• Journal of Korean Society of Coastal and Ocean Engineers
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• v.10 no.2
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• pp.64-72
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• 1998

Dynamic response analysis is carried out for slender marine structures such as tensioned risers and tethers of tension leg platform, which are subjected to floating vessel motions as well as environmental forces arising from ocean waves. A mumerical analysis procedure is developed by using finite element model of the structural member. Dynamic analses are performed in the time domain for regular waves. Parameter studies are carried out to highlight the effects of surface vessel motions on the lateral dynamics of the structures. Example results of displacements, bending stresses are compared for various in water depth, environmental condition and vessel motion. Some instability conditions of the structures due to time-varying tension by vessel heave motion are discussed through the example analyses. As the results, the interaction between vessel surge and heave motions amplifies the total structural response of a riser. In the case of a tether, the effect of vessel heave motion during heavy storm is seemed to be quite significant to lateral response of the structure.

• Journal of Embryo Transfer
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• v.24 no.1
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• pp.1-14
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• 2009

Ovarian cancer is a significant cause of cancer-related death in women, but the main biological causes remain open questions. Hormonal factors have been considered to be an important determinant causing ovarian cancer. Recent studies have shown that gonadotropin-releasing hormone (GnRH)-I and its analogs have clinically therapeutic value in the treatment of ovarian cancer. In addition, numerous studies have shown that the potential of GnRH-II in normal reproductive system or reproductive disorder. GnRH-I receptors have been detected in approximately 80% of ovarian cancer biopsy specimens as well as normal ovarian epithelial cells and immortalized ovarian surface epithelium cells. GnRH-II receptors have also been found to be more widely expressed than GnRH-I receptors in mammals, suggesting that GnRH receptors may have additional functions in reproductive system including ovarian cancer. The signal transduction pathway following the binding of GnRH to GnRH receptor has been extensively studied. The activation of protein kinase A/C (PKA/PKC) pathway is involved in the GnRH-I induced anti-proliferative effect in ovarian cancer cells. In addition, GnRH-I induced mitogen-activated protein kinase (MAPK) activation plays a role in anti-proliferative effect and apoptosis in ovarian cancer cells and the activation of transcriptional factors related to cellular responses. However, the role of GnRH-I and II receptors, there are discrepancies between previous reports. In this review, the role of GnRH in ovarian cancer and the mechanisms to induce anti-proliferation were evaluated.

• Steel and Composite Structures
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• v.27 no.6
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• pp.717-725
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• 2018

One of the most important design criteria in military tunnels and armoured doors is to resist the blast loads with minimum structural weight. This can be achieved by using steel sandwich panels. In this paper, the nonlinear behaviour of steel sandwich panels, with different core materials: (1) Hollow (no core material); (2) Rigid Polyurethane Foam (RPF); and (3) Vulcanized Rubber (VR) under free air blast loads, was investigated using detailed 3D nonlinear finite element models in Ansys Autodyn. The accuracy of the finite element model proposed was verified using available experimental test data of a similar steel sandwich panel tested. The results show the developed finite element model can be reliably used to simulate the nonlinear behaviour of the steel sandwich panels under free air blast loads. The verified finite element model was used to examine the different parameters of the steel sandwich panel with different core materials. The result shows that the sandwich panel with RPF core material is more efficient than the VR sandwich panel followed by the Hollow sandwich panels. The average maximum displacement of RPF sandwich panel under different ranges of TNT charge (1 kg to 10 kg at a standoff distance of 1 m) is 49% and 53% less than the VR and Hollow sandwich panels, respectively. Detailed empirical design equations were provided to quantify the maximum deformation of the steel sandwich panels with different core materials and core thickness under a different range of blast loads. The developed equations can be used as a guide for engineer to design steel sandwich panels with RPF and VR core material under a different range of free air blast loads.

• Journal of Korean Society of Rural Planning
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• v.17 no.3
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• pp.103-111
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• 2011

The purpose of this study is to review foreign scenic inventory map for the systematic management of natural scenic resources. Several foreign cases were surveyed and analyzed to apply the scenery inventory map in domestic, such as Visual Resource Management(VRM) from United States Bureau of Land Management, Scenery Management System(SMS) from USDA Forest Service and Visual Landscape Inventory(VLI) from British Columbia Ministry of Forest's, that were already established scenery inventory maps. The results are as follows. First, the characteristic of Korean landscape is quite a different from those of north american's, which is much smaller and more complex in topography and land use. So, it would be difficult to apply foreign system directly and we need more researches to our own system. The multi-stepped landscape unit system is highly recommended. Second, scenic quality could be estimated by the pre-built database, such as land forms, vegetation, hydrology and land uses. Historical and cultural attributes should be complemented. Third, existing scenic integrity could be grasped by scenic damage, landscape alteration caused by human activities and land exfoliation. Also, subjective evaluation method should be supplemented by objective criteria through further detailed studies. Finally, about landscape view conditions, landscape control points should be surveyed and established in advance, and viewing distance, viewing frequency, amount of observers and public interests should be considered.

• Journal of the Mineralogical Society of Korea
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• v.21 no.2
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• pp.177-182
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• 2008

The Gemological characteristics of B.C. jade from Cassiar Mine, British Colombia, Canada, have been investigated, using polarizing microscopy, Mohs' hardness, refractive index and density measurements, X-ray powder diffraction, X-ray fluorescence spectrometry, ICP-MS, Infrared absorption spectrometry, and DTA/TGA. The B.C. jade is deeply green (spinach peen or olive green) in color and is translucent. It shows a resinous or waxy luster. The principal mineral of the material is tremolite-actinolite solid solution and minor amount of Cr-garnet and unidentified opaque minerals are accompanied. Mohs' hardness value ($5.5{\sim}6$). refractive index (1.62), and specific gravity (3.01) are measured. It is very highly tough and shows hackly fracture. The high Fe content ($Fe_2O_3\;4.14{\sim}4.66\;wt%$) in B.C. jade is attributable to a deepening of green color of the material. The B.C. jade starts to dehydrate at v and dehydration is completed at $1000.8^{\circ}C$, transforming tremolite-actinolite solid solution to enstatite, diopside, quartz, and water in its place. This possible reaction is supported by the weight loss of B.C. jade (1.93 wt%) at $1000.8^{\circ}C$ indicated by TGA curve.

• Journal of Microbiology and Biotechnology
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• v.16 no.12
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• pp.1841-1848
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• 2006

Insights into gene expression have the potential for improvement of antibiotic yield and the development of robust production hosts for use in recombinant biomolecule production. $Cubicin^{TM}$ (daptomycin for injection) is a recently approved antibiotic active against many Gram(+) pathogens, including those resistant to methicillin, vancomycin, and fluoroquinolones. Daptomycin is produced as a secondary metabolite by Streptomyces roseosporus. A 128 kb region of DNA including the daptomycin biosynthetic gene cluster (dpt) has been cloned. and sequenced. Using a selected array of nucleic acid probes representing this region, we compared the expression levels of the dpt genes between S. roseosporus wild-type (WT) and derived S. roseosporus high-producer of daptomycin (HP). We observed that the majority of the biosynthetic genes were upregulated in HP compared with WT; a total of 12 genes, including those encoding daptomycin synthetase, showed consistently and significantly higher expression levels, at least 5-fold, in HP compared with WT. In contrast, some genes, flanking the dpt cluster, were expressed at higher levels in the WT strain. The expression of housekeeping genes such as S. roseosporus rpsL, rpsG, and 16S (positive controls) and presumptive intergenic regions in the dpt cluster (negative control) were identical in the two strains. In addition, we compared transcription during the early, mid-log, and early-stationary phases of growth in the HP strain. The same set of genes was upregulated and downregulated under all conditions examined; housekeeping genes showed no relative change in expression level over the periods of growth tested. Analyses of this type would be of value in studies of strain improvement and also for the identification of gene regulation processes that are important for secondary metabolite production.

• Smart Structures and Systems
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• v.1 no.1
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• pp.83-101
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• 2005

This paper summarizes the application of a rational methodology for the structural assessment of older reinforced concrete Tunisian bridges. This methodology is based on ambient vibration measurement of the bridge, identification of the structure's modal signature and finite element model updating. The selected case study is the Boujnah bridge of the Tunis-Msaken Highway. This bridge is made of a continuous four-span simply supported reinforced concrete slab without girders resting on elastomeric bearings at each support. Ambient vibration tests were conducted on the bridge using a data acquisition system with nine force-balance accelerometers placed at selected locations of the bridge. The Enhanced Frequency Domain Decomposition technique was applied to extract the dynamic characteristics of the bridge. The finite element model was updated in order to obtain a reasonable correlation between experimental and numerical modal properties. For the model updating part of the study, the parameters selected for the updating process include the concrete modulus of elasticity, the elastic bearing stiffness and the foundation spring stiffnesses. The primary objective of the paper is to demonstrate the use of the Enhanced Frequency Domain Decomposition technique combined with model updating to provide data that could be used to assess the structural condition of the selected bridge. The application of the proposed methodology led to a relatively faithful linear elastic model of the bridge in its present condition.

• ALGAE
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• v.17 no.1
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• pp.41-51
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• 2002

Three dominant rocky intertidal macroalgae, the fucoids Fucus gardneri and Pelvetiopsis limitata (Phaeophyta) and the red alga Mazzaella cornucopiae (= Iridaea cornucopiae) on the west coast of Vancouver Island, British Columbia, Canada were used in a series of field experiments to examine interspecific interactions. These experiments showed complex patterns which included an interchange of negative (inhibition) and positive (facilitation) interactions depending on neighbor distance. Less fucoid recruitment occurred in the plots with greater percent cover of a turfforming red alga, M. cornucopiae. However, experimentally removing Mazzaella turf (the turf was considered to be "blocking" fucoid recruits or "shading" growing recruits) did not increase recruitment. This result indicated that there may be another factor(s) involved in the survivorship of juvenile fucoids in the turf-removed plots. Morphological differences in adult plants between Mazzaella and the two fucoids resulted in another type of interaction; these began when fucoids successfully settled and grew nearby or within the red algal turf. By monitoring microhabitat at the individual plant level for two years, I found that survivorship of fucoid recruits showed different species-specific patterns. The patterns also varied as the microhabitat changed from Mazzaella turf edge to open space. For F. gardneri, longevity of P.limitata at all distances tested was similar. A reason for greater longevity of F. gardneri individuals at edge microhabitats may be that these sites have one side open to light and nutrients and another site that buffers them from desiccation and wave impact. In the Mazzaella-Fucus interaction, neighbor distance was a key factor in determining whether the outcome of the interaction would be competition or facilitation (or protection). This study provides experimental evidence that detectable biological interactions occur in this upper intertidal algal community where physical conditions are usually severe, and also indicates the importance of small scale examination in understanding macroalgal interactions in intertidal habitats.

• Journal of the Korean Vacuum Society
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• v.13 no.4
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• pp.175-181
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• 2004

We investigated the stability of the DLC film coated on 304 stainless steel substrate by Radio frequency assisted chemical vapor deposition method. Fracture and spallation behaviour of the coating was observed during micro-tensile test of the fil $m_strate composite. As the tensile deformation progressed, the cracks of the film were observed in the perpendicular direction to the tensile axis. Further deformation resulted in the plastic deformation with $45^{\circ}$ slip bands on the substrate surface. Spallation of the film occurred with the plastic deformation, which was initiated at the cracks of the film and was aligned along the slip directions. We found that both the cracking and the spallation behaviors are strongly dependent on the pre-treatment condition, such as Ar plasma pre-treatment. The spallation of the film was considerably suppressed in an optimized condition of the substrate cleaning by Ar glow discharge. We observed the improved stability with increasing duration of Ar plasma pre-treatment.nt.

• Journal of the Korean Institute of Landscape Architecture
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• v.40 no.1
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• pp.1-11
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• 2012

Human thermal sensation based on a human energy balance model was analyzed in the study areas, the Changwon and Nanaimo sites, on clear days during thesummer of 2009. The climatic input data were air temperature, relative humidity, wind speed and solar and terrestrial radiation. The most effective factors for human thermal sensation were direct beam solar radiation, building view factor and wind speed. Shaded locations had much lower thermal sensation, slightly warm, than sunny locations, very hot. Also, narrow streets in the Nanaimo site had higher thermal sensation than open spaces because of greater reflected solar radiation and terrestrial radiation from their surrounding buildings. Calm wind speed also produced much higher thermal sensation, which reduced sensible and latent heat loss from the human body. By adopting climatic factors into landscape architecture, the human thermal sensation analysis method promises to help create thermally comfortable outdoor areas. The method can also be used for urban heat island modification and climate change studies.