• 한국지반공학회논문집
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• 제28권5호
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• pp.77-84
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• 2012

Diatom 성분이 함유된 자연 퇴적토층의 공학적 특성은 대상층의 변형 및 강도의 특이한 특성 때문에 다수의 연구자에 의해 수 십년간 연구되어 왔다. 원반형 혹는 원통형 모양을 한 diatom의 존재는 재료의 낮은 압축성, 높은 투수성, 높은 전단강도 특성을 나타내게 하며, 이러한 특이한 차이점들은 큰 내부입자 간극과 모난 입자의 결합력으로 diatom의 특성을 나타낸다. 이러한 현상은 흙의 공학적 특성을 변화시켜서 지반개량 재료로써 diatom을 이용할 수 있음을 의미한다. 본 논문은 diatom 개량토의 공학적 특성을 연구하기 위해 diatom-kaolin 혼합토의 공학적 특성을 통상적인 지반공학 실험 및 탄성파를 이용한 미소변형 실험, 전자기파를 이용한 전기저항 측정실험 등을 통하여 평가하였다. 실험 결과에 따르면, diatom 함유량에 따라 흙의 공학적 개선이 이루어진 것을 확인할 수 있었으며, 높은 응력에서 diatom 입자의 결합이 파괴되어 일부 공학적 특성이 저감되는 것을 확인 할 수 있었다.

• Bulletin of the Korean Chemical Society
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• 제35권8호
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• pp.2494-2504
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• 2014

P38 mitogen activated protein (MAP) kinase is an important anti-inflammatory drug target, which can be activated by responding to various stimuli such as stress and immune response. Based on the conformation of the conserved DFG loop (in or out), binding inhibitors are termed as type-I and II. Type-I inhibitors are ATP competitive, whereas type-II inhibitors bind in DFG-out conformation of allosteric pocket. It remains unclear that how these allosteric inhibitors stabilize the DFG-out conformation and interact. Organosilicon compounds provide unusual opportunity to enhance potency and diversity of drug molecules due to their low toxicity. However, very few examples have been reported to utilize this property. In this regard, we performed docking of an inhibitor (BIRB) and its silicon analog (Si-BIRB) in an allosteric binding pocket of p38. Further, molecular dynamics (MD) simulations were performed to study the dynamic behavior of the simulated complexes. The difference in the biological activity and mechanism of action of the simulated inhibitors could be explained based on the molecular mechanics/generalized Born surface area (MM/GBSA) binding free energy per residue decomposition. MM/GBSA showed that biological activities were related with calculated binding free energy of inhibitors. Analyses of the per-residue decomposed energy indicated that van der Waals and non-polar interactions were predominant in the ligand-protein interactions. Further, crucial residues identified for hydrogen bond, salt bridge and hydrophobic interactions were Tyr35, Lys53, Glu71, Leu74, Leu75, Ile84, Met109, Leu167, Asp168 and Phe169. Our results indicate that stronger hydrophobic interaction of Si-BIRB with the binding site residues could be responsible for its greater binding affinity compared with BIRB.

• Korea-Australia Rheology Journal
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• 제20권3호
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• pp.109-116
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• 2008

The effect of intermolecular aggregation induced by hydrophobic and electrostatic interactions on shear and elongational flow properties of aqueous acrylic thickener solutions is discussed. Complex shear modulus is determined at frequencies up to $10^4$ rad/s employing oscillatory squeeze flow. Extensional flow behavior is characterized using Capillary Break-up Extensional Rheometry. Aqueous solutions of poly(acrylic acid)(PAA)/poly(vinylpyrrolidone-co-vinylimidazole) (PVP-VI) mixtures exhibit unusual rheological properties described here for the first time. Zero-shear viscosity of the mixtures increases with decreasing pH and can exceed that of the pure polymers in solution by more than two orders of magnitude. This is attributed to the formation of complexes induced by electrostatic interactions in the pH range, where both polymers are oppositely charged. PAA/PVP-VI mixtures are compared to the commercial thickener Sterocoll FD (BASF SE), which is a statistical co-polymer including (meth) acrylic acid and ethylacrylate (EA) forming aggregates in solution due to "sticky" contacts among hydrophobic EA-sequences. PAA/PVP-VI complexes are less compact and more deformable than the hydrophobic Sterocoll FD aggregates. Solutions of PAA/PVP-VI exhibit a higher zero-shear viscosity even at lower molecular weight of the aggregates, but are strongly shear-thinning in contrast to the weakly shear-thinning solutions of Sterocoll FD. The higher ratio of characteristic relaxation times in shear and elongation determined for PAA/PVP-VI compared to Sterocoll FD solutions reflects, that the charge-induced complexes provide a much stronger resistance to extensional flow than the aggregates formed by hydrophobic interactions. This is most likely due to a break-up of the latter in extensional flow, while there is no evidence for a break-up of complexes for PAA/PVP-VI mixtures. These flexible aggregates are more suitable for the stabilization of thin filaments in extensional flows.

• Radiation Oncology Journal
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• 제14권1호
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• pp.61-67
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• 1996

목적 : 접형동에 발생하는 일차성 암은 매우 드물어 전체 부비동 악성종양의 $0.3\%$를 차지한다. 접형동암이 드물게 발생되므로 많은 환자들을 분석하여 얻은 치료결과나 생존기간의 통계가 지금까지도 보고되지 않았다. 이에 본원에서 치료를 시행했던 접형동암 환자 1예의 치료경과를 보고하고자 한다. 증례 보고 : 일부 증례보고들과 소수의 환자들을 대상으로 했던 연구들을 재검토한 한 보고에 따르면 2년 생존율이 $7\%$였다. 본 증례는 접형동암으로 진단된 후 지금까지 29개월동안 생존하고 있다. 또한 척수내 전이는 암환자에서 드문 합병증인데 본 증례에서는 접형동암으로 진단된 후 25개월 만에 갑자기 하지 마비증세와 배뇨곤란을 호소하여 흉추부위를 MRI촬영한 결과 척수내 전이성종양을 3번 4번 흉추부위에서 관찰할 수 있었고 척수공동증을 그 이하부위에 동반하고 있었다. 저자들은 접형동암환자에서 척수공동증을 동반한 척수내 전이소견을 보인 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 한국지반환경공학회 논문집
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• 제21권5호
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• pp.5-11
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• 2020

구조물의 이상징후 판단 및 장단기 안정성, 장래 거동 등의 판단에 다양한 계측결과가 효율적으로 이용되기 위해서는 계측 데이터 내에 포함한 각종 이상치의 판정 및 제거가 필요하다. 본 연구에서는 장기 시계열 데이터에 대한 이상치 평가를 수행하기 위한 통합 이상치 분석 시스템을 개발하였다. 이상치 평가는 시계열 분석법에 의한 단일 데이터셋 대상의 1차 이상치 분석과 합성신호 기반의 다중 데이터셋에 대한 2차 이상치 분석으로 구분하여 단계별로 수행되었다. 통합 이상치 분석 시스템은 구조물에 대한 종합 안전관리 플랫폼과 실시간 연동되어 구조물의 각종 안전성 평가 및 거동 예측 등을 위한 기초자료를 제공할 수 있도록 개발되었다. 현장 적용을 통해 일정 경향을 보이는 동종의 다수 센서들의 합성신호와 개별 데이터셋 간의 상관성이 크게 증가함을 확인할 수 있었으며, 상관성에 대한 가중치 적용을 통해 차별 거동을 보이는 다양한 센서 계측치들도 모두 통합 이상치 분석에 활용될 수 있음을 확인 할 수 있었다.

• 인문언어
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• 제5권
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• pp.167-192
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• 2003

When Hart Crane′s poem cycle The Bridge was published in 1930, a group of influential reviewers accused Crane of immaturity, sentimentality, and lack of focus. They condemned crane′s wayward, fuzzy mysticism as backwards-looking and self-defeating. Even sympathetic critics, such as Harold Bloom, have consistently portrayed Crane′s poetry as the pyrotechnic final fizzle of late romanticism. These persistent, public reservations, however, have not prevented an impressive proliferation in secondary literature concerning Crane since the late 1960s. His promiscuity, alcoholism, erratic behavior, relative poverty, tragic death, and total commitment to art have since earned him the labels of New World Rimbaud and proto-Beat. His colorful career thus explains in part his retrospective fame. Nevertheless, living hard and dying young do not guarantee artistic immortality. This article poses questions as to why Crane has mattered so much to subsequent generations of U.S. readers and what these readers find so compelling in his poetry. The answer, I would argue, lies in Crane′s idiosyncratic use of language. Far from striving for transparency, he writes in an inimitably obstructive, artificial manner. There is something seductive and absurd in his wild use of words here, I would further argue, we discover the reason behind both Crane′s enduring appeal and his supposed inadequacy as a writer. Crane did "torture" syntax, semantics, and conventional associations, not because he saw his unusual language as an eccentric mannerism but because he saw it as a tool in the service of constructing a "myth of America" and reintegrating the human and divine. Understanding thy he considered this to be the case clarifies Crane′s achievement and illuminates why his work still seems so relevant today.

• 전산구조공학
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• 제10권4호
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• pp.303-313
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• 1997

계측점의 규모가 제한되어 있는 경우에 대형구조물의 모든 부재의 손상을 추정하는 것은 기술적으로 불가능하다. 따라서 본 연구에서는 최근에 국내외에서 많이 연구되고 있는 인공신경망이론을 이용하여 구조물의 손상을 추정하는 기법을 개발하였으며, 대형구조물의 손상을 계측자료로부터 보다 효과적으로 평가하기 위해 두 단계로 수행되는 손상부재 평가과정을 개발하였다. 먼저 합리적인 평가대상 부재선택을 위해 구조물의 파괴 또는 이상거동 등에 가장 큰 영향을 미치는 부재를 민감도분석을 통해 선정한 후, 선정된 부재의 손상추정에 가장 영향을 미치는 계측점과 적절한 계측기의 수를 민감도분석기법을 이용해 선정하는 기법이다. 다양한 예제를 통하여 본 연구에서 제안된 방법들의 적용가능성을 검증한 결과, 본 연구에서 개발한 기법을 적용하면 제한된 수의 계측자료를 가지고 보다 효과적으로 대형구조물의 파괴나 이상거동을 사전에 감지할 수 있는 것으로 분석되었다.

• Imaging Science in Dentistry
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• 제36권3호
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• pp.169-175
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• 2006

The Inflammatory myofibroblastic tumor (inflammatory pseudotumor) is a rarely occurring soft tissue lesion of unknown etiology. It can be of any location, but commonly it is found in lungs. It has been considered as a nonneoplastic reactive inflammatory lesion, but nowadays, confusion and dispute about its character is increasing due to its high recurrence rate and metastasis. We present a patient who had been diagnosed with an inflammatory pseudotumor in the right maxilla area, 1 year before visiting our hospital. After that, her pain and swelling did not resolved and she visit our hospital. On radiographic examination, aggressively infiltrative growth of the lesion with destruction of adjacent bony structure was noted. We found unusual aggressiveness of the inflammatory myofibroblastic tumor of the head and neck region. Because the typical behavior of the inflammatory myofibroblastic tumor is not defined yet, we recommend the surgical excision of the lesion and close follow-up.

• Tuberculosis and Respiratory Diseases
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• 제38권1호
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• pp.74-82
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• 1991

Bronchial carcinoid is one of the unusual tumors of the lung, accounting for 1 percent of all lung tumors. Carcinoids, like small cell carcinomas, are generally considered to be derived from a neurosecretary type of cell of the respiratory epithelium, the Kulchtsky's cell. So, they are no longer classified as bronchial adenoma, and are recently grouped into the neuroendocrine group of tumors, the so-called APUD (Amine Precursor Uptake Decarboxylase) group of tumors. Although usually characterized by a slow growth pattern and a low incidence of metastatic disease, bronchial carcinoids should no longer be considered as beingn, and a much higher malignant behavior has been described with a special destignation of 'atypical carcinoid'. Bronchial carcinoids are histologically confirmed by the azurophil staining and the presence of the characteristic neurosecretary granule on electron microscopy. Recently we experienced two cases of bronchial carcinoid, the first case, being peripheral-located and histologically proven as atypical carcinoid, and the second, being central-located and hitologically typical. So we report these cases with a review of the literature.

• 한국조경학회지
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• 제21권3호
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• pp.11-19
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• 1993

This study was intended to clarify the landscape characteristics of the Sosewon Gaden through interpreting the Kim, In Hu's 48 poems(in Chinese characters) which clearly represented the landscape image of th user about this garden by selecting the cultural position of how then the users of the garden interpreted and manipulated its landscape rather than the scientific position. The following were the results from the analysis and review of the review of the woodcut and the 48 poems through names and scenic element. 1. When analyzing the names, those names due to the human experience were the most. This revealed that sensitive perception and experience was emphasized in the garden life. 2. It was important that can be experienced as nature and human beings come in contact each other at stream. 3. The landscape of the Sosewon Garden empasized not only the elements of the form and their combination but also on the unusual experience of human behavior and climatic element. The elements of the form which was recognized as the subject of poet was regarded as the cultural one of this garden and had an ideological background to convey the meaning of the landscape. 4. The Sosewon Garden was divided into four characteristic spaces as it is considered in terms of the sense of place represented in the 48 poems; the approach space, the space for poetic recital, the ideal space, and the space of pleasure.