• 한국기록관리학회지
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• 제18권4호
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• pp.231-257
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• 2018

본 연구는 이산가족 찾기 기록 검색을 위한 패싯 기반 온톨로지 모델을 제안하였다. 온톨로지 모델링을 위한 패싯 분석은 상향식 방법으로 KBS 아카이브 이산가족 찾기 기록과 국가기록원 기록의 원문 내용과 기술요소를 분석하고, 하향식 방법을 통해 이산가족 찾기 기록의 특성인 방송 기록과 사건 중심 기록의 특성을 분석하여 패싯을 도출하였다. 패싯은 KBS 이산가족기록, 출처, 인물, 원본기록, 사건의 5개 상위클래스와 18개의 하위클래스로 구성되었다. 설계된 이산가족 찾기 기록 온톨로지 모델은 실제 이용자에 의해 평가가 수행되었으며, 대체로 이산가족 찾기 기록 검색과 이용 측면에서 접근점, 기록의 맥락 정보 제공, 기술요소 제공에 있어서 충분하고 적절하다고 평가되었다.

• 대한약침학회지
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• 제25권2호
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• pp.79-87
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• 2022

Since ancient times, plants have been a major source of novel drug molecules and have been used in the treatment of different infectious diseases. Secondary plant metabolites have miraculous healing properties and show potent therapeutic responses when used in combination drug therapy. The prime objective of this review is to summarize the concept of drug combination with special emphasis on the synergistic interactions between plant-derived bioactive phytochemicals with commercially available antimicrobial agents. The study also assesses the roles, importance, and applicability of phytochemicals in the management of different diseases. The review focuses on different aspects of combined antimicrobial activities, the possible mechanisms involved, and the current status of research in the field. The study was conducted based on an extensive literature survey that resulted in the following hypothesis: secondary metabolites derived from plants possess remarkable therapeutic activities. The study was designed as a systematic review that ensures unbiased and accurate representations of the relevant data and information. Jadad scale selection criteria were used for qualitative analysis of the articles to assess them based on the relevant secure score (minimum and maximum scores range between 1 and 5, respectively). Articles with secure scores > 3 were considered for the study. A comprehensive literature survey was conducted using resource databases including PubMed, Google Scholar, Bielefeld Academic Search Engine, Research Gate, Scopus, Medline, and Science Direct up to June 2019. This article contains concise information about the most commonly used bioactive phytochemicals with potent antifungal and antibacterial effects.

• Archives of Plastic Surgery
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• 제34권6호
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• pp.671-678
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• 2007

Purpose: Venous malformation(VM) which often causes pain and discomfort is the most common type of vascular malformations. Although it is presented with disfigured appearance and associated soft tissue or skeletal hypertrophy, the molecular bases of VMs are poorly understood. Differentially expressed genes(DEGs) of VMs were investigated to illuminate the molecular mechanism of the disease entity. Methods: Gene expressions of VM patients' subcutaneous tissue were studied in comparison with normal persons' by $GeneFishing^{TM}$ technique using the annealing control primers (ACPs) to identify DEGs. Candidate genes were sequenced and screened by basic local alignment search tool (BLAST) afterwards. Results: Among seventy DEGs identified, forty DEGs which had shown significantly different expression pattern were sequenced. Twenty eight out of 40 were up-regulated while 12 were down-regulated. BLAST searches revealed that 37 were known genes and 3 were unknown genes. Many genes were involved in the differentiation and remodeling of smooth muscle cells, opposed to the previous hypothesis that a lot of angiogenetic genes would be involved. Furthermore, several transcription factors and related genes, as well as cell signaling and metabolism regulators, were up regulated. Conclusion: It suggests that analysis of DEGs in VMs provide basic knowledge about its pathophysiology. and new therapeutic approaches.

• 조명전기설비학회논문지
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• 제23권1호
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• pp.162-168
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• 2009

본 논문에서는 태양전지를 가지고 일정량의 태양광으로부터 최대 유효전력을 얻기 위해 고정식 태양광 발전시스템과 태양 위치추적기를 부착한 태양광 발전시스템에서 PV모듈의 각도 변화 및 어레이 간격에 따른 최적의 발전효율에 대한 연구 및 실험을 하였다. 먼저, PV 모듈의 다양한 각도를 가지고 실험한 결과 PV 모듈 경사각 30[$^{\circ}$]에서 측정한 결과 값이 경사각 20[$^{\circ}$] 및 40[$^{\circ}$]일 때보다 발전 효율이 $12{\sim}17$[%] 상승되었다. 그러므로 본 논문의 연구 결과에서는 태양광 발전시스템의 실용화 측면에서 PV 모듈의 경사각 30[$^{\circ}$] 설치를 하여 발전을 하는 것이 가장 좋은 변환 효율을 얻을 수 있었다. 하지만 태양전지를 지붕 및 옥상에 설치를 할 경우, 면적 활용이 좁고 겨울에 눈이 쌓이게 될 경우에는 경사각에 의해 빠르게 쓸려 내려갈 수 있도록 경사각을 35[$^{\circ}$]로 선정하는 것이 타당하다.

• 생물정신의학
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• 제13권2호
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• pp.110-116
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• 2006

Objectives : Alteration of hippocampus was demonstrated in the maternal social separation(MSS) pups, separated from dams on postnatal day(pnd) 14 and placed alone. Therefore, to understand the molecular events involved in the MSS, we have initiated a search for gene profiles that are up or down-regulated in the hippocampus of MSS pups. Methods : Analysis of cDNA microarray was performed by using total RNA extracted from the hippocampus of control and MSS pups on pnd 17. Also, passive-avoidance test was demonstrated on pnd 35. Results : Up-regulation of Nedd4a was observed in the hippocampus of MSS pups. Also, MSS rats showed less elongation of latency in passive avoidance test. Conclusion : We suggest that environmental effects of MSS may be altered the neural and/or glial differentiation and synapse formation-related genes which may lead cognitive alterations in MSS rats.

• 천문학회보
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• 제36권2호
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• pp.122.2-122.2
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• 2011

For more than a decade, NEA (Near-Earth Asteroid) survey teams equipped with 1 meter-class telescopes discovered thousands of NEAs in the northern sky. As of August 2011, some 8,200 NEAs have been cataloged, yet only five percent of them has been investigated for their physical and chemical properties. In order to improve current situation, we propose a deep ecliptic survey utilizing KMTNet, for detection and characterization of NEAs in the southern sky. Thanks to the wide-field capability (four square degrees) of the telescopes, we will be able to considerably expand the search volume carrying out precision photometry down to 21.5th magnitude. We plan to focus our survey on opposition and two "sweet spots" in the ecliptic belt. Since SDSS colors characterize mineralogical properties of NEAs, g', r', i', z' filters will be employed. Based on the round-the-clock observation, we will study their rotational properties; for multiple systems, mass, density and other physical parameters can be obtained. We plan to maintain a dedicated database of the physical and mineralogical properties of NEAs. With this archive, it is expected that our understanding on the population will see a drastic change. We also plan to participate in the GAIA Follow-Up Network for ground based observation of the Solar System Objects (GAIA-FUN-SSO). The follow- up astrometry will be performed upon alerts issued by the GAIA-FUN-SSO Central Node in France.

• 동의신경정신과학회지
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• 제26권2호
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• pp.117-130
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• 2015

Objectives: Banhahoobak-tang has been used to treat plum-pit qi, chest and hypochondriac distension, moist or greasy tongue coat, and wiry slow or wiry slippery pulse. It might be used to control coughing and vomiting. We observed that Banhahoobak-tang extract (BHTe) had anti-psychological stress effect. The objective of this study was to determine the effect of BHTe on restoring the transcriptional regulation of genes related to psychological stress. Methods: After giving psychological stress to mice, BHTe was orally administered at 100 mg/kg/day for five days. After extracting whole brain tissue from the mice, the gene expression changes were determined by microarray. Transcription factor binding site (TFBS) analysis showed up- and down-regulated genes related to psychological stress were protected by BHTe and segregated according to the structure of TFBS. We performed text based Pubmed search to select significant target genes involved in psychological stress affected by BHTe. Results: 1. Serum corticosterone level was decreased in the BHTe administered group, although the psychological stress was increased. 2. The BHTe administered group had no significant change in noradrenaline content in brain tissue, but the psychological stress group had decreased level. 3. The BHTe administered group had increased time of staying at open-arm than the psychological stress group. 4. Microarray revealed that TANK and RARA genes were up-regulated genes while AES, CDC42, FOS, NCL, and PVR were down-regulated genes by psychological stress but restored by BHTe.

• Radiation Oncology Journal
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• 제19권4호
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• pp.389-396
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• 2001

목적 : 임상에서 사용하는 방사선량을 조사하여 환자의 자궁경부암 세포에서 유도되는 유전자를 검색하고자 하였다. 대상 및 방법 : 자궁경부암 환자에서 방사선치료 하루 전(대조군)과 1.8 Gy 조사후 40분 지나서(조사군) 자궁경부암 조직을 생검하여 각 군에서 total RNA를 추출하였다. differential display reverse transcription-polymerase chain reaction기법(DDRT-PCR)으로 발현이 증가 또는 감소된 유전자를 탐색하였다. 발현에 변화가 있는 cDNA를 추출하고 증폭하여 얻은 클론을 reverse Northern Blot방법을 이용하여 screening하였고, Northern Blot으로 확인하였다. sequencing을 실시한 후 NCBI database를 이용하여 blast search를 하였다. 발현이 감소한 유전자를 대상으로 다른 환자에서의 발현 양상을 확인하기 위하여 방사선치료를 받는 5명의 자궁경부암 환자를 대상으로 RT-PCR로 검사 하였다. 결과 : DDRT-PCR기법을 이용하여 방사선 조사군에서 발현이 증가 혹은 감소된 18개의 cDNA band를 발견하였다. reverse northern blot을 이용한 screening에서 발현이 증가된 10개의 클론과 감소된 1개의 클론을 확인하였다. 클로닝된 cDNA 조각들은 대부분 $400\~500\;bp$ 정도 되었으며, 그중 1개의 클론은 잘 알려져 있는 chemokine receptor CXCR4 유전자와 높은 상동성을 보였으며, 4개의 클론은 Human ESTs로 확인되었고 5개의 클론은 기능이 아직 확인되지 않은 알려져 있는 염기서열로 확인되었다. 방사선에 의하여 발현이 감소한 CxCa-11 클론이 모든 환자에서 방사선치료 전 시료에서 발현을 보였으나, 방사선치료 후 시료에서는 그 발현량이 감소하거나 발현이 안되었다. 결론 : DDRT-PCR을 이용하여 임상에서 자주 사용되는 방사선량을 환자의 자궁경부암에 조사했을 때 발현되는 유전자를 확인하였다. 이러한 유전자 발현의 확인은 방사선치료과정 중에 발생하는 일련의 기전들을 이해하는데 도움이 되리라 생각된다.

• 대한인간공학회지
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• 제31권6호
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• pp.757-764
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• 2012

Objective: The aim of this study is to find the optimal values of sliding factors which influence the mechanical emotion of users when they use sliding type mobile phones. Background: There are various researches that study the emotion of using mobile phones. They focus the correlation between emotion words and design factors and use the commercial products by the subjects in the experiment. However, it has a limit in finding the optimal point of emotional factors because we can search the restricted values in the mass production of the products. Therefore, we will find the optimal points by realizing the full range of the user's mechanical emotion. Method: First, we need to get the detailed factors which can describe the mechanical emotion in sliding up and down the mobile phone. Next, we find the control factors by considering the correlation between the factors of the sliding emotion and the possibility of quantitative design. To find the optimal points on the control factors, we make a sliding evaluation system which can help users feel the sliding mechanical emotion by realizing control factors. Finally, we find the optimal points by doing the experiment the system being used. Results: The critical values of the factors which are the main variables of this study are Open Max Force and Dead point Ratio. The optimal point of the Open Max Force is 200~250g/f, and the Dead point Ratio is 40~50%. Conclusion: In this study we develop the sliding evaluation system to realize the control factors of the sliding type phone and find the optimal values of the critical factors. Application: The results can be used as the criteria for designing sliding type phone.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.131-131
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• 2017

Though the Platycodon grandiflorum, has a broad range of pharmacologic properties, but the mechanisms underlying these effects remain unclear. In order to profile proteins from the nodal segment, callus, root and shoot, high throughput proteome approach was executed in the present study. Two-dimensional gels stained with CBB, a total of 84 differential expressed proteins were confirmed out of 839 protein spots using image analysis by Progenesis SameSpot software. Out of total differential expressed spots, 58 differential expressed protein spots (${\geq}2-fold$) were analyzed using MASCOT search engine according to the similarity of sequences with previously characterized proteins along with the UniProt database. Out of 58 differential expressed protein, 32 protein spots were up-regulated such as ribulose-1,5-bisphosphate carboxylase, endoplasmic oxidoreductin-1, heat stress transcription factor A3, RNA pseudourine synthase 4, cysteine proteinase, GntR family transcriptional regulator, E3 xyloglucan 6-xylosyltransferase, while 26 differential protein spots were down-regulated such as L-ascorbate oxidase precursor, late embryogenesis abundant protein D-34, putative SCO1 protein, oxygen-evolving enhancer protein 3. However, the frequency distribution of identified proteins using iProClass databases, and assignment by function based on gene ontology revealed that the identified proteins from the explants were mainly associated with the nucleic acid binding (17%), transferase activity (14%) and ion binding (12%). Taken together, the protein profile may provide insight clues for better understanding the characteristics of proteins and its metabolic activities in various explants of this essential medicinal plant P. grandiflorum.