서는 치과영역에서 쉽게 접할 수 있으며 비교적 저렴한 파노라마방사선 사진과 정모방사선 사진을 이용하였다. 안모 비대칭에 대한 골격적인 평가를 하고자 본 연구에 지원한 대상자 중에 특이할만한 전신 질환자나 특이한 교합을 지닌 대상을 제외한 35명을 택하여 파노라마 방사선 사진과 정모 방사선 사진을 촬영하였으며, 저작 형태와 안모 비대칭을 인지하는 정도를 설문지 형식으로 조사하여 다음과 같은 결과를 얻었다. 1. 파노라마 방사선 사진상의 좌우측 비교에서 하악의 수직적 측정 항목인 Co-Go(p<0.05), Co-Ag(p<0.05)에서 하악각 측정 항목에서는 Co-Go-Ag(p<0.05), Go-Me-Ag(p<0.01) 유의한 차이를 보였다. 2. 파노라마방사선 사진에서 저작측에 따른 평가에서는 하악의 수직적 길이측정치에서 우측 저작자는 Co-Ag(p<0.01) 좌측 저작측에서는 Co-Go(p<0.05)에서 유의성을 보였다. 3. 정모 방사선사진 상의 좌우측 안모비대칭 비교에서는 Cg-Go(p<0.01), 우측 저작자에서는 Co-Ag(p<0.01) 좌측 저작자에서는 Cg-Go(p<0.05)에서 유의한 차이를 보였다. 4. 안모비대칭이 있다고 인지하는 군에서 하악의 수직적 측정 항목인 Co-Go(p<0.05)에서 유의성을, 하악각의 측정항목인 Co-Si-Cr(p<0.05), Go-Me-Ag(p<0.05)에서 유의성을 보였다. 안모가 좌측이 더 길다고 인지하는 군에서는 Go-Ag(p<0.05)의 수평적 계측 항목이 우측이 더 길었으며, 우측안모가 길다고 인지하는 군에서는 Co-Go(p<0.05)와 Co-Ag(p<0.01)의 하악의 수직적 측정치에서 유의성을 보였다.

• 동의생리병리학회지
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• 제20권1호
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• pp.65-68
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• 2006

It was examined the effect of fermented rice wine using mycelium of Phellinus linteus (FWPL) on the gastric mucosa of rat. The gastric mucosal lesions were not seen macroscopically in normal, but ethanol-administrated rats produced congestion and edema with a few local lesions. The administration of FWPL showed a similar pattern as like normal except trace histopathological changes. The results of Western blot analyses showed that the higher expression of inducible nitric oxygenase (iNOS), cyclooxygenase (COX)-1, COX-2, tumor necrosis factor-$\alpha$ and c-fos, especially COX-2, in the ethanol-administrated rat compared with normal rat. But FWPL-administrated rat showed a trace increase of these expression compared to normal rat. About immunohistochemical observations, weaker iNOS reactions were detected in mucous cells of epithelim of ethanol administrated rat compared with normal and FWPL-administrated rat. These results suggested that FWPL-administrated rat showed a trace changes on the mucus barrier-related protein expression compared with ethanol-administrated rat and thus FWPL may be use to develop a functional alcoholic beverage.

• 대한한의학회지
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• 제42권1호
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• pp.59-74
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• 2021

Objectives: This study is to analyze Acupuncture Methods(鍼法) using Five Transport Points(五輸穴) and to consider the direction of development. Methods: This study focuses on Acupuncture Methods(鍼法) using Five Transport Points(五輸穴) that Five Phase Theory(五行學說) has been applied as a compound and it is designated Five Phase-Five Transport Points-Acupuncture Method(FPT Acupuncture Method, 五行五輸穴鍼法). Principles, Acupuncture Points(經穴), standards of diagnosis and treatment subjects of FPT Acupuncture Methods used in practices of Korean Medicine (韓醫學) were analyzed through updated literature. Next, the theoretical issues of FPT Acupuncture Methods regarding the composition of selecting exclusively on Five Transport Points(五輸穴) and targeted treatment subjects were investigated. Based upon the investigation, the future direction of development was studied. Results & Conclusions: Firstly, pattern identification and treatment of FPT Acupuncture Methods targeted mostly on Viscera and Bowels(臟腑). However, some showed the tendency to Five Phases Reductionism(五行 還元主義) which attempts to apply Five Phase Theory(五行學說) to symptoms that were not related to Viscera and Bowels(臟腑). Secondly, Five Transport Points(五輸穴) are theoretically related to 'Viscera and Bowels in Concept of Visceral Manifestation(臟象臟腑)'. Thirdly, when the cause of the symptoms exceeds the main therapeutic range of FPT Acupuncture Methods, it is effective to add Acupuncture Points(經穴) excluding Five Transport Points(五輸穴). And also, it is efficient to use Acupuncture Methods(鍼法) that is not based on principles of Five Phase Theory(五行學說). For the accomplishment, further researches on the approaches to apply basic Korean Medical principles such as Three Yin and Three Yang(三陰三陽) into Acupuncture Methods(鍼法) and Acupuncture Points(經穴) are necessary.

• 한국병원경영학회지
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• 제12권4호
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• pp.1-21
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• 2007

The relaxation of the regulation in selection of medical institution allows patients to use their own judgement in choosing proper institution for their diseases. Since the change of the regulation, there should have been many changes in medical institution selection behavior. The analysis of the change in disease specific selection pattern is critical because there be an optimal selection criteria that ensure the efficient and effective utilization of medical resources. This study analysis the institution selection factors by comparing the choice among the cases of acute diseases, the cases of chronic diseases, inpatient services, outpatient services, and emergency medical service. The comparisons performed in terms of size, class and other characteristics of medical institutions. For the study the nationally surveyed database was used and the data were analyzed using logistic regression procedure. The results indicates that the primary care facilities were not properly utilized. This study speculates that the reason for the undesirable pattern of utilization is that the roles of primary care facilities in the healthcare delivery system was not clearly defined. Based on the results, the medical policy implications are discussed.

• 대한세포병리학회지
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• 제6권2호
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• pp.193-198
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• 1995

The increased use of thyroid fine needle aspiration(FNA) has re-focused on $H\"{u}rthle$ cell lesions. The cytologic diagnosis of $H\"{u}rthle$ cell tumor is a challenge due to the presence of $H\"{u}rthle$ cells in non-neoplastic lesions and the inability to differentiate between benign and malignant $H\"{u}rthle$ cell tumor. We report a case of $H\"{u}rthle$ cell adenoma(HCA) un a 68-year old woman, with review of the cytopathologic findings. FNA revealed loosely cohesive or sheets of large oval to polygonal $H\"{u}rthle$ cells containing abundant granular cytoplasm. The hustopathologic examination confirmed the diagnosis of HCA with follicular growth pattern. Ultrastructurally, the cytoplasm was packed with variable sized mitochondria.