• Analytical Science and Technology
• /
• v.23 no.1
• /
• pp.83-88
• /
• 2010

For the evaluation of our laboratory's 11-nor-${\Delta}^9$-tetrahydrocannabinol-9-carboxylic acid (THCCOOH) urinalysis test, THCCOOH urinalysis test was carried out with Certified Reference Material (CRM). The used CRM was THCCOOH in freeze-dried urine produced by NIST as Standard Reference Material 1507b. Comparing the estimated value of our laboratory with CRM, the results was coincided in the confidence level of approximately 95%.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.17
• /
• pp.7241-7244
• /
• 2014

Background: To determine the accuracy of preoperative urinary symptoms, urinalysis, computed tomography (CT) and cystoscopic findings for the diagnosis of urinary bladder invasion in patients with colorectal cancer. Materials and Methods: Records of patients with colorectal cancer and a suspicion of bladder invasion, who underwent tumor resection with partial or total cystectomy between 2002 and 2013 at the Faculty of Medicine Siriraj Hospital, were reviewed. Correlations between preoperative urinary symptoms, urinalysis, cystoscopic finding, CT imaging and final pathological reports were analyzed. Results: This study included 90 eligible cases (71% male). The most common site of primary colorectal cancer was the sigmoid colon (44%), followed by the rectum (33%). Final pathological reports showed definite bladder invasion in 53 cases (59%). Significant features for predicting definite tumor invasion were gross hematuria (OR 13.6, sensitivity 39%, specificity 73%), and visible tumor during cystoscopy (OR 5.33, sensitivity 50%, specificity 84%). Predictive signs in CT imaging were gross tumor invasion (OR 7.07, sensitivity 89%, specificity 46%), abnormal enhancing mass at bladder wall (OR 4.09, sensitivity 68%, specificity 66%), irregular bladder mucosa (OR 3.53, sensitivity 70%, specificity 60% ), and loss of perivesical fat plane (OR 3.17, sensitivity 81%, specificity 43%). However, urinary analysis and other urinary tract symptoms were poor predictors of bladder involvement. Conclusions: The present study demonstrated that the most relevant preoperative predictors of definite bladder invasion in patients with colorectal cancer are gross hematuria, a visible tumor during cystoscopy, and abnormal CT findings.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.21 no.6
• /
• pp.1641-1645
• /
• 2007

This study was designed to investigate about the efficiency of herb treatment at the patients with urinary tract infection. The Patient group was consisted of 33 CVA patients who were diagnosed as abnormal on urinalysis at the Oriental Medical hospital of Dong-eui University from July in 2006 to April in 2007. And we divided the patient group to 3 of small groups(Bojungikitang, Kumokpaljungsan, and the others herb). Then we treated the patients with each herbs and checked urinary nitrate, leukocyte, bacteria, WBC after 3 days, 7 days. The results are as follows: Each herbs improved the results of urinalysis inspection. The efficiency of each herbs about UTI begins to be indicated after 3days. Each herbs applied to UTI is more effective after 7 days than after 3 days. As the results, the herb treatments improve effectively the result of urinalysis inspection when precsribing to UTI patients more 7 days.

• The Journal of the Institute of Internet, Broadcasting and Communication
• /
• v.23 no.4
• /
• pp.41-46
• /
• 2023

Human urine is a process of excreting waste products in the blood, and it is easy to collect and contains various substances. Urinalysis is used to check for diseases, health conditions, and urinary tract infections. There are three methods of urinalysis: physical property test, chemical test, and microscopic test, and chemical test results can be easily confirmed using urine test strips. A variety of items can be tested on the urine test strip, through which various diseases can be identified. Recently, with the spread of smart phones, research on reading urine test strips using smart phones is being conducted. There is a method of detecting and reading the color change of a urine test strip using a smartphone. This method uses the RGB values and the color difference formula to discriminate. However, there is a problem in that accuracy is lowered due to various environmental factors. This paper applies a deep learning model to solve this problem. In particular, color discrimination of a urine test strip is improved in a smartphone using a lightweight CNN (Convolutional Neural Networks) model. CNN is a useful model for image recognition and pattern finding, and a lightweight version is also available. Through this, it is possible to operate a deep learning model on a smartphone and extract accurate urine test results. Urine test strips were taken in various environments to prepare deep learning model training images, and a urine test service application was designed using MobileNet V3.

• The Journal of Internal Korean Medicine
• /
• v.26 no.4
• /
• pp.741-752
• /
• 2005

This study was done to investigate recovery effects of YJT, which has been used clinically in diabetes therapy. Mice were administerd Alloxan to induce diabetes. There body weight and kidney weight changes, BUN, creatinine, glucose, total protein and ALP activity in serum, urinalysis, excretion volume of Na+, K+ in urine were measured. The results were as follows: 1. Increase in body weight and kidney weight and the ratio of kidney to body weight of YJT treated group showed similar results with those of normal group. 2 The BUN, creatinine, ALP activity levels in serum of YJT treated group were similar with those of normal group. 3. The glucose level in serum of YJT treated group was better than that of control group 4. The result of the urinalysis in the group of YJT was almost same as that of control group The above results suggest that YJT partially improves the function of the kidney.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.18 no.6
• /
• pp.1908-1912
• /
• 2004

This study was designed to assess the clinical effects of Inginoryung-san on liver function. : Inginoryung-san was prescribed for the patient for 14 months. Symptoms were checked repeatedly, and liver function test(such as AST, ALT, ALP, GGT ect.) were done, as well as urinalysis, to evaluate improvement. After 14 months treatment with Inginoryung-san, most symptoms disappeared or improved. Liver function test and urinalysis showed improvement. The above results that Inginoryung-san is beneficial for patient with abnormal liver functions.

• The Journal of Korean Medicine
• /
• v.30 no.3
• /
• pp.79-85
• /
• 2009

Aim : To evaluate the pharmaceutical safety of the herbal formula Myelophil, composed of Astragali Radix and Salviae Radix, via systemic subacute toxicological study using SD rats. Methods : Forty male and 40 female SD rats were fed with Myelophil (5000, 2500 or 1250 mg/10 mL/kg) or distilled water for four weeks. Adverse effects were examined intensively by comparing the differences between normal and drug-administered groups using clinical signs, necropsies, histopathologic findings, hematology, urinalysis, and blood biochemical analysis. Results : No altered clinical symptoms including body weight, diarrhea, anorexia, death, and abnormal necropsy of major organs were observed in male or female rats. No drug-induced abnormalities in histopathological finding, hematological values, urinalysis, and blood biochemical values were found at any doses of Myelophil. Conclusion : Myelophil should be very safe when used in a clinical application with a wide therapeutic index.

• Biomolecules & Therapeutics
• /
• v.10 no.2
• /
• pp.117-123
• /
• 2002

CJ-10882, (E)-[(3-Cyclopentyloxy-4-methoxyphenyl)methylene]hydrazine-carboxamide, is a newly developed type IV phosphodiesterase isozyme (PDE IV) inhibitor. To investigate the subacute toxic effects of CJ-10882, it was administered to both male and female dogs at 0, 25, 50, 100 or 200 mg/kg/day orally for up to 2 weeks. During the test period, clinical signs, mortality, body weight, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, gross finding, organ weight, and histopathology were evacuated. Several clinical signs were observed in treated dogs at above 25 mg/kg, including salivation and vomiting. A reduction in the body weight was observed in both sexes at above 50 mg/kg. There were no treatment-related effects on mortality, ophthalmoscopy, urinalysis, hematology, sect biochemistry, necropsy findings, and histopathology in any treatment group. The results of this study demonstrate that CJ-10882, a selective Inhibitor of the type IV class of PDE, may cause effects on gastrointestinal tract and salivary glands. Therefore, these organs should be closely examined in studies with other PDE IV inhibitors.

• Toxicological Research
• /
• v.31 no.4
• /
• pp.393-402
• /
• 2015

This study was conducted to measure toxicity of 1-chloropropane (CAS No. : 540-54-5). According to the OECD Test Guideline 413 (Subchronic inhalation toxicity: 90-day study), SD rats were exposed to 0, 310, 1,250, and 5,000 ppm of 1-chloropropane for 6 h/day, 5 day/week for 13 weeks via whole-body inhalation. Mortality, clinical signs, body weights, food consumption, motor activity, ophthalmoscopy, hematology, serum chemistry, urinalysis, organ weights, gross and histopathological findings were compared between control and all tested groups. No mortality or remarkable clinical signs were examined during the study. No gross lesions or adverse effects on body weight, food consumption, motor activity, ophthalmoscopy, urinalysis, hematology, organ weights were observed in any of male or female rats in all tested groups. In serum biochemistry, glucose was significantly decreased in males of 1,250 and 5,000 ppm groups compared to control group in dose-dependent relationship. In histopathological examination, vacuolation of acinar cells was observed in pancreas of all male and female groups exposed to 1-chloropropane. In conclusion, no observable adverse effect level (NOAEL) was considered to be below 310 ppm/6 h/day, 5 day/week for rats.

• Toxicological Research
• /
• v.18 no.3
• /
• pp.241-248
• /
• 2002

The present study was conducted to investigate the potential subacute toxicity of CJ-10882 by a 4-week repeated oral dose in dogs. The test article was administered once dally by gavage to dogs at dose levels of 0, 2, 10, and 50 mg/kg/day for 4 weeks. During the test period, clinical signs, mortality, body weights, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, gross finding, organ weight, and histopathology were evaluated. Several clinical sign were observed in treated dogs at 50 mg/kg, including salivation and vomiting. Increase in the serum level of ALT and albumin observed in the female 50 mg/kg group was considered as a toxic effect related to the test article since the histopathological change in Liver was accompanied. There were no treatment-related effects on mortality, food and water consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, necropsy findings and organ weights in any treatment group. Based on these results, target organ was not observed and the no-observed-adverse-effect level (NOAEL) was 10 mg/kg/day and the absolute toxic dose was 50 mg/kg for both male and female dogs.